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Protein

Splicing factor, suppressor of white-apricot homolog

Gene

Sfswap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role as an alternative splicing regulator. Regulates its own expression at the level of RNA processing. Also regulates the splicing of fibronectin and CD45 genes. May act, at least in part, by interaction with other R/S-containing splicing factors. Represses the splicing of MAPT/Tau exon 10 (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRepressor, RNA-binding
Biological processmRNA processing, mRNA splicing, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Splicing factor, suppressor of white-apricot homolog
Alternative name(s):
Splicing factor, arginine/serine-rich 8
Suppressor of white apricot protein homolog
Gene namesi
Name:Sfswap
Synonyms:Sfrs8, Srsf8, Swap
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:101760 Sfswap

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004130231 – 945Splicing factor, suppressor of white-apricot homologAdd BLAST945

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei283PhosphoserineCombined sources1
Modified residuei315N6-acetyllysineBy similarity1
Modified residuei601PhosphoserineCombined sources1
Modified residuei621PhosphoserineCombined sources1
Modified residuei639PhosphothreonineCombined sources1
Modified residuei829PhosphoserineBy similarity1
Modified residuei831PhosphoserineBy similarity1
Modified residuei899PhosphoserineCombined sources1
Modified residuei903PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3USH5
MaxQBiQ3USH5
PaxDbiQ3USH5
PeptideAtlasiQ3USH5
PRIDEiQ3USH5

PTM databases

iPTMnetiQ3USH5
PhosphoSitePlusiQ3USH5

Expressioni

Gene expression databases

BgeeiENSMUSG00000029439 Expressed in 276 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ3USH5 baseline and differential
GenevisibleiQ3USH5 MM

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
SF1Q156373EBI-8387273,EBI-744603From Homo sapiens.

Protein-protein interaction databases

BioGridi231165, 1 interactor
IntActiQ3USH5, 3 interactors
MINTiQ3USH5
STRINGi10090.ENSMUSP00000062413

Structurei

3D structure databases

ProteinModelPortaliQ3USH5
SMRiQ3USH5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati211 – 253SURP motif 1Add BLAST43
Repeati458 – 498SURP motif 2Add BLAST41

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili632 – 686Sequence analysisAdd BLAST55

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi101 – 186Glu-richAdd BLAST86
Compositional biasi382 – 457Pro-richAdd BLAST76
Compositional biasi737 – 856Arg-richAdd BLAST120
Compositional biasi762 – 920Ser-richAdd BLAST159

Keywords - Domaini

Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1847 Eukaryota
ENOG410ZQGI LUCA
GeneTreeiENSGT00730000111096
HOGENOMiHOG000168244
HOVERGENiHBG079184
InParanoidiQ3USH5
OMAiVDVATYY
OrthoDBiEOG091G09RJ
TreeFamiTF106264

Family and domain databases

Gene3Di1.10.10.790, 2 hits
InterProiView protein in InterPro
IPR000061 Surp
IPR035967 SWAP/Surp_sf
IPR019147 SWAP_N_domain
PfamiView protein in Pfam
PF09750 DRY_EERY, 1 hit
PF01805 Surp, 2 hits
SMARTiView protein in SMART
SM01141 DRY_EERY, 1 hit
SM00648 SWAP, 2 hits
SUPFAMiSSF109905 SSF109905, 2 hits
PROSITEiView protein in PROSITE
PS50128 SURP, 2 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q3USH5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYGAGGGRAK PERKGGVKEE AGPGGTGTGG NRVELLVFGY ACKLFRDDER
60 70 80 90 100
ALAQEQGQHL IPWMGDPKIL IDRYDGRGHL HDLSAYDAEY ATWNRDYQLS
110 120 130 140 150
EEEARVEALC DEERYLALHT DLLEEEARQE EEYKRLSEAL AEDGNYSAVG
160 170 180 190 200
FTYGSDYYDP SEPTEEEEPS KQREKNEAEN LEENEEPFIA PLGLSVPSDV
210 220 230 240 250
ELPPTAKMHA IIERTANFVC KQGAQFEIML KAKQARNSQF DFLRFDHYLN
260 270 280 290 300
PYYKFIQKAM KEGRYTVLAE SKNEEKKKSG PTSDNEEEDD EEDGSYLHPS
310 320 330 340 350
LFASKKSSRL EELMKPLKVV DPDHPLAALV RKAQADSSAP APPTADGTPA
360 370 380 390 400
QPSQVEYTAD STVAAMYYSY YMLPDGTYCL APPPPGIDVA TYYSTLPAGV
410 420 430 440 450
TVSSSPGVTT TVPPPPGTTP PPPPTTAEPS SGVTSTTTTT SALAPVAIIP
460 470 480 490 500
PPPDIQPVID KLAEYVARNG LKFETSVRAK NDQRFEFLQP WHQYNAYYEF
510 520 530 540 550
KKQFFLQKEG GGSTQAASTA EEAPTETAVE ESGEAGEDGA PEGMAETGGR
560 570 580 590 600
GSGKKEAGSS KSTVDGKLVK ASFAPISFAI KAKENDLLPL EKNRVKLDDD
610 620 630 640 650
SEEDEESREC QESTSSVANP SPAAAPPSVA VEEKKPQLTQ EELEAKQAKQ
660 670 680 690 700
KLEDRLAAAA REKLAQASKE SKEKQLQAER KRKAALFLQT LKNPLPEAEV
710 720 730 740 750
GKLEESTFGV EDTGVMPCPL LVGGRTLPIL EGKPPERPSN RCRDPPREEE
760 770 780 790 800
REKKKKKHKK RSRTRSRSPK YHSSSKPRSR SHSKAKHSLP SAYRTVRRSR
810 820 830 840 850
SRSRSPRRRA HSPERRREER SVPTAYRMSG SPGVSRKRTR SRSPHEKKKK
860 870 880 890 900
RRSRSRTKAK ARSQSTSPSK QAAQRPSAHS AHSASISPVE SRGSSQERSR
910 920 930 940
GVSQEKDGQI SSAIVSSVQS KITQDLMAKV RAMLAASKNL QTSAS
Length:945
Mass (Da):104,190
Last modified:October 19, 2011 - v2
Checksum:i7B2CBDCB63A89AA2
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0G2JFY2A0A0G2JFY2_MOUSE
Splicing factor, suppressor of whit...
Sfswap
82Annotation score:
A0A0G2JGP0A0A0G2JGP0_MOUSE
Splicing factor, suppressor of whit...
Sfswap
69Annotation score:
A0A0G2JDQ9A0A0G2JDQ9_MOUSE
Splicing factor, suppressor of whit...
Sfswap
121Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114614 Genomic DNA No translation available.
AC114657 Genomic DNA No translation available.
AK031872 mRNA Translation: BAC27586.1
AK140369 mRNA Translation: BAE24357.1
CCDSiCCDS19694.1
RefSeqiNP_758480.2, NM_172276.3
UniGeneiMm.288714

Genome annotation databases

EnsembliENSMUST00000053737; ENSMUSP00000062413; ENSMUSG00000029439
GeneIDi231769
KEGGimmu:231769
UCSCiuc008zsu.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC114614 Genomic DNA No translation available.
AC114657 Genomic DNA No translation available.
AK031872 mRNA Translation: BAC27586.1
AK140369 mRNA Translation: BAE24357.1
CCDSiCCDS19694.1
RefSeqiNP_758480.2, NM_172276.3
UniGeneiMm.288714

3D structure databases

ProteinModelPortaliQ3USH5
SMRiQ3USH5
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi231165, 1 interactor
IntActiQ3USH5, 3 interactors
MINTiQ3USH5
STRINGi10090.ENSMUSP00000062413

PTM databases

iPTMnetiQ3USH5
PhosphoSitePlusiQ3USH5

Proteomic databases

EPDiQ3USH5
MaxQBiQ3USH5
PaxDbiQ3USH5
PeptideAtlasiQ3USH5
PRIDEiQ3USH5

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000053737; ENSMUSP00000062413; ENSMUSG00000029439
GeneIDi231769
KEGGimmu:231769
UCSCiuc008zsu.1 mouse

Organism-specific databases

CTDi6433
MGIiMGI:101760 Sfswap

Phylogenomic databases

eggNOGiKOG1847 Eukaryota
ENOG410ZQGI LUCA
GeneTreeiENSGT00730000111096
HOGENOMiHOG000168244
HOVERGENiHBG079184
InParanoidiQ3USH5
OMAiVDVATYY
OrthoDBiEOG091G09RJ
TreeFamiTF106264

Miscellaneous databases

ChiTaRSiSfswap mouse
PROiPR:Q3USH5
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029439 Expressed in 276 organ(s), highest expression level in cerebellum
ExpressionAtlasiQ3USH5 baseline and differential
GenevisibleiQ3USH5 MM

Family and domain databases

Gene3Di1.10.10.790, 2 hits
InterProiView protein in InterPro
IPR000061 Surp
IPR035967 SWAP/Surp_sf
IPR019147 SWAP_N_domain
PfamiView protein in Pfam
PF09750 DRY_EERY, 1 hit
PF01805 Surp, 2 hits
SMARTiView protein in SMART
SM01141 DRY_EERY, 1 hit
SM00648 SWAP, 2 hits
SUPFAMiSSF109905 SSF109905, 2 hits
PROSITEiView protein in PROSITE
PS50128 SURP, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiSFSWA_MOUSE
AccessioniPrimary (citable) accession number: Q3USH5
Secondary accession number(s): Q8CCZ1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 19, 2011
Last sequence update: October 19, 2011
Last modified: November 7, 2018
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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