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Entry version 131 (07 Apr 2021)
Sequence version 1 (11 Oct 2005)
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Protein

Paternally-expressed gene 3 protein

Gene

Peg3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Induces apoptosis in cooperation with SIAH1A. Acts as a mediator between p53/TP53 and BAX in a neuronal death pathway that is activated by DNA damage. Acts synergistically with TRAF2 and inhibits TNF induced apoptosis through activation of NF-kappa-B. Plays a role in regulating maternal behavior and offspring growth.4 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri325 – 347C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri850 – 872C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1091 – 1113C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1147 – 1169C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1209 – 1231C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1266 – 1289C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1317 – 1339C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1488 – 1510C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1547 – 1569C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processApoptosis
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Paternally-expressed gene 3 protein
Alternative name(s):
ASF-1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Peg3
Synonyms:Kiaa0287, Pw1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 7

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:104748, Peg3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002492291 – 1571Paternally-expressed gene 3 proteinAdd BLAST1571

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3URU2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3URU2

PeptideAtlas

More...
PeptideAtlasi
Q3URU2

PRoteomics IDEntifications database

More...
PRIDEi
Q3URU2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
287822 [Q3URU2-1]
287823 [Q3URU2-2]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3URU2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3URU2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Brain, glial cells, neurons, skeletal muscle, uterus and placenta. In the placenta it found in all trophoblast cells.4 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Strongly expressed upon gastrulation and subsequently becomes restricted to skeletal muscle and subregions of the CNS. At 9.5 dpc, expressed in the branchial arches, somites and gut but little in the heart and neural tissues. At 12.5 dpc strongly expressed in the cranial skeleton, tongue, vertebral cartilage, pituitary and the luminal epithelium.2 Publications

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced during p53/TP53 mediated apoptosis. Up-regulated by DNA damage in cortical neurons in the presence of p53/TP53.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000002265, Expressed in respiratory primordium and 316 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3URU2, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Interacts with SIAH1A and SIAH2.

Interacts with TRAF2.

3 Publications

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
202106, 3 interactors

Protein interaction database and analysis system

More...
IntActi
Q3URU2, 1 interactor

Molecular INTeraction database

More...
MINTi
Q3URU2

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000050750

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3URU2, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati942 – 9461-15
Repeati967 – 9711-25
Repeati987 – 9912-15
Repeati992 – 9961-35
Repeati997 – 10012-25
Repeati1002 – 10061-45
Repeati1007 – 10112-35
Repeati1012 – 10161-55
Repeati1017 – 10211-65
Repeati1022 – 10261-75
Repeati1027 – 10311-85
Repeati1032 – 10361-95
Repeati1047 – 10511-105

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni199 – 26510 X 5 AA repeat of P-H-X-X-EAdd BLAST67
Regioni199 – 2653 X 5 AA repeat of P-H-D-D-KAdd BLAST67

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi228 – 231Poly-Ser4
Compositional biasi695 – 698Poly-Ser4
Compositional biasi771 – 774Poly-Ser4

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The SCAN domain enables PEG3 homo- or heterodimerization to control gene expression in a combinatorial fashion.By similarity

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri325 – 347C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri378 – 400C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri436 – 458C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri520 – 542C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri850 – 872C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1091 – 1113C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1147 – 1169C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1209 – 1231C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1266 – 1289C2H2-type 9PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri1317 – 1339C2H2-type 10; degeneratePROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1488 – 1510C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri1547 – 1569C2H2-type 12PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162525

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_005305_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3URU2

Identification of Orthologs from Complete Genome Data

More...
OMAi
ECQDCGL

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3URU2

TreeFam database of animal gene trees

More...
TreeFami
TF337075

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00096, zf-C2H2, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00355, ZnF_C2H2, 12 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667, SSF57667, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 11 hits
PS50157, ZINC_FINGER_C2H2_2, 12 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3URU2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MYHHEDDTNS DMNSDDDMSR SGRETPPPRP SHAFGSERDL ERRGRSRDVE
60 70 80 90 100
PRDRWPYTRN PRSRLPQRDL SLPVMSRPHF GLDRDDDRRS MDYESRSQDA
110 120 130 140 150
ESYQNVVELK EDKKPQNPIQ DNLENYRKLL SLGVQLAEDD RHSHMTQGHS
160 170 180 190 200
SRSKRTAYPS TSRGLKPMPE AKKPSHRRGI CEDESSHGVI MEKFIKDVAR
210 220 230 240 250
NPKSGRAREL NERPPPRFPR PNDNWKDSSS SRRESVIQER GYEGSAFRGG
260 270 280 290 300
FRFNADLASR SRALERKRRY HFDSDERGSG HEHKSCVRKK PFECGAEMRQ
310 320 330 340 350
AMSMGNLNSP SFSESQSIDF GANPYVCDEC GRQFSVISEF VEHQIMHTRE
360 370 380 390 400
NLYEYGESFI HSVAVNEVQK GQGGGKRFEC KECGETFSRS AALAEHRQIH
410 420 430 440 450
AREYLAECRD QEDEETIMPS PTFSELQKMY GKDKFYECKV CKETFLHSSA
460 470 480 490 500
LIEHQKIHGR GNSDDRDNER ERERDRLRAR AREQRERERE RERERELGEP
510 520 530 540 550
FLTCPNFNEF RKMYRKDKIY ECKVCGESFL HLSSLREHQK IHTRGNPFEN
560 570 580 590 600
KSRMCEETFV PSQSLRRRQK TYREKLFDFN NARDALMGNS DSSEHQKNRS
610 620 630 640 650
RRNFFEGRGF EKPFVESQKS HTITRPPENK DDDKPFTISV NPNDKLKFPI
660 670 680 690 700
MENGSQGKSY ERSVIHSLGS AEAQKSHGGL GFSKPRPVAE SSTQSSSSIY
710 720 730 740 750
YPRAHSGGNT YEGKEYKDSI IHSLPAPRPL KRHRANDHIQ CDEGGESSIY
760 770 780 790 800
IPDIINKGRK IPAREDAYEG SSSSNYHTPN VSRAEPPSLS GESHDSKQDV
810 820 830 840 850
TFSVPSSSVR EHQKARAKKK YIEPRNNETS VIHSLPFGEL LAGHRRAKFF
860 870 880 890 900
ECQECGEAFA RRSELIEHQK IHDRERPSGS RHYERSVIRS LAPSDPQTSY
910 920 930 940 950
AQERFIQEQV RKFRAFGQRS TTSNNLSVQK IYAQETFNAE EPHDKETHGQ
960 970 980 990 1000
KIHDKEPYGK EPSGKEPHGD EPQDKEPLDQ EMRSEEPHDD KPHGQEPHDD
1010 1020 1030 1040 1050
KPHGQEPHDD KPHGQEPHGD EPHGQEPHGD EPHDKEPIDQ EMRSEEPHSE
1060 1070 1080 1090 1100
ESHGDEPHGE ESHGQEKVED ATIQASVSEE HQKDDAGDAI YECQDCGLGF
1110 1120 1130 1140 1150
TDLNDLTSHQ DTHSRKALVD SREYAHSEVH AHSVSEFEKK CSGEKLYECP
1160 1170 1180 1190 1200
KCGESFIHSS LLFEHQRVHE QDQLYSVKAC DDAFIALLPV RPRRNCTVER
1210 1220 1230 1240 1250
NPAVSGSAIR CRQCGQGFIH SSALNEHMRQ HRDNEIMEQS ELSDEIFIQG
1260 1270 1280 1290 1300
LALTEYQGSE TEEKLFECTI CGECFFTAKQ LGDHHTKVHK DEPYEYGPSY
1310 1320 1330 1340 1350
THASFLTEPL RKHIPLYECK DCGQSFLDDT VIAERMVFHP EREGGSEIVA
1360 1370 1380 1390 1400
ATAQEVEANV LIPQEVLRIQ GSNAEAAEPE VEAAEPEVEA AEPEVEAAEP
1410 1420 1430 1440 1450
NGEAEGPDGE AAEPDGEAEQ PNGEAEQPNG DADEPDGAGI EDPEERADEP
1460 1470 1480 1490 1500
EEDVEEPEGD ADEPDGADIE DPEEEGEDQE IEVEEPYYNC HECAETFASS
1510 1520 1530 1540 1550
SAFGEHLKSH ASVIIFEPAN APGECSGYIE RASTSAGGAE QADDKYFKCD
1560 1570
VCGQLFNDRL SLARHQNSHT G
Length:1,571
Mass (Da):178,932
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i915E13EF0751C6EE
GO
Isoform 2 (identifier: Q3URU2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     989-1048: Missing.
     1202-1254: PAVSGSAIRC...EIFIQGLALT → ASSLPNSSGT...TNAKIAASPS
     1255-1571: Missing.

Show »
Length:1,194
Mass (Da):136,999
Checksum:i400EC6945BF9B923
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A5F8MPW9A0A5F8MPW9_MOUSE
Paternally-expressed gene 3 protein
Peg3
1,632Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D6RGA4D6RGA4_MOUSE
Paternally-expressed gene 3 protein
Peg3
116Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC52770 differs from that shown. Reason: Frameshift.Curated
The sequence BAB85589 differs from that shown. Reason: Frameshift.Curated
The sequence BAC65520 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti5E → G (PubMed:8563758).Curated1
Sequence conflicti5E → G (PubMed:11260267).Curated1
Sequence conflicti156T → A in AAB96922 (PubMed:8563758).Curated1
Sequence conflicti321G → W in BAB85589 (PubMed:11260267).Curated1
Sequence conflicti351N → T (PubMed:10704281).Curated1
Sequence conflicti370 – 371KG → RS (PubMed:8563758).Curated2
Sequence conflicti370 – 371KG → RS (PubMed:11260267).Curated2
Sequence conflicti382E → V in BAB85589 (PubMed:11260267).Curated1
Sequence conflicti403E → R (PubMed:8806818).Curated1
Sequence conflicti567 – 568Missing (PubMed:8806818).Curated2
Sequence conflicti570K → E in BAB85589 (PubMed:11260267).Curated1
Sequence conflicti608R → G in BAB85589 (PubMed:11260267).Curated1
Sequence conflicti614F → S in BAB85589 (PubMed:11260267).Curated1
Sequence conflicti645K → E in BAB85589 (PubMed:11260267).Curated1
Sequence conflicti648F → L in AAB96922 (PubMed:8563758).Curated1
Sequence conflicti660Y → C in AAB96922 (PubMed:8563758).Curated1
Sequence conflicti669G → A (PubMed:8806818).Curated1
Sequence conflicti712E → K (PubMed:8806818).Curated1
Sequence conflicti736 – 737ND → MN in BAB85589 (PubMed:11260267).Curated2
Sequence conflicti856G → R (PubMed:8806818).Curated1
Sequence conflicti979D → V in AAB96922 (PubMed:8563758).Curated1
Sequence conflicti1011K → E (PubMed:8806818).Curated1
Sequence conflicti1051E → Q in AAH89344 (PubMed:15489334).Curated1
Sequence conflicti1123E → G (PubMed:8806818).Curated1
Sequence conflicti1171Missing in BAC65520 (PubMed:12693553).Curated1
Sequence conflicti1181D → Y (PubMed:8563758).Curated1
Sequence conflicti1181D → Y (PubMed:11260267).Curated1
Sequence conflicti1401N → I (PubMed:8563758).Curated1
Sequence conflicti1401N → I (PubMed:11260267).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_020375989 – 1048Missing in isoform 2. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_0203761202 – 1254PAVSG…GLALT → ASSLPNSSGTTTPKFTRMSP MSMGPPTPMPPFSPSPSGST SHCTNAKIAASPS in isoform 2. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_0203771255 – 1571Missing in isoform 2. 1 PublicationAdd BLAST317

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF038939 mRNA Translation: AAB96922.1
AB003040 mRNA Translation: BAB85589.1 Frameshift.
AK141217 mRNA Translation: BAE24595.1
AK163845 mRNA Translation: BAE37516.1
AK122238 Transcribed RNA Translation: BAC65520.2 Different initiation.
BC072661 mRNA Translation: AAH72661.1
BC085183 mRNA Translation: AAH85183.1
BC089344 mRNA Translation: AAH89344.1
AF105266, AF105264, AF105265 Genomic DNA Translation: AAF16868.1
U48804 Genomic DNA Translation: AAC52770.1 Frameshift.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS20783.1 [Q3URU2-1]

Protein sequence database of the Protein Information Resource

More...
PIRi
T14155
T30173

NCBI Reference Sequences

More...
RefSeqi
NP_032843.2, NM_008817.2 [Q3URU2-1]
XP_017177520.1, XM_017322031.1 [Q3URU2-1]
XP_017177521.1, XM_017322032.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000051209; ENSMUSP00000050750; ENSMUSG00000002265 [Q3URU2-1]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
18616

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:18616

UCSC genome browser

More...
UCSCi
uc009fbw.1, mouse [Q3URU2-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF038939 mRNA Translation: AAB96922.1
AB003040 mRNA Translation: BAB85589.1 Frameshift.
AK141217 mRNA Translation: BAE24595.1
AK163845 mRNA Translation: BAE37516.1
AK122238 Transcribed RNA Translation: BAC65520.2 Different initiation.
BC072661 mRNA Translation: AAH72661.1
BC085183 mRNA Translation: AAH85183.1
BC089344 mRNA Translation: AAH89344.1
AF105266, AF105264, AF105265 Genomic DNA Translation: AAF16868.1
U48804 Genomic DNA Translation: AAC52770.1 Frameshift.
CCDSiCCDS20783.1 [Q3URU2-1]
PIRiT14155
T30173
RefSeqiNP_032843.2, NM_008817.2 [Q3URU2-1]
XP_017177520.1, XM_017322031.1 [Q3URU2-1]
XP_017177521.1, XM_017322032.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi202106, 3 interactors
IntActiQ3URU2, 1 interactor
MINTiQ3URU2
STRINGi10090.ENSMUSP00000050750

PTM databases

iPTMnetiQ3URU2
PhosphoSitePlusiQ3URU2

Proteomic databases

MaxQBiQ3URU2
PaxDbiQ3URU2
PeptideAtlasiQ3URU2
PRIDEiQ3URU2
ProteomicsDBi287822 [Q3URU2-1]
287823 [Q3URU2-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
19625, 173 antibodies

Genome annotation databases

EnsembliENSMUST00000051209; ENSMUSP00000050750; ENSMUSG00000002265 [Q3URU2-1]
GeneIDi18616
KEGGimmu:18616
UCSCiuc009fbw.1, mouse [Q3URU2-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
5178
MGIiMGI:104748, Peg3

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG1721, Eukaryota
GeneTreeiENSGT00940000162525
HOGENOMiCLU_005305_0_0_1
InParanoidiQ3URU2
OMAiECQDCGL
PhylomeDBiQ3URU2
TreeFamiTF337075

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
18616, 1 hit in 53 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Peg3, mouse

Protein Ontology

More...
PROi
PR:Q3URU2
RNActiQ3URU2, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000002265, Expressed in respiratory primordium and 316 other tissues
GenevisibleiQ3URU2, MM

Family and domain databases

InterProiView protein in InterPro
IPR036236, Znf_C2H2_sf
IPR013087, Znf_C2H2_type
PfamiView protein in Pfam
PF00096, zf-C2H2, 5 hits
SMARTiView protein in SMART
SM00355, ZnF_C2H2, 12 hits
SUPFAMiSSF57667, SSF57667, 7 hits
PROSITEiView protein in PROSITE
PS00028, ZINC_FINGER_C2H2_1, 11 hits
PS50157, ZINC_FINGER_C2H2_2, 12 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPEG3_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3URU2
Secondary accession number(s): O54978
, Q3TQ69, Q5EBP7, Q61138, Q6GQS0, Q80U47, Q8R5N0, Q9QX53
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 19, 2006
Last sequence update: October 11, 2005
Last modified: April 7, 2021
This is version 131 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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