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Protein

Sorting nexin-21

Gene

Snx21

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)) and phosphatidylinositol 4,5-bisphosphate (PubMed:25882846). May be involved in several stages of intracellular trafficking.Curated1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei161Phosphatidylinositol 3-phosphate1 Publication1
Binding sitei163Phosphatidylinositol 3-phosphate; via amide nitrogen and carbonyl oxygenBy similarity1
Binding sitei188Phosphatidylinositol 3-phosphateBy similarity1
Binding sitei202Phosphatidylinositol 3-phosphateBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Sorting nexin-21Curated
Gene namesi
Name:Snx21Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1917729 Snx21

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi161R → Q: Abolishes location on endosome membranes. Abolishes binding to membranes enriched in phosphatidylinositol 3-phosphate. No significant effect on binding to membranes enriched in phosphatidylinositol 4,5-bisphosphate. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004346001 – 363Sorting nexin-21Add BLAST363

Proteomic databases

MaxQBiQ3UR97
PaxDbiQ3UR97
PeptideAtlasiQ3UR97
PRIDEiQ3UR97

PTM databases

iPTMnetiQ3UR97
PhosphoSitePlusiQ3UR97

Expressioni

Gene expression databases

BgeeiENSMUSG00000050373 Expressed in 221 organ(s), highest expression level in brown adipose tissue
ExpressionAtlasiQ3UR97 baseline and differential
GenevisibleiQ3UR97 MM

Interactioni

Subunit structurei

Monomer.1 Publication

Structurei

Secondary structure

1363
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ3UR97
SMRiQ3UR97
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini119 – 236PXPROSITE-ProRule annotationAdd BLAST118

Domaini

The PX domain mediates specific binding to membranes enriched in phosphatidylinositol 3-phosphate (PtdIns(P3)).1 Publication

Sequence similaritiesi

Belongs to the sorting nexin family.Curated

Phylogenomic databases

eggNOGiENOG410IMHU Eukaryota
ENOG41114JN LUCA
GeneTreeiENSGT00530000063759
HOGENOMiHOG000118351
HOVERGENiHBG056464
InParanoidiQ3UR97
KOiK17932
OMAiLAVCHQE
OrthoDBiEOG091G0S8F
PhylomeDBiQ3UR97
TreeFamiTF326807

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q3UR97-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MASRLLHRLR HALASDGPGE AAAGPEAEQF PESSELEDDD AEGLSSRLSG
60 70 80 90 100
TLSFTSAEDD PDDEDEDDEA GLDSPPSGDG ASGEDAERSP PPDGQRSSQL
110 120 130 140 150
LARQLQDFWK KSRNTLVPQR LLFEVTSANV VKDPPSKYVL YTLAVMGPGP
160 170 180 190 200
PDRQPAQISR RYSDFERLHR NLQRQFRGPM SAISFPRKRL RRNFTAETIA
210 220 230 240 250
RRSRAFEQFL GHLQAVPELR QAPDLQDFFV LPELRRAQSL TCTGLYREAL
260 270 280 290 300
ALWANAWQLQ TQLGTPSGPD RPLLTLAGLA VCHQELEDPG EARACSEKAL
310 320 330 340 350
QLLGDKRPHP FLAPFLEAHV RLSWRLGLDK RQSEAQLQAL QEAGLTSTPP
360
PSLKELLIKE VLD
Length:363
Mass (Da):40,308
Last modified:October 11, 2005 - v1
Checksum:i076DEBEA6EA7AC4F
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3UWM2G3UWM2_MOUSE
Sorting nexin-21
Snx21
148Annotation score:
G3UY23G3UY23_MOUSE
Sorting nexin-21
Snx21
151Annotation score:
G3UYL5G3UYL5_MOUSE
Sorting nexin-21
Snx21
142Annotation score:
G3UYX2G3UYX2_MOUSE
Sorting nexin-21
Snx21
48Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591127 Genomic DNA No translation available.
AK141663 mRNA Translation: BAE24791.1
CCDSiCCDS38328.1
RefSeqiNP_598685.2, NM_133924.3
UniGeneiMm.295647
Mm.475496
Mm.475604

Genome annotation databases

EnsembliENSMUST00000056181; ENSMUSP00000054137; ENSMUSG00000050373
GeneIDi101113
KEGGimmu:101113
UCSCiuc008nwc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL591127 Genomic DNA No translation available.
AK141663 mRNA Translation: BAE24791.1
CCDSiCCDS38328.1
RefSeqiNP_598685.2, NM_133924.3
UniGeneiMm.295647
Mm.475496
Mm.475604

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YMRX-ray2.40A/B230-363[»]
ProteinModelPortaliQ3UR97
SMRiQ3UR97
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ3UR97
PhosphoSitePlusiQ3UR97

Proteomic databases

MaxQBiQ3UR97
PaxDbiQ3UR97
PeptideAtlasiQ3UR97
PRIDEiQ3UR97

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000056181; ENSMUSP00000054137; ENSMUSG00000050373
GeneIDi101113
KEGGimmu:101113
UCSCiuc008nwc.1 mouse

Organism-specific databases

CTDi90203
MGIiMGI:1917729 Snx21

Phylogenomic databases

eggNOGiENOG410IMHU Eukaryota
ENOG41114JN LUCA
GeneTreeiENSGT00530000063759
HOGENOMiHOG000118351
HOVERGENiHBG056464
InParanoidiQ3UR97
KOiK17932
OMAiLAVCHQE
OrthoDBiEOG091G0S8F
PhylomeDBiQ3UR97
TreeFamiTF326807

Miscellaneous databases

PROiPR:Q3UR97
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050373 Expressed in 221 organ(s), highest expression level in brown adipose tissue
ExpressionAtlasiQ3UR97 baseline and differential
GenevisibleiQ3UR97 MM

Family and domain databases

Gene3Di3.30.1520.10, 1 hit
InterProiView protein in InterPro
IPR001683 Phox
IPR036871 PX_dom_sf
IPR011990 TPR-like_helical_dom_sf
PfamiView protein in Pfam
PF00787 PX, 1 hit
SMARTiView protein in SMART
SM00312 PX, 1 hit
SUPFAMiSSF48452 SSF48452, 1 hit
SSF64268 SSF64268, 1 hit
PROSITEiView protein in PROSITE
PS50195 PX, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSNX21_MOUSE
AccessioniPrimary (citable) accession number: Q3UR97
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 11, 2015
Last sequence update: October 11, 2005
Last modified: October 10, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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