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Entry version 121 (29 Sep 2021)
Sequence version 1 (11 Oct 2005)
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Protein
Submitted name:

MAM domain-containing glycosylphosphatidylinositol anchor protein 2

Gene

Mdga2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
MAM domain-containing glycosylphosphatidylinositol anchor protein 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Mdga2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2444706, Mdga2

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000034912

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1001 – 1021HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Keywords - PTMi

Glycoprotein, GPI-anchorARBA annotation, Lipoprotein

Proteomic databases

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
344812

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3UV20, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3UV20, MM

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3UV20

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini96 – 196Ig-likeInterPro annotationAdd BLAST101
Domaini203 – 301Ig-likeInterPro annotationAdd BLAST99
Domaini311 – 397Ig-likeInterPro annotationAdd BLAST87
Domaini409 – 505Ig-likeInterPro annotationAdd BLAST97
Domaini511 – 602Ig-likeInterPro annotationAdd BLAST92
Domaini609 – 696Ig-likeInterPro annotationAdd BLAST88
Domaini707 – 808Fibronectin type-IIIInterPro annotationAdd BLAST102
Domaini815 – 990MAMInterPro annotationAdd BLAST176

Keywords - Domaini

Immunoglobulin domainARBA annotation, RepeatARBA annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000155369

Identification of Orthologs from Complete Genome Data

More...
OMAi
HKDETEY

Database of Orthologous Groups

More...
OrthoDBi
118847at2759

TreeFam database of animal gene trees

More...
TreeFami
TF330345

Family and domain databases

Conserved Domains Database

More...
CDDi
cd06263, MAM, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013320, ConA-like_dom_sf
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR000998, MAM_dom

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679, I-set, 1 hit
PF00629, MAM, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409, IG, 6 hits
SM00408, IGc2, 6 hits
SM00137, MAM, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726, SSF48726, 6 hits
SSF49265, SSF49265, 1 hit
SSF49899, SSF49899, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853, FN3, 1 hit
PS50835, IG_LIKE, 6 hits
PS50060, MAM_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 6 potential isoforms that are computationally mapped.Show allAlign All

Q3UV20-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSVGCVGLQR SAHGRRQGRT DGQCFLPLLA VPGHLDSARA QVERALLAAG
60 70 80 90 100
LQKVPLRPPW AGYVHVHVKM DLVYGLVWLL TVLLEGISGQ GVYAPPTVRI
110 120 130 140 150
VHSGLACNIE EERYSERVYT IREGETLELT CLVTGHPRPQ IRWTKTAGSA
160 170 180 190 200
SDRFQDSSVF NETLRITNIQ RHQGGRYYCK AENGLGSPAI KSIRVDVYYL
210 220 230 240 250
DDPVVTVHQS IGEAKEQFYY ERTVFLRCVA NSNPPVRYSW RRGQEVLLQG
260 270 280 290 300
SDKGVEIYEP FFTQGETKIL KLKNLRPQDY ANYSCIASVR NVCNIPDKMV
310 320 330 340 350
SFRLSNKTAS PSIKLLVDDP IVVNPGEAIT LVCVTTGGEP TPSLTWVRSF
360 370 380 390 400
GTLPEKIVLN GGTLTIPAIT SDDAGTYSCI ANNNVGNPAK KSTNIIVRAL
410 420 430 440 450
KKGRFWITPD PYHKDDNIQI GREVKISCQV EAVPSEELTF SWFKNGRPLR
460 470 480 490 500
SSERMVITQT DPDVSPGTTN LDIIDLKFTD FGTYTCVASL KGGGISDISI
510 520 530 540 550
DVNISSSTVP PNLTVPQEKS PLVTREGDTI ELQCQVTGKP KPIILWSRAD
560 570 580 590 600
KEVAMPDGTM QMESYDGTLR IVNVSREMSG MYRCQTSQYN GFNVKPREAL
610 620 630 640 650
VQLIVQYPPA VEPAFLEIRQ GQDRSVTMSC RVLRAYPIRV LTYEWRLGNK
660 670 680 690 700
LLRTGQFDSQ EYTEYPLKSL SNENYGVYNC SIINEAGAGR CSFLVTGKAY
710 720 730 740 750
APEFYYDTYN PVWQNRHRVY SYSLQWTQMN PDAVDRIVAY RLGIRQAGQQ
760 770 780 790 800
RWWEQEIKIN GNIQKGELIT YNLTELIKPE AYEVRLTPLT KFGEGDSTIR
810 820 830 840 850
VIKYTAPVNP HLREFHCGFE DGNICLFTQD DTDNFDWTKQ STATRNTKYT
860 870 880 890 900
PNTGPSADRS GSKEGFYMYI ETSRPRLEGE KARLLSPVFS IAPKNPYGPT
910 920 930 940 950
NSAYCFSFFY HMYGQHIGVL NVYLRLKGQT TIENPLWSSS GNKGQRWNEA
960 970 980 990 1000
HVNIYPITSF QLIFEGIRGP GIEGDIAIDD VSIAEGECAK QDLPTKNSVD
1010 1020
GAVGILVHIW LFPVIILISI LSPRR
Length:1,025
Mass (Da):114,934
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7ECD56A50F7C2472
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P60755MDGA2_MOUSE
MAM domain-containing glycosylphosp...
Mdga2 Mamdc1
949Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A217FL82A0A217FL82_MOUSE
MAM domain-containing glycosylphosp...
Mdga2
1,009Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q3UUB8Q3UUB8_MOUSE
MAM domain-containing glycosylphosp...
Mdga2 Mamdc1
140Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VJM7A0A1Y7VJM7_MOUSE
MAM domain-containing glycosylphosp...
Mdga2
297Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1Y7VIL8A0A1Y7VIL8_MOUSE
MAM domain-containing glycosylphosp...
Mdga2
319Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6UYI7F6UYI7_MOUSE
MAM domain-containing glycosylphosp...
Mdga2
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK137667 mRNA Translation: BAE23453.1

NCBI Reference Sequences

More...
RefSeqi
NP_001180195.2, NM_001193266.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000037181; ENSMUSP00000046761; ENSMUSG00000034912

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
320772

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK137667 mRNA Translation: BAE23453.1
RefSeqiNP_001180195.2, NM_001193266.1

3D structure databases

SMRiQ3UV20
ModBaseiSearch...

Proteomic databases

ProteomicsDBi344812

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
162, 86 antibodies

The DNASU plasmid repository

More...
DNASUi
320772

Genome annotation databases

EnsembliENSMUST00000037181; ENSMUSP00000046761; ENSMUSG00000034912
GeneIDi320772

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
161357
MGIiMGI:2444706, Mdga2
VEuPathDBiHostDB:ENSMUSG00000034912

Phylogenomic databases

GeneTreeiENSGT00940000155369
OMAiHKDETEY
OrthoDBi118847at2759
TreeFamiTF330345

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
320772, 0 hits in 58 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Mdga2, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

ExpressionAtlasiQ3UV20, baseline and differential
GenevisibleiQ3UV20, MM

Family and domain databases

CDDicd06263, MAM, 1 hit
Gene3Di2.60.40.10, 7 hits
InterProiView protein in InterPro
IPR013320, ConA-like_dom_sf
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR007110, Ig-like_dom
IPR036179, Ig-like_dom_sf
IPR013783, Ig-like_fold
IPR013098, Ig_I-set
IPR003599, Ig_sub
IPR003598, Ig_sub2
IPR000998, MAM_dom
PfamiView protein in Pfam
PF07679, I-set, 1 hit
PF00629, MAM, 1 hit
SMARTiView protein in SMART
SM00409, IG, 6 hits
SM00408, IGc2, 6 hits
SM00137, MAM, 1 hit
SUPFAMiSSF48726, SSF48726, 6 hits
SSF49265, SSF49265, 1 hit
SSF49899, SSF49899, 1 hit
PROSITEiView protein in PROSITE
PS50853, FN3, 1 hit
PS50835, IG_LIKE, 6 hits
PS50060, MAM_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3UV20_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UV20
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 29, 2021
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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