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Protein
Submitted name:

Corticotropin-releasing factor receptor 2

Gene

Crhr2

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionG-protein coupled receptorSAAS annotation, Receptor, Transducer

Names & Taxonomyi

Protein namesi
Submitted name:
Corticotropin-releasing factor receptor 2Imported
Gene namesi
Name:Crhr2Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 6

Organism-specific databases

MGIiMGI:894312 Crhr2

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei134 – 160HelicalSequence analysisAdd BLAST27
Transmembranei172 – 191HelicalSequence analysisAdd BLAST20
Transmembranei211 – 232HelicalSequence analysisAdd BLAST22
Transmembranei244 – 267HelicalSequence analysisAdd BLAST24
Transmembranei287 – 306HelicalSequence analysisAdd BLAST20
Transmembranei327 – 347HelicalSequence analysisAdd BLAST21
Transmembranei359 – 381HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_501529761627 – 430Sequence analysisAdd BLAST404

Expressioni

Gene expression databases

BgeeiENSMUSG00000003476

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 122G_PROTEIN_RECEP_F2_3InterPro annotationAdd BLAST79
Domaini135 – 382G_PROTEIN_RECEP_F2_4InterPro annotationAdd BLAST248

Sequence similaritiesi

Belongs to the G-protein coupled receptor 2 family.SAAS annotation

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

eggNOGiKOG4564 Eukaryota
ENOG410XRS2 LUCA
GeneTreeiENSGT00900000140884
HOGENOMiHOG000230719
HOVERGENiHBG106921
KOiK04579
OrthoDBiEOG091G0BBY
TreeFamiTF315710

Family and domain databases

Gene3Di4.10.1240.10, 1 hit
InterProiView protein in InterPro
IPR017981 GPCR_2-like
IPR003053 GPCR_2_CRF2_rcpt
IPR003051 GPCR_2_CRF_rcpt
IPR036445 GPCR_2_extracell_dom_sf
IPR001879 GPCR_2_extracellular_dom
IPR000832 GPCR_2_secretin-like
IPR017983 GPCR_2_secretin-like_CS
PfamiView protein in Pfam
PF00002 7tm_2, 1 hit
PF02793 HRM, 1 hit
PRINTSiPR01279 CRFRECEPTOR
PR01281 CRFRECEPTOR2
PR00249 GPCRSECRETIN
SMARTiView protein in SMART
SM00008 HormR, 1 hit
SUPFAMiSSF111418 SSF111418, 1 hit
PROSITEiView protein in PROSITE
PS00649 G_PROTEIN_RECEP_F2_1, 1 hit
PS00650 G_PROTEIN_RECEP_F2_2, 1 hit
PS50227 G_PROTEIN_RECEP_F2_3, 1 hit
PS50261 G_PROTEIN_RECEP_F2_4, 1 hit

Sequencei

Sequence statusi: Complete.

Q3UQP0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGTPGSLPSA QLLLCLFSLL PVLQVAQPGQ APQDQPLWTL LEQYCHRTTT
60 70 80 90 100
GNFSGPYTYC NTTLDQIGTC WPQSAPGALV ERPCPEYFNG IKYNTTRNAY
110 120 130 140 150
RECLENGTWA SRVNYSHCEP ILDDKRKYDL HYRIALIVNY LGHCVSVVAL
160 170 180 190 200
VAAFLLFLVL RSIRCLRNVI HWNLITTFIL RNIAWFLLQL IDHEVHEGNE
210 220 230 240 250
VWCRCITTIF NYFVVTNFFW MFVEGCYLHT AIVMTYSTEH LRKWLFLFIG
260 270 280 290 300
WCIPCPIIIA WAVGKLYYEN EQCWFGKEAG DLVDYIYQGP VMLVLLINFV
310 320 330 340 350
FLFNIVRILM TKLRASTTSE TIQYRKAVKA TLVLLPLLGI TYMLFFVNPG
360 370 380 390 400
EDDLSQIVFI YFNSFLQSFQ GFFVSVFYCF FNGEVRAALR KRWHRWQDHH
410 420 430
ALRVPVARAM SIPTSPTRIS FHSIKQTAAV
Length:430
Mass (Da):49,783
Last modified:October 11, 2005 - v1
Checksum:i1F4E3B8872D89E9C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC079243 Genomic DNA No translation available.
AK142261 mRNA Translation: BAE24999.1
RefSeqiNP_001275547.1, NM_001288618.1
NP_001275548.1, NM_001288619.1
NP_001275549.1, NM_001288620.1
NP_034083.2, NM_009953.4
UniGeneiMm.236081

Genome annotation databases

EnsembliENSMUST00000003568; ENSMUSP00000003568; ENSMUSG00000003476
GeneIDi12922
KEGGimmu:12922
UCSCiuc009cak.3 mouse

Similar proteinsi

Entry informationi

Entry nameiQ3UQP0_MOUSE
AccessioniPrimary (citable) accession number: Q3UQP0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: July 18, 2018
This is version 125 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

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