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Entry version 126 (22 Apr 2020)
Sequence version 2 (18 May 2010)
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Protein

Zinc finger and SCAN domain-containing protein 10

Gene

Zscan10

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Embryonic stem (ES) cell-specific transcription factor required to maintain ES cell pluripotency. Can both activate and /or repress expression of target genes, depending on the context. Specifically binds the 5'-[GA]CGCNNGCG[CT]-3' DNA consensus sequence. Regulates expression of POU5F1/OCT4, ZSCAN4 and ALYREF/THOC4.3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri292 – 315C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri321 – 343C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri669 – 691C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri697 – 719C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • DNA-binding transcription factor activity Source: UniProtKB
  • metal ion binding Source: UniProtKB-KW
  • sequence-specific DNA binding Source: UniProtKB

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Repressor
Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger and SCAN domain-containing protein 10
Alternative name(s):
Zinc finger protein 206
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Zscan10
Synonyms:Zfp206
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:3040700 Zscan10

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003942481 – 782Zinc finger and SCAN domain-containing protein 10Add BLAST782

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei160PhosphoserineBy similarity1
Modified residuei206PhosphoserineBy similarity1
Modified residuei485N5-methylglutamineBy similarity1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Methylated at Gln-485 by N6AMT1.By similarity

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3URR7

PeptideAtlas

More...
PeptideAtlasi
Q3URR7

PRoteomics IDEntifications database

More...
PRIDEi
Q3URR7

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3URR7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3URR7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Embryonic stem (ES) cell-specific. Not expressed in adult, except in testis.2 Publications

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed throughout embryogenesis.1 Publication

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Transcriptionally regulated by POU5F1/OCT4 and SOX2.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000023902 Expressed in embryo and 58 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3URR7 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3URR7 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with POU5F1/OCT4 and SOX2.

1 Publication

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
237126, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000093255

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3URR7 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1782
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3URR7

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1 – 71SCAN boxPROSITE-ProRule annotationAdd BLAST71

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi104 – 175Pro-richAdd BLAST72

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri292 – 315C2H2-type 1PROSITE-ProRule annotationAdd BLAST24
Zinc fingeri321 – 343C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri349 – 371C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri377 – 399C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri421 – 443C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri467 – 489C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri523 – 545C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri551 – 573C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri579 – 601C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri607 – 629C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri635 – 657C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri669 – 691C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri697 – 719C2H2-type 14PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000162513

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_002678_49_8_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3URR7

KEGG Orthology (KO)

More...
KOi
K09230

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3URR7

TreeFam database of animal gene trees

More...
TreeFami
TF338010

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07936 SCAN, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.4020.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 12 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 14 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57667 SSF57667, 8 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 6 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3URR7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MLAEPVPDAL EQEHPGAVKL EEDEVGEEDP RLAESRPRPE VAHQLFRCFQ
60 70 80 90 100
YQEDMGPRAS LGRLRELCNH WLRPALHTKK QILELLVLEQ FLSVLPPHVL
110 120 130 140 150
SRLHGQPLRD GEEVVQLLEG VPRDISHMGP LDFSFSAGKN APADIISEEQ
160 170 180 190 200
NSPSQVPSHS PQTELPSEEI PALHPLNELP PPQPAPIRPA EPEEWRLAPS
210 220 230 240 250
SNWPMSPEPQ EILQDPRESN PSQGPSWLEE NSRDQELAAV LESLTFEDTS
260 270 280 290 300
EKRAWPANPL GFGSRMPDNE ELKVEEPKVT TWPVVIGAES QTEKPEVAGE
310 320 330 340 350
PLTQTVGQET SSTGWGGTPA DGSEVVKVRG ASDAPEPQGE MQFICTYCGV
360 370 380 390 400
NFPEMSHLQA HQLQSHPNLQ PHPSSRSFRC LWCGKTFGRS SILKLHMRTH
410 420 430 440 450
TDERPHACHL CNRRFRQSSH LTKHLLTHSS EPAFRCAECN QGFQRRSSLM
460 470 480 490 500
QHLLAHAQGK NLTPNPEGKT KVPEMAAVLC SHCGQTFKRR SSLKRHLRNH
510 520 530 540 550
AKDKDHLSSE DPGSLSSSQE SNPYVCSDCG KAFRQSEQLM IHTRRVHTRE
560 570 580 590 600
RPFSCQVCGR CFTQNSQLIS HQQIHTGEKP HACPQCSKRF VRRAGLARHL
610 620 630 640 650
LTHGSLRPYH CAQCGKSFRQ MRDLTRHVRC HTGEKPCRCN ECGEGFTQNA
660 670 680 690 700
HLARHQRIHT GEKPHACDIC GHRFRNSSNL ARHRRSHTGE RPYSCPTCGR
710 720 730 740 750
SFRRNAHLQR HLITHTGSKQ EKEVPQECPE CGKSFNRSCN LLRHLLVHTG
760 770 780
ARPYSCALCG RSFSRNSHLL RHLRTHARES LY
Length:782
Mass (Da):88,355
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB521507A5C617AED
GO
Isoform 2 (identifier: Q3URR7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     328-359: Missing.

Show »
Length:750
Mass (Da):84,831
Checksum:i18305E8F8E15CB34
GO
Isoform 3 (identifier: Q3URR7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     131-240: Missing.

Show »
Length:672
Mass (Da):76,254
Checksum:i0A8101311BFA9C49
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 6 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YVM1D3YVM1_MOUSE
Zinc finger and SCAN domain-contain...
Zscan10
262Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PXB1E9PXB1_MOUSE
Zinc finger and SCAN domain-contain...
Zscan10
702Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z3Z6D3Z3Z6_MOUSE
Zinc finger and SCAN domain-contain...
Zscan10
329Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3YWR9D3YWR9_MOUSE
Zinc finger and SCAN domain-contain...
Zscan10
149Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PX93E9PX93_MOUSE
Zinc finger and SCAN domain-contain...
Zscan10
190Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PV84E9PV84_MOUSE
Zinc finger and SCAN domain-contain...
Zscan10
543Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti306V → E in ABC54589 (PubMed:16971461).Curated1
Sequence conflicti306V → E in ABC54590 (PubMed:16971461).Curated1
Sequence conflicti306V → E in ABC54591 (PubMed:16971461).Curated1
Sequence conflicti306V → E in ABM45916 (PubMed:17628018).Curated1
Sequence conflicti306V → E in EDL22251 (Ref. 4) Curated1
Sequence conflicti546V → L in BAE24621 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_039227131 – 240Missing in isoform 3. 1 PublicationAdd BLAST110
Alternative sequenceiVSP_039228328 – 359Missing in isoform 2. 2 PublicationsAdd BLAST32

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
DQ323929 mRNA Translation: ABC54589.1
DQ323930 mRNA Translation: ABC54590.1
DQ323931 mRNA Translation: ABC54591.1
EF152498 mRNA Translation: ABM45916.1
AK141259 mRNA Translation: BAE24621.1
CH466606 Genomic DNA Translation: EDL22251.1
BC145638 mRNA Translation: AAI45639.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS28451.1 [Q3URR7-1]
CCDS70766.1 [Q3URR7-2]
CCDS79510.1 [Q3URR7-3]

NCBI Reference Sequences

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RefSeqi
NP_001028597.2, NM_001033425.4 [Q3URR7-1]
NP_001276410.1, NM_001289481.1 [Q3URR7-2]
NP_001276411.1, NM_001289482.1 [Q3URR7-3]
NP_001276412.1, NM_001289483.1
NP_001276413.1, NM_001289484.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENSMUST00000095595; ENSMUSP00000093255; ENSMUSG00000023902 [Q3URR7-1]
ENSMUST00000115509; ENSMUSP00000111171; ENSMUSG00000023902 [Q3URR7-3]
ENSMUST00000120967; ENSMUSP00000113386; ENSMUSG00000023902 [Q3URR7-2]

Database of genes from NCBI RefSeq genomes

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GeneIDi
332221

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:332221

UCSC genome browser

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UCSCi
uc008ask.3 mouse [Q3URR7-2]
uc008asl.2 mouse [Q3URR7-1]
uc008asm.2 mouse [Q3URR7-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ323929 mRNA Translation: ABC54589.1
DQ323930 mRNA Translation: ABC54590.1
DQ323931 mRNA Translation: ABC54591.1
EF152498 mRNA Translation: ABM45916.1
AK141259 mRNA Translation: BAE24621.1
CH466606 Genomic DNA Translation: EDL22251.1
BC145638 mRNA Translation: AAI45639.1
CCDSiCCDS28451.1 [Q3URR7-1]
CCDS70766.1 [Q3URR7-2]
CCDS79510.1 [Q3URR7-3]
RefSeqiNP_001028597.2, NM_001033425.4 [Q3URR7-1]
NP_001276410.1, NM_001289481.1 [Q3URR7-2]
NP_001276411.1, NM_001289482.1 [Q3URR7-3]
NP_001276412.1, NM_001289483.1
NP_001276413.1, NM_001289484.1

3D structure databases

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Protein Data Bank Europe

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PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4E6SX-ray1.85A36-128[»]
SMRiQ3URR7
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi237126, 1 interactor
STRINGi10090.ENSMUSP00000093255

PTM databases

iPTMnetiQ3URR7
PhosphoSitePlusiQ3URR7

Proteomic databases

PaxDbiQ3URR7
PeptideAtlasiQ3URR7
PRIDEiQ3URR7

Protocols and materials databases

Antibodypedia a portal for validated antibodies

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Antibodypediai
58023 26 antibodies

The DNASU plasmid repository

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DNASUi
332221

Genome annotation databases

EnsembliENSMUST00000095595; ENSMUSP00000093255; ENSMUSG00000023902 [Q3URR7-1]
ENSMUST00000115509; ENSMUSP00000111171; ENSMUSG00000023902 [Q3URR7-3]
ENSMUST00000120967; ENSMUSP00000113386; ENSMUSG00000023902 [Q3URR7-2]
GeneIDi332221
KEGGimmu:332221
UCSCiuc008ask.3 mouse [Q3URR7-2]
uc008asl.2 mouse [Q3URR7-1]
uc008asm.2 mouse [Q3URR7-3]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
84891
MGIiMGI:3040700 Zscan10

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000162513
HOGENOMiCLU_002678_49_8_1
InParanoidiQ3URR7
KOiK09230
OrthoDBi1318335at2759
PhylomeDBiQ3URR7
TreeFamiTF338010

Miscellaneous databases

Protein Ontology

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PROi
PR:Q3URR7
RNActiQ3URR7 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000023902 Expressed in embryo and 58 other tissues
ExpressionAtlasiQ3URR7 baseline and differential
GenevisibleiQ3URR7 MM

Family and domain databases

CDDicd07936 SCAN, 1 hit
Gene3Di1.10.4020.10, 1 hit
InterProiView protein in InterPro
IPR003309 SCAN_dom
IPR038269 SCAN_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF02023 SCAN, 1 hit
PF00096 zf-C2H2, 12 hits
SMARTiView protein in SMART
SM00431 SCAN, 1 hit
SM00355 ZnF_C2H2, 14 hits
SUPFAMiSSF57667 SSF57667, 8 hits
PROSITEiView protein in PROSITE
PS50804 SCAN_BOX, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 14 hits
PS50157 ZINC_FINGER_C2H2_2, 14 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZSC10_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3URR7
Secondary accession number(s): B7ZP53
, Q20D61, Q20D62, Q20D63
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 18, 2010
Last sequence update: May 18, 2010
Last modified: April 22, 2020
This is version 126 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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