UniProtKB - Q3UR32 (P2RX3_MOUSE)

BLAST

>sp|Q3UR32|P2RX3_MOUSE P2X purinoceptor 3 OS=Mus musculus OX=10090 GN=P2rx3 PE=2 SV=1
MNCISDFFTYETTKSVVVKSWTIGIINRAVQLLIISYFVGWVFLHEKAYQVRDTAIESSV
VTKVKGFGRYANRVMDVSDYVTPPQGTSVFVIITKMIVTENQMQGFCPENEEKYRCVSDS
QCGPERFPGGGILTGRCVNYSSVRRTCEIQGWCPTEVDTVEMPIMMEAENFTIFIKNSIR
FPLFNFEKGNLLPNLTDKDIKKCRFHPEKAPFCPILRVGDVVKFAGQDFAKLARTGGVLG
IKIGWVCDLDKAWDQCIPKYSFTRLDGVSEKSSVSPGYNFRFAKYYKMENGSEYRTLLKA
FGIRFDVLVYGNAGKFNIIPTIISSVAAFTSVGVGTVLCDIILLNFLKGADHYKARKFEE
VTETTLKGTASTNPVFTSDQATVEKQSTDSGAYSIGH

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History
Entry version 104 (07 Nov 2018)
Sequence version 1 (11 Oct 2005)
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Protein

P2X purinoceptor 3

Gene

P2rx3

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at transcript levelⁱ

Functionⁱ

Receptor for ATP that acts as a ligand-gated cation channel (By similarity). Plays a role in sensory perception (PubMed:15961431, PubMed:16322458). Required for normal perception of pain (PubMed:15961431). Required for normal taste perception (PubMed:16322458).By similarity2 Publications

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	172	ATPBy similarity	1
Binding siteⁱ	275	ATPBy similarity	1
Binding siteⁱ	299	ATPBy similarity	1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	63 – 65	ATPBy similarity		3
Nucleotide bindingⁱ	279 – 281	ATPBy similarity		3

GO - Molecular functionⁱ

ATP binding Source: UniProtKB
ATP-gated ion channel activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
extracellularly ATP-gated cation channel activity
Source: MGI
Inferred from genetic interactionⁱ
- 15081800
purinergic nucleotide receptor activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

behavioral response to formalin induced pain Source: MGI
behavioral response to pain
Source: MGI
Inferred from mutant phenotypeⁱ
- 11069181
- 11069182
cation transport
Source: MGI
Inferred from mutant phenotypeⁱ
- 11069182
cellular response to ATP Source: UniProtKB
chemical synaptic transmission
Source: MGI
Inferred from mutant phenotypeⁱ
- 17074061
ion transmembrane transport
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
ion transport
Source: MGI
Inferred from mutant phenotypeⁱ
- 11069181
modulation of chemical synaptic transmission
Source: SynGO
Inferred from mutant phenotypeⁱ
- 17074061
monovalent inorganic cation transport Source: UniProtKB
neuromuscular synaptic transmission
Source: MGI
Inferred from mutant phenotypeⁱ
- 12813150
neuronal action potential Source: MGI
peristalsis
Source: MGI
Inferred from mutant phenotypeⁱ
- 12813150
positive regulation of sensory perception of pain Source: MGI
protein homooligomerization Source: MGI
protein homotrimerization Source: UniProtKB
regulation of synaptic plasticity
Source: MGI
Inferred from mutant phenotypeⁱ
- 17074061
response to ATP
Source: MGI
Inferred from mutant phenotypeⁱ
response to carbohydrate
Source: MGI
Inferred from mutant phenotypeⁱ
- 16322458
response to cold
Source: MGI
Inferred from mutant phenotypeⁱ
- 15927378
response to heat
Source: MGI
Inferred from mutant phenotypeⁱ
- 15927378
response to hypoxia
Source: MGI
Inferred from mutant phenotypeⁱ
- 14672995
response to mechanical stimulus
Source: MGI
Inferred from mutant phenotypeⁱ
- 11466438
response to organic substance
Source: MGI
Inferred from mutant phenotypeⁱ
- 11069181
- 11069182
response to temperature stimulus
Source: MGI
Inferred from mutant phenotypeⁱ
- 11069182
sensory perception of taste
Source: MGI
Inferred from genetic interactionⁱ
- 16322458
urinary bladder smooth muscle contraction
Source: MGI
Inferred from mutant phenotypeⁱ
- 11069181
- 15961431

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Ion channel, Ligand-gated ion channel, Receptor
Biological process	Ion transport, Transport
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-139853 Elevation of cytosolic Ca2+ levels R-MMU-418346 Platelet homeostasis

Reactomeⁱ

R-MMU-139853 Elevation of cytosolic Ca2+ levels
R-MMU-418346 Platelet homeostasis

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: P2X purinoceptor 3 Short name: P2X3 Alternative name(s): ATP receptor Purinergic receptor
Gene namesⁱ	Name:P2rx3
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 2

Organism-specific databases

MGIⁱ	MGI:1097160 P2rx3

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	1 – 20	CytoplasmicCuratedAdd BLAST	20
Transmembraneⁱ	21 – 43	Helical; Name=1By similarityAdd BLAST	23
Topological domainⁱ	44 – 322	ExtracellularCuratedAdd BLAST	279
Transmembraneⁱ	323 – 341	Helical; Name=2By similarityAdd BLAST	19
Topological domainⁱ	342 – 397	CytoplasmicCuratedAdd BLAST	56

Keywords - Cellular componentⁱ

Cell membrane, Membrane

Pathology & Biotechⁱ

Disruption phenotypeⁱ

Simultaneous knockout of P2rx2 and P2rx3 results in reduced pain-related behaviors in response to intraplantar injection of formalin and reduced urinary bladder reflexes and decreased pelvic afferent nerve activity in response to bladder distension. Neurons have minimal to no response to ATP (PubMed:15961431). Simultaneous knockout of P2rx2 and P2rx3 results in defects in taste responses in the taste nerves and reduced behavioral responses to sweeteners, glutamate and bitter substances (PubMed:16322458).2 Publications

Chemistry databases

ChEMBLⁱ	CHEMBL2401608

ChEMBLⁱ

CHEMBL2401608

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000269195	1 – 397	P2X purinoceptor 3Add BLAST		397

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	107 ↔ 153	By similarity
Disulfide bondⁱ	116 ↔ 137	By similarity
Disulfide bondⁱ	122 ↔ 147	By similarity
Glycosylationⁱ	139	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	170	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	194	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	203 ↔ 213	By similarity
Disulfide bondⁱ	247 ↔ 256	By similarity
Glycosylationⁱ	290	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3UR32
PaxDbⁱ	Q3UR32
PRIDEⁱ	Q3UR32

PTM databases

iPTMnetⁱ	Q3UR32
PhosphoSitePlusⁱ	Q3UR32

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000027071 Expressed in 41 organ(s), highest expression level in dorsal root ganglion
ExpressionAtlasⁱ	Q3UR32 baseline and differential
Genevisibleⁱ	Q3UR32 MM

Interactionⁱ

Subunit structureⁱ

Homotrimer (By similarity). Functional P2XRs are organized as homomeric and heteromeric trimers (By similarity).By similarity

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000028465

STRINGⁱ

10090.ENSMUSP00000028465

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3UR32
SMRⁱ	Q3UR32
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Sequence similaritiesⁱ

Belongs to the P2X receptor family.Curated

Keywords - Domainⁱ

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGⁱ	ENOG410IFJF Eukaryota ENOG410XR0C LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00390000016028
HOGENOMⁱ	HOG000232042
HOVERGENⁱ	HBG053086
InParanoidⁱ	Q3UR32
KEGG Orthology (KO) More...KOⁱ	K05217
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0A2U
PhylomeDBⁱ	Q3UR32
TreeFamⁱ	TF328633

Family and domain databases

Gene3Dⁱ	2.60.490.10, 1 hit
InterProⁱ	View protein in InterPro IPR003046 P2X3_purnocptor IPR027309 P2X_extracellular_dom_sf IPR001429 P2X_purnocptor
PANTHERⁱ	PTHR10125 PTHR10125, 1 hit PTHR10125:SF8 PTHR10125:SF8, 1 hit
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00864 P2X_receptor, 1 hit
PIRSFⁱ	PIRSF005713 P2X_purinoceptor, 1 hit
PRINTSⁱ	PR01310 P2X3RECEPTOR PR01307 P2XRECEPTOR
TIGRFAMsⁱ	TIGR00863 P2X, 1 hit
PROSITEⁱ	View protein in PROSITE PS01212 P2X_RECEPTOR, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q3UR32-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MNCISDFFTY ETTKSVVVKS WTIGIINRAV QLLIISYFVG WVFLHEKAYQ 
        60         70         80         90        100
VRDTAIESSV VTKVKGFGRY ANRVMDVSDY VTPPQGTSVF VIITKMIVTE 
       110        120        130        140        150
NQMQGFCPEN EEKYRCVSDS QCGPERFPGG GILTGRCVNY SSVRRTCEIQ 
       160        170        180        190        200
GWCPTEVDTV EMPIMMEAEN FTIFIKNSIR FPLFNFEKGN LLPNLTDKDI 
       210        220        230        240        250
KKCRFHPEKA PFCPILRVGD VVKFAGQDFA KLARTGGVLG IKIGWVCDLD 
       260        270        280        290        300
KAWDQCIPKY SFTRLDGVSE KSSVSPGYNF RFAKYYKMEN GSEYRTLLKA 
       310        320        330        340        350
FGIRFDVLVY GNAGKFNIIP TIISSVAAFT SVGVGTVLCD IILLNFLKGA 
       360        370        380        390 
DHYKARKFEE VTETTLKGTA STNPVFTSDQ ATVEKQSTDS GAYSIGH

Length:397

Mass (Da):44,437

Last modified:October 11, 2005 - v1

Checksum:ⁱBFB90C740E5DD910

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A2AW03	A2AW03_MOUSE	p2X purinoceptor p2X purinoceptor	P2rx3	373	Annotation score:
A2AW04	A2AW04_MOUSE	p2X purinoceptor p2X purinoceptor	P2rx3	395	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	295	R → P in AAH23089 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK140283 mRNA Translation: BAE24316.1 AK141847 mRNA Translation: BAE24856.1 AL935159 Genomic DNA No translation available. BC023089 mRNA Translation: AAH23089.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS16200.1
NCBI Reference Sequences More...RefSeqⁱ	NP_663501.2, NM_145526.2
UniGeneⁱ	Mm.440375 Mm.448935

Genome annotation databases

Ensemblⁱ	ENSMUST00000028465; ENSMUSP00000028465; ENSMUSG00000027071
GeneIDⁱ	228139
KEGGⁱ	mmu:228139
UCSC genome browser More...UCSCⁱ	uc008kjr.1 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q3UR32	P2X purinoceptor 3		RAT		397	UniRef90_Q3UR32
P2X purinoceptor 3	)	HUMAN		397
p2X purinoceptor		CRIGR		464
Uncharacterized protein		NEOLE		110
p2X purinoceptor		PTEAL		408
+123

Protein	Similar proteins		Species	Score	Length	Source
Q3UR32	P2X purinoceptor 3		RAT		397	UniRef50_Q3UR32
P2X purinoceptor 3	)	HUMAN		397
p2X purinoceptor		CRIGR		464
Uncharacterized protein		NEOLE		110
p2X purinoceptor		PTEAL		408
+138

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK140283 mRNA Translation: BAE24316.1 AK141847 mRNA Translation: BAE24856.1 AL935159 Genomic DNA No translation available. BC023089 mRNA Translation: AAH23089.1
CCDSⁱ	CCDS16200.1
RefSeqⁱ	NP_663501.2, NM_145526.2
UniGeneⁱ	Mm.440375 Mm.448935

3D structure databases

ProteinModelPortalⁱ	Q3UR32
SMRⁱ	Q3UR32
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

STRINGⁱ	10090.ENSMUSP00000028465

STRINGⁱ

10090.ENSMUSP00000028465

Chemistry databases

ChEMBLⁱ	CHEMBL2401608

ChEMBLⁱ

CHEMBL2401608

PTM databases

iPTMnetⁱ	Q3UR32
PhosphoSitePlusⁱ	Q3UR32

Proteomic databases

MaxQBⁱ	Q3UR32
PaxDbⁱ	Q3UR32
PRIDEⁱ	Q3UR32

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000028465; ENSMUSP00000028465; ENSMUSG00000027071
GeneIDⁱ	228139
KEGGⁱ	mmu:228139
UCSCⁱ	uc008kjr.1 mouse

Organism-specific databases

CTDⁱ	5024
MGIⁱ	MGI:1097160 P2rx3

Phylogenomic databases

eggNOGⁱ	ENOG410IFJF Eukaryota ENOG410XR0C LUCA
GeneTreeⁱ	ENSGT00390000016028
HOGENOMⁱ	HOG000232042
HOVERGENⁱ	HBG053086
InParanoidⁱ	Q3UR32
KOⁱ	K05217
OrthoDBⁱ	EOG091G0A2U
PhylomeDBⁱ	Q3UR32
TreeFamⁱ	TF328633

Enzyme and pathway databases

Reactomeⁱ	R-MMU-139853 Elevation of cytosolic Ca2+ levels R-MMU-418346 Platelet homeostasis

Reactomeⁱ

R-MMU-139853 Elevation of cytosolic Ca2+ levels
R-MMU-418346 Platelet homeostasis

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q3UR32
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000027071 Expressed in 41 organ(s), highest expression level in dorsal root ganglion
ExpressionAtlasⁱ	Q3UR32 baseline and differential
Genevisibleⁱ	Q3UR32 MM

Family and domain databases

Gene3Dⁱ	2.60.490.10, 1 hit
InterProⁱ	View protein in InterPro IPR003046 P2X3_purnocptor IPR027309 P2X_extracellular_dom_sf IPR001429 P2X_purnocptor
PANTHERⁱ	PTHR10125 PTHR10125, 1 hit PTHR10125:SF8 PTHR10125:SF8, 1 hit
Pfamⁱ	View protein in Pfam PF00864 P2X_receptor, 1 hit
PIRSFⁱ	PIRSF005713 P2X_purinoceptor, 1 hit
PRINTSⁱ	PR01310 P2X3RECEPTOR PR01307 P2XRECEPTOR
TIGRFAMsⁱ	TIGR00863 P2X, 1 hit
PROSITEⁱ	View protein in PROSITE PS01212 P2X_RECEPTOR, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	P2RX3_MOUSE
Accessionⁱ	Q3UR32Primary (citable) accession number: Q3UR32 Secondary accession number(s): A2AW02, Q8R1U4
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 12, 2006
	Last sequence update:	October 11, 2005
	Last modified:	November 7, 2018
	This is version 104 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3UR32 (P2RX3_MOUSE)

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P2X purinoceptor 3

P2rx3

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endoplasmic reticulum

Golgi apparatus

Nucleus

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Chemistry databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ