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Entry version 98 (13 Nov 2019)
Sequence version 3 (18 Mar 2008)
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Protein

Armadillo repeat-containing protein 2

Gene

Armc2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Required for sperm flagellum axoneme organization and function (PubMed:30686508). Involved in axonemal central pair complex assembly and/or stability (PubMed:30686508).1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processDifferentiation, Spermatogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Armadillo repeat-containing protein 2Curated
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Armc21 PublicationImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1916449 Armc2

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Male mice are infertile, while female fertility is not affected (PubMed:30686508). Spermatozoa exhibit multiple morphologic abnormalities including short, thick, and/or coiled flagella, whereas sperm heads conserve an overall typical hooked shape (PubMed:30686508).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003250901 – 854Armadillo repeat-containing protein 2Add BLAST854

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3URY6

PRoteomics IDEntifications database

More...
PRIDEi
Q3URY6

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3URY6

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3URY6

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000071324 Expressed in 54 organ(s), highest expression level in metencephalon part of 4th ventricle choroid plexus (mouse)

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3URY6 baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000125583

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati255 – 294ARM 1Add BLAST40
Repeati298 – 337ARM 2Add BLAST40
Repeati356 – 396ARM 3Add BLAST41
Repeati401 – 442ARM 4Add BLAST42
Repeati455 – 496ARM 5Add BLAST42
Repeati499 – 540ARM 6Add BLAST42
Repeati544 – 583ARM 7Add BLAST40
Repeati585 – 605ARM 8Add BLAST21
Repeati606 – 649ARM 9Add BLAST44
Repeati651 – 692ARM 10Add BLAST42
Repeati694 – 733ARM 11Add BLAST40
Repeati735 – 777ARM 12Add BLAST43

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG410IUKI Eukaryota
ENOG410XPBC LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000000663

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000034054

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3URY6

Identification of Orthologs from Complete Genome Data

More...
OMAi
NDVAMEY

Database of Orthologous Groups

More...
OrthoDBi
741009at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3URY6

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.25.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR038905 ARMC2

The PANTHER Classification System

More...
PANTHERi
PTHR21356 PTHR21356, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00185 ARM, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48371 SSF48371, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3URY6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLSSNDQKLE KLDSFYRPPV SKQRTSAEII SEARNALRTV RTQRPFTPRE
60 70 80 90 100
DQRKLFGPAS SRSPENRPPS SFSLHASSFE LSDSKPISGT RLRPLELKPK
110 120 130 140 150
APASPGTEDA CLSFPKAPLD PAKIRKISGA RARFYRAASQ GMLLPDRSPP
160 170 180 190 200
AAHSKTVDES SKPVSVGSST ARRNGTHLTA SSATGQLKSP PLLTCDQGFQ
210 220 230 240 250
ETTEQEVSLL SQLRRGGDPG KRRARASSCP SSSDLSRKET RAASRASSQE
260 270 280 290 300
QETDTEVDEV FWKARIVPIL HELENEEDIE EMCAACTQLH RTLEEARMLG
310 320 330 340 350
KKFKRRTVLL KALYKLVDAD SDPLSLKLAK LILALKVSGK NLLNVCKLIF
360 370 380 390 400
KISRNEKNDT LMQEDNILES LLEVLRAEEL QSNTEAFLYC MGALKFVSGS
410 420 430 440 450
PGFLTEMVNK GAVEILAQLI KEMTEDTEKH GVCLPDSGHL LVQTTATLRN
460 470 480 490 500
LVDSPLTRSK LLNMGAFPHL CTVMEQHADD KDICTNIARI FSKLTSYRDC
510 520 530 540 550
CAALASYSRC YALFLSLLNK YQKNQDLVIR IVFILGNLTA KSNQARELFS
560 570 580 590 600
RETGSVETLL TLFQSFYHHK ENSPKLQLSE AKPQAEAEDV LVKLTRVLAN
610 620 630 640 650
IAIHPRIGPV LAANPRVVGL LLRTLESKSL GDCEELVINT IAAINNLSFY
660 670 680 690 700
QVKSSVLQHR KLYVAELLLR LLVSNNMERI LEAVRVFGNL SQDHDVCNFL
710 720 730 740 750
MQKNVHKFMI TLLEAKHQDI CFSACGVLLN LTVDKEKRAI LKEGGGIKKL
760 770 780 790 800
VDCLRDFGPS DWQLACLVCK TLWNFSENIT NASECFGDDV ANTLLILLST
810 820 830 840 850
FLDEELALNG SFDQDLESYH RLHWETEFKP VAQQLLQRIQ SHHSLLEPLP

VPSF
Length:854
Mass (Da):95,311
Last modified:March 18, 2008 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i5F6B87A7F0D5EEF2
GO
Isoform 2 (identifier: Q3URY6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-232: Missing.
     233-241: SDLSRKETR → MPFPSLHFF

Note: Due to intron retention. No experimental confirmation available.
Show »
Length:622
Mass (Da):70,192
Checksum:iB4E8335C1684C1EE
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E0CZ41E0CZ41_MOUSE
Armadillo repeat-containing protein...
Armc2
147Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8BTB2Q8BTB2_MOUSE
Armadillo repeat-containing protein...
Armc2
99Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F7B746F7B746_MOUSE
Armadillo repeat-containing protein...
Armc2
46Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0244951 – 232Missing in isoform 2. 1 PublicationAdd BLAST232
Alternative sequenceiVSP_024496233 – 241SDLSRKETR → MPFPSLHFF in isoform 2. 1 Publication9

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK141039 mRNA Translation: BAE24551.1
AC165442 Genomic DNA No translation available.
BM942469 mRNA No translation available.

NCBI Reference Sequences

More...
RefSeqi
NP_001030030.2, NM_001034858.3 [Q3URY6-1]
XP_011241459.1, XM_011243157.2 [Q3URY6-1]
XP_011241461.1, XM_011243159.1 [Q3URY6-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000095729; ENSMUSP00000093397; ENSMUSG00000071324 [Q3URY6-1]
ENSMUST00000160262; ENSMUSP00000125412; ENSMUSG00000071324 [Q3URY6-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
213402

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:213402

UCSC genome browser

More...
UCSCi
uc007eyg.3 mouse [Q3URY6-2]
uc007eyh.3 mouse [Q3URY6-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK141039 mRNA Translation: BAE24551.1
AC165442 Genomic DNA No translation available.
BM942469 mRNA No translation available.
RefSeqiNP_001030030.2, NM_001034858.3 [Q3URY6-1]
XP_011241459.1, XM_011243157.2 [Q3URY6-1]
XP_011241461.1, XM_011243159.1 [Q3URY6-1]

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000125583

PTM databases

iPTMnetiQ3URY6
PhosphoSitePlusiQ3URY6

Proteomic databases

PaxDbiQ3URY6
PRIDEiQ3URY6

Genome annotation databases

EnsembliENSMUST00000095729; ENSMUSP00000093397; ENSMUSG00000071324 [Q3URY6-1]
ENSMUST00000160262; ENSMUSP00000125412; ENSMUSG00000071324 [Q3URY6-1]
GeneIDi213402
KEGGimmu:213402
UCSCiuc007eyg.3 mouse [Q3URY6-2]
uc007eyh.3 mouse [Q3URY6-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
84071
MGIiMGI:1916449 Armc2

Phylogenomic databases

eggNOGiENOG410IUKI Eukaryota
ENOG410XPBC LUCA
GeneTreeiENSGT00390000000663
HOGENOMiHOG000034054
InParanoidiQ3URY6
OMAiNDVAMEY
OrthoDBi741009at2759
PhylomeDBiQ3URY6

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Armc2 mouse

Protein Ontology

More...
PROi
PR:Q3URY6

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000071324 Expressed in 54 organ(s), highest expression level in metencephalon part of 4th ventricle choroid plexus (mouse)
ExpressionAtlasiQ3URY6 baseline and differential

Family and domain databases

Gene3Di1.25.10.10, 2 hits
InterProiView protein in InterPro
IPR011989 ARM-like
IPR016024 ARM-type_fold
IPR000225 Armadillo
IPR038905 ARMC2
PANTHERiPTHR21356 PTHR21356, 1 hit
SMARTiView protein in SMART
SM00185 ARM, 8 hits
SUPFAMiSSF48371 SSF48371, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARMC2_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3URY6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 17, 2007
Last sequence update: March 18, 2008
Last modified: November 13, 2019
This is version 98 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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