Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

UniProtKB - Q3UTY6 (THSD4_MOUSE)

Entry version 114 (02 Dec 2020)
Sequence version 2 (15 Jan 2008)
Previous versions | rss
Add a publicationFeedback
Protein

Thrombospondin type-1 domain-containing protein 4

Gene

Thsd4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Promotes FBN1 matrix assembly. Attenuates TGFB signaling, possibly by accelerating the sequestration of large latent complexes of TGFB or active TGFB by FBN1 microfibril assembly, thereby negatively regulating the expression of TGFB regulatory targets, such as POSTN.3 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-5173214, O-glycosylation of TSR domain-containing proteins

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Thrombospondin type-1 domain-containing protein 4
Alternative name(s):
A disintegrin and metalloproteinase with thrombospondin motifs-like protein 6
Short name:
ADAMTS-like protein 6
Short name:
ADAMTSL-6
ADAMTS-like protein 4
Short name:
ADAMTSL-4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Thsd4
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:2672033, Thsd4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031358427 – 1018Thrombospondin type-1 domain-containing protein 4Add BLAST992

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q3UTY6

PRoteomics IDEntifications database

More...PRIDEi		Q3UTY6

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2766, 2 N-Linked glycans (1 site)

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q3UTY6, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q3UTY6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q3UTY6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Both isoforms are expressed in the embryo from 7 dpc through 17. Isoform 1 is widely expressed in adult tissues. Isoform 2 is detected in brain, spinal cord, eye, kidney, stomach and uterus. Mainly observed in fibrillar extracellular matrices in elastic tissues (at protein level).1 Publication

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At 16.5 dpc, detected in fibrillar structures in various elastic tissues, including developing dermis, perichondria surrounding cartilages and the vessel walls of aortae (at protein level). At postnatal day 7 (P7), weakly expressed in the early stage dental follicle, but becomes readily detectable in assembled microfibril-like structures during the periodontal ligament-forming stage of the dental follicle and in organized microfibrils in the adult periodontal ligament (P35) (at protein level). Up-regulated in the periodontal ligament during wound healing (at protein level).2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000032289, Expressed in ascending aorta and 179 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q3UTY6, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q3UTY6, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Isoform 2 interacts with FBN1. Isoform 2 may interact with TGFB1.

2 Publications

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000096257

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q3UTY6, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q3UTY6

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 307TSP type-1 1PROSITE-ProRule annotationAdd BLAST254
Domaini676 – 737TSP type-1 2PROSITE-ProRule annotationAdd BLAST62
Domaini739 – 792TSP type-1 3PROSITE-ProRule annotationAdd BLAST54
Domaini793 – 851TSP type-1 4PROSITE-ProRule annotationAdd BLAST59
Domaini852 – 911TSP type-1 5PROSITE-ProRule annotationAdd BLAST60
Domaini912 – 968TSP type-1 6PROSITE-ProRule annotationAdd BLAST57
Domaini971 – 1008PLACPROSITE-ProRule annotationAdd BLAST38

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG3538, Eukaryota
KOG4597, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156594

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000660_6_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q3UTY6

Identification of Orthologs from Complete Genome Data

More...OMAi		NRCSAEC

Database of Orthologous Groups

More...OrthoDBi		414258at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q3UTY6

TreeFam database of animal gene trees

More...TreeFami		TF316874

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		2.20.100.10, 7 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010294, ADAM_spacer1
IPR010909, PLAC
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF05986, ADAM_spacer1, 1 hit
PF08686, PLAC, 1 hit
PF00090, TSP_1, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00209, TSP1, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF82895, SSF82895, 7 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50900, PLAC, 1 hit
PS50092, TSP1, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative promoter usage. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3UTY6-1) [UniParc]FASTAAdd to basket
Also known as: ADAMTSL6-alpha

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MVSYLTSCLS ALSTLLLLLG SQLVCPQPST EHRKVPQRMA VTEGTPEDSG 
        60         70         80         90        100
SGSPGVWGSW GPWSACSRSC SGGVMEQTRP CLPSSYRARG GSRPNGRALS 
       110        120        130        140        150
ITGHVVSAVR TSVPLHRSQE DQRALAGSNA SRQGPAVVRG SRHPQARGRE 
       160        170        180        190        200
PSERRSRTRG PIGPGKYGYG KAPYILPLQT DTTHTPQRLR RQRPSSRHSR 
       210        220        230        240        250
SQEASASKQG YRPPTHQFSH SQPLYQSDSG PRSGLPPSEA SIYQLPLTHD 
       260        270        280        290        300
QSYPAASSLF HRPELSSHHG ARPHGAAQAF PQHLRSTAIS CIGAYRQYKL 
       310        320        330        340        350
CNTNACPESG RSIREVQCAS YNNKPFMGRF YEWEPFAEVK GNRKCELNCQ 
       360        370        380        390        400
ATGYRFYVRQ AEKVIDGTPC DQNGTAICVS GQCKSIGCDD FLGSDKVLDK 
       410        420        430        440        450
CGVCGGDNTG CQVVSGVFKH ALTSLGYHRV VEIPQGATKI NITEMHKSNN 
       460        470        480        490        500
YLALRSRSGR SIINGNWAID RPGKYEGGGT MFTYKRPNEV SSTAGESFLA 
       510        520        530        540        550
EGPTNEILDV YMIHQQPNPG VHYEYVIMRN NAISPQVPPH RRPGEPFNGQ 
       560        570        580        590        600
LEEEDRGQED REEREKNQEK EDSQVEAPEV FTSESTQTFP VRHPERFPSH 
       610        620        630        640        650
RPDNLVPPAP QPPRRSRDHN WKQLGTTECS TTCGKGSQYP IFRCVHRNTH 
       660        670        680        690        700
EEVPESYCDS SMKPTPEEEP CNLFPCPAFW DIGEWSECSK TCGLGMQHRQ 
       710        720        730        740        750
VLCRQVYANR SLTVQPYRCQ HLEKPETTST CQLKICSEWQ IRTDWTSCSV 
       760        770        780        790        800
PCGVGQRTRD VKCVSNIGDM VHDEECNMKL RPNDIENCDM GPCAKSWFLT 
       810        820        830        840        850
EWSERCSAEC GAGVRTRSVV CMTNHVSSLP LEGCGNNRPV EATPCDNGPC 
       860        870        880        890        900
TGKVEWFTGS WSQCSIECGS GTQQREVICV RKNADTFEVL DPYECSFLEK 
       910        920        930        940        950
PPSQQACHLK PCGAKWFSTE WSMCSKSCQG GFRVREVRCL SDDMTPSSLC 
       960        970        980        990       1000
DPQLKPEERE SCNTQDCVPE VDENCKDKYY NCNVVVQARL CVYNYYKTAC 
      1010 
CASCTRVANR HVGFLGSR
Length:1,018
Mass (Da):113,243
Last modified:January 15, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB066DE8A9F7EEC71
GO
Isoform 2 (identifier: Q3UTY6-2) [UniParc]FASTAAdd to basket
Also known as: ADAMTSL6-beta

The sequence of this isoform differs from the canonical sequence as follows:
     1-360: Missing.
     361-384: AEKVIDGTPCDQNGTAICVSGQCK → MFVSYLLLTLFHTETAMLARPGGE

Show »
Length:658
Mass (Da):73,967
Checksum:iC33A9F4B4AB60EA5
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z044D3Z044_MOUSE
Thrombospondin type-1 domain-contai...
Thsd4
134Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti486R → Q in BAE23844 (PubMed:16141072).Curated1
Sequence conflicti571E → K in BAE23844 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0300421 – 360Missing in isoform 2. 1 PublicationAdd BLAST360
Alternative sequenceiVSP_030043361 – 384AEKVI…SGQCK → MFVSYLLLTLFHTETAMLAR PGGE in isoform 2. 1 PublicationAdd BLAST24

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK045414 mRNA Translation: BAC32352.1
AK138976 mRNA Translation: BAE23844.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS23256.1 [Q3UTY6-2]
CCDS40661.1 [Q3UTY6-1]

NCBI Reference Sequences

More...RefSeqi		NP_001035516.2, NM_001040426.3 [Q3UTY6-1]
NP_766032.1, NM_172444.4 [Q3UTY6-2]
XP_006510969.1, XM_006510906.3 [Q3UTY6-1]
XP_006510970.1, XM_006510907.3 [Q3UTY6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000034829; ENSMUSP00000034829; ENSMUSG00000032289 [Q3UTY6-2]
ENSMUST00000098660; ENSMUSP00000096257; ENSMUSG00000032289 [Q3UTY6-1]
ENSMUST00000171654; ENSMUSP00000131418; ENSMUSG00000032289 [Q3UTY6-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		207596

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:207596

UCSC genome browser

More...UCSCi		uc009pyx.2, mouse [Q3UTY6-2]
uc009pyy.2, mouse [Q3UTY6-1]

Keywords - Coding sequence diversityi

Alternative promoter usage

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK045414 mRNA Translation: BAC32352.1
AK138976 mRNA Translation: BAE23844.1
CCDSiCCDS23256.1 [Q3UTY6-2]
CCDS40661.1 [Q3UTY6-1]
RefSeqiNP_001035516.2, NM_001040426.3 [Q3UTY6-1]
NP_766032.1, NM_172444.4 [Q3UTY6-2]
XP_006510969.1, XM_006510906.3 [Q3UTY6-1]
XP_006510970.1, XM_006510907.3 [Q3UTY6-1]

3D structure databases

SMRiQ3UTY6
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000096257

PTM databases

GlyConnecti2766, 2 N-Linked glycans (1 site)
GlyGeniQ3UTY6, 1 site
iPTMnetiQ3UTY6
PhosphoSitePlusiQ3UTY6

Proteomic databases

PaxDbiQ3UTY6
PRIDEiQ3UTY6

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		26512, 7 antibodies

Genome annotation databases

EnsembliENSMUST00000034829; ENSMUSP00000034829; ENSMUSG00000032289 [Q3UTY6-2]
ENSMUST00000098660; ENSMUSP00000096257; ENSMUSG00000032289 [Q3UTY6-1]
ENSMUST00000171654; ENSMUSP00000131418; ENSMUSG00000032289 [Q3UTY6-1]
GeneIDi207596
KEGGimmu:207596
UCSCiuc009pyx.2, mouse [Q3UTY6-2]
uc009pyy.2, mouse [Q3UTY6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		79875
MGIiMGI:2672033, Thsd4

Phylogenomic databases

eggNOGiKOG3538, Eukaryota
KOG4597, Eukaryota
GeneTreeiENSGT00940000156594
HOGENOMiCLU_000660_6_0_1
InParanoidiQ3UTY6
OMAiNRCSAEC
OrthoDBi414258at2759
PhylomeDBiQ3UTY6
TreeFamiTF316874

Enzyme and pathway databases

ReactomeiR-MMU-5173214, O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		207596, 1 hit in 17 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Thsd4, mouse

Protein Ontology

More...PROi		PR:Q3UTY6
RNActiQ3UTY6, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000032289, Expressed in ascending aorta and 179 other tissues
ExpressionAtlasiQ3UTY6, baseline and differential
GenevisibleiQ3UTY6, MM

Family and domain databases

Gene3Di2.20.100.10, 7 hits
InterProiView protein in InterPro
IPR010294, ADAM_spacer1
IPR010909, PLAC
IPR000884, TSP1_rpt
IPR036383, TSP1_rpt_sf
PfamiView protein in Pfam
PF05986, ADAM_spacer1, 1 hit
PF08686, PLAC, 1 hit
PF00090, TSP_1, 1 hit
SMARTiView protein in SMART
SM00209, TSP1, 7 hits
SUPFAMiSSF82895, SSF82895, 7 hits
PROSITEiView protein in PROSITE
PS50900, PLAC, 1 hit
PS50092, TSP1, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiTHSD4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UTY6
Secondary accession number(s): Q8BLE5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: January 15, 2008
Last modified: December 2, 2020
This is version 114 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again