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Entry version 118 (29 Sep 2021)
Sequence version 2 (29 May 2007)
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Protein

TBC1 domain family member 24

Gene

Tbc1d24

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a GTPase-activating protein for Rab family protein(s) (PubMed:20727515).

Involved in neuronal projections development, probably through a negative modulation of ARF6 function (PubMed:20727515).

Involved in the regulation of synaptic vesicle trafficking (By similarity).

By similarity1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei36PhosphatidylinositolBy similarity1
Binding sitei40PhosphatidylinositolBy similarity1
Binding sitei238PhosphatidylinositolBy similarity1
Binding sitei242PhosphatidylinositolBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGTPase activation

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-8854214, TBC/RABGAPs

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TBC1 domain family member 24
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Tbc1d24
Synonyms:Kiaa1171
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443456, Tbc1d24

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000036473

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Cytoplasm, Cytoplasmic vesicle, Membrane, Synapse

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002885051 – 561TBC1 domain family member 24Add BLAST561

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei475PhosphoserineBy similarity1
Modified residuei482PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3UUG6

PeptideAtlas

More...
PeptideAtlasi
Q3UUG6

PRoteomics IDEntifications database

More...
PRIDEi
Q3UUG6

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
254825 [Q3UUG6-1]
254826 [Q3UUG6-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3UUG6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3UUG6

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q3UUG6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain, particularly at the level of the cortex and the hippocampus. Expressed in the inner ear in spiral ganglion cells, a collection of neurons critical for hearing and balance.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036473, Expressed in retina and 308 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3UUG6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3UUG6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ARF6.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000127005

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3UUG6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3UUG6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini45 – 236Rab-GAP TBCAdd BLAST192
Domaini343 – 556TLDcPROSITE-ProRule annotationAdd BLAST214

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni293 – 297Phosphatidylinositol bindingBy similarity5

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The Rab-GAP TBC domain is essential for phosphatidylinositol binding.By similarity

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2801, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00410000025739

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_018035_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3UUG6

Identification of Orthologs from Complete Genome Data

More...
OMAi
KFYRKHK

Database of Orthologous Groups

More...
OrthoDBi
1047825at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3UUG6

TreeFam database of animal gene trees

More...
TreeFami
TF315420

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000195, Rab-GTPase-TBC_dom
IPR035969, Rab-GTPase_TBC_sf
IPR040149, TBC1D24
IPR006571, TLDc_dom

The PANTHER Classification System

More...
PANTHERi
PTHR23353:SF6, PTHR23353:SF6, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00566, RabGAP-TBC, 1 hit
PF07534, TLD, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00164, TBC, 1 hit
SM00584, TLDc, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47923, SSF47923, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51886, TLDC, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3UUG6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MDPPGYNCFV DKDKMDASIQ DLGPKELNCT ELQELKQLAR QGYWAQSHTL
60 70 80 90 100
RGKVYQRLIR DIPCRTVTPD ASVYSDIVGK IVGKHSSSSL PLPEFVDNTQ
110 120 130 140 150
VPTYCLNTRG EGAVRKILLC IANQFPDISF CPALPAVVAL LLHYSIDEAE
160 170 180 190 200
CFEKACRILS CNDPTKKLID QSFLAFESSC MTFGDLVNKY CQAAHKLMVA
210 220 230 240 250
VSEDVLQVYS DWQRWLFGEL PLNYFARVFD VFLVEGYKVL YRVALAILKF
260 270 280 290 300
FHKVRAGQPL ESDNVKQDIR MFVKDIAKTV SPEKLLEKAF AIRLFSRKEI
310 320 330 340 350
QLLQMANEKA LRQKGITVKQ KSVSLSKRQF VHLAVHAENF HSEIVSVKEM
360 370 380 390 400
RDIWSWIPER FALCQPLLLF SSLQHGYSLS RFYFQCEGHE PTLLLIKTTQ
410 420 430 440 450
KEVCGAYLST DWSERTKFGG KLGFFGTGEC FVFRLQPEVQ RYEWVVIKHP
460 470 480 490 500
ELTKATSLKS SEAAGSSSLI SHCSSDPADR LSPFLAARHF NLPSKTESMF
510 520 530 540 550
MAGGNDCLII GGGGGQALYV DGDLNRGRTG HCDTFNNQPL CSENFLIAAV
560
EAWGFQDPDT E
Length:561
Mass (Da):63,236
Last modified:May 29, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C35837B82FF093E
GO
Isoform 2 (identifier: Q3UUG6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     322-327: Missing.

Show »
Length:555
Mass (Da):62,634
Checksum:i3EFB65D9F9E0A18F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0J9YUB2A0A0J9YUB2_MOUSE
TBC1 domain family member 24
Tbc1d24
182Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8BRB6Q8BRB6_MOUSE
TBC1 domain family member 24
Tbc1d24
325Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAC39035 differs from that shown. Reason: Frameshift.Curated
The sequence BAC98114 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3P → H in BAE23659 (PubMed:16141072).Curated1
Sequence conflicti14K → R in BAE36174 (PubMed:16141072).Curated1
Sequence conflicti266K → E in BAC39644 (PubMed:16141072).Curated1
Sequence conflicti308E → G in BAC39255 (PubMed:16141072).Curated1
Sequence conflicti471S → G in BAC98114 (PubMed:14621295).Curated1
Sequence conflicti505N → I in BAE28046 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_025702322 – 327Missing in isoform 2. 3 Publications6

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK129304 mRNA Translation: BAC98114.1 Different initiation.
AK049306 mRNA Translation: BAC33671.1
AK049754 mRNA Translation: BAC33904.1
AK083833 mRNA Translation: BAC39035.1 Frameshift.
AK084693 mRNA Translation: BAC39255.1
AK086293 mRNA Translation: BAC39644.1
AK138431 mRNA Translation: BAE23659.1
AK147647 mRNA Translation: BAE28046.1
AK161054 mRNA Translation: BAE36174.1
BC080845 mRNA Translation: AAH80845.1
BC094417 mRNA Translation: AAH94417.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS28477.1 [Q3UUG6-2]
CCDS50012.1 [Q3UUG6-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001157319.1, NM_001163847.1 [Q3UUG6-1]
NP_001157320.1, NM_001163848.1 [Q3UUG6-1]
NP_001157321.1, NM_001163849.1 [Q3UUG6-1]
NP_001157322.1, NM_001163850.1 [Q3UUG6-2]
NP_001157323.1, NM_001163851.1 [Q3UUG6-2]
NP_001157324.1, NM_001163852.1 [Q3UUG6-2]
NP_001157325.1, NM_001163853.1 [Q3UUG6-2]
NP_775278.3, NM_173186.4 [Q3UUG6-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000040474; ENSMUSP00000036458; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000097376; ENSMUSP00000094989; ENSMUSG00000036473 [Q3UUG6-1]
ENSMUST00000167791; ENSMUSP00000127005; ENSMUSG00000036473 [Q3UUG6-1]
ENSMUST00000168378; ENSMUSP00000126107; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000168410; ENSMUSP00000128868; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000171189; ENSMUSP00000128001; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000201089; ENSMUSP00000144250; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000201301; ENSMUSP00000143949; ENSMUSG00000036473 [Q3UUG6-1]
ENSMUST00000201805; ENSMUSP00000143883; ENSMUSG00000036473 [Q3UUG6-1]
ENSMUST00000201960; ENSMUSP00000144208; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000202925; ENSMUSP00000144575; ENSMUSG00000036473 [Q3UUG6-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
224617

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:224617

UCSC genome browser

More...
UCSCi
uc008auq.2, mouse [Q3UUG6-1]
uc008aus.2, mouse [Q3UUG6-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK129304 mRNA Translation: BAC98114.1 Different initiation.
AK049306 mRNA Translation: BAC33671.1
AK049754 mRNA Translation: BAC33904.1
AK083833 mRNA Translation: BAC39035.1 Frameshift.
AK084693 mRNA Translation: BAC39255.1
AK086293 mRNA Translation: BAC39644.1
AK138431 mRNA Translation: BAE23659.1
AK147647 mRNA Translation: BAE28046.1
AK161054 mRNA Translation: BAE36174.1
BC080845 mRNA Translation: AAH80845.1
BC094417 mRNA Translation: AAH94417.1
CCDSiCCDS28477.1 [Q3UUG6-2]
CCDS50012.1 [Q3UUG6-1]
RefSeqiNP_001157319.1, NM_001163847.1 [Q3UUG6-1]
NP_001157320.1, NM_001163848.1 [Q3UUG6-1]
NP_001157321.1, NM_001163849.1 [Q3UUG6-1]
NP_001157322.1, NM_001163850.1 [Q3UUG6-2]
NP_001157323.1, NM_001163851.1 [Q3UUG6-2]
NP_001157324.1, NM_001163852.1 [Q3UUG6-2]
NP_001157325.1, NM_001163853.1 [Q3UUG6-2]
NP_775278.3, NM_173186.4 [Q3UUG6-2]

3D structure databases

SMRiQ3UUG6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000127005

PTM databases

iPTMnetiQ3UUG6
PhosphoSitePlusiQ3UUG6
SwissPalmiQ3UUG6

Proteomic databases

PaxDbiQ3UUG6
PeptideAtlasiQ3UUG6
PRIDEiQ3UUG6
ProteomicsDBi254825 [Q3UUG6-1]
254826 [Q3UUG6-2]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
224617

Genome annotation databases

EnsembliENSMUST00000040474; ENSMUSP00000036458; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000097376; ENSMUSP00000094989; ENSMUSG00000036473 [Q3UUG6-1]
ENSMUST00000167791; ENSMUSP00000127005; ENSMUSG00000036473 [Q3UUG6-1]
ENSMUST00000168378; ENSMUSP00000126107; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000168410; ENSMUSP00000128868; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000171189; ENSMUSP00000128001; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000201089; ENSMUSP00000144250; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000201301; ENSMUSP00000143949; ENSMUSG00000036473 [Q3UUG6-1]
ENSMUST00000201805; ENSMUSP00000143883; ENSMUSG00000036473 [Q3UUG6-1]
ENSMUST00000201960; ENSMUSP00000144208; ENSMUSG00000036473 [Q3UUG6-2]
ENSMUST00000202925; ENSMUSP00000144575; ENSMUSG00000036473 [Q3UUG6-2]
GeneIDi224617
KEGGimmu:224617
UCSCiuc008auq.2, mouse [Q3UUG6-1]
uc008aus.2, mouse [Q3UUG6-2]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
57465
MGIiMGI:2443456, Tbc1d24
VEuPathDBiHostDB:ENSMUSG00000036473

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
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Phylogenomic databases

eggNOGiKOG2801, Eukaryota
GeneTreeiENSGT00410000025739
HOGENOMiCLU_018035_1_1_1
InParanoidiQ3UUG6
OMAiKFYRKHK
OrthoDBi1047825at2759
PhylomeDBiQ3UUG6
TreeFamiTF315420

Enzyme and pathway databases

ReactomeiR-MMU-8854214, TBC/RABGAPs

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
224617, 1 hit in 62 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Tbc1d24, mouse

Protein Ontology

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PROi
PR:Q3UUG6
RNActiQ3UUG6, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000036473, Expressed in retina and 308 other tissues
ExpressionAtlasiQ3UUG6, baseline and differential
GenevisibleiQ3UUG6, MM

Family and domain databases

InterProiView protein in InterPro
IPR000195, Rab-GTPase-TBC_dom
IPR035969, Rab-GTPase_TBC_sf
IPR040149, TBC1D24
IPR006571, TLDc_dom
PANTHERiPTHR23353:SF6, PTHR23353:SF6, 1 hit
PfamiView protein in Pfam
PF00566, RabGAP-TBC, 1 hit
PF07534, TLD, 1 hit
SMARTiView protein in SMART
SM00164, TBC, 1 hit
SM00584, TLDc, 1 hit
SUPFAMiSSF47923, SSF47923, 2 hits
PROSITEiView protein in PROSITE
PS51886, TLDC, 1 hit

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTBC24_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UUG6
Secondary accession number(s): A5D6Q7
, Q3TTZ8, Q3UH11, Q6ZPW4, Q8BH92, Q8BNF2, Q8C3C6, Q8C3W8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: May 29, 2007
Last modified: September 29, 2021
This is version 118 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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