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Entry version 129 (02 Jun 2021)
Sequence version 1 (11 Oct 2005)
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Protein

Integrin beta-2-like protein

Gene

Itgb2l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

During inflammatory stimulation, plays a role in retaining Cxcl13-expressing cells at the site of the inflammatory response.

1 Publication

Miscellaneous

The human orthologous protein seems not to exist.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIntegrin
Biological processInflammatory response

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Integrin beta-2-like protein
Alternative name(s):
Protein pactolus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Itgb2lImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 16

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1277979, Itgb2l

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini23 – 671ExtracellularSequence analysisAdd BLAST649
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei672 – 692HelicalSequence analysisAdd BLAST21
Topological domaini693 – 738CytoplasmicSequence analysisAdd BLAST46

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice display normal neutrophil maturation and function including appropriate migration into sites of inflammation and response to bacterial infection. Following inflammatory stimulus in the peritoneal cavity, they display decreased levels of Cxcl13 due to the migration of resident Cxcl13-expressing macrophages from the peritoneal cavity during the inflammatory response.2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000027812423 – 738Integrin beta-2-like proteinAdd BLAST716

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi25 ↔ 419By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi29N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi33 ↔ 43By similarity
Disulfide bondi36 ↔ 73By similarity
Disulfide bondi46 ↔ 62By similarity
Glycosylationi50N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi102N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi173N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi218 ↔ 258By similarity
Glycosylationi226N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi252N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi342N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi358 ↔ 372By similarity
Glycosylationi360N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi386N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi417 ↔ 421By similarity
Disulfide bondi439 ↔ 478By similarity
Disulfide bondi444 ↔ 453By similarity
Disulfide bondi455 ↔ 469By similarity
Glycosylationi473N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi484 ↔ 489By similarity
Disulfide bondi486 ↔ 521By similarity
Disulfide bondi491 ↔ 506By similarity
Disulfide bondi508 ↔ 513By similarity
Disulfide bondi529 ↔ 534By similarity
Disulfide bondi531 ↔ 562By similarity
Disulfide bondi536 ↔ 545By similarity
Disulfide bondi547 ↔ 554By similarity
Disulfide bondi568 ↔ 573By similarity
Disulfide bondi575 ↔ 584By similarity
Disulfide bondi594 ↔ 603By similarity
Disulfide bondi600 ↔ 664By similarity
Glycosylationi627N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi669N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3UV74

PRoteomics IDEntifications database

More...
PRIDEi
Q3UV74

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
269345 [Q3UV74-1]
269346 [Q3UV74-2]
269347 [Q3UV74-3]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...
GlyGeni
Q3UV74, 12 sites

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3UV74

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3UV74

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed predominantly in maturing and mature neutrophils.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000000157, Expressed in granulocyte and 76 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3UV74, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3UV74, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer and homodimer (Probable). Unlike integrin beta chains, no alpha chain partner has yet been found.

Curated2 Publications

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000000161

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3UV74, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1738
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Biological Magnetic Resonance Data Bank

More...
BMRBi
Q3UV74

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3UV74

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q3UV74

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 74PSISequence analysisAdd BLAST51
Domaini126 – 329VWFASequence analysisAdd BLAST204

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni709 – 738DisorderedSequence analysisAdd BLAST30

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the integrin beta chain family.Sequence analysis

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1226, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT01030000234611

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_011772_4_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3UV74

Identification of Orthologs from Complete Genome Data

More...
OMAi
SERECIE

Database of Orthologous Groups

More...
OrthoDBi
473040at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3UV74

TreeFam database of animal gene trees

More...
TreeFami
TF105392

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.40.50.410, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033760, Integrin_beta_N
IPR015812, Integrin_bsu
IPR015439, Integrin_bsu-2
IPR012896, Integrin_bsu_tail
IPR036349, Integrin_bsu_tail_dom_sf
IPR002369, Integrin_bsu_VWA
IPR032695, Integrin_dom_sf
IPR016201, PSI
IPR036465, vWFA_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR10082, PTHR10082, 2 hits
PTHR10082:SF15, PTHR10082:SF15, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00362, Integrin_beta, 2 hits
PF17205, PSI_integrin, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF002512, Integrin_B, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR01186, INTEGRINB

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00187, INB, 1 hit
SM01242, Integrin_B_tail, 1 hit
SM00423, PSI, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF53300, SSF53300, 1 hit
SSF69179, SSF69179, 1 hit
SSF69687, SSF69687, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 3 hits
PS00243, INTEGRIN_BETA, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q3UV74-1) [UniParc]FASTAAdd to basket
Also known as: A1 Publication, Membrane-bound1 Publication

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLGQCTLLPV LAGLLSLESA LSQLCTKDNV STCQDCIRSG PSCAWCQKLN
60 70 80 90 100
FTGRGEPDSV RCDTPEQLLL KGCTSEYLVD PKSLAESQED KERDQRQLSP
110 120 130 140 150
RNVTVFLRPG QAATFKVDFQ RTQDNSVDLY FLMGLSGSAQ GHLSNVQTLG
160 170 180 190 200
SDLLKALNEI SRSGRIGFGS IVNMTFQHIL KLTADSSQFQ RELRKQLVSG
210 220 230 240 250
KLATPKGQLD AVVQVAICLG EIGWRNGTRF LVLVTDNDFH LAKDKTLGTR
260 270 280 290 300
QNTSDGRCHL DDGMYRSRGE PDYQSVVQLA SKLAENNIQP IFVVPSRMVK
310 320 330 340 350
TYEKLTTFIP KLTIGELSDD SSNVAQLIRN AYSKLSSIVV LNHSTIPSIL
360 370 380 390 400
KVTYDSYCSN GTSNPGKPSG DCSGVQINDQ VTFQVNITAS ECFREQFFFI
410 420 430 440 450
QALGFMDSVT VRVLPLCECQ CQEQSQHHSL CGGKGAMECG ICRCNSGYAG
460 470 480 490 500
KNCECQTQGP SSQDLEGSCR KDNSSIMCSG LGDCICGQCE CHTSDIPNKE
510 520 530 540 550
IYGQYCECNN VNCERYDGQV CGGPERGHCS CGRCFCRYGF VGSACQCRMS
560 570 580 590 600
TSGCLNNRMV ECSGHGRCYC NRCLCDPGYQ PPLCEKRPGY FHRCSEYYSC
610 620 630 640 650
ARCLKDNSAI KCRECWNLLF SNTPFSNKTC MTERDSEGCW TTYTLYQPDQ
660 670 680 690 700
SDINSIYIKE SLVCAEISNT TILLGVIVGV LLAVIFLLVY CMVYLKGTQK
710 720 730
AAKLPRKGGA QSTLAQQPHF QEPHHVEPVW NQERQGTQ
Length:738
Mass (Da):81,547
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCCAA3138FEFF0D5A
GO
Isoform 21 Publication (identifier: Q3UV74-2) [UniParc]FASTAAdd to basket
Also known as: B1 Publication, Truncated1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     525-540: ERGHCSCGRCFCRYGF → ASWAQPASAGCPLQAV
     541-738: Missing.

Show »
Length:540
Mass (Da):58,892
Checksum:i73ADCB17A9533ED9
GO
Isoform 31 Publication (identifier: Q3UV74-3) [UniParc]FASTAAdd to basket
Also known as: C1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
     432-490: GGKGAMECGI...LGDCICGQCE → LQEDESWQPR...GVQWPWSMLL
     491-738: Missing.

Show »
Length:490
Mass (Da):54,554
Checksum:iD6869101C85F9F75
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YXH8D3YXH8_MOUSE
Integrin beta
Itgb2l
795Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti509N → D in AAC25502 (PubMed:9535848).Curated1
Sequence conflicti509N → D in AAI13143 (PubMed:15489334).Curated1
Sequence conflicti710A → V in AAC25502 (PubMed:9535848).Curated1

<p>This subsection of the 'Sequence' section provides information on polymorphic variants. If the variant is associated with a disease state, the description of the latter can be found in the <a href="http://www.uniprot.org/manual/involvement%5Fin%5Fdisease">'Involvement in disease'</a> subsection.<p><a href='/help/polymorphism' target='_top'>More...</a></p>Polymorphismi

Strain C57BL/6 preferentially expresses isoform 1 while strains BALB/c and C3H/HeJ preferentially express isoform 2. This is due to a single nucleotide difference at the second splice acceptor site in exon 13 which results in production of isoform 2 when this splice site is used in strains BALB/c and C3H/HeJ.1 Publication

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti539G → S in strain: BALB/c and C3H/HeJ. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_052319432 – 490GGKGA…CGQCE → LQEDESWQPRLFSRKRPLLL WPMLLSLQLRGLSLPVPDVH FRLSEQQDGGVQWPWSMLL in isoform 3. 1 PublicationAdd BLAST59
Alternative sequenceiVSP_052320491 – 738Missing in isoform 3. 1 PublicationAdd BLAST248
Alternative sequenceiVSP_052321525 – 540ERGHC…CRYGF → ASWAQPASAGCPLQAV in isoform 2. 1 PublicationAdd BLAST16
Alternative sequenceiVSP_052322541 – 738Missing in isoform 2. 1 PublicationAdd BLAST198

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF051367 mRNA Translation: AAC25502.1
AK137534 mRNA Translation: BAE23399.1
BC113142 mRNA Translation: AAI13143.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS28358.1 [Q3UV74-1]

NCBI Reference Sequences

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RefSeqi
NP_032431.2, NM_008405.3 [Q3UV74-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000000161; ENSMUSP00000000161; ENSMUSG00000000157 [Q3UV74-1]
ENSMUST00000131567; ENSMUSP00000114497; ENSMUSG00000000157 [Q3UV74-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
16415

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:16415

UCSC genome browser

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UCSCi
uc008adb.1, mouse [Q3UV74-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF051367 mRNA Translation: AAC25502.1
AK137534 mRNA Translation: BAE23399.1
BC113142 mRNA Translation: AAI13143.1
CCDSiCCDS28358.1 [Q3UV74-1]
RefSeqiNP_032431.2, NM_008405.3 [Q3UV74-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2IUENMR-A124-335[»]
BMRBiQ3UV74
SMRiQ3UV74
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000000161

PTM databases

GlyGeniQ3UV74, 12 sites
iPTMnetiQ3UV74
PhosphoSitePlusiQ3UV74

Proteomic databases

PaxDbiQ3UV74
PRIDEiQ3UV74
ProteomicsDBi269345 [Q3UV74-1]
269346 [Q3UV74-2]
269347 [Q3UV74-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
1501, 2021 antibodies

The DNASU plasmid repository

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DNASUi
16415

Genome annotation databases

EnsembliENSMUST00000000161; ENSMUSP00000000161; ENSMUSG00000000157 [Q3UV74-1]
ENSMUST00000131567; ENSMUSP00000114497; ENSMUSG00000000157 [Q3UV74-2]
GeneIDi16415
KEGGimmu:16415
UCSCiuc008adb.1, mouse [Q3UV74-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
16415
MGIiMGI:1277979, Itgb2l

Phylogenomic databases

eggNOGiKOG1226, Eukaryota
GeneTreeiENSGT01030000234611
HOGENOMiCLU_011772_4_0_1
InParanoidiQ3UV74
OMAiSERECIE
OrthoDBi473040at2759
PhylomeDBiQ3UV74
TreeFamiTF105392

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
16415, 0 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Itgb2l, mouse
EvolutionaryTraceiQ3UV74

Protein Ontology

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PROi
PR:Q3UV74
RNActiQ3UV74, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000000157, Expressed in granulocyte and 76 other tissues
ExpressionAtlasiQ3UV74, baseline and differential
GenevisibleiQ3UV74, MM

Family and domain databases

Gene3Di3.40.50.410, 1 hit
InterProiView protein in InterPro
IPR033760, Integrin_beta_N
IPR015812, Integrin_bsu
IPR015439, Integrin_bsu-2
IPR012896, Integrin_bsu_tail
IPR036349, Integrin_bsu_tail_dom_sf
IPR002369, Integrin_bsu_VWA
IPR032695, Integrin_dom_sf
IPR016201, PSI
IPR036465, vWFA_dom_sf
PANTHERiPTHR10082, PTHR10082, 2 hits
PTHR10082:SF15, PTHR10082:SF15, 2 hits
PfamiView protein in Pfam
PF00362, Integrin_beta, 2 hits
PF17205, PSI_integrin, 1 hit
PIRSFiPIRSF002512, Integrin_B, 1 hit
PRINTSiPR01186, INTEGRINB
SMARTiView protein in SMART
SM00187, INB, 1 hit
SM01242, Integrin_B_tail, 1 hit
SM00423, PSI, 1 hit
SUPFAMiSSF53300, SSF53300, 1 hit
SSF69179, SSF69179, 1 hit
SSF69687, SSF69687, 1 hit
PROSITEiView protein in PROSITE
PS00022, EGF_1, 2 hits
PS01186, EGF_2, 3 hits
PS00243, INTEGRIN_BETA, 3 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiITB2L_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UV74
Secondary accession number(s): O88424, Q2KHL5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 20, 2007
Last sequence update: October 11, 2005
Last modified: June 2, 2021
This is version 129 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
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