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Protein

TBC1 domain family member 24

Gene

Tbc1d24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May act as a GTPase-activating protein for Rab family protein(s) (PubMed:20727515). Involved in neuronal projections development, probably through a negative modulation of ARF6 function (PubMed:20727515).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei36PhosphatidylinositolBy similarity1
Binding sitei40PhosphatidylinositolBy similarity1
Binding sitei238PhosphatidylinositolBy similarity1
Binding sitei242PhosphatidylinositolBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionGTPase activation

Names & Taxonomyi

Protein namesi
Recommended name:
TBC1 domain family member 24
Gene namesi
Name:Tbc1d24
Synonyms:Kiaa1171
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2443456 Tbc1d24

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoplasmic vesicle, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002885051 – 561TBC1 domain family member 24Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei475PhosphoserineBy similarity1
Modified residuei482PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ3UUG6
PeptideAtlasiQ3UUG6
PRIDEiQ3UUG6

PTM databases

iPTMnetiQ3UUG6
PhosphoSitePlusiQ3UUG6

Expressioni

Tissue specificityi

Expressed in brain, particularly at the level of the cortex and the hippocampus. Expressed in the inner ear in spiral ganglion cells, a collection of neurons critical for hearing and balance.2 Publications

Gene expression databases

BgeeiENSMUSG00000036473 Expressed in 285 organ(s), highest expression level in retina
CleanExiMM_TBC1D24
ExpressionAtlasiQ3UUG6 baseline and differential
GenevisibleiQ3UUG6 MM

Interactioni

Subunit structurei

Interacts with ARF6.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094989

Structurei

3D structure databases

ProteinModelPortaliQ3UUG6
SMRiQ3UUG6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini45 – 236Rab-GAP TBCAdd BLAST192
Domaini368 – 556TLDAdd BLAST189

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni293 – 297Phosphatidylinositol bindingBy similarity5

Domaini

The Rab-GAP TBC domain is essential for phosphatidylinositol binding.By similarity

Phylogenomic databases

eggNOGiKOG2801 Eukaryota
ENOG410ZI2X LUCA
GeneTreeiENSGT00890000139348
HOVERGENiHBG068667
InParanoidiQ3UUG6
KOiK21841
OrthoDBiEOG091G03K9
PhylomeDBiQ3UUG6
TreeFamiTF315420

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR006571 TLDc_dom
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
PF07534 TLD, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SM00584 TLDc, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q3UUG6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPPGYNCFV DKDKMDASIQ DLGPKELNCT ELQELKQLAR QGYWAQSHTL
60 70 80 90 100
RGKVYQRLIR DIPCRTVTPD ASVYSDIVGK IVGKHSSSSL PLPEFVDNTQ
110 120 130 140 150
VPTYCLNTRG EGAVRKILLC IANQFPDISF CPALPAVVAL LLHYSIDEAE
160 170 180 190 200
CFEKACRILS CNDPTKKLID QSFLAFESSC MTFGDLVNKY CQAAHKLMVA
210 220 230 240 250
VSEDVLQVYS DWQRWLFGEL PLNYFARVFD VFLVEGYKVL YRVALAILKF
260 270 280 290 300
FHKVRAGQPL ESDNVKQDIR MFVKDIAKTV SPEKLLEKAF AIRLFSRKEI
310 320 330 340 350
QLLQMANEKA LRQKGITVKQ KSVSLSKRQF VHLAVHAENF HSEIVSVKEM
360 370 380 390 400
RDIWSWIPER FALCQPLLLF SSLQHGYSLS RFYFQCEGHE PTLLLIKTTQ
410 420 430 440 450
KEVCGAYLST DWSERTKFGG KLGFFGTGEC FVFRLQPEVQ RYEWVVIKHP
460 470 480 490 500
ELTKATSLKS SEAAGSSSLI SHCSSDPADR LSPFLAARHF NLPSKTESMF
510 520 530 540 550
MAGGNDCLII GGGGGQALYV DGDLNRGRTG HCDTFNNQPL CSENFLIAAV
560
EAWGFQDPDT E
Length:561
Mass (Da):63,236
Last modified:May 29, 2007 - v2
Checksum:i1C35837B82FF093E
GO
Isoform 2 (identifier: Q3UUG6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     322-327: Missing.

Show »
Length:555
Mass (Da):62,634
Checksum:i3EFB65D9F9E0A18F
GO

Sequence cautioni

The sequence BAC39035 differs from that shown. Reason: Frameshift at position 113.Curated
The sequence BAC98114 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti3P → H in BAE23659 (PubMed:16141072).Curated1
Sequence conflicti14K → R in BAE36174 (PubMed:16141072).Curated1
Sequence conflicti266K → E in BAC39644 (PubMed:16141072).Curated1
Sequence conflicti308E → G in BAC39255 (PubMed:16141072).Curated1
Sequence conflicti471S → G in BAC98114 (PubMed:14621295).Curated1
Sequence conflicti505N → I in BAE28046 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025702322 – 327Missing in isoform 2. 3 Publications6

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129304 mRNA Translation: BAC98114.1 Different initiation.
AK049306 mRNA Translation: BAC33671.1
AK049754 mRNA Translation: BAC33904.1
AK083833 mRNA Translation: BAC39035.1 Frameshift.
AK084693 mRNA Translation: BAC39255.1
AK086293 mRNA Translation: BAC39644.1
AK138431 mRNA Translation: BAE23659.1
AK147647 mRNA Translation: BAE28046.1
AK161054 mRNA Translation: BAE36174.1
BC080845 mRNA Translation: AAH80845.1
BC094417 mRNA Translation: AAH94417.1
CCDSiCCDS28477.1 [Q3UUG6-2]
CCDS50012.1 [Q3UUG6-1]
RefSeqiNP_001157319.1, NM_001163847.1 [Q3UUG6-1]
NP_001157320.1, NM_001163848.1 [Q3UUG6-1]
NP_001157321.1, NM_001163849.1 [Q3UUG6-1]
NP_001157322.1, NM_001163850.1 [Q3UUG6-2]
NP_001157323.1, NM_001163851.1 [Q3UUG6-2]
NP_001157324.1, NM_001163852.1 [Q3UUG6-2]
NP_001157325.1, NM_001163853.1 [Q3UUG6-2]
NP_775278.3, NM_173186.4 [Q3UUG6-2]
UniGeneiMm.301585

Genome annotation databases

EnsembliENSMUST00000040474; ENSMUSP00000036458; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000097376; ENSMUSP00000094989; ENSMUSG00000036473 [Q3UUG6-1]
ENSMUST00000167791; ENSMUSP00000127005; ENSMUSG00000036473 [Q3UUG6-1]
ENSMUST00000168378; ENSMUSP00000126107; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000168410; ENSMUSP00000128868; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000171189; ENSMUSP00000128001; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000201089; ENSMUSP00000144250; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000201301; ENSMUSP00000143949; ENSMUSG00000036473 [Q3UUG6-1]
ENSMUST00000201805; ENSMUSP00000143883; ENSMUSG00000036473 [Q3UUG6-1]
ENSMUST00000201960; ENSMUSP00000144208; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000202925; ENSMUSP00000144575; ENSMUSG00000036473 [Q3UUG6-2]
GeneIDi224617
KEGGimmu:224617
UCSCiuc008auq.2 mouse [Q3UUG6-1]
uc008aus.2 mouse [Q3UUG6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129304 mRNA Translation: BAC98114.1 Different initiation.
AK049306 mRNA Translation: BAC33671.1
AK049754 mRNA Translation: BAC33904.1
AK083833 mRNA Translation: BAC39035.1 Frameshift.
AK084693 mRNA Translation: BAC39255.1
AK086293 mRNA Translation: BAC39644.1
AK138431 mRNA Translation: BAE23659.1
AK147647 mRNA Translation: BAE28046.1
AK161054 mRNA Translation: BAE36174.1
BC080845 mRNA Translation: AAH80845.1
BC094417 mRNA Translation: AAH94417.1
CCDSiCCDS28477.1 [Q3UUG6-2]
CCDS50012.1 [Q3UUG6-1]
RefSeqiNP_001157319.1, NM_001163847.1 [Q3UUG6-1]
NP_001157320.1, NM_001163848.1 [Q3UUG6-1]
NP_001157321.1, NM_001163849.1 [Q3UUG6-1]
NP_001157322.1, NM_001163850.1 [Q3UUG6-2]
NP_001157323.1, NM_001163851.1 [Q3UUG6-2]
NP_001157324.1, NM_001163852.1 [Q3UUG6-2]
NP_001157325.1, NM_001163853.1 [Q3UUG6-2]
NP_775278.3, NM_173186.4 [Q3UUG6-2]
UniGeneiMm.301585

3D structure databases

ProteinModelPortaliQ3UUG6
SMRiQ3UUG6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000094989

PTM databases

iPTMnetiQ3UUG6
PhosphoSitePlusiQ3UUG6

Proteomic databases

PaxDbiQ3UUG6
PeptideAtlasiQ3UUG6
PRIDEiQ3UUG6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000040474; ENSMUSP00000036458; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000097376; ENSMUSP00000094989; ENSMUSG00000036473 [Q3UUG6-1]
ENSMUST00000167791; ENSMUSP00000127005; ENSMUSG00000036473 [Q3UUG6-1]
ENSMUST00000168378; ENSMUSP00000126107; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000168410; ENSMUSP00000128868; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000171189; ENSMUSP00000128001; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000201089; ENSMUSP00000144250; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000201301; ENSMUSP00000143949; ENSMUSG00000036473 [Q3UUG6-1]
ENSMUST00000201805; ENSMUSP00000143883; ENSMUSG00000036473 [Q3UUG6-1]
ENSMUST00000201960; ENSMUSP00000144208; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000202925; ENSMUSP00000144575; ENSMUSG00000036473 [Q3UUG6-2]
GeneIDi224617
KEGGimmu:224617
UCSCiuc008auq.2 mouse [Q3UUG6-1]
uc008aus.2 mouse [Q3UUG6-2]

Organism-specific databases

CTDi57465
MGIiMGI:2443456 Tbc1d24
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2801 Eukaryota
ENOG410ZI2X LUCA
GeneTreeiENSGT00890000139348
HOVERGENiHBG068667
InParanoidiQ3UUG6
KOiK21841
OrthoDBiEOG091G03K9
PhylomeDBiQ3UUG6
TreeFamiTF315420

Miscellaneous databases

PROiPR:Q3UUG6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000036473 Expressed in 285 organ(s), highest expression level in retina
CleanExiMM_TBC1D24
ExpressionAtlasiQ3UUG6 baseline and differential
GenevisibleiQ3UUG6 MM

Family and domain databases

InterProiView protein in InterPro
IPR000195 Rab-GTPase-TBC_dom
IPR035969 Rab-GTPase_TBC_sf
IPR006571 TLDc_dom
PfamiView protein in Pfam
PF00566 RabGAP-TBC, 1 hit
PF07534 TLD, 1 hit
SMARTiView protein in SMART
SM00164 TBC, 1 hit
SM00584 TLDc, 1 hit
SUPFAMiSSF47923 SSF47923, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiTBC24_MOUSE
AccessioniPrimary (citable) accession number: Q3UUG6
Secondary accession number(s): A5D6Q7
, Q3TTZ8, Q3UH11, Q6ZPW4, Q8BH92, Q8BNF2, Q8C3C6, Q8C3W8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: November 7, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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