UniProtKB - Q3UVY1 (GP149_MOUSE)
Protein
Probable G-protein coupled receptor 149
Gene
Gpr149
Organism
Mus musculus (Mouse)
Status
Functioni
Orphan receptor.
GO - Molecular functioni
- G protein-coupled receptor activity Source: GO_Central
- neuropeptide binding Source: GO_Central
- peptide binding Source: GO_Central
GO - Biological processi
- antral ovarian follicle growth Source: MGI
- negative regulation of ovulation Source: MGI
- neuropeptide signaling pathway Source: GO_Central
- preantral ovarian follicle growth Source: MGI
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: Probable G-protein coupled receptor 149Alternative name(s): G-protein coupled receptor PGR10 |
Gene namesi | Name:Gpr149 Synonyms:Pgr10 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2443628, Gpr149 |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
Other locations
- neuron projection Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 36 | ExtracellularSequence analysisAdd BLAST | 36 | |
Transmembranei | 37 – 57 | Helical; Name=1Sequence analysisAdd BLAST | 21 | |
Topological domaini | 58 – 69 | CytoplasmicSequence analysisAdd BLAST | 12 | |
Transmembranei | 70 – 90 | Helical; Name=2Sequence analysisAdd BLAST | 21 | |
Topological domaini | 91 – 110 | ExtracellularSequence analysisAdd BLAST | 20 | |
Transmembranei | 111 – 133 | Helical; Name=3Sequence analysisAdd BLAST | 23 | |
Topological domaini | 134 – 156 | CytoplasmicSequence analysisAdd BLAST | 23 | |
Transmembranei | 157 – 177 | Helical; Name=4Sequence analysisAdd BLAST | 21 | |
Topological domaini | 178 – 190 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 191 – 211 | Helical; Name=5Sequence analysisAdd BLAST | 21 | |
Topological domaini | 212 – 311 | CytoplasmicSequence analysisAdd BLAST | 100 | |
Transmembranei | 312 – 332 | Helical; Name=6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 333 – 343 | ExtracellularSequence analysisAdd BLAST | 11 | |
Transmembranei | 344 – 364 | Helical; Name=7Sequence analysisAdd BLAST | 21 | |
Topological domaini | 365 – 732 | CytoplasmicSequence analysisAdd BLAST | 368 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069627 | 1 – 732 | Probable G-protein coupled receptor 149Add BLAST | 732 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 7 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 106 ↔ 183 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q3UVY1 |
PRIDEi | Q3UVY1 |
PTM databases
GlyGeni | Q3UVY1, 1 site |
iPTMneti | Q3UVY1 |
PhosphoSitePlusi | Q3UVY1 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000043441, Expressed in secondary oocyte and 73 other tissues |
Genevisiblei | Q3UVY1, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000060893 |
Miscellaneous databases
RNActi | Q3UVY1, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0331, Eukaryota |
GeneTreei | ENSGT00390000003715 |
HOGENOMi | CLU_021967_0_0_1 |
InParanoidi | Q3UVY1 |
OMAi | NYECETT |
OrthoDBi | 352121at2759 |
PhylomeDBi | Q3UVY1 |
TreeFami | TF331679 |
Family and domain databases
InterProi | View protein in InterPro IPR017452, GPCR_Rhodpsn_7TM |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3UVY1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSFFLSNLTN DSNLWKASHN STETDLMNSP ATLTLSLFCL ICIMTLAALV
60 70 80 90 100
GSIFSLVSLL TMQYRTVLSI LVTSWSVDDL LSVLSVAIFM VLQWPKEAQG
110 120 130 140 150
YFQSLCTTSA LLYMCQGLSS NLKATLIVCY NFYTMNRTVE SQSSSWRLGQ
160 170 180 190 200
VLGVTLTVWA VSLLLASLPL CGWGVFVRTP WGCLTDCSSP YVLLLFAVYA
210 220 230 240 250
SAFGLLAVLS VPLTHQLLCS EEPLRLHANY QEISRGASTP GTPAAAGRVL
260 270 280 290 300
CLPPEDVEIP ALRCTGGCSP SSDVVFAPGQ PAASGAGAGR RENPGTPQGT
310 320 330 340 350
NSFPLSLAQK RFSLILALTK VILWLPMMIH MVVKHVVGFQ SLPVDMLSFL
360 370 380 390 400
LSLLASSVTP VFVLSKRWAH LPCGCIINCQ PDTYSVAFDG KKSKRKGFEF
410 420 430 440 450
NLSFQQSYGL YKIPHADCYD DDENSISYHN PKNYECEATK EPWGDNRSVF
460 470 480 490 500
NTITVEISTT PPLDSATLTG VHKCTNTDIP ESKQAMKEEK GAFSVKTESD
510 520 530 540 550
INYGETTSFE GPERRLSHEE NQKPDLSDWE WCRSKSERTP RQRSGGGLAI
560 570 580 590 600
PICAFQGTVS LQAPTGKTLS LSTYEVSAEG QKITPASKKI EVYRSKSVGH
610 620 630 640 650
EPNSEESPST FADTSVKIHL EVLEICDNDE ALDTVSIISN ISQSSTKVRS
660 670 680 690 700
PSLRYSRKEN RFVSCDLGET ASYSLFLPTS DPDGDINISI PDTVEAHRQN
710 720 730
SRRQHEERDG YQEEIQLLNK AYRKREAESK GD
Sequence cautioni
The sequence BAC33315 differs from that shown. Reason: Erroneous initiation.Curated
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 239 | T → S in BAC33315 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 366 | K → E in BAE38531 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 368 | W → G in BAC33315 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK035931 mRNA Translation: BAC29247.1 AK048373 mRNA Translation: BAC33315.1 Different initiation. AK136826 mRNA Translation: BAE23138.1 AK166029 mRNA Translation: BAE38531.1 AY255591 mRNA Translation: AAO85103.1 |
CCDSi | CCDS17380.1 |
RefSeqi | NP_796320.2, NM_177346.4 |
Genome annotation databases
Ensembli | ENSMUST00000058535; ENSMUSP00000060893; ENSMUSG00000043441 |
GeneIDi | 229357 |
KEGGi | mmu:229357 |
UCSCi | uc008pjo.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK035931 mRNA Translation: BAC29247.1 AK048373 mRNA Translation: BAC33315.1 Different initiation. AK136826 mRNA Translation: BAE23138.1 AK166029 mRNA Translation: BAE38531.1 AY255591 mRNA Translation: AAO85103.1 |
CCDSi | CCDS17380.1 |
RefSeqi | NP_796320.2, NM_177346.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000060893 |
Protein family/group databases
GPCRDBi | Search... |
PTM databases
GlyGeni | Q3UVY1, 1 site |
iPTMneti | Q3UVY1 |
PhosphoSitePlusi | Q3UVY1 |
Proteomic databases
PaxDbi | Q3UVY1 |
PRIDEi | Q3UVY1 |
Protocols and materials databases
Antibodypediai | 9095, 207 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000058535; ENSMUSP00000060893; ENSMUSG00000043441 |
GeneIDi | 229357 |
KEGGi | mmu:229357 |
UCSCi | uc008pjo.1, mouse |
Organism-specific databases
CTDi | 344758 |
MGIi | MGI:2443628, Gpr149 |
Phylogenomic databases
eggNOGi | KOG0331, Eukaryota |
GeneTreei | ENSGT00390000003715 |
HOGENOMi | CLU_021967_0_0_1 |
InParanoidi | Q3UVY1 |
OMAi | NYECETT |
OrthoDBi | 352121at2759 |
PhylomeDBi | Q3UVY1 |
TreeFami | TF331679 |
Miscellaneous databases
BioGRID-ORCSi | 229357, 1 hit in 17 CRISPR screens |
PROi | PR:Q3UVY1 |
RNActi | Q3UVY1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000043441, Expressed in secondary oocyte and 73 other tissues |
Genevisiblei | Q3UVY1, MM |
Family and domain databases
InterProi | View protein in InterPro IPR017452, GPCR_Rhodpsn_7TM |
PROSITEi | View protein in PROSITE PS50262, G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GP149_MOUSE | |
Accessioni | Q3UVY1Primary (citable) accession number: Q3UVY1 Secondary accession number(s): Q3TMB1 Q8BZC0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 20, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families