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Protein

STE20-related kinase adapter protein alpha

Gene

Strada

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Pseudokinase which, in complex with CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta), binds to and activates STK11/LKB1. Adopts a closed conformation typical of active protein kinases and binds STK11/LKB1 as a pseudosubstrate, promoting conformational change of STK11/LKB1 in an active conformation (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processCell cycle

Enzyme and pathway databases

ReactomeiR-MMU-380972 Energy dependent regulation of mTOR by LKB1-AMPK

Names & Taxonomyi

Protein namesi
Recommended name:
STE20-related kinase adapter protein alpha
Short name:
STRAD alpha
Alternative name(s):
STE20-related adapter protein
Gene namesi
Name:Strada
Synonyms:Lyk5, Strad
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:1919399 Strada

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002600371 – 431STE20-related kinase adapter protein alphaAdd BLAST431

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2PhosphoserineBy similarity1
Modified residuei46PhosphoserineBy similarity1
Modified residuei419Phosphothreonine; by LKB1By similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3UUJ4
PeptideAtlasiQ3UUJ4
PRIDEiQ3UUJ4

PTM databases

iPTMnetiQ3UUJ4
PhosphoSitePlusiQ3UUJ4

Expressioni

Gene expression databases

BgeeiENSMUSG00000069631 Expressed in 200 organ(s), highest expression level in testis
CleanExiMM_2610019A05RIK
ExpressionAtlasiQ3UUJ4 baseline and differential
GenevisibleiQ3UUJ4 MM

Interactioni

Subunit structurei

Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity.By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ3UUJ4, 2 interactors
MINTiQ3UUJ4
STRINGi10090.ENSMUSP00000007444

Structurei

3D structure databases

ProteinModelPortaliQ3UUJ4
SMRiQ3UUJ4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini69 – 379Protein kinasePROSITE-ProRule annotationAdd BLAST311

Domaini

The protein kinase domain is predicted to be catalytically inactive.Sequence analysis

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0582 Eukaryota
ENOG410XSWS LUCA
GeneTreeiENSGT00930000150829
HOGENOMiHOG000237355
HOVERGENiHBG055069
InParanoidiQ3UUJ4
KOiK08271
OMAiQEIMSSF
OrthoDBiEOG091G0E7D
PhylomeDBiQ3UUJ4
TreeFamiTF319817

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 11 Publication (identifier: Q3UUJ4-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSFLVSKPER IRRWVSEKFI VEGLRDLELF GEQPPGDTRR KANEASSESI
60 70 80 90 100
ASFSKPEMMS SFLPEGGCYE LLTIIGKGFE DLMTVNLARY KPTGEYVTVR
110 120 130 140 150
RINLEACSNE MVTFLQGELH VSKLFSHPNI VPYRATFIAD NELWVVTSFM
160 170 180 190 200
AYGSAKDLIG THFMDGMNEL AIAYILQGVL KALDYIHHMG YVHRSVKASH
210 220 230 240 250
ILISTDGKVY LSGLRSNLSM ISHGQRQRAV HDFPKYSIKV LPWLSPEVLQ
260 270 280 290 300
QNLQGYDAKS DIYSVGITAC ELANGHVPFK DMPATQMLLE KLNGTVPCLL
310 320 330 340 350
DTSTIPAEEL TMSPSRSIAN PGLNDSLAAG SLRPSNGDSP SHPYHRTFSP
360 370 380 390 400
HFHNFVEQCL QRNPDARPNA STLLNHSFFK QIKRRASEAL PELLRPVTPI
410 420 430
TNFEGSQSQD HSGIFGLVTN LEDLEVDDWE F
Length:431
Mass (Da):48,236
Last modified:October 11, 2005 - v1
Checksum:i6E4B14CC9B2B1D7D
GO
Isoform 21 Publication (identifier: Q3UUJ4-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     5-41: Missing.
     370-381: Missing.

Note: No experimental confirmation available.Curated
Show »
Length:382
Mass (Da):42,454
Checksum:i9EFCD966627136AA
GO
Isoform 32 Publications (identifier: Q3UUJ4-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     5-41: Missing.

Show »
Length:394
Mass (Da):43,829
Checksum:iC743BFE801ADDB8D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B1AR89B1AR89_MOUSE
STE20-related kinase adapter protei...
Strada
65Annotation score:
B1AR92B1AR92_MOUSE
STE20-related kinase adapter protei...
Strada
158Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0522175 – 41Missing in isoform 2 and isoform 3. 3 PublicationsAdd BLAST37
Alternative sequenceiVSP_052218370 – 381Missing in isoform 2. 1 PublicationAdd BLAST12

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341872 mRNA Translation: AAQ24157.1
AY341878 mRNA Translation: AAQ24162.1
AK011451 mRNA Translation: BAB27626.1
AK138358 mRNA Translation: BAE23631.1
BC058517 mRNA Translation: AAH58517.1
CCDSiCCDS25550.1 [Q3UUJ4-3]
CCDS56816.1 [Q3UUJ4-1]
RefSeqiNP_001239377.1, NM_001252448.1 [Q3UUJ4-1]
NP_001239378.1, NM_001252449.1 [Q3UUJ4-2]
NP_082402.1, NM_028126.3 [Q3UUJ4-3]
XP_006534358.1, XM_006534295.1 [Q3UUJ4-3]
XP_011247572.1, XM_011249270.1 [Q3UUJ4-1]
UniGeneiMm.403722

Genome annotation databases

EnsembliENSMUST00000007444; ENSMUSP00000007444; ENSMUSG00000069631 [Q3UUJ4-1]
ENSMUST00000103072; ENSMUSP00000099361; ENSMUSG00000069631 [Q3UUJ4-3]
GeneIDi72149
KEGGimmu:72149
UCSCiuc007lyf.2 mouse [Q3UUJ4-3]
uc007lyg.2 mouse [Q3UUJ4-1]
uc011ygi.2 mouse [Q3UUJ4-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY341872 mRNA Translation: AAQ24157.1
AY341878 mRNA Translation: AAQ24162.1
AK011451 mRNA Translation: BAB27626.1
AK138358 mRNA Translation: BAE23631.1
BC058517 mRNA Translation: AAH58517.1
CCDSiCCDS25550.1 [Q3UUJ4-3]
CCDS56816.1 [Q3UUJ4-1]
RefSeqiNP_001239377.1, NM_001252448.1 [Q3UUJ4-1]
NP_001239378.1, NM_001252449.1 [Q3UUJ4-2]
NP_082402.1, NM_028126.3 [Q3UUJ4-3]
XP_006534358.1, XM_006534295.1 [Q3UUJ4-3]
XP_011247572.1, XM_011249270.1 [Q3UUJ4-1]
UniGeneiMm.403722

3D structure databases

ProteinModelPortaliQ3UUJ4
SMRiQ3UUJ4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3UUJ4, 2 interactors
MINTiQ3UUJ4
STRINGi10090.ENSMUSP00000007444

PTM databases

iPTMnetiQ3UUJ4
PhosphoSitePlusiQ3UUJ4

Proteomic databases

PaxDbiQ3UUJ4
PeptideAtlasiQ3UUJ4
PRIDEiQ3UUJ4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000007444; ENSMUSP00000007444; ENSMUSG00000069631 [Q3UUJ4-1]
ENSMUST00000103072; ENSMUSP00000099361; ENSMUSG00000069631 [Q3UUJ4-3]
GeneIDi72149
KEGGimmu:72149
UCSCiuc007lyf.2 mouse [Q3UUJ4-3]
uc007lyg.2 mouse [Q3UUJ4-1]
uc011ygi.2 mouse [Q3UUJ4-2]

Organism-specific databases

CTDi92335
MGIiMGI:1919399 Strada

Phylogenomic databases

eggNOGiKOG0582 Eukaryota
ENOG410XSWS LUCA
GeneTreeiENSGT00930000150829
HOGENOMiHOG000237355
HOVERGENiHBG055069
InParanoidiQ3UUJ4
KOiK08271
OMAiQEIMSSF
OrthoDBiEOG091G0E7D
PhylomeDBiQ3UUJ4
TreeFamiTF319817

Enzyme and pathway databases

ReactomeiR-MMU-380972 Energy dependent regulation of mTOR by LKB1-AMPK

Miscellaneous databases

PROiPR:Q3UUJ4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000069631 Expressed in 200 organ(s), highest expression level in testis
CleanExiMM_2610019A05RIK
ExpressionAtlasiQ3UUJ4 baseline and differential
GenevisibleiQ3UUJ4 MM

Family and domain databases

InterProiView protein in InterPro
IPR011009 Kinase-like_dom_sf
IPR000719 Prot_kinase_dom
PfamiView protein in Pfam
PF00069 Pkinase, 1 hit
SUPFAMiSSF56112 SSF56112, 1 hit
PROSITEiView protein in PROSITE
PS50011 PROTEIN_KINASE_DOM, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSTRAA_MOUSE
AccessioniPrimary (citable) accession number: Q3UUJ4
Secondary accession number(s): Q6VEU7, Q9D0G8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 14, 2006
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 123 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
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Main funding by: National Institutes of Health

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