UniProtKB - Q3UTH8 (ARHG9_MOUSE)
Protein
Rho guanine nucleotide exchange factor 9
Gene
Arhgef9
Organism
Mus musculus (Mouse)
Status
Functioni
Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters (By similarity).By similarity
GO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: MGI
GO - Biological processi
- receptor clustering Source: MGI
- small GTPase mediated signal transduction Source: MGI
Keywordsi
Molecular function | Guanine-nucleotide releasing factor |
Enzyme and pathway databases
Reactomei | R-MMU-193648, NRAGE signals death through JNK R-MMU-194840, Rho GTPase cycle R-MMU-416482, G alpha (12/13) signalling events R-MMU-977443, GABA receptor activation |
Names & Taxonomyi
Protein namesi | Recommended name: Rho guanine nucleotide exchange factor 9Alternative name(s): Collybistin Rac/Cdc42 guanine nucleotide exchange factor 9 |
Gene namesi | Name:Arhgef9 Synonyms:Kiaa0424 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2442233, Arhgef9 |
Subcellular locationi
Other locations
- Cytoplasm By similarity
- postsynaptic density 1 Publication
Cytosol
- cytosol Source: MGI
Plasma Membrane
- plasma membrane Source: GOC
Other locations
- cell cortex Source: MGI
- GABA-ergic synapse Source: MGI
- glycinergic synapse Source: MGI
- postsynaptic density Source: UniProtKB
- postsynaptic specialization Source: MGI
Keywords - Cellular componenti
Cell junction, Cytoplasm, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000253896 | 1 – 516 | Rho guanine nucleotide exchange factor 9Add BLAST | 516 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 502 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
PhosphoproteinProteomic databases
PaxDbi | Q3UTH8 |
PeptideAtlasi | Q3UTH8 |
PRIDEi | Q3UTH8 |
PTM databases
iPTMneti | Q3UTH8 |
PhosphoSitePlusi | Q3UTH8 |
Expressioni
Tissue specificityi
Detected in embryonic and adult brain.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000025656, Expressed in superior frontal gyrus and 180 other tissues |
ExpressionAtlasi | Q3UTH8, baseline and differential |
Genevisiblei | Q3UTH8, MM |
Interactioni
Subunit structurei
Interacts with GPHN.
By similarityGO - Molecular functioni
- guanyl-nucleotide exchange factor activity Source: MGI
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000109516 |
Miscellaneous databases
RNActi | Q3UTH8, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 8 – 67 | SH3PROSITE-ProRule annotationAdd BLAST | 60 | |
Domaini | 103 – 287 | DHPROSITE-ProRule annotationAdd BLAST | 185 | |
Domaini | 318 – 425 | PHPROSITE-ProRule annotationAdd BLAST | 108 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 100 – 110 | Interaction with GPHNBy similarityAdd BLAST | 11 |
Keywords - Domaini
SH3 domainPhylogenomic databases
eggNOGi | KOG3519, Eukaryota |
GeneTreei | ENSGT00940000154103 |
HOGENOMi | CLU_008436_2_1_1 |
InParanoidi | Q3UTH8 |
OMAi | VFEFAEP |
OrthoDBi | 428887at2759 |
PhylomeDBi | Q3UTH8 |
Family and domain databases
CDDi | cd00160, RhoGEF, 1 hit cd11975, SH3_ARHGEF9, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR035728, ARHGEF9_SH3 IPR035899, DBL_dom_sf IPR000219, DH-domain IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00621, RhoGEF, 1 hit PF00018, SH3_1, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS50002, SH3, 1 hit |
s (4+)i Sequence
Sequence statusi: Complete.
This entry describes 4 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 4 described isoforms and 13 potential isoforms that are computationally mapped.Show allAlign All
Isoform 1 (identifier: Q3UTH8-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MYDLITGDSI VSAEAVWDHV TMANRELAFK AGDVIKVLDA SNKDWWWGQI
60 70 80 90 100
DDEEGWFPAS FVRLWVNQED GVEEGPSDVQ NGHLDPNSDC LCLGRPLQNR
110 120 130 140 150
DQMRANVINE IMSTERHYIK HLKDICEGYL KQCRKRRDMF SDEQLKVIFG
160 170 180 190 200
NIEDIYRFQM GFVRDLEKQY NNDDPHLSEI GPCFLEHQDG FWIYSEYCNN
210 220 230 240 250
HLDACMELSK LMKDSRYQHF FEACRLLQQM IDIAIDGFLL TPVQKICKYP
260 270 280 290 300
LQLAELLKYT AQDHSDYRYV AAALAVMRNV TQQINERKRR LENIDKIAQW
310 320 330 340 350
QASVLDWEGE DILDRSSELI YTGEMAWIYQ PYGRNQQRVF FLFDHQMVLC
360 370 380 390 400
KKDLIRRDIL YYKGRIDMDK YEVIDIEDGR DDDFNVSMKN AFKLHNKETE
410 420 430 440 450
EVHLFFAKKL EEKIRWLRAF REERKMVQED EKIGFEISEN QKRQAAMTVR
460 470 480 490 500
KASKQKGVNS ARSVPPSYPP PQDPLNQGQY LVPDGIAQSQ VFEFTEPKRS
510
QSPFWQNFSR LTPFKK
Computationally mapped potential isoform sequencesi
There are 13 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketB1AXI4 | B1AXI4_MOUSE | Collybistin | Arhgef9 | 515 | Annotation score: | ||
B1AXI6 | B1AXI6_MOUSE | Collybistin | Arhgef9 | 560 | Annotation score: | ||
A0A0G2JE35 | A0A0G2JE35_MOUSE | Collybistin | Arhgef9 | 442 | Annotation score: | ||
B1AXI2 | B1AXI2_MOUSE | Rho guanine nucleotide exchange fac... | Arhgef9 | 414 | Annotation score: | ||
A0A0G2JEH1 | A0A0G2JEH1_MOUSE | Rho guanine nucleotide exchange fac... | Arhgef9 | 463 | Annotation score: | ||
A0A0G2JEU6 | A0A0G2JEU6_MOUSE | Rho guanine nucleotide exchange fac... | Arhgef9 | 236 | Annotation score: | ||
A0A0G2JFA1 | A0A0G2JFA1_MOUSE | Rho guanine nucleotide exchange fac... | Arhgef9 | 258 | Annotation score: | ||
A0A0G2JEU0 | A0A0G2JEU0_MOUSE | Rho guanine nucleotide exchange fac... | Arhgef9 | 219 | Annotation score: | ||
S4R1K5 | S4R1K5_MOUSE | Rho guanine nucleotide exchange fac... | Arhgef9 | 411 | Annotation score: | ||
S4R1A7 | S4R1A7_MOUSE | Rho guanine nucleotide exchange fac... | Arhgef9 | 54 | Annotation score: | ||
There are more potential isoformsShow all |
Sequence cautioni
The sequence BAC65562 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_021143 | 1 – 21 | Missing in isoform 2. 1 PublicationAdd BLAST | 21 | |
Alternative sequenceiVSP_021144 | 1 – 3 | MYD → MQWIRGGTGM in isoform 3. 1 Publication | 3 | |
Alternative sequenceiVSP_021145 | 1 – 3 | MYD → MTL in isoform 4. 1 Publication | 3 | |
Alternative sequenceiVSP_021146 | 458 – 516 | VNSAR…TPFKK → TSAFTPPNPLTVCVGLGNHG VCVFTFLGSFLY in isoform 3. 1 PublicationAdd BLAST | 59 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK122280 mRNA Translation: BAC65562.1 Different initiation. AK038840 mRNA Translation: BAC30147.2 Different termination. AK163874 mRNA Translation: BAE37525.1 AK139416 mRNA Translation: BAE24002.1 AL807821 Genomic DNA No translation available. BX470092 Genomic DNA No translation available. BC141385 mRNA Translation: AAI41386.1 |
CCDSi | CCDS53137.1 [Q3UTH8-1] CCDS72409.1 [Q3UTH8-2] |
RefSeqi | NP_001028501.1, NM_001033329.3 [Q3UTH8-1] NP_001277313.1, NM_001290384.1 [Q3UTH8-2] NP_001277314.1, NM_001290385.1 [Q3UTH8-2] XP_011245884.1, XM_011247582.2 [Q3UTH8-4] XP_011245885.1, XM_011247583.2 [Q3UTH8-1] XP_017173962.1, XM_017318473.1 [Q3UTH8-2] |
Genome annotation databases
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK122280 mRNA Translation: BAC65562.1 Different initiation. AK038840 mRNA Translation: BAC30147.2 Different termination. AK163874 mRNA Translation: BAE37525.1 AK139416 mRNA Translation: BAE24002.1 AL807821 Genomic DNA No translation available. BX470092 Genomic DNA No translation available. BC141385 mRNA Translation: AAI41386.1 |
CCDSi | CCDS53137.1 [Q3UTH8-1] CCDS72409.1 [Q3UTH8-2] |
RefSeqi | NP_001028501.1, NM_001033329.3 [Q3UTH8-1] NP_001277313.1, NM_001290384.1 [Q3UTH8-2] NP_001277314.1, NM_001290385.1 [Q3UTH8-2] XP_011245884.1, XM_011247582.2 [Q3UTH8-4] XP_011245885.1, XM_011247583.2 [Q3UTH8-1] XP_017173962.1, XM_017318473.1 [Q3UTH8-2] |
3D structure databases
BMRBi | Q3UTH8 |
SMRi | Q3UTH8 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000109516 |
PTM databases
iPTMneti | Q3UTH8 |
PhosphoSitePlusi | Q3UTH8 |
Proteomic databases
PaxDbi | Q3UTH8 |
PeptideAtlasi | Q3UTH8 |
PRIDEi | Q3UTH8 |
Protocols and materials databases
ABCDi | Q3UTH8, 2 sequenced antibodies |
Antibodypediai | 27024, 172 antibodies |
Genome annotation databases
Organism-specific databases
CTDi | 23229 |
MGIi | MGI:2442233, Arhgef9 |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG3519, Eukaryota |
GeneTreei | ENSGT00940000154103 |
HOGENOMi | CLU_008436_2_1_1 |
InParanoidi | Q3UTH8 |
OMAi | VFEFAEP |
OrthoDBi | 428887at2759 |
PhylomeDBi | Q3UTH8 |
Enzyme and pathway databases
Reactomei | R-MMU-193648, NRAGE signals death through JNK R-MMU-194840, Rho GTPase cycle R-MMU-416482, G alpha (12/13) signalling events R-MMU-977443, GABA receptor activation |
Miscellaneous databases
BioGRID-ORCSi | 236915, 2 hits in 17 CRISPR screens |
ChiTaRSi | Arhgef9, mouse |
PROi | PR:Q3UTH8 |
RNActi | Q3UTH8, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025656, Expressed in superior frontal gyrus and 180 other tissues |
ExpressionAtlasi | Q3UTH8, baseline and differential |
Genevisiblei | Q3UTH8, MM |
Family and domain databases
CDDi | cd00160, RhoGEF, 1 hit cd11975, SH3_ARHGEF9, 1 hit |
Gene3Di | 1.20.900.10, 1 hit 2.30.29.30, 1 hit |
InterProi | View protein in InterPro IPR035728, ARHGEF9_SH3 IPR035899, DBL_dom_sf IPR000219, DH-domain IPR011993, PH-like_dom_sf IPR001849, PH_domain IPR036028, SH3-like_dom_sf IPR001452, SH3_domain |
Pfami | View protein in Pfam PF00169, PH, 1 hit PF00621, RhoGEF, 1 hit PF00018, SH3_1, 1 hit |
SMARTi | View protein in SMART SM00233, PH, 1 hit SM00325, RhoGEF, 1 hit SM00326, SH3, 1 hit |
SUPFAMi | SSF48065, SSF48065, 1 hit SSF50044, SSF50044, 1 hit |
PROSITEi | View protein in PROSITE PS50010, DH_2, 1 hit PS50003, PH_DOMAIN, 1 hit PS50002, SH3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ARHG9_MOUSE | |
Accessioni | Q3UTH8Primary (citable) accession number: Q3UTH8 Secondary accession number(s): B1AXI3 Q8CAF9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 17, 2006 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 118 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot