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Protein

Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2

Gene

Lingo2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • positive regulation of synapse assembly Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2
Alternative name(s):
Leucine-rich repeat neuronal protein 6C
Gene namesi
Name:Lingo2
Synonyms:Lrrn6c
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 4

Organism-specific databases

MGIiMGI:2442298 Lingo2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini28 – 545ExtracellularSequence analysisAdd BLAST518
Transmembranei546 – 566HelicalSequence analysisAdd BLAST21
Topological domaini567 – 606CytoplasmicSequence analysisAdd BLAST40

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 27Sequence analysisAdd BLAST27
ChainiPRO_000032439028 – 606Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 2Add BLAST579

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi38N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi130N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi250N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi260N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi279N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi327N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi432 ↔ 483PROSITE-ProRule annotation
Glycosylationi491N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi522N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi527N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ3URE9
PaxDbiQ3URE9
PRIDEiQ3URE9

PTM databases

iPTMnetiQ3URE9
PhosphoSitePlusiQ3URE9

Expressioni

Gene expression databases

BgeeiENSMUSG00000045083 Expressed in 79 organ(s), highest expression level in mesenchyme of fronto-nasal process
CleanExiMM_LINGO2
ExpressionAtlasiQ3URE9 baseline and differential
GenevisibleiQ3URE9 MM

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069772

Structurei

3D structure databases

ProteinModelPortaliQ3URE9
SMRiQ3URE9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 57LRRNTAdd BLAST30
Repeati58 – 79LRR 1Add BLAST22
Repeati82 – 103LRR 2Add BLAST22
Repeati106 – 127LRR 3Add BLAST22
Repeati130 – 151LRR 4Add BLAST22
Repeati154 – 175LRR 5Add BLAST22
Repeati178 – 199LRR 6Add BLAST22
Repeati202 – 223LRR 7Add BLAST22
Repeati226 – 247LRR 8Add BLAST22
Repeati250 – 271LRR 9Add BLAST22
Repeati274 – 295LRR 10Add BLAST22
Repeati298 – 319LRR 11Add BLAST22
Repeati322 – 343LRR 12Add BLAST22
Domaini355 – 409LRRCTAdd BLAST55

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118831
HOGENOMiHOG000246971
HOVERGENiHBG057546
InParanoidiQ3URE9
OMAiSYYVTCT
OrthoDBiEOG091G047N
PhylomeDBiQ3URE9
TreeFamiTF334360

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13855 LRR_8, 2 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 9 hits
SM00013 LRRNT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 11 hits

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q3URE9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLHTAIPCWQ PFLGLAVVLL LMGSTIGCPA RCECSAQNKS VSCHRRRLLA
60 70 80 90 100
IPEGIPIETK ILDLSKNRLK SINPEEFISY PLLEEIDLSD NIIANVEPGA
110 120 130 140 150
FNNLFNLRSL RLKGNRLKLV PLGVFTGLSN LTKLDISENK IVILLDYMFQ
160 170 180 190 200
DLHNLKSLEV GDNDLVYISH RAFSGLLSLE QLTLEKCNLT AVPTEALSHL
210 220 230 240 250
RSLIALHLKH LNINNMPVYA FKRLFHLKNL EIDYWPLLDL MPANSLYGLN
260 270 280 290 300
LTSLSITNTN LSTVPFLAFK HLVYLTHLNL SYNPISTIEA GMFSDLIRLQ
310 320 330 340 350
ELHIVGAQLR TIEPHSFQGL RFLRVLNVSQ NLLETLEENV FSSPRALEVL
360 370 380 390 400
SINNNPLACD CRLLWLLQRQ PNLQFGGQQP MCAGPDTIRE RSFKDFHSTA
410 420 430 440 450
LSFYFTCKKP KIREKKLQHL LVDEGQTVQL ECNADGDPQP VISWVTPRRR
460 470 480 490 500
FITTKSNGRA TVLGDGTLEI RFAQDQDSGM YVCIASNAAG NDTFTASLTV
510 520 530 540 550
KGFTSDRFLY ANRTPMYMTD SNDTVSNGTN ANTFSLDLKT ILVSTAMGCF
560 570 580 590 600
TFLGVVLFCF LLLFVWSRGK GKHKNSIDLE YVPRKNNGAV VEGEVAGPRR

FNMKMI
Length:606
Mass (Da):68,069
Last modified:October 11, 2005 - v1
Checksum:i4E0930B9E948AE33
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti537D → G in BAC32442 (PubMed:16141072).Curated1
Sequence conflicti550F → Y in BAC29183 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035778 mRNA Translation: BAC29183.1
AK045639 mRNA Translation: BAC32442.1
AK141568 mRNA Translation: BAE24739.1
BC090619 mRNA Translation: AAH90619.1
BC145692 mRNA Translation: AAI45693.1
CCDSiCCDS18040.1
RefSeqiNP_001159471.1, NM_001165999.1
NP_001159472.1, NM_001166000.1
NP_001159473.1, NM_001166001.1
NP_780725.2, NM_175516.4
XP_006537965.1, XM_006537902.2
XP_006537966.1, XM_006537903.2
XP_006537967.1, XM_006537904.3
XP_011248319.1, XM_011250017.2
XP_011248320.1, XM_011250018.2
XP_011248321.1, XM_011250019.2
XP_011248322.1, XM_011250020.2
XP_011248324.1, XM_011250022.2
XP_011248325.1, XM_011250023.2
XP_011248327.1, XM_011250025.2
XP_011248328.1, XM_011250026.2
XP_017175684.1, XM_017320195.1
XP_017175685.1, XM_017320196.1
XP_017175686.1, XM_017320197.1
XP_017175687.1, XM_017320198.1
UniGeneiMm.132507

Genome annotation databases

EnsembliENSMUST00000065173; ENSMUSP00000069772; ENSMUSG00000045083
ENSMUST00000098151; ENSMUSP00000095754; ENSMUSG00000045083
ENSMUST00000108122; ENSMUSP00000103757; ENSMUSG00000045083
ENSMUST00000108124; ENSMUSP00000103759; ENSMUSG00000045083
ENSMUST00000164772; ENSMUSP00000130423; ENSMUSG00000045083
GeneIDi242384
KEGGimmu:242384
UCSCiuc008sgz.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK035778 mRNA Translation: BAC29183.1
AK045639 mRNA Translation: BAC32442.1
AK141568 mRNA Translation: BAE24739.1
BC090619 mRNA Translation: AAH90619.1
BC145692 mRNA Translation: AAI45693.1
CCDSiCCDS18040.1
RefSeqiNP_001159471.1, NM_001165999.1
NP_001159472.1, NM_001166000.1
NP_001159473.1, NM_001166001.1
NP_780725.2, NM_175516.4
XP_006537965.1, XM_006537902.2
XP_006537966.1, XM_006537903.2
XP_006537967.1, XM_006537904.3
XP_011248319.1, XM_011250017.2
XP_011248320.1, XM_011250018.2
XP_011248321.1, XM_011250019.2
XP_011248322.1, XM_011250020.2
XP_011248324.1, XM_011250022.2
XP_011248325.1, XM_011250023.2
XP_011248327.1, XM_011250025.2
XP_011248328.1, XM_011250026.2
XP_017175684.1, XM_017320195.1
XP_017175685.1, XM_017320196.1
XP_017175686.1, XM_017320197.1
XP_017175687.1, XM_017320198.1
UniGeneiMm.132507

3D structure databases

ProteinModelPortaliQ3URE9
SMRiQ3URE9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069772

PTM databases

iPTMnetiQ3URE9
PhosphoSitePlusiQ3URE9

Proteomic databases

MaxQBiQ3URE9
PaxDbiQ3URE9
PRIDEiQ3URE9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065173; ENSMUSP00000069772; ENSMUSG00000045083
ENSMUST00000098151; ENSMUSP00000095754; ENSMUSG00000045083
ENSMUST00000108122; ENSMUSP00000103757; ENSMUSG00000045083
ENSMUST00000108124; ENSMUSP00000103759; ENSMUSG00000045083
ENSMUST00000164772; ENSMUSP00000130423; ENSMUSG00000045083
GeneIDi242384
KEGGimmu:242384
UCSCiuc008sgz.2 mouse

Organism-specific databases

CTDi158038
MGIiMGI:2442298 Lingo2

Phylogenomic databases

eggNOGiKOG0619 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00760000118831
HOGENOMiHOG000246971
HOVERGENiHBG057546
InParanoidiQ3URE9
OMAiSYYVTCT
OrthoDBiEOG091G047N
PhylomeDBiQ3URE9
TreeFamiTF334360

Miscellaneous databases

PROiPR:Q3URE9
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045083 Expressed in 79 organ(s), highest expression level in mesenchyme of fronto-nasal process
CleanExiMM_LINGO2
ExpressionAtlasiQ3URE9 baseline and differential
GenevisibleiQ3URE9 MM

Family and domain databases

Gene3Di2.60.40.10, 1 hit
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR000372 LRRNT
PfamiView protein in Pfam
PF07679 I-set, 1 hit
PF13855 LRR_8, 2 hits
PF01462 LRRNT, 1 hit
SMARTiView protein in SMART
SM00409 IG, 1 hit
SM00408 IGc2, 1 hit
SM00369 LRR_TYP, 9 hits
SM00013 LRRNT, 1 hit
SUPFAMiSSF48726 SSF48726, 1 hit
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 1 hit
PS51450 LRR, 11 hits
ProtoNetiSearch...

Entry informationi

Entry nameiLIGO2_MOUSE
AccessioniPrimary (citable) accession number: Q3URE9
Secondary accession number(s): Q8BLC0, Q8BZD4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: October 11, 2005
Last modified: September 12, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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