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Entry version 115 (02 Jun 2021)
Sequence version 1 (11 Oct 2005)
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Protein
Submitted name:

Uncharacterized protein

Gene

Lamb2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Uncharacterized proteinImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lamb2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:99916, Lamb2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 35Sequence analysisAdd BLAST35
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500423017436 – 1375Sequence analysisAdd BLAST1340

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi315 ↔ 324PROSITE-ProRule annotation
Disulfide bondi380 ↔ 389PROSITE-ProRule annotation
Disulfide bondi443 ↔ 452PROSITE-ProRule annotation
Disulfide bondi496 ↔ 505PROSITE-ProRule annotation
Disulfide bondi508 ↔ 522PROSITE-ProRule annotation
Disulfide bondi525 ↔ 537PROSITE-ProRule annotation
Disulfide bondi527 ↔ 544PROSITE-ProRule annotation
Disulfide bondi546 ↔ 555PROSITE-ProRule annotation
Disulfide bondi784 ↔ 796PROSITE-ProRule annotation
Disulfide bondi786 ↔ 803PROSITE-ProRule annotation
Disulfide bondi805 ↔ 814PROSITE-ProRule annotation
Disulfide bondi832 ↔ 844PROSITE-ProRule annotation
Disulfide bondi834 ↔ 851PROSITE-ProRule annotation
Disulfide bondi853 ↔ 862PROSITE-ProRule annotation
Disulfide bondi897 ↔ 906PROSITE-ProRule annotation
Disulfide bondi957 ↔ 966PROSITE-ProRule annotation
Disulfide bondi1011 ↔ 1020PROSITE-ProRule annotation
Disulfide bondi1068 ↔ 1077PROSITE-ProRule annotation
Disulfide bondi1096 ↔ 1108PROSITE-ProRule annotation
Disulfide bondi1098 ↔ 1115PROSITE-ProRule annotation
Disulfide bondi1117 ↔ 1126PROSITE-ProRule annotation
Disulfide bondi1144 ↔ 1156PROSITE-ProRule annotation
Disulfide bondi1146 ↔ 1163PROSITE-ProRule annotation
Disulfide bondi1165 ↔ 1174PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationARBA annotation, GlycoproteinARBA annotation

Proteomic databases

PeptideAtlas

More...
PeptideAtlasi
Q3USI2

PRoteomics IDEntifications database

More...
PRIDEi
Q3USI2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3USI2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q3USI2, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini46 – 285Laminin N-terminalInterPro annotationAdd BLAST240
Domaini286 – 349Laminin EGF-likeInterPro annotationAdd BLAST64
Domaini350 – 412Laminin EGF-likeInterPro annotationAdd BLAST63
Domaini413 – 472Laminin EGF-likeInterPro annotationAdd BLAST60
Domaini473 – 524Laminin EGF-likeInterPro annotationAdd BLAST52
Domaini525 – 565Laminin EGF-likeInterPro annotationAdd BLAST41
Domaini564 – 778Laminin IV type BInterPro annotationAdd BLAST215
Domaini784 – 831Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini832 – 877Laminin EGF-likeInterPro annotationAdd BLAST46
Domaini878 – 927Laminin EGF-likeInterPro annotationAdd BLAST50
Domaini928 – 986Laminin EGF-likeInterPro annotationAdd BLAST59
Domaini987 – 1038Laminin EGF-likeInterPro annotationAdd BLAST52
Domaini1039 – 1095Laminin EGF-likeInterPro annotationAdd BLAST57
Domaini1096 – 1143Laminin EGF-likeInterPro annotationAdd BLAST48
Domaini1144 – 1190Laminin EGF-likeInterPro annotationAdd BLAST47

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1339 – 1365DisorderedSequence analysisAdd BLAST27

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1263 – 1297Sequence analysisAdd BLAST35

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1344 – 1365Polar residuesSequence analysisAdd BLAST22

Keywords - Domaini

Coiled coilSequence analysis, Laminin EGF-like domainPROSITE-ProRule annotationARBA annotation, SignalSequence analysis

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
65841at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.1490, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000742, EGF-like_dom
IPR002049, Laminin_EGF
IPR013015, Laminin_IV_B
IPR008211, Laminin_N
IPR038684, Laminin_N_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00053, Laminin_EGF, 13 hits
PF00055, Laminin_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181, EGF, 8 hits
SM00180, EGF_Lam, 13 hits
SM00136, LamNT, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01248, EGF_LAM_1, 5 hits
PS50027, EGF_LAM_2, 13 hits
PS51116, LAMININ_IVB, 1 hit
PS51117, LAMININ_NTER, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q3USI2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEWASGEPGR GRQGQPLPWE LRLGLLLSVL AATLAQAPSL DVPGCSRGSC
60 70 80 90 100
YPATGDLLVG RADRLTASST CGLHSPQPYC IVSHLQDEKK CFLCDSRRPF
110 120 130 140 150
SARDNPNSHR IQNVVTSFAP QRRTAWWQSE NGVPMVTIQL DLEAEFHFTH
160 170 180 190 200
LIMTFKTFRP AAMLVERSAD FGRTWHVYRY FSYDCGADFP GIPLAPPRRW
210 220 230 240 250
DDVVCESRYS EIEPSTEGEV IYRVLDPAIP IPDPYSSRIQ NLLKITNLRV
260 270 280 290 300
NLTRLHTLGD NLLDPRREIR EKYYYALYEL VIRGNCFCYG HASQCAPAPG
310 320 330 340 350
APAHAEGMVH GACICKHNTR GLNCEQCQDF YQDLPWHPAE DGHTHACRKC
360 370 380 390 400
ECNGHTHSCH FDMAVYLASG NVSGGVCDGC QHNTAGRHCE FCRPFFYRDP
410 420 430 440 450
TKDMRDPAVC RPCDCDPMGS QDGGRCDSHD DPVLGLVSGQ CRCKEHVVGT
460 470 480 490 500
RCQQCRDGFF GLSASDPRGC QRCQCNSRGT VPGSSPCDSS SGTCFCKRLV
510 520 530 540 550
TGHGCDRCLP GHWGLSHDLL GCRPCDCDVG GALDPQCDEA TGQCRCRQHM
560 570 580 590 600
IGRRCEQVQP GYFRPFLDHL TWEAEAAQGQ GLEVVERLVT NRETPSWTGP
610 620 630 640 650
GFVRLREGQE VEFLVTSLPR AMDYDLLLRW EPQVPEQWAE LELMVQRPGP
660 670 680 690 700
VSAHSPCGHV LPKDDRIQGM LHPNTRFLVF PRPVCLEPGI SYKLKLKLIG
710 720 730 740 750
TGGRAQPETS YSGLLIDSLV LQPHVLVLEM FSGGDAAALE RRTTFERYRC
760 770 780 790 800
HEEGLMPSKA PLSETCAPLL ISVSALIYNG ALPCQCDPQG SLSSECSPHG
810 820 830 840 850
GQCRCKPGVV GRRCDVCATG YYGFGPAGCQ ACQCSPDGAL SALCEGTSGQ
860 870 880 890 900
CPCRPGAFGL RCDHCQRGQW GFPNCRPCVC NGRADECDTH TGACLGCRDY
910 920 930 940 950
TGGEHCERCI AGFHGDPRLP YGGQCRPCPC PEGPGSQRHF ATSCHRDGYS
960 970 980 990 1000
QQIVCQCREG YTGLRCEACA PGHFGDPSKP GGRCQLCECS GNIDPMDPDA
1010 1020 1030 1040 1050
CDPHTGQCLR CLHNTEGPHC GYCKPGFHGQ AARQSCHRCT CNLLGTDPRR
1060 1070 1080 1090 1100
CPSTDLCHCD PSTGQCPCLP HVQGLNCDHC APNFWNFTSG RGCQPCACHP
1110 1120 1130 1140 1150
SRARGPTCNE FTGQCHCHAG FGGRTCSECQ ELYWGDPGLQ CRACDCDPRG
1160 1170 1180 1190 1200
IDKPQCHRST GHCSCRPGVS GVRCDQCARG FSGVFPACHP CHACFGDWDR
1210 1220 1230 1240 1250
VVQDLAARTR RLEQWAQELQ QTGVLGAFES SFLNMQGKLG MVQAIMSARN
1260 1270 1280 1290 1300
ASAASTAKLV EATEGLRHEI GKTTERLTQL EAELTAVQDE NFNANHALSG
1310 1320 1330 1340 1350
LERDGLALNL TLRQLDQHLE ILKHSNFLGA YDSIRHAHSQ STEAERRANA
1360 1370
STFAVPSPVS NSADTRRRTE VLMGA
Length:1,375
Mass (Da):150,818
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7284196271879080
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1375Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK140351 mRNA Translation: BAE24350.1

NCBI Reference Sequences

More...
RefSeqi
NP_032509.2, NM_008483.3

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
16779

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:16779

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK140351 mRNA Translation: BAE24350.1
RefSeqiNP_032509.2, NM_008483.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ3USI2, 1 interactor

Proteomic databases

PeptideAtlasiQ3USI2
PRIDEiQ3USI2

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
16779

Genome annotation databases

GeneIDi16779
KEGGimmu:16779

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
3913
MGIiMGI:99916, Lamb2

Phylogenomic databases

OrthoDBi65841at2759

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
16779, 1 hit in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Lamb2, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiQ3USI2, MM

Family and domain databases

Gene3Di2.60.120.1490, 1 hit
InterProiView protein in InterPro
IPR000742, EGF-like_dom
IPR002049, Laminin_EGF
IPR013015, Laminin_IV_B
IPR008211, Laminin_N
IPR038684, Laminin_N_sf
PfamiView protein in Pfam
PF00053, Laminin_EGF, 13 hits
PF00055, Laminin_N, 1 hit
SMARTiView protein in SMART
SM00181, EGF, 8 hits
SM00180, EGF_Lam, 13 hits
SM00136, LamNT, 1 hit
PROSITEiView protein in PROSITE
PS01248, EGF_LAM_1, 5 hits
PS50027, EGF_LAM_2, 13 hits
PS51116, LAMININ_IVB, 1 hit
PS51117, LAMININ_NTER, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3USI2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3USI2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: June 2, 2021
This is version 115 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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