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Protein

Protein CUSTOS

Gene

Custos

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Plays a role in the regulation of Wnt signaling pathway during early development.By similarity

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein
Biological processWnt signaling pathway

Names & Taxonomyi

Protein namesi
Recommended name:
Protein CUSTOSBy similarity
Gene namesi
Name:CustosBy similarity
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1919607 2210016L21Rik

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002768511 – 256Protein CUSTOSAdd BLAST256

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei62PhosphoserineBy similarity1
Modified residuei80PhosphothreonineBy similarity1
Modified residuei139PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ3UY34
MaxQBiQ3UY34
PaxDbiQ3UY34
PeptideAtlasiQ3UY34
PRIDEiQ3UY34

PTM databases

iPTMnetiQ3UY34
PhosphoSitePlusiQ3UY34

Expressioni

Gene expression databases

CleanExiMM_2210016L21RIK

Structurei

3D structure databases

SMRiQ3UY34
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi228 – 235Nucleolar localization signal (NLS)By similarity8

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi14 – 19Poly-Ser6
Compositional biasi183 – 237Lys-richAdd BLAST55

Sequence similaritiesi

Belongs to the CUSTOS family.Curated

Phylogenomic databases

eggNOGiENOG410IYW6 Eukaryota
ENOG410YR2K LUCA
HOGENOMiHOG000111759
HOVERGENiHBG081238
InParanoidiQ3UY34
PhylomeDBiQ3UY34
TreeFamiTF336221

Family and domain databases

InterProiView protein in InterPro
IPR026694 CUSTOS
PANTHERiPTHR14482 PTHR14482, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q3UY34-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVAPSGAMSD SENSSSSSSD AEELARCREA ATPAWGLEQR PGAAERPEAG
60 70 80 90 100
AADKQAPTPQ PSRRHEVNQH EEDGNDLRTT PEFRAHVAKK LGALLDSSIA
110 120 130 140 150
IAEVWKKSQK AKMQQVAKEE DGFRLFFTSI PGGHKKEASP RPCRKRQPPS
160 170 180 190 200
SSEDSDEELQ RCREAAVSAS DILQESAIHC PAKAEEKKKL KKKAKKKVDN
210 220 230 240 250
ADLAAAPGLE QVKEAGVVNG DPVSLGIQKK RKKKAKKSRE APLCPPAECA

AAKPEN
Length:256
Mass (Da):27,631
Last modified:October 11, 2005 - v1
Checksum:i1A1A49C83836E1BC
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J099A0A0R4J099_MOUSE
RIKEN cDNA 2210016L21 gene
2210016L21Rik mCG_19228
256Annotation score:
H3BLG8H3BLG8_MOUSE
RIKEN cDNA 2210016L21 gene
2210016L21Rik
74Annotation score:
D6RDR6D6RDR6_MOUSE
RIKEN cDNA 2210016L21 gene
2210016L21Rik
19Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008740 mRNA Translation: BAB25869.1
AK135000 mRNA Translation: BAE22379.1
AK159360 mRNA Translation: BAE35018.1
BC031162 mRNA Translation: AAH31162.1
CCDSiCCDS19576.1
RefSeqiNP_082487.1, NM_028211.1
UniGeneiMm.292672

Genome annotation databases

GeneIDi72357
KEGGimmu:72357
UCSCiuc008zcy.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK008740 mRNA Translation: BAB25869.1
AK135000 mRNA Translation: BAE22379.1
AK159360 mRNA Translation: BAE35018.1
BC031162 mRNA Translation: AAH31162.1
CCDSiCCDS19576.1
RefSeqiNP_082487.1, NM_028211.1
UniGeneiMm.292672

3D structure databases

SMRiQ3UY34
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ3UY34
PhosphoSitePlusiQ3UY34

Proteomic databases

EPDiQ3UY34
MaxQBiQ3UY34
PaxDbiQ3UY34
PeptideAtlasiQ3UY34
PRIDEiQ3UY34

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi72357
KEGGimmu:72357
UCSCiuc008zcy.1 mouse

Organism-specific databases

MGIiMGI:1919607 2210016L21Rik

Phylogenomic databases

eggNOGiENOG410IYW6 Eukaryota
ENOG410YR2K LUCA
HOGENOMiHOG000111759
HOVERGENiHBG081238
InParanoidiQ3UY34
PhylomeDBiQ3UY34
TreeFamiTF336221

Miscellaneous databases

PROiPR:Q3UY34
SOURCEiSearch...

Gene expression databases

CleanExiMM_2210016L21RIK

Family and domain databases

InterProiView protein in InterPro
IPR026694 CUSTOS
PANTHERiPTHR14482 PTHR14482, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCSTOS_MOUSE
AccessioniPrimary (citable) accession number: Q3UY34
Secondary accession number(s): Q3TX98, Q8K0K9, Q9CVB7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: October 11, 2005
Last modified: October 10, 2018
This is version 67 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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