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Protein

Protein Niban

Gene

Fam129a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates phosphorylation of a number of proteins involved in translation regulation including EIF2A, EIF4EBP1 and RPS6KB1. May be involved in the endoplasmic reticulum stress response.1 Publication

Miscellaneous

'Niban' means 'second' in Japanese.1 Publication

GO - Biological processi

  • negative regulation of protein phosphorylation Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB
  • positive regulation of translation Source: UniProtKB
  • response to endoplasmic reticulum stress Source: UniProtKB

Keywordsi

Biological processStress response, Translation regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Niban1 Publication
Alternative name(s):
Protein FAM129A
Gene namesi
Name:Fam129a
Synonyms:Niban
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2137237 Fam129a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Membrane

Pathology & Biotechi

Disruption phenotypei

No obvious phenotypic abnormalities but mice show increased phosphorylation of Eif2a and decreased phosphorylation of Eif4ebp1 and Rps6kb1.1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003555832 – 926Protein NibanAdd BLAST925

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi2N-myristoyl glycineBy similarity1
Modified residuei578PhosphoserineCombined sources1
Modified residuei581PhosphoserineCombined sources1
Modified residuei595PhosphoserineCombined sources1
Modified residuei601PhosphoserineCombined sources1
Modified residuei640PhosphoserineBy similarity1
Modified residuei699PhosphoserineBy similarity1
Modified residuei755PhosphoserineBy similarity1
Modified residuei923PhosphoserineBy similarity1

Keywords - PTMi

Lipoprotein, Myristate, Phosphoprotein

Proteomic databases

EPDiQ3UW53
MaxQBiQ3UW53
PaxDbiQ3UW53
PeptideAtlasiQ3UW53
PRIDEiQ3UW53

PTM databases

iPTMnetiQ3UW53
PhosphoSitePlusiQ3UW53

Expressioni

Inductioni

By endoplasmic reticulum stress-inducing agents such as tunicamycin and thapsigargin in liver, kidney and cerebrum.1 Publication

Gene expression databases

BgeeiENSMUSG00000026483 Expressed in 198 organ(s), highest expression level in iris
ExpressionAtlasiQ3UW53 baseline and differential
GenevisibleiQ3UW53 MM

Interactioni

Protein-protein interaction databases

BioGridi211004, 1 interactor
IntActiQ3UW53, 2 interactors
MINTiQ3UW53

Structurei

3D structure databases

ProteinModelPortaliQ3UW53
SMRiQ3UW53
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Niban family.Sequence analysis

Phylogenomic databases

eggNOGiENOG410IFR1 Eukaryota
ENOG41102BB LUCA
GeneTreeiENSGT00530000063284
HOGENOMiHOG000113785
HOVERGENiHBG108186
InParanoidiQ3UW53
OrthoDBiEOG091G02BX
PhylomeDBiQ3UW53
TreeFamiTF333351

Family and domain databases

InterProiView protein in InterPro
IPR026088 Niban-like
PANTHERiPTHR14392 PTHR14392, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q3UW53-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGGSASSQLD EGKCAYIRGK TEASIKNFSP YYSRQYSVAF CNHVRSEVEQ
60 70 80 90 100
QRDLTSQFLK TKPPLEPGTV LYEAELSQFA EDIRKWKDRY IVIKNDFAVE
110 120 130 140 150
SYESKEAYQR GAVPKSRILP AGGKVLTSEE EYSLLSDKHF PDPTASSEKN
160 170 180 190 200
SQPFVLLPKA FPVYLWQPYL RHGYFCFHEA AEQQKFSALL NDCIRHLNHD
210 220 230 240 250
YMKQTTFEAQ AFLEAVQFFR QEKGHYGSWE MTTGDEVQVL SKLVMEELLP
260 270 280 290 300
TLQTDLLPKL KGKKNDRKRA WFGLLEEAYN LVQHQVSEGL NALKEECRAL
310 320 330 340 350
TKDLEGTIRS DMDQIVTSKN FLTGKIRAMV AQPAEQCCGE SVQPFLASIL
360 370 380 390 400
EELMGPVSSG FSEVRALFEK EVDELSQSFH ATQDSAQLKE GLQQLMKLPL
410 420 430 440 450
DSVKMEPCYT KVTLLPERLL DLQSRFRFPH VDLVVQRTQN YMQELMENAV
460 470 480 490 500
FTFEQLLSPY LQGEASRIPV AIEKVKLRVL KQYDYDSSTI RKKIFQEALI
510 520 530 540 550
QITLPTVQKA LASTCKPELQ KYEQFIFADH TNMIHVENVY EEILYEILLD
560 570 580 590 600
ETLKVITEAA ILKKHNLFED NMALPSESVS SLTDLKTAMG SNQASPARRV
610 620 630 640 650
SAILPGAPDN ELPSNEVFQE PEEKKEQPGV PGSLAISASS CPSGGDGQVS
660 670 680 690 700
VDHSAGGPLT VENTAGPLSS HLSEVEAGGT LKDEEPTCQS PEPSAVPGSL
710 720 730 740 750
KELKKLLTVT VSVESAPVVE NDIHNGTPVP QENIKEEESK IHPEASHPAA
760 770 780 790 800
IQQDSCEERE VREKEAQPLE AEAPGVDLGI LPEGRGSTSQ STSGGLTENT
810 820 830 840 850
SCPGPIEEPF EAQEPAEKVL PAIVSTEDSP QAGGEAEHSV TVTPQEDATL
860 870 880 890 900
SSNPICPMES NEVAQASGDQ EVLGGEDSSA LGMDTEQVND THEHACQWLV
910 920
EDTLSTDILA VHDFDVSSPE QPSEEW
Length:926
Mass (Da):102,649
Last modified:December 16, 2008 - v2
Checksum:iD41F603AF127673C
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PYV4E9PYV4_MOUSE
Protein Niban
Fam129a
584Annotation score:
D3Z233D3Z233_MOUSE
Protein Niban
Fam129a
274Annotation score:
D3YYZ9D3YYZ9_MOUSE
Protein Niban
Fam129a
114Annotation score:

Sequence cautioni

The sequence AAH21332 differs from that shown. Contaminating sequence. Potential poly-A sequence.Curated
The sequence AAH58234 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence AAI37844 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAB17052 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence BAC26641 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti2 – 4GGS → ASA in BAB17052 (PubMed:11011112).Curated3
Sequence conflicti437R → G in AAH21332 (PubMed:15489334).Curated1
Sequence conflicti608P → Q in BAE41736 (PubMed:16141072).Curated1
Sequence conflicti651V → E in AAH21332 (PubMed:15489334).Curated1
Sequence conflicti680T → S in AAH21332 (PubMed:15489334).Curated1
Sequence conflicti693P → S in AAH21332 (PubMed:15489334).Curated1
Sequence conflicti705K → E in AAH21332 (PubMed:15489334).Curated1
Sequence conflicti911V → L in BAE23066 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029847 mRNA Translation: BAC26641.1 Sequence problems.
AK136597 mRNA Translation: BAE23066.1
AK170347 mRNA Translation: BAE41736.1
BC021332 mRNA Translation: AAH21332.1 Sequence problems.
BC058234 mRNA Translation: AAH58234.2 Different initiation.
BC137843 mRNA Translation: AAI37844.1 Different initiation.
AB049355 mRNA Translation: BAB17052.1 Different initiation.
CCDSiCCDS48393.1
RefSeqiNP_071301.2, NM_022018.3
XP_006529839.1, XM_006529776.3
UniGeneiMm.157700
Mm.482559

Genome annotation databases

EnsembliENSMUST00000148810; ENSMUSP00000115822; ENSMUSG00000026483
GeneIDi63913
KEGGimmu:63913
UCSCiuc007cyz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK029847 mRNA Translation: BAC26641.1 Sequence problems.
AK136597 mRNA Translation: BAE23066.1
AK170347 mRNA Translation: BAE41736.1
BC021332 mRNA Translation: AAH21332.1 Sequence problems.
BC058234 mRNA Translation: AAH58234.2 Different initiation.
BC137843 mRNA Translation: AAI37844.1 Different initiation.
AB049355 mRNA Translation: BAB17052.1 Different initiation.
CCDSiCCDS48393.1
RefSeqiNP_071301.2, NM_022018.3
XP_006529839.1, XM_006529776.3
UniGeneiMm.157700
Mm.482559

3D structure databases

ProteinModelPortaliQ3UW53
SMRiQ3UW53
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi211004, 1 interactor
IntActiQ3UW53, 2 interactors
MINTiQ3UW53

PTM databases

iPTMnetiQ3UW53
PhosphoSitePlusiQ3UW53

Proteomic databases

EPDiQ3UW53
MaxQBiQ3UW53
PaxDbiQ3UW53
PeptideAtlasiQ3UW53
PRIDEiQ3UW53

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000148810; ENSMUSP00000115822; ENSMUSG00000026483
GeneIDi63913
KEGGimmu:63913
UCSCiuc007cyz.2 mouse

Organism-specific databases

CTDi116496
MGIiMGI:2137237 Fam129a

Phylogenomic databases

eggNOGiENOG410IFR1 Eukaryota
ENOG41102BB LUCA
GeneTreeiENSGT00530000063284
HOGENOMiHOG000113785
HOVERGENiHBG108186
InParanoidiQ3UW53
OrthoDBiEOG091G02BX
PhylomeDBiQ3UW53
TreeFamiTF333351

Miscellaneous databases

PROiPR:Q3UW53
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026483 Expressed in 198 organ(s), highest expression level in iris
ExpressionAtlasiQ3UW53 baseline and differential
GenevisibleiQ3UW53 MM

Family and domain databases

InterProiView protein in InterPro
IPR026088 Niban-like
PANTHERiPTHR14392 PTHR14392, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiNIBAN_MOUSE
AccessioniPrimary (citable) accession number: Q3UW53
Secondary accession number(s): A0PJB3
, Q3TD68, Q6PE79, Q9ESL7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 16, 2008
Last sequence update: December 16, 2008
Last modified: November 7, 2018
This is version 96 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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