P2X purinoceptor 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB
• extracellularly ATP-gated cation channel activity Source: MGI <p>Inferred from Genetic Interaction</p> <p>Used to describe "traditional" genetic interactions such as suppressors and synthetic lethals as well as other techniques such as functional complementation, rescue experiments, or inferences about a gene drawn from the phenotype of a mutation in a different gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#igi">GO evidence code guide</a></p> Inferred from genetic interactionⁱ
  • "Identification of P2X receptors in cultured mouse and rat parasympathetic otic ganglion neurones including P2X knockout studies."
    Ma B., Ruan H.Z., Cockayne D.A., Ford A.P., Burnstock G., Dunn P.M.
    Neuropharmacology 46:1039-1048(2004) [PubMed] [Europe PMC] [Abstract]
• identical protein binding Source: MGI
• purinergic nucleotide receptor activity Source: UniProtKB

GO - Biological processⁱ

• behavioral response to formalin induced pain Source: MGI
• behavioral response to pain Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice."
    Cockayne D.A., Hamilton S.G., Zhu Q.M., Dunn P.M., Zhong Y., Novakovic S., Malmberg A.B., Cain G., Berson A., Kassotakis L., Hedley L., Lachnit W.G., Burnstock G., McMahon S.B., Ford A.P.
    Nature 407:1011-1015(2000) [PubMed] [Europe PMC] [Abstract]
  • "Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors."
    Souslova V., Cesare P., Ding Y., Akopian A.N., Stanfa L., Suzuki R., Carpenter K., Dickenson A., Boyce S., Hill R., Nebenuis-Oosthuizen D., Smith A.J., Kidd E.J., Wood J.N.
    Nature 407:1015-1017(2000) [PubMed] [Europe PMC] [Abstract]
• cation transport Source: MGIInferred from mutant phenotypeⁱ
  • "Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors."
    Souslova V., Cesare P., Ding Y., Akopian A.N., Stanfa L., Suzuki R., Carpenter K., Dickenson A., Boyce S., Hill R., Nebenuis-Oosthuizen D., Smith A.J., Kidd E.J., Wood J.N.
    Nature 407:1015-1017(2000) [PubMed] [Europe PMC] [Abstract]
• cellular response to ATP Source: UniProtKB
• chemical synaptic transmission Source: MGIInferred from mutant phenotypeⁱ
  • "Impaired long-term depression in P2X3 deficient mice is not associated with a spatial learning deficit."
    Wang Y., Mackes J., Chan S., Haughey N.J., Guo Z., Ouyang X., Furukawa K., Ingram D.K., Mattson M.P.
    J Neurochem 99:1425-1434(2006) [PubMed] [Europe PMC] [Abstract]
• inorganic cation transmembrane transport Source: UniProtKB
• ion transport Source: MGIInferred from mutant phenotypeⁱ
  • "Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice."
    Cockayne D.A., Hamilton S.G., Zhu Q.M., Dunn P.M., Zhong Y., Novakovic S., Malmberg A.B., Cain G., Berson A., Kassotakis L., Hedley L., Lachnit W.G., Burnstock G., McMahon S.B., Ford A.P.
    Nature 407:1011-1015(2000) [PubMed] [Europe PMC] [Abstract]
• modulation of chemical synaptic transmission Source: SynGOInferred from mutant phenotypeⁱ
  • "Impaired long-term depression in P2X3 deficient mice is not associated with a spatial learning deficit."
    Wang Y., Mackes J., Chan S., Haughey N.J., Guo Z., Ouyang X., Furukawa K., Ingram D.K., Mattson M.P.
    J Neurochem 99:1425-1434(2006) [PubMed] [Europe PMC] [Abstract]
• neuromuscular synaptic transmission Source: MGIInferred from mutant phenotypeⁱ
  • "Peristalsis is impaired in the small intestine of mice lacking the P2X3 subunit."
    Bian X., Ren J., DeVries M., Schnegelsberg B., Cockayne D.A., Ford A.P., Galligan J.J.
    J Physiol 551:309-322(2003) [PubMed] [Europe PMC] [Abstract]
• neuronal action potential Source: MGI
• peristalsis Source: MGIInferred from mutant phenotypeⁱ
  • "Peristalsis is impaired in the small intestine of mice lacking the P2X3 subunit."
    Bian X., Ren J., DeVries M., Schnegelsberg B., Cockayne D.A., Ford A.P., Galligan J.J.
    J Physiol 551:309-322(2003) [PubMed] [Europe PMC] [Abstract]
• positive regulation of sensory perception of pain Source: MGI
• protein homotrimerization Source: UniProtKB
• regulation of synaptic plasticity Source: MGIInferred from mutant phenotypeⁱ
  • "Impaired long-term depression in P2X3 deficient mice is not associated with a spatial learning deficit."
    Wang Y., Mackes J., Chan S., Haughey N.J., Guo Z., Ouyang X., Furukawa K., Ingram D.K., Mattson M.P.
    J Neurochem 99:1425-1434(2006) [PubMed] [Europe PMC] [Abstract]
• response to ATP Source: MGIInferred from mutant phenotypeⁱ
  • "Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice."
    Cockayne D.A., Hamilton S.G., Zhu Q.M., Dunn P.M., Zhong Y., Novakovic S., Malmberg A.B., Cain G., Berson A., Kassotakis L., Hedley L., Lachnit W.G., Burnstock G., McMahon S.B., Ford A.P.
    Nature 407:1011-1015(2000) [PubMed] [Europe PMC] [Abstract]
  • "Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors."
    Souslova V., Cesare P., Ding Y., Akopian A.N., Stanfa L., Suzuki R., Carpenter K., Dickenson A., Boyce S., Hill R., Nebenuis-Oosthuizen D., Smith A.J., Kidd E.J., Wood J.N.
    Nature 407:1015-1017(2000) [PubMed] [Europe PMC] [Abstract]
  • "P2X3 knock-out mice reveal a major sensory role for urothelially released ATP."
    Vlaskovska M., Kasakov L., Rong W., Bodin P., Bardini M., Cockayne D.A., Ford A.P., Burnstock G.
    J Neurosci 21:5670-5677(2001) [PubMed] [Europe PMC] [Abstract]
  • "Peristalsis is impaired in the small intestine of mice lacking the P2X3 subunit."
    Bian X., Ren J., DeVries M., Schnegelsberg B., Cockayne D.A., Ford A.P., Galligan J.J.
    J Physiol 551:309-322(2003) [PubMed] [Europe PMC] [Abstract]
  • "Impaired long-term depression in P2X3 deficient mice is not associated with a spatial learning deficit."
    Wang Y., Mackes J., Chan S., Haughey N.J., Guo Z., Ouyang X., Furukawa K., Ingram D.K., Mattson M.P.
    J Neurochem 99:1425-1434(2006) [PubMed] [Europe PMC] [Abstract]
• response to carbohydrate Source: MGIInferred from mutant phenotypeⁱ
  • Ref.5

    "ATP signaling is crucial for communication from taste buds to gustatory nerves."
    Finger T.E., Danilova V., Barrows J., Bartel D.L., Vigers A.J., Stone L., Hellekant G., Kinnamon S.C.
    Science 310:1495-1499(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: DISRUPTION PHENOTYPE, FUNCTION.
• response to cold Source: MGIInferred from mutant phenotypeⁱ
  • "Enhanced thermal avoidance in mice lacking the ATP receptor P2X3."
    Shimizu I., Iida T., Guan Y., Zhao C., Raja S.N., Jarvis M.F., Cockayne D.A., Caterina M.J.
    Pain 116:96-108(2005) [PubMed] [Europe PMC] [Abstract]
• response to heat Source: MGIInferred from mutant phenotypeⁱ
  • "Enhanced thermal avoidance in mice lacking the ATP receptor P2X3."
    Shimizu I., Iida T., Guan Y., Zhao C., Raja S.N., Jarvis M.F., Cockayne D.A., Caterina M.J.
    Pain 116:96-108(2005) [PubMed] [Europe PMC] [Abstract]
• response to hypoxia Source: MGIInferred from mutant phenotypeⁱ
  • "Pivotal role of nucleotide P2X2 receptor subunit of the ATP-gated ion channel mediating ventilatory responses to hypoxia."
    Rong W., Gourine A.V., Cockayne D.A., Xiang Z., Ford A.P., Spyer K.M., Burnstock G.
    J. Neurosci. 23:11315-11321(2003) [PubMed] [Europe PMC] [Abstract]
• response to mechanical stimulus Source: MGIInferred from mutant phenotypeⁱ
  • "P2X3 knock-out mice reveal a major sensory role for urothelially released ATP."
    Vlaskovska M., Kasakov L., Rong W., Bodin P., Bardini M., Cockayne D.A., Ford A.P., Burnstock G.
    J Neurosci 21:5670-5677(2001) [PubMed] [Europe PMC] [Abstract]
• response to organic substance Source: MGIInferred from mutant phenotypeⁱ
  • "Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice."
    Cockayne D.A., Hamilton S.G., Zhu Q.M., Dunn P.M., Zhong Y., Novakovic S., Malmberg A.B., Cain G., Berson A., Kassotakis L., Hedley L., Lachnit W.G., Burnstock G., McMahon S.B., Ford A.P.
    Nature 407:1011-1015(2000) [PubMed] [Europe PMC] [Abstract]
  • "Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors."
    Souslova V., Cesare P., Ding Y., Akopian A.N., Stanfa L., Suzuki R., Carpenter K., Dickenson A., Boyce S., Hill R., Nebenuis-Oosthuizen D., Smith A.J., Kidd E.J., Wood J.N.
    Nature 407:1015-1017(2000) [PubMed] [Europe PMC] [Abstract]
• response to temperature stimulus Source: MGIInferred from mutant phenotypeⁱ
  • "Warm-coding deficits and aberrant inflammatory pain in mice lacking P2X3 receptors."
    Souslova V., Cesare P., Ding Y., Akopian A.N., Stanfa L., Suzuki R., Carpenter K., Dickenson A., Boyce S., Hill R., Nebenuis-Oosthuizen D., Smith A.J., Kidd E.J., Wood J.N.
    Nature 407:1015-1017(2000) [PubMed] [Europe PMC] [Abstract]
• sensory perception of taste Source: MGIInferred from genetic interactionⁱ
  • Ref.5

    "ATP signaling is crucial for communication from taste buds to gustatory nerves."
    Finger T.E., Danilova V., Barrows J., Bartel D.L., Vigers A.J., Stone L., Hellekant G., Kinnamon S.C.
    Science 310:1495-1499(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: DISRUPTION PHENOTYPE, FUNCTION.
• urinary bladder smooth muscle contraction Source: MGIInferred from mutant phenotypeⁱ
  • "Urinary bladder hyporeflexia and reduced pain-related behaviour in P2X3-deficient mice."
    Cockayne D.A., Hamilton S.G., Zhu Q.M., Dunn P.M., Zhong Y., Novakovic S., Malmberg A.B., Cain G., Berson A., Kassotakis L., Hedley L., Lachnit W.G., Burnstock G., McMahon S.B., Ford A.P.
    Nature 407:1011-1015(2000) [PubMed] [Europe PMC] [Abstract]
  • Ref.4

    "P2X2 knockout mice and P2X2/P2X3 double knockout mice reveal a role for the P2X2 receptor subunit in mediating multiple sensory effects of ATP."
    Cockayne D.A., Dunn P.M., Zhong Y., Rong W., Hamilton S.G., Knight G.E., Ruan H.Z., Ma B., Yip P., Nunn P., McMahon S.B., Burnstock G., Ford A.P.
    J. Physiol. (Lond.) 567:621-639(2005) [PubMed] [Europe PMC] [Abstract]

    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

• UniProt annotation
• GO - Cellular component

Topology

Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypeⁱ

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

GO - Molecular functionⁱ

• identical protein binding Source: MGI

Protein-protein interaction databases

Chemistry databases

Miscellaneous databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)ⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

        10         20         30         40         50
MNCISDFFTY ETTKSVVVKS WTIGIINRAV QLLIISYFVG WVFLHEKAYQ 
        60         70         80         90        100
VRDTAIESSV VTKVKGFGRY ANRVMDVSDY VTPPQGTSVF VIITKMIVTE 
       110        120        130        140        150
NQMQGFCPEN EEKYRCVSDS QCGPERFPGG GILTGRCVNY SSVRRTCEIQ 
       160        170        180        190        200
GWCPTEVDTV EMPIMMEAEN FTIFIKNSIR FPLFNFEKGN LLPNLTDKDI 
       210        220        230        240        250
KKCRFHPEKA PFCPILRVGD VVKFAGQDFA KLARTGGVLG IKIGWVCDLD 
       260        270        280        290        300
KAWDQCIPKY SFTRLDGVSE KSSVSPGYNF RFAKYYKMEN GSEYRTLLKA 
       310        320        330        340        350
FGIRFDVLVY GNAGKFNIIP TIISSVAAFT SVGVGTVLCD IILLNFLKGA 
       360        370        380        390 
DHYKARKFEE VTETTLKGTA STNPVFTSDQ ATVEKQSTDS GAYSIGH    

Experimental Info

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ

Documents

1. MGD cross-references
   Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
2. SIMILARITY comments
   Index of protein domains and families