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Entry version 94 (26 Feb 2020)
Sequence version 1 (11 Oct 2005)
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Protein

SLP adapter and CSK-interacting membrane protein

Gene

Scimp

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Lipid tetraspanin-associated transmembrane adapter/mediator that acts as a scaffold for Src-family kinases and other signaling proteins in immune cells (PubMed:27288407, PubMed:28290451, PubMed:28098138). It is involved in major histocompatibility complex class II (MHC-II) signaling transduction in B cells, where it is required in generating the calcium response and enhancing ERK activity upon MHC-II stimulation (By similarity). In dendritic cells, it is involved in sustaining CLEC7A/DECTIN1 signaling after CLEC7A activation by fungal beta-glucans (PubMed:27288407). It also acts as an agonist-inducible signaling adapter for TLR1, TLR2, TLR3, TLR4, and TLR7 by selectively enabling the expression of pro-inflammatory cytokines IL6 and IL12B in macrophages and acting as a scaffold for phosphorylation of Toll-like receptors by Src-family kinases (PubMed:28098138).By similarity3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
SLP adapter and CSK-interacting membrane protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Scimp
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3610314 Scimp

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei8 – 28HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasmic vesicle, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Mice exhibit no difference in leukocyte development and subset representation in lymphoid organs (PubMed:27288407). No effect on B cell mediated activation of antigen-specific T cells and MHCII glycoprotein downstream signaling in B cells (PubMed:27288407). In dendritic cells, mutants show decreased cytokine production beyond 24 hours after stimulation of CLEC7A signaling (PubMed:27288407).1 Publication

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi58Y → F: Inhibits interaction with BLNK. Slightly inhibits interaction with GRB2. No effect on interactions with TLR4 and CSK. 2 Publications1
Mutagenesisi95W → A: Inhibits interaction with TLR4. Inhibits IL12B expression after TLR4 activation by lipopolysaccharide. No effect on interaction with LYN. 1 Publication1
Mutagenesisi96Y → F: Inhibits interaction with TLR4. Decreases IL12B expression after TLR4 activation by lipopolysaccharide. Inhibits interaction with CSK. No effect on interactions with LYN, GRB2, and BLNK. 2 Publications1
Mutagenesisi97S → A: No effect on interaction with TLR4. 1 Publication1
Mutagenesisi98S → A: No effect on interaction with TLR4. 1 Publication1
Mutagenesisi99V → A: No effect on interaction with TLR4. 1 Publication1
Mutagenesisi120Y → F: Inhibits interaction with BLNK. No effect on interactions with TLR4, GRB2 and CSK. 2 Publications1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002952381 – 150SLP adapter and CSK-interacting membrane proteinAdd BLAST150

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position(s) and the type of covalently attached lipid group(s).<p><a href='/help/lipid' target='_top'>More...</a></p>Lipidationi29S-palmitoyl cysteineBy similarity1
Lipidationi31S-palmitoyl cysteineBy similarity1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei58Phosphotyrosine1 Publication1
Modified residuei65PhosphoserineCombined sources1
Modified residuei77PhosphoserineCombined sources1
Modified residuei96Phosphotyrosine; by LYN2 Publications1
Modified residuei120PhosphotyrosineCombined sources1 Publication1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Phosphorylated by the Src-family protein tyrosine kinases LYN and SRC (PubMed:27288407). Phosphorylation occurs on tyrosine residues upon MHC-II stimulation (PubMed:21930792, PubMed:27288407). Phosphorylation also occurs on tyrosine residues after activation of CLEC7A/DECTIN1 by particulate beta-glucan (PubMed:27288407). Lipopolysaccharide (LPS) induces phosphorylation of Tyr-58, Tyr-96 and Tyr-120 differentially to allow temporal recruitment of effector proteins GRB2, CSK and BLNK (PubMed:28290451). Phosphorylation of Tyr-58 is immediately induced by LPS stimulation and allows GRB2 to bind (PubMed:28290451). Tyr-96 is phosphorylated 5 minutes after LPS stimulation, which then allows CSK to bind, followed by phosphorylation of Tyr-120 10 minutes after LPS induction, which allows BLNK to bind (PubMed:28290451). Phosphorylation at Tyr-96 by LYN occurs after activation of TLR4 by LPS; phosphorylation enhances binding to TLR4 (PubMed:28098138, PubMed:28290451).4 Publications
Palmitoylated.By similarity

Keywords - PTMi

Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3UU41

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3UU41

PRoteomics IDEntifications database

More...
PRIDEi
Q3UU41

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3UU41

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3UU41

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q3UU41

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in peripheral blood leukocytes (PBLs) (at protein level) (PubMed:21930792). Expressed in dendritic cells, splenocytes and B cells (at protein level) (PubMed:27288407). Strongly expressed in the spleen and lymph nodes and weakly in other tissues of the immune system, including bone marrow, peripheral blood leukocytes (PBLs) and thymus (PubMed:21930792). Not detected in the majority of nonimmune tissues, with the exception of lung (PubMed:21930792). Expressed in antigen-presenting cells (PubMed:21930792). Expressed in macrophages (PubMed:28098138).3 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced in bone marrow-derived macrophages by CSF2 and particulate beta-glucan.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000057135 Expressed in spleen and 15 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3UU41 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with CD37, CD53 and CD81 (By similarity).

Interacts (via proline-rich region) with LYN (via SH3 domain) (PubMed:28098138).

Interacts with CSK (via SH2 domain); this interaction is dependent on phosphorylation of Tyr-96 (PubMed:28290451).

Interacts with BLNK (via SH2 domain); this interaction is dependent on phosphorylation of Tyr-120 (PubMed:21930792, PubMed:28290451).

Interacts with GRB2 (via SH2 domain); this interaction may be dependent on phosphorylation of Tyr-58 (PubMed:21930792, PubMed:28098138).

Interacts with TLR4; this interaction occurs upon lipopolysaccharide activation of TLR4 and is enhanced by phosphorylation of Tyr-96 by LYN (PubMed:28098138). This interaction facilitates the phosphorylation of TLR4 by LYN which elicits a selective cytokine response in macrophages (PubMed:28098138).

By similarity3 Publications

GO - Molecular functioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q3UU41, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000104174

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3UU41 protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni70 – 75Proline-rich region necessary for constitutive interaction with LYN1 Publication6
Regioni93 – 150Interaction with TLR41 PublicationAdd BLAST58

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410J1IN Eukaryota
ENOG41114KD LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000007003

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_1781827_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3UU41

Identification of Orthologs from Complete Genome Data

More...
OMAi
PPTYSLV

Database of Orthologous Groups

More...
OrthoDBi
1442988at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3UU41

TreeFam database of animal gene trees

More...
TreeFami
TF340362

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028181 SCIMP

The PANTHER Classification System

More...
PANTHERi
PTHR12044:SF11 PTHR12044:SF11, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15050 SCIMP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q3UU41-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSWWRDNFWI ILAMSIIFIS LVLGLILYCV CRWQLRQGRN WEIAKPSKQD
60 70 80 90 100
GRDEEKMYEN VLNSSPGQLP ALPPRGSPFP GDLAPQEAPR QPSAWYSSVK
110 120 130 140 150
KVRNKKVFAI SGSTEPENDY DDVEIPATTE TQHSKTTPFW QAEVGLHSSF
Length:150
Mass (Da):17,140
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0837B592EFC13582
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8WHN0F8WHN0_MOUSE
SLP adapter and CSK-interacting mem...
Scimp A430084P05Rik
81Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence CAI25187 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence CAM28154 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK138818 mRNA Translation: BAE23788.1
AL596117 Genomic DNA Translation: CAI25187.1 Different initiation.
CR933735 Genomic DNA Translation: CAM28154.1 Different initiation.
BC147177 mRNA Translation: AAI47178.1
BC147178 mRNA Translation: AAI47179.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS24967.1

NCBI Reference Sequences

More...
RefSeqi
NP_001038991.1, NM_001045526.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000108534; ENSMUSP00000104174; ENSMUSG00000057135

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
327957

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:327957

UCSC genome browser

More...
UCSCi
uc007jwp.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK138818 mRNA Translation: BAE23788.1
AL596117 Genomic DNA Translation: CAI25187.1 Different initiation.
CR933735 Genomic DNA Translation: CAM28154.1 Different initiation.
BC147177 mRNA Translation: AAI47178.1
BC147178 mRNA Translation: AAI47179.1
CCDSiCCDS24967.1
RefSeqiNP_001038991.1, NM_001045526.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ3UU41, 2 interactors
STRINGi10090.ENSMUSP00000104174

PTM databases

iPTMnetiQ3UU41
PhosphoSitePlusiQ3UU41
SwissPalmiQ3UU41

Proteomic databases

MaxQBiQ3UU41
PaxDbiQ3UU41
PRIDEiQ3UU41

Genome annotation databases

EnsembliENSMUST00000108534; ENSMUSP00000104174; ENSMUSG00000057135
GeneIDi327957
KEGGimmu:327957
UCSCiuc007jwp.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
388325
MGIiMGI:3610314 Scimp

Phylogenomic databases

eggNOGiENOG410J1IN Eukaryota
ENOG41114KD LUCA
GeneTreeiENSGT00390000007003
HOGENOMiCLU_1781827_0_0_1
InParanoidiQ3UU41
OMAiPPTYSLV
OrthoDBi1442988at2759
PhylomeDBiQ3UU41
TreeFamiTF340362

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Scimp mouse

Protein Ontology

More...
PROi
PR:Q3UU41
RNActiQ3UU41 protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000057135 Expressed in spleen and 15 other tissues
ExpressionAtlasiQ3UU41 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR028181 SCIMP
PANTHERiPTHR12044:SF11 PTHR12044:SF11, 1 hit
PfamiView protein in Pfam
PF15050 SCIMP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSCIMP_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UU41
Secondary accession number(s): B2RVG2, Q5SX69
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 10, 2007
Last sequence update: October 11, 2005
Last modified: February 26, 2020
This is version 94 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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