UniProtKB - Q3USZ2 (UBFL1_MOUSE)
Protein
Upstream-binding factor 1-like protein 1
Gene
Ubtfl1
Organism
Mus musculus (Mouse)
Status
Functioni
Essential for proliferation of the inner cell mass and trophectodermal cells in peri-implantation development.1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 101 – 169 | HMG box 1PROSITE-ProRule annotationAdd BLAST | 69 | |
DNA bindingi | 225 – 291 | HMG box 2PROSITE-ProRule annotationAdd BLAST | 67 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
GO - Biological processi
- blastocyst growth Source: MGI
- embryo implantation Source: MGI
- regulation of gene expression Source: MGI
Keywordsi
Molecular function | Developmental protein, DNA-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Upstream-binding factor 1-like protein 1CuratedAlternative name(s): HMG-box preimplantation embryo-specific protein1 Publication Short name: HMGPI1 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:3588290, Ubtfl1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000386641 | 1 – 394 | Upstream-binding factor 1-like protein 1Add BLAST | 394 |
Proteomic databases
PaxDbi | Q3USZ2 |
PRIDEi | Q3USZ2 |
PTM databases
iPTMneti | Q3USZ2 |
PhosphoSitePlusi | Q3USZ2 |
Expressioni
Developmental stagei
Transcriptionally activated at the 2-cell stage, peaks at the 4-cell stage and then gradually decreased until the blastocyst stage. The protein is detected from the 4-cell stage until the blastocyst stage. In blastocysts, expressed both by inner cell mass and trophectodermal cells (at protein level). Not detected in post-implentation, neither in fetal, nor adult tissues.1 Publication
Gene expression databases
Bgeei | ENSMUSG00000074502, Expressed in cleaving embryo and 21 other tissues |
Genevisiblei | Q3USZ2, MM |
Interactioni
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000129611 |
Miscellaneous databases
RNActi | Q3USZ2, protein |
Family & Domainsi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0381, Eukaryota |
GeneTreei | ENSGT00940000163858 |
HOGENOMi | CLU_021068_0_0_1 |
InParanoidi | Q3USZ2 |
OMAi | LECMENN |
OrthoDBi | 1237679at2759 |
PhylomeDBi | Q3USZ2 |
TreeFami | TF328989 |
Family and domain databases
Gene3Di | 1.10.30.10, 2 hits |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 2 hits |
SUPFAMi | SSF47095, SSF47095, 2 hits |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 2 hits |
i Sequence
Sequence statusi: Complete.
Q3USZ2-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTSLDNQGLW SEKDILKLLE CMEHNIPSDD SREFKKSQAD LNWSKVAFGL
60 70 80 90 100
FSGEMCKQKW MEISYNLRKF RTLTELVQEA KFSFTKKTHK NKILTEHPDR
110 120 130 140 150
PKRPLTAYLR FYKEQRAKYC QMYPKYSNAQ LTKILAEKYR QLPAEIKQRY
160 170 180 190 200
IMDFKKEKED FQKKMRQFKK RHPVSGHPKK SVVPQSHPTK VPTKSQGDIK
210 220 230 240 250
NVKSLVKTES PRTVSSDMKF QGEPRKPPMN AYHKFHQESW SSPELRHLSF
260 270 280 290 300
RKRWVEISRR WHQVPENEKE HYSNQVKRLQ KQYRVKLDLW LKRLSPEEYA
310 320 330 340 350
AYKEAKATCG KRKNMSMSGG RSSKFGRTEQ SSSEKGLQIK PGEVEELLDP
360 370 380 390
GTDSSGTIQG HHDGAQSSRQ DFTDDSEEDD SSTSSDSSST DEDD
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 344 | V → L in BAE37262 (PubMed:16141072).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK139937 mRNA Translation: BAE24188.1 AK163257 mRNA Translation: BAE37262.1 CH466522 Genomic DNA Translation: EDL25044.1 CH466522 Genomic DNA Translation: EDL25045.1 BC139141 mRNA Translation: AAI39142.1 BC145822 mRNA Translation: AAI45823.1 |
CCDSi | CCDS40540.1 |
RefSeqi | NP_001028965.1, NM_001033793.3 XP_011240880.1, XM_011242578.1 |
Genome annotation databases
Ensembli | ENSMUST00000098973; ENSMUSP00000096572; ENSMUSG00000074502 ENSMUST00000164441; ENSMUSP00000129611; ENSMUSG00000074502 ENSMUST00000169398; ENSMUSP00000126540; ENSMUSG00000074502 |
GeneIDi | 546118 |
KEGGi | mmu:546118 |
UCSCi | uc009ogq.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK139937 mRNA Translation: BAE24188.1 AK163257 mRNA Translation: BAE37262.1 CH466522 Genomic DNA Translation: EDL25044.1 CH466522 Genomic DNA Translation: EDL25045.1 BC139141 mRNA Translation: AAI39142.1 BC145822 mRNA Translation: AAI45823.1 |
CCDSi | CCDS40540.1 |
RefSeqi | NP_001028965.1, NM_001033793.3 XP_011240880.1, XM_011242578.1 |
3D structure databases
SMRi | Q3USZ2 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000129611 |
PTM databases
iPTMneti | Q3USZ2 |
PhosphoSitePlusi | Q3USZ2 |
Proteomic databases
PaxDbi | Q3USZ2 |
PRIDEi | Q3USZ2 |
Protocols and materials databases
Antibodypediai | 74795, 23 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000098973; ENSMUSP00000096572; ENSMUSG00000074502 ENSMUST00000164441; ENSMUSP00000129611; ENSMUSG00000074502 ENSMUST00000169398; ENSMUSP00000126540; ENSMUSG00000074502 |
GeneIDi | 546118 |
KEGGi | mmu:546118 |
UCSCi | uc009ogq.1, mouse |
Organism-specific databases
CTDi | 642623 |
MGIi | MGI:3588290, Ubtfl1 |
Phylogenomic databases
eggNOGi | KOG0381, Eukaryota |
GeneTreei | ENSGT00940000163858 |
HOGENOMi | CLU_021068_0_0_1 |
InParanoidi | Q3USZ2 |
OMAi | LECMENN |
OrthoDBi | 1237679at2759 |
PhylomeDBi | Q3USZ2 |
TreeFami | TF328989 |
Miscellaneous databases
BioGRID-ORCSi | 546118, 0 hits in 17 CRISPR screens |
PROi | PR:Q3USZ2 |
RNActi | Q3USZ2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000074502, Expressed in cleaving embryo and 21 other tissues |
Genevisiblei | Q3USZ2, MM |
Family and domain databases
Gene3Di | 1.10.30.10, 2 hits |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 2 hits |
SUPFAMi | SSF47095, SSF47095, 2 hits |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | UBFL1_MOUSE | |
Accessioni | Q3USZ2Primary (citable) accession number: Q3USZ2 Secondary accession number(s): Q3TQX0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 3, 2009 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 101 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot