Nuclear receptor subfamily 1 group D member 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: MGI <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors."
    Forman B.M., Chen J., Blumberg B., Kliewer S.A., Henshaw R., Ong E., Evans R.M.
    Mol. Endocrinol. 8:1253-1261(1994) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription factor activity Source: MGIInferred from direct assayⁱ
  • "The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator."
    Preitner N., Damiola F., Lopez-Molina L., Zakany J., Duboule D., Albrecht U., Schibler U.
    Cell 110:251-260(2002) [PubMed] [Europe PMC] [Abstract]
  • "Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors."
    Forman B.M., Chen J., Blumberg B., Kliewer S.A., Henshaw R., Ong E., Evans R.M.
    Mol. Endocrinol. 8:1253-1261(1994) [PubMed] [Europe PMC] [Abstract]
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
• E-box binding Source: UniProtKBInferred from direct assayⁱ
  • Ref.9

    "Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha."
    Duez H., van der Veen J.N., Duhem C., Pourcet B., Touvier T., Fontaine C., Derudas B., Bauge E., Havinga R., Bloks V.W., Wolters H., van der Sluijs F.H., Vennstrom B., Kuipers F., Staels B.
    Gastroenterology 135:689-698(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• heme binding Source: MGI
• nuclear receptor activity Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
• RNA polymerase II transcription regulatory region sequence-specific DNA binding Source: MGIInferred from sequence orthologyⁱ
  • "The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes."
    Journiac N., Jolly S., Jarvis C., Gautheron V., Rogard M., Trembleau A., Blondeau J.P., Mariani J., Vernet-der Garabedian B.
    Proc Natl Acad Sci U S A 106:21365-21370(2009) [PubMed] [Europe PMC] [Abstract]
• sequence-specific double-stranded DNA binding Source: MGI
• transcription cis-regulatory region binding Source: MGI
• transcription corepressor binding Source: UniProtKB
• zinc ion binding Source: InterPro

GO - Biological processⁱ

• cell differentiation Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• cellular glucose homeostasis Source: UniProtKB
• cellular response to interleukin-1 Source: UniProtKBInferred from direct assayⁱ
  • Ref.40

    "Circadian clock component REV-ERBalpha controls homeostatic regulation of pulmonary inflammation."
    Pariollaud M., Gibbs J.E., Hopwood T.W., Brown S., Begley N., Vonslow R., Poolman T., Guo B., Saer B., Jones D.H., Tellam J.P., Bresciani S., Tomkinson N.C., Wojno-Picon J., Cooper A.W., Daniels D.A., Trump R.P., Grant D.

    , Zuercher W., Willson T.M., MacDonald A.S., Bolognese B., Podolin P.L., Sanchez Y., Loudon A.S., Ray D.W.
    J. Clin. Invest. 128:2281-2296(2018) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE, UBIQUITINATION, PROTEASOMAL DEGRADATION, SUMOYLATION.
• cellular response to lipopolysaccharide Source: MGI
• cellular response to tumor necrosis factor Source: UniProtKBInferred from direct assayⁱ
  • Ref.40

    "Circadian clock component REV-ERBalpha controls homeostatic regulation of pulmonary inflammation."
    Pariollaud M., Gibbs J.E., Hopwood T.W., Brown S., Begley N., Vonslow R., Poolman T., Guo B., Saer B., Jones D.H., Tellam J.P., Bresciani S., Tomkinson N.C., Wojno-Picon J., Cooper A.W., Daniels D.A., Trump R.P., Grant D.

    , Zuercher W., Willson T.M., MacDonald A.S., Bolognese B., Podolin P.L., Sanchez Y., Loudon A.S., Ray D.W.
    J. Clin. Invest. 128:2281-2296(2018) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE, UBIQUITINATION, PROTEASOMAL DEGRADATION, SUMOYLATION.
• cholesterol homeostasis Source: UniProtKB <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • Ref.13

    "REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis."
    Le Martelot G., Claudel T., Gatfield D., Schaad O., Kornmann B., Lo Sasso G., Moschetta A., Schibler U.
    PLoS Biol. 7:E1000181-E1000181(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• circadian regulation of gene expression Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.14

    "The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors."
    Schmutz I., Ripperger J.A., Baeriswyl-Aebischer S., Albrecht U.
    Genes Dev. 24:345-357(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN CIRCADIAN RHYTHMS, INTERACTION WITH PER2, DISRUPTION PHENOTYPE, MUTAGENESIS OF LYS-456.
• circadian rhythm Source: MGIInferred from direct assayⁱ
  • "The orphan nuclear receptor REV-ERBalpha controls circadian transcription within the positive limb of the mammalian circadian oscillator."
    Preitner N., Damiola F., Lopez-Molina L., Zakany J., Duboule D., Albrecht U., Schibler U.
    Cell 110:251-260(2002) [PubMed] [Europe PMC] [Abstract]
• circadian temperature homeostasis Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.28

    "The nuclear receptor Rev-erbalpha controls circadian thermogenic plasticity."
    Gerhart-Hines Z., Feng D., Emmett M.J., Everett L.J., Loro E., Briggs E.R., Bugge A., Hou C., Ferrara C., Seale P., Pryma D.A., Khurana T.S., Lazar M.A.
    Nature 503:410-413(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• glycogen biosynthetic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.14

    "The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors."
    Schmutz I., Ripperger J.A., Baeriswyl-Aebischer S., Albrecht U.
    Genes Dev. 24:345-357(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN CIRCADIAN RHYTHMS, INTERACTION WITH PER2, DISRUPTION PHENOTYPE, MUTAGENESIS OF LYS-456.
• hormone-mediated signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• negative regulation of astrocyte activation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.43

    "Circadian clock protein Rev-erbalpha regulates neuroinflammation."
    Griffin P., Dimitry J.M., Sheehan P.W., Lananna B.V., Guo C., Robinette M.L., Hayes M.E., Cedeno M.R., Nadarajah C.J., Ezerskiy L.A., Colonna M., Zhang J., Bauer A.Q., Burris T.P., Musiek E.S.
    Proc. Natl. Acad. Sci. U.S.A. 116:5102-5107(2019) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• negative regulation of cold-induced thermogenesis Source: YuBioLabInferred from mutant phenotypeⁱ
  • Ref.28

    "The nuclear receptor Rev-erbalpha controls circadian thermogenic plasticity."
    Gerhart-Hines Z., Feng D., Emmett M.J., Everett L.J., Loro E., Briggs E.R., Bugge A., Hou C., Ferrara C., Seale P., Pryma D.A., Khurana T.S., Lazar M.A.
    Nature 503:410-413(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• negative regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.43

    "Circadian clock protein Rev-erbalpha regulates neuroinflammation."
    Griffin P., Dimitry J.M., Sheehan P.W., Lananna B.V., Guo C., Robinette M.L., Hayes M.E., Cedeno M.R., Nadarajah C.J., Ezerskiy L.A., Colonna M., Zhang J., Bauer A.Q., Burris T.P., Musiek E.S.
    Proc. Natl. Acad. Sci. U.S.A. 116:5102-5107(2019) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• negative regulation of inflammatory response Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.40

    "Circadian clock component REV-ERBalpha controls homeostatic regulation of pulmonary inflammation."
    Pariollaud M., Gibbs J.E., Hopwood T.W., Brown S., Begley N., Vonslow R., Poolman T., Guo B., Saer B., Jones D.H., Tellam J.P., Bresciani S., Tomkinson N.C., Wojno-Picon J., Cooper A.W., Daniels D.A., Trump R.P., Grant D.

    , Zuercher W., Willson T.M., MacDonald A.S., Bolognese B., Podolin P.L., Sanchez Y., Loudon A.S., Ray D.W.
    J. Clin. Invest. 128:2281-2296(2018) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE, UBIQUITINATION, PROTEASOMAL DEGRADATION, SUMOYLATION.
• negative regulation of microglial cell activation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.43

    "Circadian clock protein Rev-erbalpha regulates neuroinflammation."
    Griffin P., Dimitry J.M., Sheehan P.W., Lananna B.V., Guo C., Robinette M.L., Hayes M.E., Cedeno M.R., Nadarajah C.J., Ezerskiy L.A., Colonna M., Zhang J., Bauer A.Q., Burris T.P., Musiek E.S.
    Proc. Natl. Acad. Sci. U.S.A. 116:5102-5107(2019) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• negative regulation of neuroinflammatory response Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.43

    "Circadian clock protein Rev-erbalpha regulates neuroinflammation."
    Griffin P., Dimitry J.M., Sheehan P.W., Lananna B.V., Guo C., Robinette M.L., Hayes M.E., Cedeno M.R., Nadarajah C.J., Ezerskiy L.A., Colonna M., Zhang J., Bauer A.Q., Burris T.P., Musiek E.S.
    Proc. Natl. Acad. Sci. U.S.A. 116:5102-5107(2019) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• negative regulation of toll-like receptor 4 signaling pathway Source: MGI
• negative regulation of transcription, DNA-templated Source: UniProtKBInferred from direct assayⁱ
  • Ref.16

    "A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbalpha."
    Valnegri P., Khelfaoui M., Dorseuil O., Bassani S., Lagneaux C., Gianfelice A., Benfante R., Chelly J., Billuart P., Sala C., Passafaro M.
    Nat. Neurosci. 14:1293-1301(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH OPHN1, PROTEASOMAL DEGRADATION, TISSUE SPECIFICITY.
  • Ref.26

    "Transcription factor NF-Y is a functional regulator of the transcription of core clock gene Bmal1."
    Xiao J., Zhou Y., Lai H., Lei S., Chi L.H., Mo X.
    J. Biol. Chem. 288:31930-31936(2013) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • Ref.37

    "E4bp4 regulates carboxylesterase 2 enzymes through repression of the nuclear receptor Rev-erbalpha in mice."
    Zhao M., Zhang T., Yu F., Guo L., Wu B.
    Biochem. Pharmacol. 152:293-301(2018) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH NFIL3.
  • Ref.39

    "Transcriptional programming of lipid and amino acid metabolism by the skeletal muscle circadian clock."
    Dyar K.A., Hubert M.J., Mir A.A., Ciciliot S., Lutter D., Greulich F., Quagliarini F., Kleinert M., Fischer K., Eichmann T.O., Wright L.E., Pena Paz M.I., Casarin A., Pertegato V., Romanello V., Albiero M., Mazzucco S., Rizzuto R.

    , Salviati L., Biolo G., Blaauw B., Schiaffino S., Uhlenhaut N.H.
    PLoS Biol. 16:E2005886-E2005886(2018) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • Ref.41

    "Small heterodimer partner regulates circadian cytochromes p450 and drug-induced hepatotoxicity."
    Zhang T., Yu F., Guo L., Chen M., Yuan X., Wu B.
    Theranostics 8:5246-5258(2018) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH NR0B2.
• negative regulation of transcription by RNA polymerase II Source: MGIInferred from sequence orthologyⁱ
  • "The nuclear receptor ROR(alpha) exerts a bi-directional regulation of IL-6 in resting and reactive astrocytes."
    Journiac N., Jolly S., Jarvis C., Gautheron V., Rogard M., Trembleau A., Blondeau J.P., Mariani J., Vernet-der Garabedian B.
    Proc Natl Acad Sci U S A 106:21365-21370(2009) [PubMed] [Europe PMC] [Abstract]
• positive regulation of bile acid biosynthetic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.9

    "Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha."
    Duez H., van der Veen J.N., Duhem C., Pourcet B., Touvier T., Fontaine C., Derudas B., Bauge E., Havinga R., Bloks V.W., Wolters H., van der Sluijs F.H., Vennstrom B., Kuipers F., Staels B.
    Gastroenterology 135:689-698(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • Ref.13

    "REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis."
    Le Martelot G., Claudel T., Gatfield D., Schaad O., Kornmann B., Lo Sasso G., Moschetta A., Schibler U.
    PLoS Biol. 7:E1000181-E1000181(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• positive regulation of circadian rhythm Source: MGI
• positive regulation of transcription, DNA-templated Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.9

    "Regulation of bile acid synthesis by the nuclear receptor Rev-erbalpha."
    Duez H., van der Veen J.N., Duhem C., Pourcet B., Touvier T., Fontaine C., Derudas B., Bauge E., Havinga R., Bloks V.W., Wolters H., van der Sluijs F.H., Vennstrom B., Kuipers F., Staels B.
    Gastroenterology 135:689-698(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
• positive regulation of transcription by RNA polymerase II Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• proteasomal protein catabolic process Source: UniProtKBInferred from direct assayⁱ
  • Ref.10

    "Bifunctional role of Rev-erbalpha in adipocyte differentiation."
    Wang J., Lazar M.A.
    Mol. Cell. Biol. 28:2213-2220(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY, PROTEASOMAL DEGRADATION.
  • Ref.16

    "A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbalpha."
    Valnegri P., Khelfaoui M., Dorseuil O., Bassani S., Lagneaux C., Gianfelice A., Benfante R., Chelly J., Billuart P., Sala C., Passafaro M.
    Nat. Neurosci. 14:1293-1301(2011) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, SUBCELLULAR LOCATION, INTERACTION WITH OPHN1, PROTEASOMAL DEGRADATION, TISSUE SPECIFICITY.
• protein destabilization Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.35

    "REV-ERBalpha influences the stability and nuclear localization of the glucocorticoid receptor."
    Okabe T., Chavan R., Fonseca Costa S.S., Brenna A., Ripperger J.A., Albrecht U.
    J. Cell Sci. 129:4143-4154(2016) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, INTERACTION WITH HSP90AA1 AND HSP90AB1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
• regulation of circadian rhythm Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.13

    "REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis."
    Le Martelot G., Claudel T., Gatfield D., Schaad O., Kornmann B., Lo Sasso G., Moschetta A., Schibler U.
    PLoS Biol. 7:E1000181-E1000181(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • Ref.14

    "The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors."
    Schmutz I., Ripperger J.A., Baeriswyl-Aebischer S., Albrecht U.
    Genes Dev. 24:345-357(2010) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION IN CIRCADIAN RHYTHMS, INTERACTION WITH PER2, DISRUPTION PHENOTYPE, MUTAGENESIS OF LYS-456.
  • Ref.40

    "Circadian clock component REV-ERBalpha controls homeostatic regulation of pulmonary inflammation."
    Pariollaud M., Gibbs J.E., Hopwood T.W., Brown S., Begley N., Vonslow R., Poolman T., Guo B., Saer B., Jones D.H., Tellam J.P., Bresciani S., Tomkinson N.C., Wojno-Picon J., Cooper A.W., Daniels D.A., Trump R.P., Grant D.

    , Zuercher W., Willson T.M., MacDonald A.S., Bolognese B., Podolin P.L., Sanchez Y., Loudon A.S., Ray D.W.
    J. Clin. Invest. 128:2281-2296(2018) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE, UBIQUITINATION, PROTEASOMAL DEGRADATION, SUMOYLATION.
• regulation of circadian sleep/wake cycle Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.43

    "Circadian clock protein Rev-erbalpha regulates neuroinflammation."
    Griffin P., Dimitry J.M., Sheehan P.W., Lananna B.V., Guo C., Robinette M.L., Hayes M.E., Cedeno M.R., Nadarajah C.J., Ezerskiy L.A., Colonna M., Zhang J., Bauer A.Q., Burris T.P., Musiek E.S.
    Proc. Natl. Acad. Sci. U.S.A. 116:5102-5107(2019) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.
• regulation of fat cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.10

    "Bifunctional role of Rev-erbalpha in adipocyte differentiation."
    Wang J., Lazar M.A.
    Mol. Cell. Biol. 28:2213-2220(2008) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY, PROTEASOMAL DEGRADATION.
• regulation of hepatic stellate cell activation Source: MGI
• regulation of insulin secretion involved in cellular response to glucose stimulus Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.19

    "The clock gene Rev-erbalpha regulates pancreatic beta-cell function: modulation by leptin and high-fat diet."
    Vieira E., Marroqui L., Batista T.M., Caballero-Garrido E., Carneiro E.M., Boschero A.C., Nadal A., Quesada I.
    Endocrinology 153:592-601(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• regulation of lipid metabolic process Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.13

    "REV-ERBalpha participates in circadian SREBP signaling and bile acid homeostasis."
    Le Martelot G., Claudel T., Gatfield D., Schaad O., Kornmann B., Lo Sasso G., Moschetta A., Schibler U.
    PLoS Biol. 7:E1000181-E1000181(2009) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION.
  • Ref.19

    "The clock gene Rev-erbalpha regulates pancreatic beta-cell function: modulation by leptin and high-fat diet."
    Vieira E., Marroqui L., Batista T.M., Caballero-Garrido E., Carneiro E.M., Boschero A.C., Nadal A., Quesada I.
    Endocrinology 153:592-601(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• regulation of transcription, DNA-templated Source: MGIInferred from direct assayⁱ
  • "Cross-talk among ROR alpha 1 and the Rev-erb family of orphan nuclear receptors."
    Forman B.M., Chen J., Blumberg B., Kliewer S.A., Henshaw R., Ong E., Evans R.M.
    Mol. Endocrinol. 8:1253-1261(1994) [PubMed] [Europe PMC] [Abstract]
• regulation of type B pancreatic cell proliferation Source: UniProtKBInferred from mutant phenotypeⁱ
  • Ref.19

    "The clock gene Rev-erbalpha regulates pancreatic beta-cell function: modulation by leptin and high-fat diet."
    Vieira E., Marroqui L., Batista T.M., Caballero-Garrido E., Carneiro E.M., Boschero A.C., Nadal A., Quesada I.
    Endocrinology 153:592-601(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.
• response to leptin Source: UniProtKBInferred from direct assayⁱ
  • Ref.19

    "The clock gene Rev-erbalpha regulates pancreatic beta-cell function: modulation by leptin and high-fat diet."
    Vieira E., Marroqui L., Batista T.M., Caballero-Garrido E., Carneiro E.M., Boschero A.C., Nadal A., Quesada I.
    Endocrinology 153:592-601(2012) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, TISSUE SPECIFICITY.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stageⁱ

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• transcription corepressor binding Source: UniProtKB

Protein-protein interaction databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Zinc finger

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MTTLDSNNNT GGVITYIGSS GSSPSRTSPE SLYSDSSNGS FQSLTQGCPT 
        60         70         80         90        100
YFPPSPTGSL TQDPARSFGS APPSLSDDSS PSSASSSSSS SSSSFYNGSP 
       110        120        130        140        150
PGSLQVAMED SSRVSPSKGT SNITKLNGMV LLCKVCGDVA SGFHYGVHAC 
       160        170        180        190        200
EGCKGFFRRS IQQNIQYKRC LKNENCSIVR INRNRCQQCR FKKCLSVGMS 
       210        220        230        240        250
RDAVRFGRIP KREKQRMLAE MQSAMNLANN QLSSLCPLET SPTPHPTSGS 
       260        270        280        290        300
MGPSPPPAPA PTPLVGFSQF PQQLTPPRSP SPEPTMEDVI SQVARAHREI 
       310        320        330        340        350
FTYAHDKLGT SPGNFNANHA SGSPSATTPH RWESQGCPSA PNDNNLLAAQ 
       360        370        380        390        400
RHNEALNGLR QGPSSYPPTW PSGPTHHSCH QPNSNGHRLC PTHVYSAPEG 
       410        420        430        440        450
EAPANSLRQG NTKNVLLACP MNMYPHGRSG RTVQEIWEDF SMSFTPAVRE 
       460        470        480        490        500
VVEFAKHIPG FRDLSQHDQV TLLKAGTFEV LMVRFASLFN VKDQTVMFLS 
       510        520        530        540        550
RTTYSLQELG AMGMGDLLNA MFDFSEKLNS LALTEEELGL FTAVVLVSAD 
       560        570        580        590        600
RSGMENSASV EQLQETLLRA LRALVLKNRP SETSRFTKLL LKLPDLRTLN 
       610 
NMHSEKLLSF RVDAQ                                       

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families