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Protein

WAP four-disulfide core domain protein 6A

Gene

Wfdc6a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Serine protease inhibitor

Protein family/group databases

MEROPSiI17.953

Names & Taxonomyi

Protein namesi
Recommended name:
WAP four-disulfide core domain protein 6A
Alternative name(s):
Putative protease inhibitor WAP6A
Gene namesi
Name:Wfdc6a
Synonyms:Gm122
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2684968 Wfdc6a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000041585128 – 136WAP four-disulfide core domain protein 6AAdd BLAST109

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi33 ↔ 61By similarity
Disulfide bondi40 ↔ 65By similarity
Disulfide bondi48 ↔ 60By similarity
Disulfide bondi54 ↔ 69By similarity
Disulfide bondi77 ↔ 127By similarity
Disulfide bondi86 ↔ 110By similarity
Disulfide bondi102 ↔ 123By similarity

Keywords - PTMi

Disulfide bond

Proteomic databases

PaxDbiQ3UW55
PRIDEiQ3UW55

Expressioni

Gene expression databases

BgeeiENSMUSG00000074595 Expressed in 11 organ(s), highest expression level in testis
GenevisibleiQ3UW55 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096694

Structurei

3D structure databases

ProteinModelPortaliQ3UW55
SMRiQ3UW55
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 73WAPPROSITE-ProRule annotationAdd BLAST46
Domaini77 – 127BPTI/Kunitz inhibitorPROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiKOG4295 Eukaryota
ENOG410XQNP LUCA
GeneTreeiENSGT00730000110932
HOGENOMiHOG000115819
HOVERGENiHBG004024
InParanoidiQ3UW55
OMAiHRDCPEN
OrthoDBiEOG091G09P2
PhylomeDBiQ3UW55
TreeFamiTF342459

Family and domain databases

CDDicd00109 KU, 1 hit
Gene3Di4.10.410.10, 1 hit
4.10.75.10, 1 hit
InterProiView protein in InterPro
IPR036645 Elafin-like_sf
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR008197 WAP_dom
PfamiView protein in Pfam
PF00014 Kunitz_BPTI, 1 hit
PF00095 WAP, 1 hit
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00131 KU, 1 hit
SUPFAMiSSF57256 SSF57256, 1 hit
SSF57362 SSF57362, 1 hit
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit
PS51390 WAP, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3UW55-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRLWGLLPFL VPFILLWSIQ EPELAEGFFI RTCPRVRVKC EVEERNECTR
60 70 80 90 100
HRQCPNKKRC CLFSCGKKCM DLRQDVCSLP QDPGPCLAYL PRWWYNQETD
110 120 130
LCTEFIYGGC QGNPNNFPSE GICTVVCKKK QMSSWI
Length:136
Mass (Da):15,903
Last modified:October 11, 2005 - v1
Checksum:i2FE97819A16B7FAB
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136589 mRNA Translation: BAE23064.1
AL591478 Genomic DNA No translation available.
BC147597 mRNA Translation: AAI47598.1
BC147615 mRNA Translation: AAI47616.1
CCDSiCCDS17042.1
RefSeqiNP_001028412.1, NM_001033240.4
NP_001171319.1, NM_001177848.1
UniGeneiMm.293365

Genome annotation databases

EnsembliENSMUST00000099096; ENSMUSP00000096694; ENSMUSG00000074595
ENSMUST00000109342; ENSMUSP00000104966; ENSMUSG00000074595
GeneIDi209351
KEGGimmu:209351
UCSCiuc008nvg.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136589 mRNA Translation: BAE23064.1
AL591478 Genomic DNA No translation available.
BC147597 mRNA Translation: AAI47598.1
BC147615 mRNA Translation: AAI47616.1
CCDSiCCDS17042.1
RefSeqiNP_001028412.1, NM_001033240.4
NP_001171319.1, NM_001177848.1
UniGeneiMm.293365

3D structure databases

ProteinModelPortaliQ3UW55
SMRiQ3UW55
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096694

Protein family/group databases

MEROPSiI17.953

Proteomic databases

PaxDbiQ3UW55
PRIDEiQ3UW55

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099096; ENSMUSP00000096694; ENSMUSG00000074595
ENSMUST00000109342; ENSMUSP00000104966; ENSMUSG00000074595
GeneIDi209351
KEGGimmu:209351
UCSCiuc008nvg.2 mouse

Organism-specific databases

CTDi209351
MGIiMGI:2684968 Wfdc6a

Phylogenomic databases

eggNOGiKOG4295 Eukaryota
ENOG410XQNP LUCA
GeneTreeiENSGT00730000110932
HOGENOMiHOG000115819
HOVERGENiHBG004024
InParanoidiQ3UW55
OMAiHRDCPEN
OrthoDBiEOG091G09P2
PhylomeDBiQ3UW55
TreeFamiTF342459

Miscellaneous databases

PROiPR:Q3UW55
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074595 Expressed in 11 organ(s), highest expression level in testis
GenevisibleiQ3UW55 MM

Family and domain databases

CDDicd00109 KU, 1 hit
Gene3Di4.10.410.10, 1 hit
4.10.75.10, 1 hit
InterProiView protein in InterPro
IPR036645 Elafin-like_sf
IPR002223 Kunitz_BPTI
IPR036880 Kunitz_BPTI_sf
IPR020901 Prtase_inh_Kunz-CS
IPR008197 WAP_dom
PfamiView protein in Pfam
PF00014 Kunitz_BPTI, 1 hit
PF00095 WAP, 1 hit
PRINTSiPR00759 BASICPTASE
SMARTiView protein in SMART
SM00131 KU, 1 hit
SUPFAMiSSF57256 SSF57256, 1 hit
SSF57362 SSF57362, 1 hit
PROSITEiView protein in PROSITE
PS00280 BPTI_KUNITZ_1, 1 hit
PS50279 BPTI_KUNITZ_2, 1 hit
PS51390 WAP, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiWFC6A_MOUSE
AccessioniPrimary (citable) accession number: Q3UW55
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 22, 2012
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 106 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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