Probable G-protein coupled receptor 149

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• G protein-coupled receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• neuropeptide binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• peptide binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• antral ovarian follicle growth Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Deletion of the novel oocyte-enriched gene, Gpr149, leads to increased fertility in mice."
    Edson M.A., Lin Y.N., Matzuk M.M.
    Endocrinology 151:358-368(2010) [PubMed] [Europe PMC] [Abstract]
• negative regulation of ovulation Source: MGIInferred from mutant phenotypeⁱ
  • "Deletion of the novel oocyte-enriched gene, Gpr149, leads to increased fertility in mice."
    Edson M.A., Lin Y.N., Matzuk M.M.
    Endocrinology 151:358-368(2010) [PubMed] [Europe PMC] [Abstract]
• neuropeptide signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief. Bioinformatics 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• preantral ovarian follicle growth Source: MGIInferred from mutant phenotypeⁱ
  • "Deletion of the novel oocyte-enriched gene, Gpr149, leads to increased fertility in mice."
    Edson M.A., Lin Y.N., Matzuk M.M.
    Endocrinology 151:358-368(2010) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Topology

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

Protein-protein interaction databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MSFFLSNLTN DSNLWKASHN STETDLMNSP ATLTLSLFCL ICIMTLAALV 
        60         70         80         90        100
GSIFSLVSLL TMQYRTVLSI LVTSWSVDDL LSVLSVAIFM VLQWPKEAQG 
       110        120        130        140        150
YFQSLCTTSA LLYMCQGLSS NLKATLIVCY NFYTMNRTVE SQSSSWRLGQ 
       160        170        180        190        200
VLGVTLTVWA VSLLLASLPL CGWGVFVRTP WGCLTDCSSP YVLLLFAVYA 
       210        220        230        240        250
SAFGLLAVLS VPLTHQLLCS EEPLRLHANY QEISRGASTP GTPAAAGRVL 
       260        270        280        290        300
CLPPEDVEIP ALRCTGGCSP SSDVVFAPGQ PAASGAGAGR RENPGTPQGT 
       310        320        330        340        350
NSFPLSLAQK RFSLILALTK VILWLPMMIH MVVKHVVGFQ SLPVDMLSFL 
       360        370        380        390        400
LSLLASSVTP VFVLSKRWAH LPCGCIINCQ PDTYSVAFDG KKSKRKGFEF 
       410        420        430        440        450
NLSFQQSYGL YKIPHADCYD DDENSISYHN PKNYECEATK EPWGDNRSVF 
       460        470        480        490        500
NTITVEISTT PPLDSATLTG VHKCTNTDIP ESKQAMKEEK GAFSVKTESD 
       510        520        530        540        550
INYGETTSFE GPERRLSHEE NQKPDLSDWE WCRSKSERTP RQRSGGGLAI 
       560        570        580        590        600
PICAFQGTVS LQAPTGKTLS LSTYEVSAEG QKITPASKKI EVYRSKSVGH 
       610        620        630        640        650
EPNSEESPST FADTSVKIHL EVLEICDNDE ALDTVSIISN ISQSSTKVRS 
       660        670        680        690        700
PSLRYSRKEN RFVSCDLGET ASYSLFLPTS DPDGDINISI PDTVEAHRQN 
       710        720        730 
SRRQHEERDG YQEEIQLLNK AYRKREAESK GD                    

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. SIMILARITY comments
   Index of protein domains and families
2. 7-transmembrane G-linked receptors
   List of 7-transmembrane G-linked receptor entries
3. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot