Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Uncharacterized protein

Gene

Egf

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

GO - Molecular functioni

Keywordsi

LigandCalciumSAAS annotation

Names & Taxonomyi

Protein namesi
Submitted name:
Uncharacterized proteinImported
Gene namesi
Name:EgfImported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

MGIiMGI:95290 Egf

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei538 – 562HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi489 ↔ 506PROSITE-ProRule annotation
Disulfide bondi508 ↔ 517PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

Structurei

3D structure databases

ProteinModelPortaliQ3UWD7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati1 – 28LDL-receptor class BPROSITE-ProRule annotationAdd BLAST28
Repeati29 – 71LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati72 – 114LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Repeati115 – 158LDL-receptor class BPROSITE-ProRule annotationAdd BLAST44
Repeati159 – 201LDL-receptor class BPROSITE-ProRule annotationAdd BLAST43
Domaini337 – 375EGF-likeInterPro annotationAdd BLAST39
Domaini376 – 417EGF-likeInterPro annotationAdd BLAST42
Domaini418 – 458EGF-likeInterPro annotationAdd BLAST41
Domaini477 – 518EGF-likeInterPro annotationAdd BLAST42

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiENOG410IPSY Eukaryota
ENOG410ZVIM LUCA
KOiK04357

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR000033 LDLR_classB_rpt
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF07645 EGF_CA, 2 hits
PF00058 Ldl_recept_b, 3 hits
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 5 hits
SM00135 LY, 5 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 1 hit
PS51120 LDLRB, 5 hits

Sequencei

Sequence statusi: Complete.

Q3UWD7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MHFDGTDYKV LLSRQMGMVF ALDYDPVESK IYFAQTALKW IERANMDGSQ
60 70 80 90 100
RERLITEGVD TLEGLALDWI GRRIYWTDSG KSVVGGSDLS GKHHRIIIQE
110 120 130 140 150
RISRPRGIAV HPRARRLFWT DVGMSPRIES ASLQGSDRVL IASSSLLEPS
160 170 180 190 200
GITIDYLTDT LYWCDTKRSV IEMANLDGSK RRRLIQNDVG HPFSLAVFED
210 220 230 240 250
HLWVSDWAIP SVIRVNKRTG QNRVRLQGSM LKPSSLVVVH PLAKPGADPC
260 270 280 290 300
LYRNGGCEHI CQESLGTARC LCREGFVKAW DGKMCLPQDY PILSGENADL
310 320 330 340 350
SKEVTSLSNS TQAEVPDDDG TESSTLVAEI MVSGMNYEDD CGPGGCGSHA
360 370 380 390 400
RCVSDGETAE CQCLKGFARD GNLCSDIDEC VLARSDCPST SSRCINTEGG
410 420 430 440 450
YVCRCSEGYE GDGISCFDID ECQRGAHNCG ENAACTNTEG GYNCTCAGRP
460 470 480 490 500
SSPGLSCPDS TAPSLLGEDG HHLDRNSYPG CPSSYDGYCL NGGVCMHIES
510 520 530 540 550
LDSYTCNCVI GYSGDRCQTR DLRWWELRHA GYGQKHDIMV VAVCMVALVL
560 570 580 590 600
LLVLGMWGTY YYRTRKQLSN PPKNPCDEPS GSVSSSGPNS SSGAAVASCP
610 620 630 640 650
QPWFVVLEKH QDPKNGSLPA DGTNGAVVDA GLSPSLQLGS VHLTSWRQKP
660 670 680 690 700
HIDGMGTGQS CWIPPSSDRG PQEIEGNSHL PSYRPVGPEK LHSLQSANGS
710
CHERAPDLPR QTEPVQ
Length:716
Mass (Da):77,941
Last modified:October 11, 2005 - v1
Checksum:iCC1CA29F49966D98
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136439 mRNA Translation: BAE22978.1
RefSeqiNP_001297666.1, NM_001310737.1
NP_034243.2, NM_010113.4
UniGeneiMm.252481

Genome annotation databases

GeneIDi13645
KEGGimmu:13645

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136439 mRNA Translation: BAE22978.1
RefSeqiNP_001297666.1, NM_001310737.1
NP_034243.2, NM_010113.4
UniGeneiMm.252481

3D structure databases

ProteinModelPortaliQ3UWD7
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi13645
KEGGimmu:13645

Organism-specific databases

CTDi1950
MGIiMGI:95290 Egf

Phylogenomic databases

eggNOGiENOG410IPSY Eukaryota
ENOG410ZVIM LUCA
KOiK04357

Miscellaneous databases

ChiTaRSiEgf mouse
SOURCEiSearch...

Family and domain databases

Gene3Di2.120.10.30, 1 hit
InterProiView protein in InterPro
IPR011042 6-blade_b-propeller_TolB-like
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR000033 LDLR_classB_rpt
PfamiView protein in Pfam
PF00008 EGF, 1 hit
PF07645 EGF_CA, 2 hits
PF00058 Ldl_recept_b, 3 hits
SMARTiView protein in SMART
SM00181 EGF, 5 hits
SM00179 EGF_CA, 5 hits
SM00135 LY, 5 hits
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 2 hits
PS00022 EGF_1, 1 hit
PS01186 EGF_2, 3 hits
PS50026 EGF_3, 4 hits
PS01187 EGF_CA, 1 hit
PS51120 LDLRB, 5 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ3UWD7_MOUSE
AccessioniPrimary (citable) accession number: Q3UWD7
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: February 28, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again