UniProtKB - Q3UR94 (Q3UR94_MOUSE)
Protein
DNA polymerase epsilon catalytic subunit
Gene
Pole
Organism
Mus musculus (Mouse)
Status
Functioni
DNA polymerase II participates in chromosomal DNA replication.UniRule annotation
Catalytic activityi
- EC:2.7.7.7UniRule annotation
Cofactori
[4Fe-4S] clusterUniRule annotation
GO - Molecular functioni
- 4 iron, 4 sulfur cluster binding Source: UniProtKB-KW
- DNA binding Source: UniProtKB-KW
- DNA-directed DNA polymerase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- nucleotide binding Source: InterPro
GO - Biological processi
- DNA repair Source: InterPro
- DNA replication Source: UniProtKB-KW
Keywordsi
Molecular function | DNA-bindingUniRule annotation, DNA-directed DNA polymeraseUniRule annotationARBA annotation, Nucleotidyltransferase, Transferase |
Biological process | DNA replicationUniRule annotation |
Ligand | 4Fe-4SUniRule annotationARBA annotation, Iron, Iron-sulfur, Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: DNA polymerase epsilon catalytic subunitUniRule annotation (EC:2.7.7.7UniRule annotation) |
Gene namesi | Name:PoleImported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Organism-specific databases
MGIi | MGI:1196391, Pole |
Subcellular locationi
Nucleus
- Nucleus UniRule annotation
Nucleus
- epsilon DNA polymerase complex Source: InterPro
Keywords - Cellular componenti
NucleusUniRule annotationFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 87 – 426 | DNA_pol_B_exo1InterPro annotationAdd BLAST | 340 | |
Domaini | 714 – 1145 | DNA_pol_BInterPro annotationAdd BLAST | 432 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 32 | DisorderedSequence analysisAdd BLAST | 32 |
Sequence similaritiesi
Keywords - Domaini
Zinc-fingerUniRule annotationPhylogenomic databases
OrthoDBi | 39650at2759 |
Family and domain databases
Gene3Di | 1.10.132.60, 1 hit 3.30.420.10, 1 hit |
InterProi | View protein in InterPro IPR006172, DNA-dir_DNA_pol_B IPR006133, DNA-dir_DNA_pol_B_exonuc IPR006134, DNA-dir_DNA_pol_B_multi_dom IPR043502, DNA/RNA_pol_sf IPR042087, DNA_pol_B_C IPR029703, POL2 IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
PANTHERi | PTHR10670, PTHR10670, 1 hit |
Pfami | View protein in Pfam PF00136, DNA_pol_B, 1 hit PF03104, DNA_pol_B_exo1, 1 hit |
SMARTi | View protein in SMART SM00486, POLBc, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit |
i Sequence
Sequence statusi: Fragment.
Q3UR94-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVLRNSGRRH PEPGADGEGS RDDGPSSSVS ALKRLERSQW TDKMDLRFGF
60 70 80 90 100
ERLKEPGERT GWLINMHPTE ILDEDKRLVS AVDYYFIQDD GSRFKVALPY
110 120 130 140 150
MPYFYIAARK GCDREVSSFL SKKFQGKIAK LENVPKEDLD LPNHLVGLKR
160 170 180 190 200
SYIKLSFHTV EDLVKVRKEI SPAVKKNREQ DHASDEYTTM LSSILQGGSV
210 220 230 240 250
ITDEDETSKK IADQLDNIVD MREYDVPYHI RLSIDLRIHV AHWYNVRFRG
260 270 280 290 300
NAFPVEITRR DDLVERPDPV VLAFDIETTK LPLKFPDAET DQIMMISYMI
310 320 330 340 350
DGQGYLITNR EIVSEDIEDF EFTPKPEYEG PFCVFNEPDE VHLIQRWFEH
360 370 380 390 400
IQETKPTIMV TYNGDFFDWP FVEARAAIHG LSMYQEIGFQ KDSQGEYKAP
410 420 430 440 450
QCIHMDCLRW VKRDSYLPVG SHNLKAAAKA KLGYDPVELD PEDMCRMATE
460 470 480 490 500
QPQTLATYSV SDAVATYYLY MKYVHPFIFA LCTIIPMEPD EVLRKGSGTL
510 520 530 540 550
CEALLMVQAF HANIIFPNKQ EQEFNKLTDD GHMLDAETYV GGHVEALESG
560 570 580 590 600
VFRSDIPCRF RMNPAAFDFL LQRVEKTMRH AIEEEEKVPV EQATNFQEVC
610 620 630 640 650
EQIKTKLTSL KDVPNRIECP LIYHLDVGAM YPNIILTNRL QPSAIVDEAT
660 670 680 690 700
CAACDFNKPG ASCQRKMAWQ WRGEFMPASR SEYHRIQHQL ESEKFPPLFP
710 720 730 740 750
EGPARAFHEL SREEQAKYEK RRLADYCRKA YKKIHVTKVE ERLTTICQRE
760 770 780 790 800
NSFYVDTVRA FRDRRYEFKG LHKVWKKKLS AAVEVGDASE VKRCKNMEIL
810 820 830 840 850
YDSLQLAHKC ILNSFYGYVM RKGARWYSME MAGIVCFTGA NIITQARELI
860 870 880 890 900
EQIGRPLELD TDGIWCVLPN SFPENFVIKT TNAKKPKLTI SYPGAMLNIM
910 920 930 940 950
VKEGFTNHQY QELTEPSSLT YVTHSENSIF FEVDGPYLAM ILPASKEEGK
960 970 980 990 1000
KLKKRYAVFN EDGSLAELKG FEVKRRGELQ LIKIFQSSVF EAFLKGSTLE
1010 1020 1030 1040 1050
EVYGSVAKVA DYWLDVLYSK AANMPDSELF ELISENRSMS RKLEDYGEQK
1060 1070 1080 1090 1100
STSISTAKRL AEFLGDQMVK DAGLSCRYII SRKPEGSPVT ERAIPLAIFQ
1110 1120 1130 1140 1150
AEPTVRKHFL RKWLKSSSLQ DFDIRTILDW DYYIERLGSA IQKIITIPAA
1160 1170 1180 1190 1200
LQQVKNPVPR VKHPDWLHKK LLEKNDIYKQ KKISELFVLE GKRQIVMAQA
1210 1220 1230 1240 1250
SENSLSLCTP DMEDIGLTKP HHSTVPVATK RKRVWETQKE SQDIALTVPW
1260 1270
QEVLGQPPSL GTTQEEWLVW LQF
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1273 | Imported | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK141674 mRNA Translation: BAE24794.1 |
RefSeqi | NP_035262.2, NM_011132.2 |
Genome annotation databases
GeneIDi | 18973 |
KEGGi | mmu:18973 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK141674 mRNA Translation: BAE24794.1 |
RefSeqi | NP_035262.2, NM_011132.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PeptideAtlasi | Q3UR94 |
Protocols and materials databases
DNASUi | 18973 |
Genome annotation databases
GeneIDi | 18973 |
KEGGi | mmu:18973 |
Organism-specific databases
CTDi | 5426 |
MGIi | MGI:1196391, Pole |
Phylogenomic databases
OrthoDBi | 39650at2759 |
Miscellaneous databases
BioGRID-ORCSi | 18973, 19 hits in 50 CRISPR screens |
ChiTaRSi | Pole, mouse |
SOURCEi | Search... |
Gene expression databases
Genevisiblei | Q3UR94, MM |
Family and domain databases
Gene3Di | 1.10.132.60, 1 hit 3.30.420.10, 1 hit |
InterProi | View protein in InterPro IPR006172, DNA-dir_DNA_pol_B IPR006133, DNA-dir_DNA_pol_B_exonuc IPR006134, DNA-dir_DNA_pol_B_multi_dom IPR043502, DNA/RNA_pol_sf IPR042087, DNA_pol_B_C IPR029703, POL2 IPR012337, RNaseH-like_sf IPR036397, RNaseH_sf |
PANTHERi | PTHR10670, PTHR10670, 1 hit |
Pfami | View protein in Pfam PF00136, DNA_pol_B, 1 hit PF03104, DNA_pol_B_exo1, 1 hit |
SMARTi | View protein in SMART SM00486, POLBc, 1 hit |
SUPFAMi | SSF53098, SSF53098, 1 hit SSF56672, SSF56672, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3UR94_MOUSE | |
Accessioni | Q3UR94Primary (citable) accession number: Q3UR94 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | April 7, 2021 | |
This is version 109 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |