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Protein

Ankyrin repeat domain-containing protein 13C

Gene

Ankrd13c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a molecular chaperone for G protein-coupled receptors, regulating their biogenesis and exit from the ER.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChaperone

Names & Taxonomyi

Protein namesi
Recommended name:
Ankyrin repeat domain-containing protein 13C
Gene namesi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2139746 Ankrd13c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002406461 – 541Ankyrin repeat domain-containing protein 13CAdd BLAST541

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei411PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3UX43
PRIDEiQ3UX43

PTM databases

iPTMnetiQ3UX43
PhosphoSitePlusiQ3UX43

Expressioni

Gene expression databases

BgeeiENSMUSG00000039988 Expressed in 294 organ(s), highest expression level in saccule of membranous labyrinth
CleanExiMM_ANKRD13C
ExpressionAtlasiQ3UX43 baseline and differential
GenevisibleiQ3UX43 MM

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038662

Structurei

3D structure databases

ProteinModelPortaliQ3UX43
SMRiQ3UX43
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati111 – 142ANK 1Add BLAST32
Repeati143 – 172ANK 2Add BLAST30
Repeati176 – 205ANK 3Add BLAST30

Keywords - Domaini

ANK repeat, Repeat

Phylogenomic databases

eggNOGiKOG0522 Eukaryota
ENOG410XNMS LUCA
GeneTreeiENSGT00410000025381
HOGENOMiHOG000007095
HOVERGENiHBG079639
InParanoidiQ3UX43
KOiK21437
OMAiYPMHQSV
OrthoDBiEOG091G06FU
PhylomeDBiQ3UX43
TreeFamiTF314176

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR021832 ANKRD13
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PANTHERiPTHR12447 PTHR12447, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF11904 GPCR_chapero_1, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3UX43-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MTGEKIRSLR RDHKPSKEDG DVLEPCEEEA TAALGGAFTG GRSGPGGSGK
60 70 80 90 100
GGKACHKIFS HHHRLQLKAP AVPGPGVPAP PQHNAVTATC PAPACLGGSN
110 120 130 140 150
PALVADGGGC PSLYPVHECV FKGDVRRLSS LIRTHNIGQK DNHGNTPLHL
160 170 180 190 200
AVMLGNKECA HLLLAHNAPV KVKNAQGWSP LAEAISYGDR QMITALLRKL
210 220 230 240 250
KQQSRESVGE KRPRLLKALK ELGDFYLELH WDFQSWVPLL SRILPSDACK
260 270 280 290 300
IYKQGINIRL DTTLIDFTDM KCQRGDLSFI FNGDAAPSES FVVLDNEQKV
310 320 330 340 350
YQRIHHEESE METEEEVDIL MSSDIYSATL STKSISFTRA QTGWLFREDK
360 370 380 390 400
TERVGNFLAD FYLVNGLVLE SRKRREHLSE EDILRNKAIM ESLSKGGSLA
410 420 430 440 450
EQSFEPVRRQ SLTPPPQNTI TWEEYISAEN GKAPHLGREL VCKESKKTFK
460 470 480 490 500
ATVAMSQEFP LGIESLLNVL EVIAPFKHFN KLREFVQMKL PPGFPVKLDI
510 520 530 540
PVFPTITATV TFQEFRCDEF DGSIFAIPED YKEDPSRFPD L
Length:541
Mass (Da):60,150
Last modified:June 27, 2006 - v2
Checksum:iF270FA45C62F2A7F
GO
Isoform 2 (identifier: Q3UX43-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-249: VPLLSRILPSDAC → GKSVLRFIIKVQL
     250-541: Missing.

Note: No experimental confirmation available.
Show »
Length:249
Mass (Da):26,807
Checksum:i71D1BF484626E8EF
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JG55A0A0G2JG55_MOUSE
Ankyrin repeat domain-containing pr...
Ankrd13c
249Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti69 – 111APAVP…GGGCP → VSSEALARGAGERWLRRVFP SEEEAAAAAPGVVRSWSLEL RLS in BAE22720 (Ref. 2) CuratedAdd BLAST43

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_019409237 – 249VPLLS…PSDAC → GKSVLRFIIKVQL in isoform 2. 1 PublicationAdd BLAST13
Alternative sequenceiVSP_019410250 – 541Missing in isoform 2. 1 PublicationAdd BLAST292

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135906 mRNA Translation: BAE22720.1
BY751496 mRNA No translation available.
CH466532 Genomic DNA Translation: EDL11855.1
BC065088 mRNA Translation: AAH65088.1
BC138991 mRNA Translation: AAI38992.1
BC138992 mRNA Translation: AAI38993.1
CCDSiCCDS17933.1 [Q3UX43-1]
RefSeqiNP_001013828.1, NM_001013806.1 [Q3UX43-1]
UniGeneiMm.265806
Mm.486326

Genome annotation databases

EnsembliENSMUST00000040787; ENSMUSP00000038662; ENSMUSG00000039988 [Q3UX43-1]
ENSMUST00000164582; ENSMUSP00000125831; ENSMUSG00000039988 [Q3UX43-1]
GeneIDi433667
KEGGimmu:433667
UCSCiuc008rvk.1 mouse [Q3UX43-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK135906 mRNA Translation: BAE22720.1
BY751496 mRNA No translation available.
CH466532 Genomic DNA Translation: EDL11855.1
BC065088 mRNA Translation: AAH65088.1
BC138991 mRNA Translation: AAI38992.1
BC138992 mRNA Translation: AAI38993.1
CCDSiCCDS17933.1 [Q3UX43-1]
RefSeqiNP_001013828.1, NM_001013806.1 [Q3UX43-1]
UniGeneiMm.265806
Mm.486326

3D structure databases

ProteinModelPortaliQ3UX43
SMRiQ3UX43
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000038662

PTM databases

iPTMnetiQ3UX43
PhosphoSitePlusiQ3UX43

Proteomic databases

PaxDbiQ3UX43
PRIDEiQ3UX43

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040787; ENSMUSP00000038662; ENSMUSG00000039988 [Q3UX43-1]
ENSMUST00000164582; ENSMUSP00000125831; ENSMUSG00000039988 [Q3UX43-1]
GeneIDi433667
KEGGimmu:433667
UCSCiuc008rvk.1 mouse [Q3UX43-1]

Organism-specific databases

CTDi81573
MGIiMGI:2139746 Ankrd13c

Phylogenomic databases

eggNOGiKOG0522 Eukaryota
ENOG410XNMS LUCA
GeneTreeiENSGT00410000025381
HOGENOMiHOG000007095
HOVERGENiHBG079639
InParanoidiQ3UX43
KOiK21437
OMAiYPMHQSV
OrthoDBiEOG091G06FU
PhylomeDBiQ3UX43
TreeFamiTF314176

Miscellaneous databases

ChiTaRSiAnkrd13c mouse
PROiPR:Q3UX43
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000039988 Expressed in 294 organ(s), highest expression level in saccule of membranous labyrinth
CleanExiMM_ANKRD13C
ExpressionAtlasiQ3UX43 baseline and differential
GenevisibleiQ3UX43 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 1 hit
InterProiView protein in InterPro
IPR021832 ANKRD13
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
PANTHERiPTHR12447 PTHR12447, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 1 hit
PF11904 GPCR_chapero_1, 1 hit
SMARTiView protein in SMART
SM00248 ANK, 2 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiAN13C_MOUSE
AccessioniPrimary (citable) accession number: Q3UX43
Secondary accession number(s): B2RST2, Q6P1G4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 27, 2006
Last sequence update: June 27, 2006
Last modified: September 12, 2018
This is version 92 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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