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Entry version 117 (16 Oct 2019)
Sequence version 2 (26 Feb 2008)
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Protein

Myelin regulatory factor

Gene

Myrf

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Myelin regulatory factor: Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes.2 Publications
Myelin regulatory factor, C-terminal: Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage.1 Publication
Myelin regulatory factor, N-terminal: Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination (PubMed:19596243, PubMed:22956843, PubMed:23966833, PubMed:24204311, PubMed:27532821). Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:19596243, PubMed:22956843, PubMed:23966833).5 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi250 – 541NDT80PROSITE-ProRule annotationAdd BLAST292

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActivator, DNA-binding, Hydrolase, Protease
Biological processDifferentiation, Transcription, Transcription regulation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin regulatory factor (EC:3.4.-.-2 Publications)
Alternative name(s):
Myelin gene regulatory factor
Cleaved into the following 2 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myrf
Synonyms:Gm1804, Gm98, Mrf
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2684944 Myrf

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 768CytoplasmicSequence analysisAdd BLAST768
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei769 – 789HelicalSequence analysisAdd BLAST21
Topological domaini790 – 1138LumenalSequence analysisAdd BLAST349

Keywords - Cellular componenti

Cytoplasm, Endoplasmic reticulum, Membrane, Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Embryos die around 12.5 dpc. Conditional knockout mice in which Mrf is lacking within the oligodendrocyte lineage display severe deficits in myelin gene expression and premyelinating oligodendrocytes fail to myelinate. These mice display severe neurological abnormalities and die because of seizures during the third postnatal week.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology_and_biotech_section">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi254 – 256KKR → AAA: Abolishes nuclear localization. 3
Mutagenesisi384G → R: Does not affect subcellular location. Impaired DNA-binding. 1 Publication1
Mutagenesisi399K → A: Abolishes DNA-binding. 1 Publication1
Mutagenesisi439 – 441Missing : Loss of trimerization; when associated with R-469. 1 Publication3
Mutagenesisi454R → A: Abolishes DNA-binding. 1 Publication1
Mutagenesisi469E → R: Loss of trimerization; when associated with 439-E--L-441 DEL. 1 Publication1
Mutagenesisi478R → A: Abolishes DNA-binding. 1 Publication1
Mutagenesisi587S → A: Prevents autocatalytic cleavage and generation of Myelin regulatory factor, N-terminal part. 2 Publications1
Mutagenesisi587S → C: Does not affect autocatalytic cleavage and generation of Myelin regulatory factor, N-terminal part. 1 Publication1
Mutagenesisi592K → H, R or M: Prevents autocatalytic cleavage and generation of Myelin regulatory factor, N-terminal part. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003189201 – 1138Myelin regulatory factorAdd BLAST1138
ChainiPRO_00004243121 – 586Myelin regulatory factor, N-terminal1 PublicationAdd BLAST586
ChainiPRO_0000424313587 – 1138Myelin regulatory factor, C-terminal1 PublicationAdd BLAST552

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei123N6-acetyllysineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi1030N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1052N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1116N-linked (GlcNAc...) asparagineSequence analysis1

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Myelin regulatory factor, C-terminal: Glycosylated.By similarity
Myelin regulatory factor: Follows autocatalytic cleavage via the peptidase S74 domain. Autoprocessing is apparently constitutive and is essential for transcriptional activity (PubMed:23966833, PubMed:28623291, PubMed:30249802). Autocatalytic cleavage is inhibited by interaction with TMEM98 (PubMed:30249802).3 Publications

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei586 – 587Cleavage; by autolysisPROSITE-ProRule annotation1 Publication2

Keywords - PTMi

Acetylation, Autocatalytic cleavage, Glycoprotein

Proteomic databases

The CPTAC Assay portal

More...
CPTACi
non-CPTAC-3480

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3UR85

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3UR85

PeptideAtlas

More...
PeptideAtlasi
Q3UR85

PRoteomics IDEntifications database

More...
PRIDEi
Q3UR85

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3UR85

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3UR85

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q3UR85

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Specifically expressed by postmitotic oligodendrocytes in the CNS. Not detected in the peripheral nervous system (PNS).2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

At postnatal day 3 (P3), the expression is restricted to cells in the hindbrain and cerebellum, subsequently spreading rostrally throughout the white matter tracks over the first 2 weeks postnatal, mirroring the expression of Plp1.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is directly regulated by SOX10.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000036098 Expressed in 153 organ(s), highest expression level in pyloric antrum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q3UR85 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

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Genevisiblei
Q3UR85 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homotrimer (PubMed:23966833, PubMed:28623291).

Interacts (via C-terminal region) with TMEM98; the interaction inhibits MYRF self-cleavage (PubMed:30249802).

3 Publications

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...
BioGridi
230445, 1 interactor

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000139601

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11138
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q3UR85

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini587 – 696Peptidase S74PROSITE-ProRule annotationAdd BLAST110

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni765 – 1003Required for interaction with TMEM981 PublicationAdd BLAST239

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili680 – 711Sequence analysisAdd BLAST32

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi254 – 257Nuclear localization signal1 Publication4
Motifi491 – 494Nuclear localization signal1 Publication4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi60 – 330Pro-richAdd BLAST271

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

Myelin regulatory factor, N-terminal: The nuclear localization signals mediate translocation to the nucleus.1 Publication
Myelin regulatory factor: The peptidase S74 domain, also named Intramolecular Chaperone Auto-processed (ICA) domain or Intramolecuar Chaperone Domain (ICD), has protease activity and mediates autocatalytic processing of the protein to generate the Myelin regulatory factor, N-terminal active transcription factor and the Myelin regulatory factor, C-terminal components.1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MRF family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3661 Eukaryota
ENOG410XPRK LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063626

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000111718

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3UR85

Identification of Orthologs from Complete Genome Data

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OMAi
SPFTHLQ

Database of Orthologous Groups

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OrthoDBi
311898at2759

Database for complete collections of gene phylogenies

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PhylomeDBi
Q3UR85

TreeFam database of animal gene trees

More...
TreeFami
TF312888

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR026933 MRF
IPR026932 MRF_C1
IPR025719 MRF_C2
IPR024061 NDT80_DNA-bd_dom
IPR008967 p53-like_TF_DNA-bd
IPR030392 S74_ICA

The PANTHER Classification System

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PANTHERi
PTHR13029:SF16 PTHR13029:SF16, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF13887 MRF_C1, 1 hit
PF13888 MRF_C2, 1 hit
PF05224 NDT80_PhoG, 1 hit
PF13884 Peptidase_S74, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF49417 SSF49417, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51688 ICA, 1 hit
PS51517 NDT80, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3UR85-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEVVDETEAL QRFFEGHDIS GALEPSNIDT SILEEYIGKE DASDLCFPEI
60 70 80 90 100
SAPASTASFP HGPPAIPGSS GLHHLSPPGS GPSPGRHGPL PPPTYGTPLN
110 120 130 140 150
CNNNNGMGTA PKPFLGGSGP PIKAEPKAPY APGTLPDSPP DSGSEAYSPQ
160 170 180 190 200
QVNDPHLLRT ITPETLCHVG VSSRLEHPPP PPAHLPGPPP PPPPPPHYPV
210 220 230 240 250
LQRDLYMKAE PPVPPYAAMG PGLVPPELHH TQQTQVLHQL LQQHGAELPP
260 270 280 290 300
HPSKKRKHSE SPPNTLNAQM LNGMIKQEPG TVTALPPHPA RAPSPPWPPQ
310 320 330 340 350
GPLSPGTGSL PLSIARAQTP PWHPPGAPSP GLLQDSDSLS GSYLDPNYQS
360 370 380 390 400
IKWQPHQQNK WATLYDANYK ELPMLTYRVD ADKGFNFSVG DDAFVCQKKN
410 420 430 440 450
HFQVTVYIGM LGEPKYVKTP EGLKPLDCFY LKLHGVKLEA LNQSINIEQS
460 470 480 490 500
QSDRSKRPFN PVTVNLPPEQ VTKVTVGRLH FSETTANNMR KKGKPNPDQR
510 520 530 540 550
YFMLVVALQA HAQNQNYTLA AQISERIIVR ASNPGQFESD SDVLWQRAQL
560 570 580 590 600
PDTVFHHGRV GINTDRPDEA LVVHGNVKVM GSLMHPSDLR AKEHVQEVDT
610 620 630 640 650
TEQLKRISRM RLVHYRYKPE FAASAGIEAT APETGVIAQE VKEILPEAVK
660 670 680 690 700
DTGDVVFANG KTIENFLVVN KERIFMENVG AVKELCKLTD NLETRIDELE
710 720 730 740 750
RWSHKLAKLR RLDSLKSTGS SGAFSHAGSQ FSRAGSVPHK KRPPKLANKS
760 770 780 790 800
SPAVPDQACI SQRFLQGTII ALVVVMAFSV VSMSTLYVLS LRSEEDLVDA
810 820 830 840 850
DGSLAVSTSC LLALLRPQDP GGSEAMCPWS SQSFGTTQLR QSSMTTGLPG
860 870 880 890 900
TQPSLLLVTK SASGPALRAL DLCSSQPCPI VCCSPPVSSP ATDPALGPTL
910 920 930 940 950
TPTPSPSSNP KHSGPGQMAP LPVTNIRAKS WGISANGISY SKHSKSLEPL
960 970 980 990 1000
ASPVVPFPGG QSKTKNSPSF NLQSRARRGA PQPSPSPAQF TQTQGQLDPA
1010 1020 1030 1040 1050
PSLTSIQLLE NSMPITSQYC VPEGACRLGN FTYHIPVSSS TPLHLSLTLQ
1060 1070 1080 1090 1100
MNSSTPVSVV LCSLTSEEEP CEEGGFLQRF HPHQDTQGTS HQWPVTILSF
1110 1120 1130
REFTYHFRVT LLGQANCSSE AIVQPATDYY FHFYRLCD
Length:1,138
Mass (Da):123,288
Last modified:February 26, 2008 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA59CDDA18CDE7054
GO
Isoform 2 (identifier: Q3UR85-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     779-779: S → R
     780-1138: Missing.

Note: No experimental confirmation available. May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay. Dubious isoform due to intron retention.
Show »
Length:779
Mass (Da):85,068
Checksum:i13042B6B4CCDAE40
GO
Isoform 3 (identifier: Q3UR85-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     803-829: SLAVSTSCLLALLRPQDPGGSEAMCPW → R

Note: No experimental confirmation available.
Show »
Length:1,112
Mass (Da):120,659
Checksum:iC42BABF26400584F
GO
Isoform 4 (identifier: Q3UR85-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     46-247: Missing.
     829-829: W → CR

Note: No experimental confirmation available.
Show »
Length:937
Mass (Da):102,396
Checksum:i89CD4B0356717BF2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A087WRZ9A0A087WRZ9_MOUSE
Myelin regulatory factor
Myrf
477Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti860K → N in AAI57943 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_05399246 – 247Missing in isoform 4. 1 PublicationAdd BLAST202
Alternative sequenceiVSP_031303779S → R in isoform 2. 1 Publication1
Alternative sequenceiVSP_031304780 – 1138Missing in isoform 2. 1 PublicationAdd BLAST359
Alternative sequenceiVSP_053374803 – 829SLAVS…AMCPW → R in isoform 3. CuratedAdd BLAST27
Alternative sequenceiVSP_053993829W → CR in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK039649 mRNA Translation: BAE20548.1
AK141695 mRNA Translation: BAE24803.1
AC132148 Genomic DNA No translation available.
BC157942 mRNA Translation: AAI57943.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS50387.1 [Q3UR85-3]

NCBI Reference Sequences

More...
RefSeqi
NP_001028653.1, NM_001033481.1 [Q3UR85-3]
XP_006526992.1, XM_006526929.3 [Q3UR85-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000088013; ENSMUSP00000085329; ENSMUSG00000036098 [Q3UR85-1]
ENSMUST00000186056; ENSMUSP00000140871; ENSMUSG00000036098 [Q3UR85-5]
ENSMUST00000189897; ENSMUSP00000139601; ENSMUSG00000036098 [Q3UR85-3]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
225908

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:225908

UCSC genome browser

More...
UCSCi
uc008gpk.2 mouse [Q3UR85-1]
uc012bil.1 mouse [Q3UR85-3]
uc012bim.1 mouse [Q3UR85-5]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK039649 mRNA Translation: BAE20548.1
AK141695 mRNA Translation: BAE24803.1
AC132148 Genomic DNA No translation available.
BC157942 mRNA Translation: AAI57943.1
CCDSiCCDS50387.1 [Q3UR85-3]
RefSeqiNP_001028653.1, NM_001033481.1 [Q3UR85-3]
XP_006526992.1, XM_006526929.3 [Q3UR85-1]

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5H5PX-ray2.46A351-532[»]
SMRiQ3UR85
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGridi230445, 1 interactor
STRINGi10090.ENSMUSP00000139601

PTM databases

iPTMnetiQ3UR85
PhosphoSitePlusiQ3UR85
SwissPalmiQ3UR85

Proteomic databases

CPTACinon-CPTAC-3480
MaxQBiQ3UR85
PaxDbiQ3UR85
PeptideAtlasiQ3UR85
PRIDEiQ3UR85

Genome annotation databases

EnsembliENSMUST00000088013; ENSMUSP00000085329; ENSMUSG00000036098 [Q3UR85-1]
ENSMUST00000186056; ENSMUSP00000140871; ENSMUSG00000036098 [Q3UR85-5]
ENSMUST00000189897; ENSMUSP00000139601; ENSMUSG00000036098 [Q3UR85-3]
GeneIDi225908
KEGGimmu:225908
UCSCiuc008gpk.2 mouse [Q3UR85-1]
uc012bil.1 mouse [Q3UR85-3]
uc012bim.1 mouse [Q3UR85-5]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
745
MGIiMGI:2684944 Myrf

Phylogenomic databases

eggNOGiKOG3661 Eukaryota
ENOG410XPRK LUCA
GeneTreeiENSGT00530000063626
HOGENOMiHOG000111718
InParanoidiQ3UR85
OMAiSPFTHLQ
OrthoDBi311898at2759
PhylomeDBiQ3UR85
TreeFamiTF312888

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Myrf mouse

Protein Ontology

More...
PROi
PR:Q3UR85

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000036098 Expressed in 153 organ(s), highest expression level in pyloric antrum
ExpressionAtlasiQ3UR85 baseline and differential
GenevisibleiQ3UR85 MM

Family and domain databases

InterProiView protein in InterPro
IPR026933 MRF
IPR026932 MRF_C1
IPR025719 MRF_C2
IPR024061 NDT80_DNA-bd_dom
IPR008967 p53-like_TF_DNA-bd
IPR030392 S74_ICA
PANTHERiPTHR13029:SF16 PTHR13029:SF16, 1 hit
PfamiView protein in Pfam
PF13887 MRF_C1, 1 hit
PF13888 MRF_C2, 1 hit
PF05224 NDT80_PhoG, 1 hit
PF13884 Peptidase_S74, 1 hit
SUPFAMiSSF49417 SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS51688 ICA, 1 hit
PS51517 NDT80, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMYRF_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UR85
Secondary accession number(s): B2RXQ7, F8WJJ9, Q3V3K4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: February 26, 2008
Last modified: October 16, 2019
This is version 117 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
  3. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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