UniProtKB - Q3US12 (Q3US12_MOUSE)
Protein
G_PROTEIN_RECEP_F1_2 domain-containing protein
Gene
Agtr2
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- angiotensin type II receptor activity Source: InterPro
GO - Biological processi
- inflammatory response Source: InterPro
- regulation of apoptotic process Source: InterPro
- regulation of blood vessel diameter Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptorUniRule annotation, Receptor, Transducer |
Names & Taxonomyi
Protein namesi | Recommended name: G_PROTEIN_RECEP_F1_2 domain-containing proteinInterPro annotation |
Gene namesi | Name:Agtr2Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:87966 Agtr2 |
Subcellular locationi
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 79 – 100 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 112 – 130 | HelicalSequence analysisAdd BLAST | 19 | |
Transmembranei | 150 – 170 | HelicalSequence analysisAdd BLAST | 21 | |
Transmembranei | 190 – 211 | HelicalSequence analysisAdd BLAST | 22 | |
Transmembranei | 247 – 264 | HelicalSequence analysisAdd BLAST | 18 | |
Transmembranei | 284 – 308 | HelicalSequence analysisAdd BLAST | 25 | |
Transmembranei | 328 – 351 | HelicalSequence analysisAdd BLAST | 24 |
Keywords - Cellular componenti
MembraneFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 91 – 348 | G_PROTEIN_RECEP_F1_2InterPro annotationAdd BLAST | 258 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family.UniRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
HOGENOMi | HOG000234122 |
KOi | K04167 |
OrthoDBi | 685818at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR000147 ATII_AT2_rcpt IPR000248 ATII_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00241 ANGIOTENSINR PR00636 ANGIOTENSN2R PR00237 GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q3US12-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRELSKLIYD NCFKHWQLKR CKNLELLQFN MKDNFSFAAT SRNITSSRPF
60 70 80 90 100
DNLNATGTNE SAFNCSHKPS DKHLEAIPVL YYMIFVIGFA VNIVVVSLFC
110 120 130 140 150
CQKGPKKVSS IYIFNLALAD LLLLATLPLW ATYYSYRYDW LFGPVMCKVF
160 170 180 190 200
GSFLTLNMFA SIFFITCMSV DRYQSVIYPF LSQRRNPWQA SYVVPLVWCM
210 220 230 240 250
ACLSSXPTFY FRDVRTIEYL GVNACIMAFP PEKYAQWSAG IALMKNILGF
260 270 280 290 300
IIPLIFIATC YFGIRKHLLK TNSYGKNRIT RDQVLKMAAA VVLAFIICWL
310 320 330 340 350
PFHVLTFLDA LTWMGIINSC EVIAVIDLAL PFAILLGFTN SCVNPFLYCF
360 370 380 390
VGNRFQQKLR SVFRVPITWL QGKRETMSCR KGSSLREMDT FVS
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK140941 mRNA Translation: BAE24525.1 |
RefSeqi | NP_031455.1, NM_007429.5 |
Genome annotation databases
GeneIDi | 11609 |
KEGGi | mmu:11609 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK140941 mRNA Translation: BAE24525.1 |
RefSeqi | NP_031455.1, NM_007429.5 |
3D structure databases
ModBasei | Search... |
Protein family/group databases
GPCRDBi | Search... |
Genome annotation databases
GeneIDi | 11609 |
KEGGi | mmu:11609 |
Organism-specific databases
CTDi | 186 |
MGIi | MGI:87966 Agtr2 |
Phylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
HOGENOMi | HOG000234122 |
KOi | K04167 |
OrthoDBi | 685818at2759 |
Miscellaneous databases
ChiTaRSi | Agtr2 mouse |
SOURCEi | Search... |
Family and domain databases
InterProi | View protein in InterPro IPR000147 ATII_AT2_rcpt IPR000248 ATII_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR00241 ANGIOTENSINR PR00636 ANGIOTENSN2R PR00237 GPCRRHODOPSN |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3US12_MOUSE | |
Accessioni | Q3US12Primary (citable) accession number: Q3US12 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | October 16, 2019 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |