UniProtKB - Q3UVL4 (VPS51_MOUSE)
Vacuolar protein sorting-associated protein 51 homolog
Vps51
Functioni
GO - Biological processi
- autophagy Source: MGI
- endocytic recycling Source: UniProtKB
- Golgi organization Source: GO_Central
- Golgi vesicle transport Source: GO_Central
- lipid transport Source: UniProtKB-KW
- lysosomal transport Source: MGI
- protein transport Source: UniProtKB-KW
- retrograde transport, endosome to Golgi Source: UniProtKB
Keywordsi
Biological process | Lipid transport, Protein transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-6811440, Retrograde transport at the Trans-Golgi-Network |
Names & Taxonomyi
Protein namesi | Recommended name: Vacuolar protein sorting-associated protein 51 homologAlternative name(s): Protein fat-free homolog |
Gene namesi | Name:Vps51 Synonyms:Ffr |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915755, Vps51 |
Subcellular locationi
Endosome
- Recycling endosome By similarity
Golgi apparatus
- trans-Golgi network By similarity
Note: Localizes to the trans-Golgi network as part of the GARP complex, while it localizes to recycling endosomes as part of the EARP complex.By similarity
Cytosol
- cytosol Source: GOC
Endosome
- EARP complex Source: UniProtKB
- recycling endosome Source: UniProtKB
Golgi apparatus
- GARP complex Source: UniProtKB
- Golgi apparatus Source: UniProtKB
- trans-Golgi network Source: MGI
Nucleus
- nucleolus Source: MGI
Other locations
- intracellular membrane-bounded organelle Source: MGI
- membrane Source: MGI
Keywords - Cellular componenti
Endosome, Golgi apparatusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000358913 | 2 – 782 | Vacuolar protein sorting-associated protein 51 homologAdd BLAST | 781 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Modified residuei | 18 | PhosphoserineBy similarity | 1 | |
Modified residuei | 44 | PhosphoserineCombined sources | 1 | |
Modified residuei | 649 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Acetylation, PhosphoproteinProteomic databases
EPDi | Q3UVL4 |
jPOSTi | Q3UVL4 |
PaxDbi | Q3UVL4 |
PeptideAtlasi | Q3UVL4 |
PRIDEi | Q3UVL4 |
PTM databases
iPTMneti | Q3UVL4 |
PhosphoSitePlusi | Q3UVL4 |
SwissPalmi | Q3UVL4 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000024797, Expressed in granulocyte and 220 other tissues |
ExpressionAtlasi | Q3UVL4, baseline and differential |
Genevisiblei | Q3UVL4, MM |
Interactioni
Subunit structurei
Component of the Golgi-associated retrograde protein (GARP) complex, also called VFT (VPS fifty-three) complex, composed of VPS51, VPS52, VPS53 and VPS54 (By similarity).
Component of the endosome-associated retrograde protein (EARP) complex, composed of VPS51, VPS52, VPS53 and VPS50/Syndetin (By similarity). EIPR1 interacts with both EARP and GARP complexes and mediates the recruitment of the GARP complex to the trans-Golgi network (By similarity).
Interacts with STX6 (By similarity).
Interacts with VPS50 and VPS54 in an EIPR1-independent manner (By similarity).
By similarityProtein-protein interaction databases
BioGRIDi | 212892, 13 interactors |
STRINGi | 10090.ENSMUSP00000123994 |
Miscellaneous databases
RNActi | Q3UVL4, protein |
Family & Domainsi
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 116 – 148 | Sequence analysisAdd BLAST | 33 | |
Coiled coili | 270 – 292 | Sequence analysisAdd BLAST | 23 |
Sequence similaritiesi
Keywords - Domaini
Coiled coilPhylogenomic databases
eggNOGi | KOG2346, Eukaryota |
GeneTreei | ENSGT00390000001738 |
HOGENOMi | CLU_020677_0_0_1 |
InParanoidi | Q3UVL4 |
OMAi | HTIEPRT |
OrthoDBi | 1305393at2759 |
TreeFami | TF314825 |
Family and domain databases
InterProi | View protein in InterPro IPR016159, Cullin_repeat-like_dom_sf IPR014812, Vps51 |
PANTHERi | PTHR15954, PTHR15954, 1 hit |
SUPFAMi | SSF74788, SSF74788, 1 hit |
s (3+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry describes 3 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MAAAAAVGPG LGSGPGDSPE GPEADAPERR RKAHGMLKLY YGLSEGEVAG
60 70 80 90 100
HPAGPDPLDP TDLNGAHFDP EVYLDKLRRE CPLAQLMDSE TDMVRQIRAL
110 120 130 140 150
DSDMQTLVYE NYNKFISATD TIRKMKNDFR KMEDEMDRLA TNMAVITNFS
160 170 180 190 200
ARISATLQDR HERITKLAGV HALLRKLQFL FELPSRLTKC VELGAYGQAV
210 220 230 240 250
RYQGRARAVL QQYQHLPSFR AIQDDCQVIT ARLAQQLRQR FREGCSGAPE
260 270 280 290 300
QAECVELLLA LGEPAEELCE EFLAHARGRL EEELSSLEAE LGPSPPAPDV
310 320 330 340 350
LEFTDRGGNG FVGGLCQVAA AYQELFAAQG PAGAEKLAAF AQELGGRYFA
360 370 380 390 400
LVERRLAQEQ GGSDNSLLVR ALDRFHRRLR APGALLAAAG LSESATEIVE
410 420 430 440 450
RVARERLSHH LQGLKAAFLS SLTDVRQALA APRLAGKEGP SLAELLANVA
460 470 480 490 500
SSILSHIKTS LASVHLFTAK EVSFSNKPYF RGEFCSQGVR EGLIVGFIRS
510 520 530 540 550
MCQTAQSFCD SPGEKGGATP PALLLLLSRL CLDYETATIS YILTLTDEQF
560 570 580 590 600
LVQDQSPVTP VSTLCAEARE TARRLLTHYV KVQGLVISQM LRKSVETRDW
610 620 630 640 650
LSTLEPRNVR AVMKRVVEDT TAIDVQVGLL YEEGVRKAQS SDSSKRTFSV
660 670 680 690 700
YSSSRQQGRY APSYTPSAPM DTNLLSNIQK LFSERIDVFS PVEFNKVSVL
710 720 730 740 750
TGIIKISLKT LLECVRLRTF GRFGLQQVQV DCHFLQLYLW RFVADEELVH
760 770 780
LLLDEVVASA ALRCPDPVPM EPSVVEVICE RG
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6TKZ2 | F6TKZ2_MOUSE | Vacuolar protein sorting-associated... | Vps51 | 120 | Annotation score: | ||
E0CX85 | E0CX85_MOUSE | Vacuolar protein sorting-associated... | Vps51 | 81 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 265 | A → P in BAE26981 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 339 | A → D in BAE23255 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 409 | H → R in BAE26981 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 422 | L → M in BAE26981 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_036126 | 120 – 140 | DTIRK…MDRLA → GDPTGTHSSVLHHPHQVLTP C in isoform 3. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_036127 | 141 – 782 | Missing in isoform 3. 1 PublicationAdd BLAST | 642 | |
Alternative sequenceiVSP_036128 | 482 – 577 | GEFCS…RRLLT → VCCPLALLIRSADWPSSSLL LVFGEPWDMSPAPHNTVSST LRVESHSQEAVWRRKCYAAG LKLEGYQGPHCCQPYHRGSE AGWGGLWRRVKAKREE in isoform 2. 1 PublicationAdd BLAST | 96 | |
Alternative sequenceiVSP_036129 | 578 – 782 | Missing in isoform 2. 1 PublicationAdd BLAST | 205 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK014229 mRNA Translation: BAB29217.1 AK137155 mRNA Translation: BAE23255.1 AK146211 mRNA Translation: BAE26981.1 AC131692 Genomic DNA No translation available. CH466612 Genomic DNA Translation: EDL33203.1 BC118930 mRNA Translation: AAI18931.1 BC118931 mRNA Translation: AAI18932.1 Frameshift. |
CCDSi | CCDS37894.1 [Q3UVL4-1] |
RefSeqi | NP_001074510.1, NM_001081041.1 [Q3UVL4-1] |
Genome annotation databases
Ensembli | ENSMUST00000025711; ENSMUSP00000025711; ENSMUSG00000024797 [Q3UVL4-1] ENSMUST00000160590; ENSMUSP00000123857; ENSMUSG00000024797 [Q3UVL4-3] |
GeneIDi | 68505 |
KEGGi | mmu:68505 |
UCSCi | uc008ghb.1, mouse [Q3UVL4-1] uc008ghc.1, mouse [Q3UVL4-2] uc008ghd.1, mouse [Q3UVL4-3] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK014229 mRNA Translation: BAB29217.1 AK137155 mRNA Translation: BAE23255.1 AK146211 mRNA Translation: BAE26981.1 AC131692 Genomic DNA No translation available. CH466612 Genomic DNA Translation: EDL33203.1 BC118930 mRNA Translation: AAI18931.1 BC118931 mRNA Translation: AAI18932.1 Frameshift. |
CCDSi | CCDS37894.1 [Q3UVL4-1] |
RefSeqi | NP_001074510.1, NM_001081041.1 [Q3UVL4-1] |
3D structure databases
SMRi | Q3UVL4 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 212892, 13 interactors |
STRINGi | 10090.ENSMUSP00000123994 |
PTM databases
iPTMneti | Q3UVL4 |
PhosphoSitePlusi | Q3UVL4 |
SwissPalmi | Q3UVL4 |
Proteomic databases
EPDi | Q3UVL4 |
jPOSTi | Q3UVL4 |
PaxDbi | Q3UVL4 |
PeptideAtlasi | Q3UVL4 |
PRIDEi | Q3UVL4 |
Protocols and materials databases
Antibodypediai | 49945, 80 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000025711; ENSMUSP00000025711; ENSMUSG00000024797 [Q3UVL4-1] ENSMUST00000160590; ENSMUSP00000123857; ENSMUSG00000024797 [Q3UVL4-3] |
GeneIDi | 68505 |
KEGGi | mmu:68505 |
UCSCi | uc008ghb.1, mouse [Q3UVL4-1] uc008ghc.1, mouse [Q3UVL4-2] uc008ghd.1, mouse [Q3UVL4-3] |
Organism-specific databases
CTDi | 738 |
MGIi | MGI:1915755, Vps51 |
Phylogenomic databases
eggNOGi | KOG2346, Eukaryota |
GeneTreei | ENSGT00390000001738 |
HOGENOMi | CLU_020677_0_0_1 |
InParanoidi | Q3UVL4 |
OMAi | HTIEPRT |
OrthoDBi | 1305393at2759 |
TreeFami | TF314825 |
Enzyme and pathway databases
Reactomei | R-MMU-6811440, Retrograde transport at the Trans-Golgi-Network |
Miscellaneous databases
BioGRID-ORCSi | 68505, 6 hits in 19 CRISPR screens |
ChiTaRSi | Vps51, mouse |
PROi | PR:Q3UVL4 |
RNActi | Q3UVL4, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000024797, Expressed in granulocyte and 220 other tissues |
ExpressionAtlasi | Q3UVL4, baseline and differential |
Genevisiblei | Q3UVL4, MM |
Family and domain databases
InterProi | View protein in InterPro IPR016159, Cullin_repeat-like_dom_sf IPR014812, Vps51 |
PANTHERi | PTHR15954, PTHR15954, 1 hit |
SUPFAMi | SSF74788, SSF74788, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | VPS51_MOUSE | |
Accessioni | Q3UVL4Primary (citable) accession number: Q3UVL4 Secondary accession number(s): Q0VF89 Q9CXM6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 20, 2009 |
Last sequence update: | January 20, 2009 | |
Last modified: | February 10, 2021 | |
This is version 106 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families