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Protein

Eukaryotic translation initiation factor 4E type 1B

Gene

Eif4e1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.By similarity

GO - Molecular functioni

Keywordsi

Molecular functionInitiation factor, RNA-binding
Biological processProtein biosynthesis

Names & Taxonomyi

Protein namesi
Recommended name:
Eukaryotic translation initiation factor 4E type 1B
Alternative name(s):
Oocyte-specific eukaryotic translation initiation factor 4E-like
Gene namesi
Name:Eif4e1b
Synonyms:Gm273
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2685119 Eif4e1b

Subcellular locationi

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003425141 – 244Eukaryotic translation initiation factor 4E type 1BAdd BLAST244

Proteomic databases

PaxDbiQ3UTA9
PRIDEiQ3UTA9

PTM databases

PhosphoSitePlusiQ3UTA9

Expressioni

Gene expression databases

BgeeiENSMUSG00000074895 Expressed in 16 organ(s), highest expression level in female gonad
ExpressionAtlasiQ3UTA9 baseline and differential

Interactioni

Subunit structurei

EIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least EIF4A, EIF4E AND EIF4G (By similarity).By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105630

Structurei

3D structure databases

ProteinModelPortaliQ3UTA9
SMRiQ3UTA9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni65 – 68EIF4EBP1/2/3 bindingBy similarity4
Regioni84 – 857-methylguanosine-containing mRNA cap bindingBy similarity2
Regioni101 – 105EIF4EBP1/2/3 bindingBy similarity5
Regioni130 – 1317-methylguanosine-containing mRNA cap bindingBy similarity2
Regioni160 – 167EIF4EBP1/2/3 bindingBy similarity8
Regioni185 – 1907-methylguanosine-containing mRNA cap bindingBy similarity6
Regioni233 – 2357-methylguanosine-containing mRNA cap bindingBy similarity3

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1670 Eukaryota
COG5053 LUCA
GeneTreeiENSGT00520000055549
HOGENOMiHOG000186751
HOVERGENiHBG006130
InParanoidiQ3UTA9
KOiK03259
PhylomeDBiQ3UTA9
TreeFamiTF101526

Family and domain databases

Gene3Di3.30.760.10, 1 hit
InterProiView protein in InterPro
IPR023398 TIF_eIF4e-like
IPR001040 TIF_eIF_4E
IPR019770 TIF_eIF_4E_CS
PANTHERiPTHR11960 PTHR11960, 1 hit
PfamiView protein in Pfam
PF01652 IF4E, 1 hit
SUPFAMiSSF55418 SSF55418, 1 hit
PROSITEiView protein in PROSITE
PS00813 IF4E, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Note: Additional isoforms seem to exist.

This entry has 2 described isoforms and 7 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3UTA9-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MNKVEGGGHK EEVVVKEKEV VKEKPSEATA EGVQAGEAKD LPGSLKTQRR
60 70 80 90 100
KAHREHPPEV LSKLHPLQYR WVLWFFKNDR SRAWQDNLQL VTKFNTVEDF
110 120 130 140 150
WAVYSHIKLA SKLSSGCDYA LFKEGILPMW EDNRNKQGGR WLLSIDKQLR
160 170 180 190 200
HFELDRLWLE TLLCLVGNCF EEYSREVCGA VVNIRTKRDK IALWTSEAED
210 220 230 240
KAGVMQIGQI YKERLGISTK TIIGYQAHAD TAAKSNNLAN KFVV
Length:244
Mass (Da):27,985
Last modified:October 11, 2005 - v1
Checksum:i04D3CD02BF38B299
GO
Isoform 2 (identifier: Q3UTA9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     162-183: LLCLVGNCFEEYSREVCGAVVN → QGSVRCCREHPHEEGQDCPVDE
     184-244: Missing.

Note: No experimental confirmation available.
Show »
Length:183
Mass (Da):21,332
Checksum:iF97D0F2BB4EF7F69
GO

Computationally mapped potential isoform sequencesi

There are 7 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q27ZI8Q27ZI8_MOUSE
Eukaryotic translation initiation f...
Eif4e1b Gm273
162Annotation score:
Q27ZI7Q27ZI7_MOUSE
Eukaryotic translation initiation f...
Eif4e1b Gm273
103Annotation score:
Q27ZI6Q27ZI6_MOUSE
Eukaryotic translation initiation f...
Eif4e1b Gm273
156Annotation score:
E9PVZ9E9PVZ9_MOUSE
Eukaryotic translation initiation f...
Eif4e1b
250Annotation score:
E9Q929E9Q929_MOUSE
Eukaryotic translation initiation f...
Eif4e1b
188Annotation score:
E9Q0M0E9Q0M0_MOUSE
Eukaryotic translation initiation f...
Eif4e1b
243Annotation score:
E9Q8Z2E9Q8Z2_MOUSE
Eukaryotic translation initiation f...
Eif4e1b
134Annotation score:

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034476162 – 183LLCLV…GAVVN → QGSVRCCREHPHEEGQDCPV DE in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_034477184 – 244Missing in isoform 2. 1 PublicationAdd BLAST61

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ279473 mRNA Translation: ABB88894.1
DQ279474 mRNA Translation: ABB88895.1
AK139577 mRNA Translation: BAE24071.1
BC139143 mRNA Translation: AAI39144.1
BC139144 mRNA Translation: AAI39145.1
CCDSiCCDS49269.1 [Q3UTA9-1]
CCDS49270.1 [Q3UTA9-2]
RefSeqiNP_001028441.1, NM_001033269.3 [Q3UTA9-1]
NP_001034772.1, NM_001039683.2 [Q3UTA9-2]
NP_001273107.1, NM_001286178.1
NP_001273108.1, NM_001286179.1
NP_001273109.1, NM_001286180.1
XP_017170974.1, XM_017315485.1 [Q3UTA9-1]
XP_017170975.1, XM_017315486.1 [Q3UTA9-2]
UniGeneiMm.425821

Genome annotation databases

EnsembliENSMUST00000110003; ENSMUSP00000105630; ENSMUSG00000074895 [Q3UTA9-1]
ENSMUST00000132728; ENSMUSP00000123294; ENSMUSG00000074895 [Q3UTA9-1]
ENSMUST00000152204; ENSMUSP00000120619; ENSMUSG00000074895 [Q3UTA9-2]
GeneIDi218268
KEGGimmu:218268
UCSCiuc007qpg.2 mouse [Q3UTA9-2]
uc007qph.2 mouse [Q3UTA9-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ279473 mRNA Translation: ABB88894.1
DQ279474 mRNA Translation: ABB88895.1
AK139577 mRNA Translation: BAE24071.1
BC139143 mRNA Translation: AAI39144.1
BC139144 mRNA Translation: AAI39145.1
CCDSiCCDS49269.1 [Q3UTA9-1]
CCDS49270.1 [Q3UTA9-2]
RefSeqiNP_001028441.1, NM_001033269.3 [Q3UTA9-1]
NP_001034772.1, NM_001039683.2 [Q3UTA9-2]
NP_001273107.1, NM_001286178.1
NP_001273108.1, NM_001286179.1
NP_001273109.1, NM_001286180.1
XP_017170974.1, XM_017315485.1 [Q3UTA9-1]
XP_017170975.1, XM_017315486.1 [Q3UTA9-2]
UniGeneiMm.425821

3D structure databases

ProteinModelPortaliQ3UTA9
SMRiQ3UTA9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000105630

PTM databases

PhosphoSitePlusiQ3UTA9

Proteomic databases

PaxDbiQ3UTA9
PRIDEiQ3UTA9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110003; ENSMUSP00000105630; ENSMUSG00000074895 [Q3UTA9-1]
ENSMUST00000132728; ENSMUSP00000123294; ENSMUSG00000074895 [Q3UTA9-1]
ENSMUST00000152204; ENSMUSP00000120619; ENSMUSG00000074895 [Q3UTA9-2]
GeneIDi218268
KEGGimmu:218268
UCSCiuc007qpg.2 mouse [Q3UTA9-2]
uc007qph.2 mouse [Q3UTA9-1]

Organism-specific databases

CTDi253314
MGIiMGI:2685119 Eif4e1b

Phylogenomic databases

eggNOGiKOG1670 Eukaryota
COG5053 LUCA
GeneTreeiENSGT00520000055549
HOGENOMiHOG000186751
HOVERGENiHBG006130
InParanoidiQ3UTA9
KOiK03259
PhylomeDBiQ3UTA9
TreeFamiTF101526

Miscellaneous databases

PROiPR:Q3UTA9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000074895 Expressed in 16 organ(s), highest expression level in female gonad
ExpressionAtlasiQ3UTA9 baseline and differential

Family and domain databases

Gene3Di3.30.760.10, 1 hit
InterProiView protein in InterPro
IPR023398 TIF_eIF4e-like
IPR001040 TIF_eIF_4E
IPR019770 TIF_eIF_4E_CS
PANTHERiPTHR11960 PTHR11960, 1 hit
PfamiView protein in Pfam
PF01652 IF4E, 1 hit
SUPFAMiSSF55418 SSF55418, 1 hit
PROSITEiView protein in PROSITE
PS00813 IF4E, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiI4E1B_MOUSE
AccessioniPrimary (citable) accession number: Q3UTA9
Secondary accession number(s): Q27ZJ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 22, 2008
Last sequence update: October 11, 2005
Last modified: September 12, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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