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UniProtKB - Q3UVL4 (VPS51_MOUSE)

Entry version 109 (29 Sep 2021)
Sequence version 2 (20 Jan 2009)
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Protein

Vacuolar protein sorting-associated protein 51 homolog

Gene

Vps51

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of protein retrieval from endosomes to the TGN, acid hydrolase sorting, lysosome function, endosomal cholesterol traffic and autophagy. VPS51 participates in retrograde transport of acid hydrolase receptors, likely by promoting tethering and SNARE-dependent fusion of endosome-derived carriers to the TGN. Acts as component of the EARP complex that is involved in endocytic recycling. The EARP complex associates with Rab4-positive endosomes and promotes recycling of internalized transferrin receptor (TFRC) to the plasma membrane.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processLipid transport, Protein transport, Transport

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-6811440, Retrograde transport at the Trans-Golgi-Network

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Vacuolar protein sorting-associated protein 51 homolog
Alternative name(s):
Protein fat-free homolog
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Vps51
Synonyms:Ffr
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1915755, Vps51

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSMUSG00000024797

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Endosome, Golgi apparatus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedBy similarity
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003589132 – 782Vacuolar protein sorting-associated protein 51 homologAdd BLAST781

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylalanineBy similarity1
Modified residuei18PhosphoserineBy similarity1
Modified residuei44PhosphoserineCombined sources1
Modified residuei649PhosphoserineBy similarity1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q3UVL4

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q3UVL4

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q3UVL4

PeptideAtlas

More...PeptideAtlasi		Q3UVL4

PRoteomics IDEntifications database

More...PRIDEi		Q3UVL4

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		297820 [Q3UVL4-1]
297821 [Q3UVL4-2]
297822 [Q3UVL4-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q3UVL4

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q3UVL4

SwissPalm database of S-palmitoylation events

More...SwissPalmi		Q3UVL4

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000024797, Expressed in bone marrow and 227 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q3UVL4, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q3UVL4, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54 (By similarity).

Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin (By similarity). EIPR1 interacts with both EARP and GARP complexes and mediates the recruitment of the GARP complex to the trans-Golgi network (By similarity).

Interacts with STX6 (By similarity).

Interacts with VPS50 and VPS54 in an EIPR1-independent manner (By similarity).

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		212892, 13 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000123994

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q3UVL4, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q3UVL4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 31DisorderedSequence analysisAdd BLAST31

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili116 – 148Sequence analysisAdd BLAST33
Coiled coili270 – 292Sequence analysisAdd BLAST23

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the VPS51 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2346, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000001738

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_020677_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q3UVL4

Identification of Orthologs from Complete Genome Data

More...OMAi		HTIEPRT

Database of Orthologous Groups

More...OrthoDBi		1305393at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q3UVL4

TreeFam database of animal gene trees

More...TreeFami		TF314825

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR016159, Cullin_repeat-like_dom_sf
IPR014812, Vps51

The PANTHER Classification System

More...PANTHERi		PTHR15954, PTHR15954, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF74788, SSF74788, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3UVL4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAAAVGPG LGSGPGDSPE GPEADAPERR RKAHGMLKLY YGLSEGEVAG 
        60         70         80         90        100
HPAGPDPLDP TDLNGAHFDP EVYLDKLRRE CPLAQLMDSE TDMVRQIRAL 
       110        120        130        140        150
DSDMQTLVYE NYNKFISATD TIRKMKNDFR KMEDEMDRLA TNMAVITNFS 
       160        170        180        190        200
ARISATLQDR HERITKLAGV HALLRKLQFL FELPSRLTKC VELGAYGQAV 
       210        220        230        240        250
RYQGRARAVL QQYQHLPSFR AIQDDCQVIT ARLAQQLRQR FREGCSGAPE 
       260        270        280        290        300
QAECVELLLA LGEPAEELCE EFLAHARGRL EEELSSLEAE LGPSPPAPDV 
       310        320        330        340        350
LEFTDRGGNG FVGGLCQVAA AYQELFAAQG PAGAEKLAAF AQELGGRYFA 
       360        370        380        390        400
LVERRLAQEQ GGSDNSLLVR ALDRFHRRLR APGALLAAAG LSESATEIVE 
       410        420        430        440        450
RVARERLSHH LQGLKAAFLS SLTDVRQALA APRLAGKEGP SLAELLANVA 
       460        470        480        490        500
SSILSHIKTS LASVHLFTAK EVSFSNKPYF RGEFCSQGVR EGLIVGFIRS 
       510        520        530        540        550
MCQTAQSFCD SPGEKGGATP PALLLLLSRL CLDYETATIS YILTLTDEQF 
       560        570        580        590        600
LVQDQSPVTP VSTLCAEARE TARRLLTHYV KVQGLVISQM LRKSVETRDW 
       610        620        630        640        650
LSTLEPRNVR AVMKRVVEDT TAIDVQVGLL YEEGVRKAQS SDSSKRTFSV 
       660        670        680        690        700
YSSSRQQGRY APSYTPSAPM DTNLLSNIQK LFSERIDVFS PVEFNKVSVL 
       710        720        730        740        750
TGIIKISLKT LLECVRLRTF GRFGLQQVQV DCHFLQLYLW RFVADEELVH 
       760        770        780 
LLLDEVVASA ALRCPDPVPM EPSVVEVICE RG
Length:782
Mass (Da):86,187
Last modified:January 20, 2009 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i377198219AAF5F6C
GO
Isoform 2 (identifier: Q3UVL4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     482-577: GEFCSQGVRE...ARETARRLLT → VCCPLALLIR...WRRVKAKREE
     578-782: Missing.

Show »
Length:577
Mass (Da):63,318
Checksum:i9C21CFEF405C608A
GO
Isoform 3 (identifier: Q3UVL4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     120-140: DTIRKMKNDFRKMEDEMDRLA → GDPTGTHSSVLHHPHQVLTPC
     141-782: Missing.

Show »
Length:140
Mass (Da):15,017
Checksum:iA9EFFD841D632FDA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6TKZ2F6TKZ2_MOUSE
Vacuolar protein sorting-associated...
Vps51
120Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E0CX85E0CX85_MOUSE
Vacuolar protein sorting-associated...
Vps51
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAI18932 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti265A → P in BAE26981 (PubMed:16141072).Curated1
Sequence conflicti339A → D in BAE23255 (PubMed:16141072).Curated1
Sequence conflicti409H → R in BAE26981 (PubMed:16141072).Curated1
Sequence conflicti422L → M in BAE26981 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_036126120 – 140DTIRK…MDRLA → GDPTGTHSSVLHHPHQVLTP C in isoform 3. 1 PublicationAdd BLAST21
Alternative sequenceiVSP_036127141 – 782Missing in isoform 3. 1 PublicationAdd BLAST642
Alternative sequenceiVSP_036128482 – 577GEFCS…RRLLT → VCCPLALLIRSADWPSSSLL LVFGEPWDMSPAPHNTVSST LRVESHSQEAVWRRKCYAAG LKLEGYQGPHCCQPYHRGSE AGWGGLWRRVKAKREE in isoform 2. 1 PublicationAdd BLAST96
Alternative sequenceiVSP_036129578 – 782Missing in isoform 2. 1 PublicationAdd BLAST205

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK014229 mRNA Translation: BAB29217.1
AK137155 mRNA Translation: BAE23255.1
AK146211 mRNA Translation: BAE26981.1
AC131692 Genomic DNA No translation available.
CH466612 Genomic DNA Translation: EDL33203.1
BC118930 mRNA Translation: AAI18931.1
BC118931 mRNA Translation: AAI18932.1 Frameshift.

The Consensus CDS (CCDS) project

More...CCDSi		CCDS37894.1 [Q3UVL4-1]

NCBI Reference Sequences

More...RefSeqi		NP_001074510.1, NM_001081041.1 [Q3UVL4-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000025711; ENSMUSP00000025711; ENSMUSG00000024797 [Q3UVL4-1]
ENSMUST00000160590; ENSMUSP00000123857; ENSMUSG00000024797 [Q3UVL4-3]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		68505

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:68505

UCSC genome browser

More...UCSCi		uc008ghb.1, mouse [Q3UVL4-1]
uc008ghc.1, mouse [Q3UVL4-2]
uc008ghd.1, mouse [Q3UVL4-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK014229 mRNA Translation: BAB29217.1
AK137155 mRNA Translation: BAE23255.1
AK146211 mRNA Translation: BAE26981.1
AC131692 Genomic DNA No translation available.
CH466612 Genomic DNA Translation: EDL33203.1
BC118930 mRNA Translation: AAI18931.1
BC118931 mRNA Translation: AAI18932.1 Frameshift.
CCDSiCCDS37894.1 [Q3UVL4-1]
RefSeqiNP_001074510.1, NM_001081041.1 [Q3UVL4-1]

3D structure databases

SMRiQ3UVL4
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi212892, 13 interactors
STRINGi10090.ENSMUSP00000123994

PTM databases

iPTMnetiQ3UVL4
PhosphoSitePlusiQ3UVL4
SwissPalmiQ3UVL4

Proteomic databases

EPDiQ3UVL4
jPOSTiQ3UVL4
PaxDbiQ3UVL4
PeptideAtlasiQ3UVL4
PRIDEiQ3UVL4
ProteomicsDBi297820 [Q3UVL4-1]
297821 [Q3UVL4-2]
297822 [Q3UVL4-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		49945, 86 antibodies

Genome annotation databases

EnsembliENSMUST00000025711; ENSMUSP00000025711; ENSMUSG00000024797 [Q3UVL4-1]
ENSMUST00000160590; ENSMUSP00000123857; ENSMUSG00000024797 [Q3UVL4-3]
GeneIDi68505
KEGGimmu:68505
UCSCiuc008ghb.1, mouse [Q3UVL4-1]
uc008ghc.1, mouse [Q3UVL4-2]
uc008ghd.1, mouse [Q3UVL4-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		738
MGIiMGI:1915755, Vps51
VEuPathDBiHostDB:ENSMUSG00000024797

Phylogenomic databases

eggNOGiKOG2346, Eukaryota
GeneTreeiENSGT00390000001738
HOGENOMiCLU_020677_0_0_1
InParanoidiQ3UVL4
OMAiHTIEPRT
OrthoDBi1305393at2759
PhylomeDBiQ3UVL4
TreeFamiTF314825

Enzyme and pathway databases

ReactomeiR-MMU-6811440, Retrograde transport at the Trans-Golgi-Network

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		68505, 14 hits in 63 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Vps51, mouse

Protein Ontology

More...PROi		PR:Q3UVL4
RNActiQ3UVL4, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000024797, Expressed in bone marrow and 227 other tissues
ExpressionAtlasiQ3UVL4, baseline and differential
GenevisibleiQ3UVL4, MM

Family and domain databases

InterProiView protein in InterPro
IPR016159, Cullin_repeat-like_dom_sf
IPR014812, Vps51
PANTHERiPTHR15954, PTHR15954, 1 hit
SUPFAMiSSF74788, SSF74788, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVPS51_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UVL4
Secondary accession number(s): Q0VF89
, Q0VF90, Q3UK22, Q9CXM6
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 20, 2009
Last sequence update: January 20, 2009
Last modified: September 29, 2021
This is version 109 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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