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Entry version 123 (07 Apr 2021)
Sequence version 2 (02 Oct 2007)
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Protein

Ral guanine nucleotide dissociation stimulator-like 3

Gene

Rgl3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Guanine nucleotide exchange factor (GEF) for Ral-A. Potential effector of GTPase HRas and Ras-related protein M-Ras. Negatively regulates Elk-1-dependent gene induction downstream of HRas and MEKK1.2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-5673001, RAF/MAP kinase cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ral guanine nucleotide dissociation stimulator-like 3
Short name:
RalGDS-like 3
Alternative name(s):
RalGDS-related effector protein of M-Ras
Ras pathway modulator
Short name:
RPM
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Rgl3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1918996, Rgl3

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003068001 – 709Ral guanine nucleotide dissociation stimulator-like 3Add BLAST709

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei506PhosphoserineCombined sources1
Modified residuei510PhosphoserineCombined sources1
Modified residuei553PhosphoserineCombined sources1
Modified residuei568PhosphoserineCombined sources1
Modified residuei572PhosphoserineCombined sources1
Modified residuei577PhosphoserineCombined sources1
Modified residuei600PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3UYI5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3UYI5

PeptideAtlas

More...
PeptideAtlasi
Q3UYI5

PRoteomics IDEntifications database

More...
PRIDEi
Q3UYI5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
255320 [Q3UYI5-1]
255321 [Q3UYI5-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3UYI5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3UYI5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed. Expressed at high levels in the liver and kidney.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040146, Expressed in uterus and 140 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3UYI5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3UYI5, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with GTP-bound forms of RIT1, HRAS and MRAS.

2 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
214896, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000035726

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3UYI5, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini64 – 201N-terminal Ras-GEFPROSITE-ProRule annotationAdd BLAST138
Domaini248 – 503Ras-GEFPROSITE-ProRule annotationAdd BLAST256
Domaini612 – 699Ras-associatingPROSITE-ProRule annotationAdd BLAST88

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni611 – 706Interaction with HRAS, MRAS and RIT12 PublicationsAdd BLAST96

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi114 – 123Pro-rich10
Compositional biasi535 – 598Pro-richAdd BLAST64

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Ras-associating domain plays a central role in the activation of Ral-A GDP/GTP exchange activity.1 Publication

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3629, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161935

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_010252_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3UYI5

Identification of Orthologs from Complete Genome Data

More...
OMAi
FWDPPAH

Database of Orthologous Groups

More...
OrthoDBi
940219at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3UYI5

TreeFam database of animal gene trees

More...
TreeFami
TF315204

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00155, RasGEF, 1 hit
cd06224, REM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.840.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000159, RA_dom
IPR008937, Ras-like_GEF
IPR000651, Ras-like_Gua-exchang_fac_N
IPR019804, Ras_G-nucl-exch_fac_CS
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf
IPR030750, RGL3
IPR029071, Ubiquitin-like_domsf

The PANTHER Classification System

More...
PANTHERi
PTHR23113, PTHR23113, 1 hit
PTHR23113:SF220, PTHR23113:SF220, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00788, RA, 1 hit
PF00617, RasGEF, 1 hit
PF00618, RasGEF_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00314, RA, 1 hit
SM00147, RasGEF, 1 hit
SM00229, RasGEFN, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48366, SSF48366, 1 hit
SSF54236, SSF54236, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50200, RA, 1 hit
PS00720, RASGEF, 1 hit
PS50009, RASGEF_CAT, 1 hit
PS50212, RASGEF_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3UYI5-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MERTAGKELA LAPLQDWGEE TEDGAVYSVS LRRQRSQRST PERSGEGQTP
60 70 80 90 100
IPATDTFLHY RTSKVRALRA ARLERLVHEL VSGDREQDPG FVPAFLATHR
110 120 130 140 150
AFVPTARVLG FLLPPPPPPP PPPAGVDSKR TEGQDLNFSK NLRAVVSVLG
160 170 180 190 200
SWLRNHPQDF RDPPDHQNLG NVRIFLGWAA PGGAEAREAE KLLEDFLKEA
210 220 230 240 250
KGEQTEEEKR LAWSGPPRIA QTPGSEFAED CVEEEGPSSE GPELLDFSVD
260 270 280 290 300
DVAEQLTLMD VELFLRVRSC ECLGSMWSQR DRPGAAGISP TVRATVAQFN
310 320 330 340 350
TVTGCVLGSV LAAPGLAASQ RAQRIEKWIR IAQRCRELRN FSSLRAILSA
360 370 380 390 400
LQSNPIYRLK RSWGAVSREP LSVFRKLSQI FSDEDNHLSS RAILSQEETT
410 420 430 440 450
EDDDCPSGSL PSKLPPGPVP YLGTFLTDLV MLDTALPDTL KGNLINFEKR
460 470 480 490 500
RKEWEILARI QQLQQRCQRY SLSPRPPILA ALRAQRQLSE EQSYRVSRVI
510 520 530 540 550
EPPAASCPSS PRIRRRISLT KRLSAKLSRE KNSSPGGSPG DPSSPTSSVS
560 570 580 590 600
PGSPPSSPRN REPPPPGSPP ASPGPQSPST KLSLTMDPPG PWPVTLTPSS
610 620 630 640 650
SRVPLLGQQT SEARVIRVSI NNNHGNLYRS ILLTCQDKAP SVVQRALEKH
660 670 680 690 700
NVPQPWARDY QLFQVLPGDR ELLIPDGANV FYAMSPAAPG DFLLRRKEGT

GHTLSASPT
Length:709
Mass (Da):77,945
Last modified:October 2, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i60F7CEA71873E609
GO
Isoform 2 (identifier: Q3UYI5-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-99: Missing.
     100-125: RAFVPTARVLGFLLPPPPPPPPPPAG → MAPCTASPCGGSAASARPQRGLEKAR
     442-442: G → V
     443-709: Missing.

Show »
Length:343
Mass (Da):37,545
Checksum:iB6646773E9E973B0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1ST67A0A1L1ST67_MOUSE
Ral guanine nucleotide dissociation...
Rgl3
87Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC35425 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti179A → V in AAF78208 (PubMed:10869344).Curated1
Sequence conflicti321R → K in BAB23634 (PubMed:16141072).Curated1
Sequence conflicti478I → N in BAE22227 (PubMed:16141072).Curated1
Sequence conflicti613A → T in BAC35425 (PubMed:16141072).Curated1
Sequence conflicti626N → K in BAC35425 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0284711 – 99Missing in isoform 2. 1 PublicationAdd BLAST99
Alternative sequenceiVSP_028472100 – 125RAFVP…PPPAG → MAPCTASPCGGSAASARPQR GLEKAR in isoform 2. 1 PublicationAdd BLAST26
Alternative sequenceiVSP_028473442G → V in isoform 2. 1 Publication1
Alternative sequenceiVSP_028474443 – 709Missing in isoform 2. 1 PublicationAdd BLAST267

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF237669 mRNA Translation: AAF78208.1
AF239661 mRNA Translation: AAK91126.1
AK004876 mRNA Translation: BAB23634.1
AK053550 mRNA Translation: BAC35425.1 Frameshift.
AK134654 mRNA Translation: BAE22227.1
AK131140 Transcribed RNA Translation: BAD21390.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS22916.1 [Q3UYI5-1]

NCBI Reference Sequences

More...
RefSeqi
NP_076111.2, NM_023622.4 [Q3UYI5-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000045726; ENSMUSP00000035726; ENSMUSG00000040146 [Q3UYI5-1]
ENSMUST00000214026; ENSMUSP00000148965; ENSMUSG00000040146 [Q3UYI5-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
71746

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:71746

UCSC genome browser

More...
UCSCi
uc009onf.1, mouse [Q3UYI5-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF237669 mRNA Translation: AAF78208.1
AF239661 mRNA Translation: AAK91126.1
AK004876 mRNA Translation: BAB23634.1
AK053550 mRNA Translation: BAC35425.1 Frameshift.
AK134654 mRNA Translation: BAE22227.1
AK131140 Transcribed RNA Translation: BAD21390.1
CCDSiCCDS22916.1 [Q3UYI5-1]
RefSeqiNP_076111.2, NM_023622.4 [Q3UYI5-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi214896, 4 interactors
STRINGi10090.ENSMUSP00000035726

PTM databases

iPTMnetiQ3UYI5
PhosphoSitePlusiQ3UYI5

Proteomic databases

jPOSTiQ3UYI5
PaxDbiQ3UYI5
PeptideAtlasiQ3UYI5
PRIDEiQ3UYI5
ProteomicsDBi255320 [Q3UYI5-1]
255321 [Q3UYI5-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
52109, 34 antibodies

The DNASU plasmid repository

More...
DNASUi
71746

Genome annotation databases

EnsembliENSMUST00000045726; ENSMUSP00000035726; ENSMUSG00000040146 [Q3UYI5-1]
ENSMUST00000214026; ENSMUSP00000148965; ENSMUSG00000040146 [Q3UYI5-1]
GeneIDi71746
KEGGimmu:71746
UCSCiuc009onf.1, mouse [Q3UYI5-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57139
MGIiMGI:1918996, Rgl3

Phylogenomic databases

eggNOGiKOG3629, Eukaryota
GeneTreeiENSGT00940000161935
HOGENOMiCLU_010252_1_1_1
InParanoidiQ3UYI5
OMAiFWDPPAH
OrthoDBi940219at2759
PhylomeDBiQ3UYI5
TreeFamiTF315204

Enzyme and pathway databases

ReactomeiR-MMU-5673001, RAF/MAP kinase cascade

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
71746, 3 hits in 52 CRISPR screens

Protein Ontology

More...
PROi
PR:Q3UYI5
RNActiQ3UYI5, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000040146, Expressed in uterus and 140 other tissues
ExpressionAtlasiQ3UYI5, baseline and differential
GenevisibleiQ3UYI5, MM

Family and domain databases

CDDicd00155, RasGEF, 1 hit
cd06224, REM, 1 hit
Gene3Di1.10.840.10, 1 hit
InterProiView protein in InterPro
IPR000159, RA_dom
IPR008937, Ras-like_GEF
IPR000651, Ras-like_Gua-exchang_fac_N
IPR019804, Ras_G-nucl-exch_fac_CS
IPR023578, Ras_GEF_dom_sf
IPR001895, RASGEF_cat_dom
IPR036964, RASGEF_cat_dom_sf
IPR030750, RGL3
IPR029071, Ubiquitin-like_domsf
PANTHERiPTHR23113, PTHR23113, 1 hit
PTHR23113:SF220, PTHR23113:SF220, 1 hit
PfamiView protein in Pfam
PF00788, RA, 1 hit
PF00617, RasGEF, 1 hit
PF00618, RasGEF_N, 1 hit
SMARTiView protein in SMART
SM00314, RA, 1 hit
SM00147, RasGEF, 1 hit
SM00229, RasGEFN, 1 hit
SUPFAMiSSF48366, SSF48366, 1 hit
SSF54236, SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50200, RA, 1 hit
PS00720, RASGEF, 1 hit
PS50009, RASGEF_CAT, 1 hit
PS50212, RASGEF_NTER, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRGL3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UYI5
Secondary accession number(s): Q6KAR7
, Q8BKD3, Q924M8, Q9DBL8, Q9JID4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 2, 2007
Last sequence update: October 2, 2007
Last modified: April 7, 2021
This is version 123 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Direct protein sequencing, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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