UniProtKB - Q3UQ28 (PXDN_MOUSE)

BLAST

>sp|Q3UQ28|PXDN_MOUSE Peroxidasin homolog OS=Mus musculus OX=10090 GN=Pxdn PE=1 SV=2
MAVRPTRRCLLALLLCFAWWAMAVVASKQGAGCPSRCLCFRTTVRCMHLLLEAVPAVAPQ
TSILDLRFNRIREIQPGAFRRLRSLNTLLLNNNQIKKIPNGAFEDLENLKYLYLYKNEIQ
SIDRQAFKGLASLEQLYLHFNQIETLDPESFQHLPKLERLFLHNNRITHLVPGTFSQLES
MKRLRLDSNALHCDCEILWLADLLKTYAQSGNAQAAATCEYPRRIQGRSVATITPEELNC
ERPRITSEPQDADVTSGNTVYFTCRAEGNPKPEIIWLRNNNELSMKTDSRLNLLDDGTLM
IQNTQEADEGVYQCMAKNVAGEAKTQEVTLRYLGSPARPTFVIQPQNTEVLVGESVTLEC
SATGHPLPQITWTRGDRTPLPIDPRVNITPSGGLYIQNVAQSDSGEYTCFASNSVDSIHA
TAFIIVQALPQFTVTPQSRVVIEGQTVDFQCAAKGHPQPVIAWTKGGSQLSVDRRHLVLS
SGTLRISGVALHDQGQYECQAVNIIGSQKVVAHLTVQPRVTPVFASIPSDMTVEVGTNVQ
LPCSSQGEPEPAITWNKDGVQVTESGKFHISPEGFLTINDVGTADAGRYECVARNTIGYA
SVSMVLSVNVPDVSRNGDPYVATSIVEAIATVDRAINSTRTHLFDSRPRSPNDLLALFRY
PRDPYTVGQARAGEIFERTLQLIQEHVQHGLMVDLNGTSYHYNDLVSPQYLSLIANLSGC
TAHRRVNNCSDMCFHQKYRTHDGTCNNLQHPMWGASLTAFERLLKAVYENGFNTPRGINS
QRQYNGHVLPMPRLVSTTLIGTEVITPDEQFTHMLMQWGQFLDHDLDSTVVALSQARFSD
GQHCSSVCSNDPPCFSVMIPPNDPRVRSGARCMFFVRSSPVCGSGMTSLLMNSVYPREQI
NQLTSYIDASNVYGSTDHEARSIRDLASHRGLLRQGIVQRSGKPLLPFATGPPTECMRDE
NESPIPCFLAGDHRANEQLGLTSMHTLWFREHNRIAAELLKLNPHWDGDTVYHETRKIVG
AEIQHITYRHWLPKILGEVGMKMLGEYRGYDPSVNAGIFNAFATAAFRFGHTLINPLLYR
LDENFEPIPQGHVPLHKAFFSPFRIVNEGGIDPLLRGLFGVAGKMRIPSQLLNTELTERL
FSMAHTVALDLAAINIQRGRDHGIPPYHDYRVYCNLSAAYTFEDLKNEIKSPVIREKLQR
LYGSTLNIDLFPALMVEDLVPGSRLGPTLMCLLSTQFRRLRDGDRLWYENPGVFSPAQLT
QLKQTSLARILCDNSDNITRVQQDVFRVAEFPHGYSSCEDIPRVDLRVWQDCCEDCRTRG
QFNAFSYHFRGRRSLEFSYEDDKPTKRARWRKALSVKHGKHLSNATSATHEHLEGPATND
LKEFVLEMQKIITDLRKQINSLESRLSTTECVDDSGESHGGNTKWKKDPCTVCECKNGQI
TCFVEACQPAACPQPVKVEGACCPVCLKNTAEEKP

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History
Entry version 125 (07 Nov 2018)
Sequence version 2 (27 Jul 2011)
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Protein

Peroxidasin homolog

Gene

Pxdn

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Displays low peroxidase activity and is likely to participate in H₂O₂ metabolism and peroxidative reactions in the cardiovascular system (By similarity). Plays a role in extracellular matrix formation.By similarity

Catalytic activityⁱ

2 phenolic donor + H₂O₂ = 2 phenoxyl radical of the donor + 2 H₂O.

Cofactorⁱ

Protein has several cofactor binding sites:

Ca²⁺By similarityNote: Binds 1 Ca²⁺ ion per subunit.By similarity
heme bBy similarityNote: Binds 1 heme b (iron(II)-protoporphyrin IX) group covalently per subunit.By similarity

Sites

Feature key	Position(s)	DescriptionActions	Length
Binding siteⁱ	823	Heme (covalent; via 2 links)By similarity	1
Active siteⁱ	824	Proton acceptorPROSITE-ProRule annotation	1
Metal bindingⁱ	825	CalciumPROSITE-ProRule annotation	1
Metal bindingⁱ	904	CalciumPROSITE-ProRule annotation	1
Metal bindingⁱ	906	Calcium; via carbonyl oxygenPROSITE-ProRule annotation	1
Metal bindingⁱ	908	CalciumPROSITE-ProRule annotation	1
Metal bindingⁱ	910	CalciumPROSITE-ProRule annotation	1
Siteⁱ	974	Transition state stabilizerPROSITE-ProRule annotation	1
Binding siteⁱ	977	Heme (covalent; via 2 links)By similarity	1
Metal bindingⁱ	1071	Iron (heme axial ligand)PROSITE-ProRule annotation	1

GO - Molecular functionⁱ

extracellular matrix structural constituent
Source: BHF-UCL
Inferred from high throughput direct assayⁱ
- 22159717
- 28071719
heme binding Source: UniProtKB
metal ion binding Source: UniProtKB-KW
peroxidase activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

extracellular matrix organization
Source: UniProtKB
Inferred from direct assayⁱ
- 19590037
hydrogen peroxide catabolic process Source: UniProtKB
oxidation-reduction process Source: UniProtKB
response to oxidative stress Source: InterPro

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Oxidoreductase, Peroxidase
Biological process	Hydrogen peroxide
Ligand	Calcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2243919 Crosslinking of collagen fibrils

Reactomeⁱ

R-MMU-2243919 Crosslinking of collagen fibrils

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Peroxidasin homolog (EC:1.11.1.7)
Gene namesⁱ	Name:Pxdn Synonyms:Kiaa0230
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 12

Organism-specific databases

MGIⁱ	MGI:1916925 Pxdn

Keywords - Cellular componentⁱ

Extracellular matrix, Secreted

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 23	Sequence analysisAdd BLAST		23
ChainⁱPRO_0000319620	24 – 1475	Peroxidasin homologAdd BLAST		1452

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Disulfide bondⁱ	264 ↔ 314	By similarity
Disulfide bondⁱ	360 ↔ 409	By similarity
Disulfide bondⁱ	451 ↔ 499	By similarity
Disulfide bondⁱ	543 ↔ 591	By similarity
Glycosylationⁱ	637	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	696	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	716	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	728	N-linked (GlcNAc...) asparagineSequence analysis	1
Disulfide bondⁱ	729 ↔ 745	By similarity
Disulfide bondⁱ	844 ↔ 854	By similarity
Disulfide bondⁱ	848 ↔ 872	By similarity
Disulfide bondⁱ	956 ↔ 967	By similarity
Modified residueⁱ	1173	PhosphotyrosineBy similarity	1
Disulfide bondⁱ	1174 ↔ 1231	By similarity
Glycosylationⁱ	1175	N-linked (GlcNAc...) asparagineSequence analysis	1
Modified residueⁱ	1177	PhosphoserineBy similarity	1
Disulfide bondⁱ	1272 ↔ 1298	By similarity
Glycosylationⁱ	1277	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	1364	N-linked (GlcNAc...) asparagineSequence analysis	1

Keywords - PTMⁱ

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3UQ28
PaxDbⁱ	Q3UQ28
PRIDEⁱ	Q3UQ28

PTM databases

iPTMnetⁱ	Q3UQ28
PhosphoSitePlusⁱ	Q3UQ28

Expressionⁱ

Tissue specificityⁱ

Highly expressed in the cardiovascular system. In the embryo, expressed in the corneal epithelial layer. In the adult eyes, expressed in the corneal and lens epithelium.2 Publications

Developmental stageⁱ

Expressed in all embryonic tissues at 10 dpc. Detected at 7 dpc.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000020674 Expressed in 239 organ(s), highest expression level in metanephros
CleanExⁱ	MM_PXDN
ExpressionAtlasⁱ	Q3UQ28 baseline and differential
Genevisibleⁱ	Q3UQ28 MM

Interactionⁱ

Protein-protein interaction databases

BioGridⁱ	213608, 2 interactors
STRINGⁱ	10090.ENSMUSP00000113703

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3UQ28
SMRⁱ	Q3UQ28
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	24 – 60	LRRNTAdd BLAST	37
Repeatⁱ	84 – 105	LRR 1Add BLAST	22
Repeatⁱ	108 – 129	LRR 2Add BLAST	22
Repeatⁱ	132 – 153	LRR 3Add BLAST	22
Repeatⁱ	156 – 177	LRR 4Add BLAST	22
Domainⁱ	189 – 242	LRRCTAdd BLAST	54
Domainⁱ	243 – 329	Ig-like C2-type 1Add BLAST	87
Domainⁱ	339 – 425	Ig-like C2-type 2Add BLAST	87
Domainⁱ	430 – 517	Ig-like C2-type 3Add BLAST	88
Domainⁱ	518 – 607	Ig-like C2-type 4Add BLAST	90
Domainⁱ	1409 – 1467	VWFCPROSITE-ProRule annotationAdd BLAST	59

Sequence similaritiesⁱ

Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGⁱ	KOG2408 Eukaryota ENOG410XPZ3 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00550000074325
HOGENOMⁱ	HOG000016084
HOVERGENⁱ	HBG108312
InParanoidⁱ	Q3UQ28
KEGG Orthology (KO) More...KOⁱ	K19511
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0236
TreeFamⁱ	TF314316

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd09826 peroxidasin_like, 1 hit
Gene3Dⁱ	1.10.640.10, 1 hit 2.60.40.10, 4 hits 3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000483 Cys-rich_flank_reg_C IPR010255 Haem_peroxidase IPR019791 Haem_peroxidase_animal IPR037120 Haem_peroxidase_sf IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf IPR034828 Peroxidasin IPR034824 Peroxidasin_peroxidase IPR001007 VWF_dom
PANTHERⁱ	PTHR11475:SF75 PTHR11475:SF75, 3 hits
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF03098 An_peroxidase, 1 hit PF07679 I-set, 4 hits PF13855 LRR_8, 1 hit PF00093 VWC, 1 hit
PRINTSⁱ	PR00457 ANPEROXIDASE
SMARTⁱ	View protein in SMART SM00409 IG, 4 hits SM00408 IGc2, 4 hits SM00406 IGv, 3 hits SM00369 LRR_TYP, 5 hits SM00082 LRRCT, 1 hit SM00214 VWC, 1 hit
SUPFAMⁱ	SSF48113 SSF48113, 1 hit SSF48726 SSF48726, 4 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 4 hits PS51450 LRR, 5 hits PS50292 PEROXIDASE_3, 1 hit PS01208 VWFC_1, 1 hit PS50184 VWFC_2, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show all Align All

Q3UQ28-1 [UniParc]FASTA Add to basket

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        10         20         30         40         50
MAVRPTRRCL LALLLCFAWW AMAVVASKQG AGCPSRCLCF RTTVRCMHLL 
        60         70         80         90        100
LEAVPAVAPQ TSILDLRFNR IREIQPGAFR RLRSLNTLLL NNNQIKKIPN 
       110        120        130        140        150
GAFEDLENLK YLYLYKNEIQ SIDRQAFKGL ASLEQLYLHF NQIETLDPES 
       160        170        180        190        200
FQHLPKLERL FLHNNRITHL VPGTFSQLES MKRLRLDSNA LHCDCEILWL 
       210        220        230        240        250
ADLLKTYAQS GNAQAAATCE YPRRIQGRSV ATITPEELNC ERPRITSEPQ 
       260        270        280        290        300
DADVTSGNTV YFTCRAEGNP KPEIIWLRNN NELSMKTDSR LNLLDDGTLM 
       310        320        330        340        350
IQNTQEADEG VYQCMAKNVA GEAKTQEVTL RYLGSPARPT FVIQPQNTEV 
       360        370        380        390        400
LVGESVTLEC SATGHPLPQI TWTRGDRTPL PIDPRVNITP SGGLYIQNVA 
       410        420        430        440        450
QSDSGEYTCF ASNSVDSIHA TAFIIVQALP QFTVTPQSRV VIEGQTVDFQ 
       460        470        480        490        500
CAAKGHPQPV IAWTKGGSQL SVDRRHLVLS SGTLRISGVA LHDQGQYECQ 
       510        520        530        540        550
AVNIIGSQKV VAHLTVQPRV TPVFASIPSD MTVEVGTNVQ LPCSSQGEPE 
       560        570        580        590        600
PAITWNKDGV QVTESGKFHI SPEGFLTIND VGTADAGRYE CVARNTIGYA 
       610        620        630        640        650
SVSMVLSVNV PDVSRNGDPY VATSIVEAIA TVDRAINSTR THLFDSRPRS 
       660        670        680        690        700
PNDLLALFRY PRDPYTVGQA RAGEIFERTL QLIQEHVQHG LMVDLNGTSY 
       710        720        730        740        750
HYNDLVSPQY LSLIANLSGC TAHRRVNNCS DMCFHQKYRT HDGTCNNLQH 
       760        770        780        790        800
PMWGASLTAF ERLLKAVYEN GFNTPRGINS QRQYNGHVLP MPRLVSTTLI 
       810        820        830        840        850
GTEVITPDEQ FTHMLMQWGQ FLDHDLDSTV VALSQARFSD GQHCSSVCSN 
       860        870        880        890        900
DPPCFSVMIP PNDPRVRSGA RCMFFVRSSP VCGSGMTSLL MNSVYPREQI 
       910        920        930        940        950
NQLTSYIDAS NVYGSTDHEA RSIRDLASHR GLLRQGIVQR SGKPLLPFAT 
       960        970        980        990       1000
GPPTECMRDE NESPIPCFLA GDHRANEQLG LTSMHTLWFR EHNRIAAELL 
      1010       1020       1030       1040       1050
KLNPHWDGDT VYHETRKIVG AEIQHITYRH WLPKILGEVG MKMLGEYRGY 
      1060       1070       1080       1090       1100
DPSVNAGIFN AFATAAFRFG HTLINPLLYR LDENFEPIPQ GHVPLHKAFF 
      1110       1120       1130       1140       1150
SPFRIVNEGG IDPLLRGLFG VAGKMRIPSQ LLNTELTERL FSMAHTVALD 
      1160       1170       1180       1190       1200
LAAINIQRGR DHGIPPYHDY RVYCNLSAAY TFEDLKNEIK SPVIREKLQR 
      1210       1220       1230       1240       1250
LYGSTLNIDL FPALMVEDLV PGSRLGPTLM CLLSTQFRRL RDGDRLWYEN 
      1260       1270       1280       1290       1300
PGVFSPAQLT QLKQTSLARI LCDNSDNITR VQQDVFRVAE FPHGYSSCED 
      1310       1320       1330       1340       1350
IPRVDLRVWQ DCCEDCRTRG QFNAFSYHFR GRRSLEFSYE DDKPTKRARW 
      1360       1370       1380       1390       1400
RKALSVKHGK HLSNATSATH EHLEGPATND LKEFVLEMQK IITDLRKQIN 
      1410       1420       1430       1440       1450
SLESRLSTTE CVDDSGESHG GNTKWKKDPC TVCECKNGQI TCFVEACQPA 
      1460       1470 
ACPQPVKVEG ACCPVCLKNT AEEKP

Length:1,475

Mass (Da):165,103

Last modified:July 27, 2011 - v2

Checksum:ⁱ7F49A5B0D4CDBEB6

Computationally mapped potential isoform sequencesⁱ

There are 2 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A1W2P6L9	A0A1W2P6L9_MOUSE	Peroxidasin homolog Peroxidasin homolog	Pxdn	1,295	Annotation score:
D3Z5M7	D3Z5M7_MOUSE	Peroxidasin homolog Peroxidasin homolog	Pxdn	307	Annotation score:

Experimental Info

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Sequence conflictⁱ	549	P → Q in BAE25216 (PubMed:16141072).Curated		1
Sequence conflictⁱ	1298	C → R in AAI12914 (PubMed:15489334).Curated		1

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK142872 mRNA Translation: BAE25216.1 AC159626 Genomic DNA No translation available. AC165078 Genomic DNA No translation available. BC112913 mRNA Translation: AAI12914.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS25856.1
NCBI Reference Sequences More...RefSeqⁱ	NP_852060.2, NM_181395.2
UniGeneⁱ	Mm.251774

Genome annotation databases

Ensemblⁱ	ENSMUST00000122328; ENSMUSP00000113703; ENSMUSG00000020674
GeneIDⁱ	69675
KEGGⁱ	mmu:69675
UCSC genome browser More...UCSCⁱ	uc007ngl.2 mouse

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q3UQ28	Peroxidasin homolog		HUMAN		1479	UniRef90_Q92626
peroxidasin homolog		TARSY		1690
Uncharacterized protein		COLAP		1482
PXDN isoform 2		PANTR		1479
Peroxidasin homolog		CALJA		1479
+33

Protein	Similar proteins		Species	Score	Length	Source
Q3UQ28	Peroxidasin homolog		HUMAN		1479	UniRef50_Q92626
peroxidasin homolog		TARSY		1690
Uncharacterized protein		COLAP		1482
Peroxidasin homolog		CALJA		1479
PXDN isoform 2		PANTR		1479
+246

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AK142872 mRNA Translation: BAE25216.1 AC159626 Genomic DNA No translation available. AC165078 Genomic DNA No translation available. BC112913 mRNA Translation: AAI12914.1
CCDSⁱ	CCDS25856.1
RefSeqⁱ	NP_852060.2, NM_181395.2
UniGeneⁱ	Mm.251774

3D structure databases

ProteinModelPortalⁱ	Q3UQ28
SMRⁱ	Q3UQ28
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	213608, 2 interactors
STRINGⁱ	10090.ENSMUSP00000113703

PTM databases

iPTMnetⁱ	Q3UQ28
PhosphoSitePlusⁱ	Q3UQ28

Proteomic databases

MaxQBⁱ	Q3UQ28
PaxDbⁱ	Q3UQ28
PRIDEⁱ	Q3UQ28

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000122328; ENSMUSP00000113703; ENSMUSG00000020674
GeneIDⁱ	69675
KEGGⁱ	mmu:69675
UCSCⁱ	uc007ngl.2 mouse

Organism-specific databases

CTDⁱ	7837
MGIⁱ	MGI:1916925 Pxdn
Rougeⁱ	Search...

Phylogenomic databases

eggNOGⁱ	KOG2408 Eukaryota ENOG410XPZ3 LUCA
GeneTreeⁱ	ENSGT00550000074325
HOGENOMⁱ	HOG000016084
HOVERGENⁱ	HBG108312
InParanoidⁱ	Q3UQ28
KOⁱ	K19511
OrthoDBⁱ	EOG091G0236
TreeFamⁱ	TF314316

Enzyme and pathway databases

Reactomeⁱ	R-MMU-2243919 Crosslinking of collagen fibrils

Reactomeⁱ

R-MMU-2243919 Crosslinking of collagen fibrils

Miscellaneous databases

ChiTaRSⁱ	Pxdn mouse
Protein Ontology More...PROⁱ	PR:Q3UQ28
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000020674 Expressed in 239 organ(s), highest expression level in metanephros
CleanExⁱ	MM_PXDN
ExpressionAtlasⁱ	Q3UQ28 baseline and differential
Genevisibleⁱ	Q3UQ28 MM

Family and domain databases

CDDⁱ	cd09826 peroxidasin_like, 1 hit
Gene3Dⁱ	1.10.640.10, 1 hit 2.60.40.10, 4 hits 3.80.10.10, 1 hit
InterProⁱ	View protein in InterPro IPR000483 Cys-rich_flank_reg_C IPR010255 Haem_peroxidase IPR019791 Haem_peroxidase_animal IPR037120 Haem_peroxidase_sf IPR007110 Ig-like_dom IPR036179 Ig-like_dom_sf IPR013783 Ig-like_fold IPR013098 Ig_I-set IPR003599 Ig_sub IPR003598 Ig_sub2 IPR013106 Ig_V-set IPR001611 Leu-rich_rpt IPR003591 Leu-rich_rpt_typical-subtyp IPR032675 LRR_dom_sf IPR034828 Peroxidasin IPR034824 Peroxidasin_peroxidase IPR001007 VWF_dom
PANTHERⁱ	PTHR11475:SF75 PTHR11475:SF75, 3 hits
Pfamⁱ	View protein in Pfam PF03098 An_peroxidase, 1 hit PF07679 I-set, 4 hits PF13855 LRR_8, 1 hit PF00093 VWC, 1 hit
PRINTSⁱ	PR00457 ANPEROXIDASE
SMARTⁱ	View protein in SMART SM00409 IG, 4 hits SM00408 IGc2, 4 hits SM00406 IGv, 3 hits SM00369 LRR_TYP, 5 hits SM00082 LRRCT, 1 hit SM00214 VWC, 1 hit
SUPFAMⁱ	SSF48113 SSF48113, 1 hit SSF48726 SSF48726, 4 hits
PROSITEⁱ	View protein in PROSITE PS50835 IG_LIKE, 4 hits PS51450 LRR, 5 hits PS50292 PEROXIDASE_3, 1 hit PS01208 VWFC_1, 1 hit PS50184 VWFC_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	PXDN_MOUSE
Accessionⁱ	Q3UQ28Primary (citable) accession number: Q3UQ28 Secondary accession number(s): A4FU83, E9QNQ9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	February 26, 2008
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 125 of the entry and version 2 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q3UQ28 (PXDN_MOUSE)

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Peroxidasin homolog

Pxdn

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted

Endoplasmic reticulum

Extracellular region or secreted

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ