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Entry version 89 (16 Oct 2019)
Sequence version 2 (18 Sep 2013)
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Protein

Divergent protein kinase domain 2A

Gene

Dipk2a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in cardiomyocyte proliferation through paracrine signaling and activation of the PI3-kinase signaling cascade.1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Divergent protein kinase domain 2ACurated
Alternative name(s):
Deleted in autism protein 1 homolog
Golgi Protein of 49 kDa
Short name:
GoPro49
Hypoxia and AKT-induced stem cell factor
Short name:
HASF
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Dipk2a
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1916111 Dipk2a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000022603836 – 430Divergent protein kinase domain 2AAdd BLAST395

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q3USZ8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3USZ8

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3USZ8

PeptideAtlas

More...
PeptideAtlasi
Q3USZ8

PRoteomics IDEntifications database

More...
PRIDEi
Q3USZ8

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3USZ8

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q3USZ8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in heart, brain, liver, spleen, kidney, lung, thymus, testis, ovary and muscle.1 Publication

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

As early as 12.5 dpc to 16.5 dpc, intense expression is restricted to mesenchymal condensations, which form the different cartilage elements of the developing skeleton. At 12.5 dpc, strongly expressed in all vertebrae, heart ventricle, dental follicle, interdigital tissue, tongue and cartilages of the basioccipital bone, maxilla, mandible and the region of the future nasal septum. At 14.5 and 16.5 dpc, expressed in ribs, long bones, interdigital tissue, metatarsals, dental follicle, cartilages of the mandible and nasal septum as well as vertebrae with stronger expression in posterior vertebrae. At 16.5 dpc, also expressed in paw bones and, in vertebrae, the expression is limited to mainly columnar, proliferating chondrocytes. At 4 days postnatal, intense expression in nasal cartilages, hair, dental and vibrissa follicles.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000045414 Expressed in 309 organ(s), highest expression level in cerebellum lobe

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3USZ8 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000108651

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the DIPK family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IKM0 Eukaryota
ENOG410XR52 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00520000055625

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234327

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3USZ8

Identification of Orthologs from Complete Genome Data

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OMAi
FGFYLTD

Database of Orthologous Groups

More...
OrthoDBi
1199714at2759

TreeFam database of animal gene trees

More...
TreeFami
TF313319

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR020519 DIPK2A/B
IPR022049 FAM69_kinase_dom

The PANTHER Classification System

More...
PANTHERi
PTHR32073 PTHR32073, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF12260 PIP49_C, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q3USZ8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWRLVPLKLG RLSRALKLAA LGSLLVLMLL HSPSLLASWQ RNELADRRFL
60 70 80 90 100
QLNKCPACFG TSWCRRFLNG QVGFETWGRL RLLDFLNVKN VYFAQYGEPR
110 120 130 140 150
EGGRRRVVLK RLGSQRELAQ LDQSICKRAT GRPRCDLLQA MPRTEFARLN
160 170 180 190 200
GDVRLLTPEA VEGWSDLVHC PSQRLLDRLV RRYAETKDSG SFLLRNLKDS
210 220 230 240 250
ERMQLLLTLA FNPEPLVLQS FPSDEGWPFA KYLGACGRMV AVNYVGEELW
260 270 280 290 300
SYFNAPWEKR VDLAWQLMEI AEQLTNNDFE FALYLLDVSF DNFAVGPRDG
310 320 330 340 350
KVIIVDAENV LVADKRLIRQ NKPENWDVWY ESKFDDCDKE ACLSFSKEIL
360 370 380 390 400
CARVTVDHNY YAVCQNLLSR HATWRGTSGG LLHDPPSEIA KDGRLEALLD
410 420 430
ECTNPKKRYG RFQAAKELRG YLAQLSHNVR
Length:430
Mass (Da):49,463
Last modified:September 18, 2013 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i4A63FFC4E13379D0
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti3 – 22RLVPL…LAALG → MAVVLRMSNI in BAE24182 (PubMed:16141072).CuratedAdd BLAST20
Sequence conflicti426 – 430SHNVR → KSQCEVVSSDLYIFFAEKAL TKLNHQKNCLE in BAE24182 (PubMed:16141072).Curated5

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK139920 mRNA Translation: BAE24182.1
AC160129 Genomic DNA No translation available.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS40725.1

NCBI Reference Sequences

More...
RefSeqi
NP_001028317.2, NM_001033145.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000113028; ENSMUSP00000108651; ENSMUSG00000045414

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
68861

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:68861

UCSC genome browser

More...
UCSCi
uc009rax.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK139920 mRNA Translation: BAE24182.1
AC160129 Genomic DNA No translation available.
CCDSiCCDS40725.1
RefSeqiNP_001028317.2, NM_001033145.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000108651

PTM databases

PhosphoSitePlusiQ3USZ8
SwissPalmiQ3USZ8

Proteomic databases

EPDiQ3USZ8
MaxQBiQ3USZ8
PaxDbiQ3USZ8
PeptideAtlasiQ3USZ8
PRIDEiQ3USZ8

Genome annotation databases

EnsembliENSMUST00000113028; ENSMUSP00000108651; ENSMUSG00000045414
GeneIDi68861
KEGGimmu:68861
UCSCiuc009rax.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
205428
MGIiMGI:1916111 Dipk2a

Phylogenomic databases

eggNOGiENOG410IKM0 Eukaryota
ENOG410XR52 LUCA
GeneTreeiENSGT00520000055625
HOGENOMiHOG000234327
InParanoidiQ3USZ8
OMAiFGFYLTD
OrthoDBi1199714at2759
TreeFamiTF313319

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q3USZ8

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000045414 Expressed in 309 organ(s), highest expression level in cerebellum lobe
GenevisibleiQ3USZ8 MM

Family and domain databases

InterProiView protein in InterPro
IPR020519 DIPK2A/B
IPR022049 FAM69_kinase_dom
PANTHERiPTHR32073 PTHR32073, 1 hit
PfamiView protein in Pfam
PF12260 PIP49_C, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiDIK2A_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3USZ8
Secondary accession number(s): E9Q9E9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: September 18, 2013
Last modified: October 16, 2019
This is version 89 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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