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Protein

P2X purinoceptor

Gene

P2rx5

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Receptor for ATP that acts as a ligand-gated ion channel.UniRule annotation

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionIon channelUniRule annotation, ReceptorUniRule annotationImported
Biological processIon transport, Transport

Enzyme and pathway databases

ReactomeiR-MMU-139853 Elevation of cytosolic Ca2+ levels
R-MMU-418346 Platelet homeostasis

Names & Taxonomyi

Protein namesi
Recommended name:
P2X purinoceptorUniRule annotation
Gene namesi
Name:P2rx5Imported
ORF Names:mCG_125429Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2137026 P2rx5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei31 – 50HelicalUniRule annotationAdd BLAST20
Transmembranei340 – 362HelicalUniRule annotationAdd BLAST23

Keywords - Cellular componenti

Membrane

Expressioni

Gene expression databases

BgeeiENSMUSG00000005950 Expressed in 119 organ(s), highest expression level in brown adipose tissue

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000006104

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili375 – 395Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the P2X receptor family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

eggNOGiENOG410IFJF Eukaryota
ENOG410XR0C LUCA
GeneTreeiENSGT00390000016028
HOVERGENiHBG053086
KOiK05219
OMAiAGAFFCD
OrthoDBiEOG091G0A2U
TreeFamiTF328633

Family and domain databases

Gene3Di2.60.490.10, 1 hit
InterProiView protein in InterPro
IPR003048 P2X5_purnocptor
IPR027309 P2X_extracellular_dom_sf
IPR001429 P2X_purnocptor
PANTHERiPTHR10125 PTHR10125, 1 hit
PTHR10125:SF12 PTHR10125:SF12, 1 hit
PfamiView protein in Pfam
PF00864 P2X_receptor, 1 hit
PIRSFiPIRSF005713 P2X_purinoceptor, 1 hit
PRINTSiPR01312 P2X5RECEPTOR
PR01307 P2XRECEPTOR
TIGRFAMsiTIGR00863 P2X, 1 hit
PROSITEiView protein in PROSITE
PS01212 P2X_RECEPTOR, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.iShow all

Q3UYI1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGQAAWKGFV LSLFDYKTAK FVVAKSKKVG LLYRVLQLTI LLYLLIWVFL
60 70 80 90 100
IKKSYQDIDT SLQSAVVTKV KGVAYTNTTM LGERLWDVAD FVIPSQGENV
110 120 130 140 150
FFVVTNLIVT PNQRQGICAE REGIPDGECS EDTDCHAGES VVAGHGLKTG
160 170 180 190 200
RCLRVGNSTR GTCEIFAWCP VETKSMPTDP LLKDAEGFTI FIKNFIRFPK
210 220 230 240 250
FNFSKANVLE TGNKHFLKTC HFSSTNLYCP IFRLGSIVRW AGADFQDIAL
260 270 280 290 300
KGGVIGIHIE WDCDLDKAAS HCNPHYYFNR LDNKHTQSIS SGYNFRFARY
310 320 330 340 350
YRDPHGVEFR DLMKAYGIRF DVIVNGKAGK FSIIPTVINI GSGLALMGAG
360 370 380 390 400
AFFCDLVLIY LIRKSEFYRD KKFEKVRGQK EEDNVEVEAN EMEQELPEDK
410 420 430 440 450
PLERVHQDEQ ALELAQSGRK QNSNCQVLFE PARSGLQENA FVNMKPSQIL

QTVKT
Length:455
Mass (Da):51,362
Last modified:February 5, 2008 - v1
Checksum:i16C126E191CBECB0
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AUD7B1AUD7_MOUSE
p2X purinoceptor
P2rx5
354Annotation score:
B1AUD6B1AUD6_MOUSE
Purinergic receptor P2X, ligand-gat...
P2rx5
330Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL670399 Genomic DNA No translation available.
AK134662 mRNA Translation: BAE22231.1
CH466596 Genomic DNA Translation: EDL12711.1
RefSeqiNP_201578.2, NM_033321.3
UniGeneiMm.156893

Genome annotation databases

EnsembliENSMUST00000006104; ENSMUSP00000006104; ENSMUSG00000005950
GeneIDi94045
KEGGimmu:94045
UCSCiuc007kaa.2 mouse

Similar proteinsi

Entry informationi

Entry nameiQ3UYI1_MOUSE
AccessioniPrimary (citable) accession number: Q3UYI1
Entry historyiIntegrated into UniProtKB/TrEMBL: February 5, 2008
Last sequence update: February 5, 2008
Last modified: September 12, 2018
This is version 97 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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