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UniProtKB - Q3UQ28 (PXDN_MOUSE)

Entry version 132 (18 Sep 2019)
Sequence version 2 (27 Jul 2011)
Previous versions | rss
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Protein

Peroxidasin homolog

Gene

Pxdn

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Displays low peroxidase activity and is likely to participate in H2O2 metabolism and peroxidative reactions in the cardiovascular system (By similarity). Plays a role in extracellular matrix formation.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei823Heme (covalent; via 2 links)By similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei824Proton acceptorPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi825CalciumPROSITE-ProRule annotation1
Metal bindingi904CalciumPROSITE-ProRule annotation1
Metal bindingi906Calcium; via carbonyl oxygenPROSITE-ProRule annotation1
Metal bindingi908CalciumPROSITE-ProRule annotation1
Metal bindingi910CalciumPROSITE-ProRule annotation1
<p>This subsection describes interesting single amino acid sites on the sequence that are not defined in any other subsection. This subsection can be displayed in different sections (‘Function’, ‘PTM / Processing’, ‘Pathology and Biotech’) according to its content.<p><a href='/help/site' target='_top'>More...</a></p>Sitei974Transition state stabilizerPROSITE-ProRule annotation1
Binding sitei977Heme (covalent; via 2 links)By similarity1
Metal bindingi1071Iron (heme axial ligand)PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase, Peroxidase
Biological processHydrogen peroxide
LigandCalcium, Heme, Iron, Metal-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-MMU-2243919 Crosslinking of collagen fibrils

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Peroxidasin homolog (EC:1.11.1.7)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Pxdn
Synonyms:Kiaa0230
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1916925 Pxdn

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 23Sequence analysisAdd BLAST23
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000031962024 – 1475Peroxidasin homologAdd BLAST1452

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi264 ↔ 314By similarity
Disulfide bondi360 ↔ 409By similarity
Disulfide bondi451 ↔ 499By similarity
Disulfide bondi543 ↔ 591By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi637N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi696N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi716N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi728N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi729 ↔ 745By similarity
Disulfide bondi844 ↔ 854By similarity
Disulfide bondi848 ↔ 872By similarity
Disulfide bondi956 ↔ 967By similarity
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1173PhosphotyrosineBy similarity1
Disulfide bondi1174 ↔ 1231By similarity
Glycosylationi1175N-linked (GlcNAc...) asparagineSequence analysis1
Modified residuei1177PhosphoserineBy similarity1
Disulfide bondi1272 ↔ 1298By similarity
Glycosylationi1277N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1364N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q3UQ28

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q3UQ28

PRoteomics IDEntifications database

More...PRIDEi		Q3UQ28

PTM databases

GlyConnect protein glycosylation platform

More...GlyConnecti		2580

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q3UQ28

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q3UQ28

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Highly expressed in the cardiovascular system. In the embryo, expressed in the corneal epithelial layer. In the adult eyes, expressed in the corneal and lens epithelium.2 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Expressed in all embryonic tissues at 10 dpc. Detected at 7 dpc.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000020674 Expressed in 239 organ(s), highest expression level in metanephros

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q3UQ28 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q3UQ28 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		213608, 2 interactors

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000113703

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q3UQ28

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini24 – 60LRRNTAdd BLAST37
<p>This subsection of the ‘Family and Domains’ section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati84 – 105LRR 1Add BLAST22
Repeati108 – 129LRR 2Add BLAST22
Repeati132 – 153LRR 3Add BLAST22
Repeati156 – 177LRR 4Add BLAST22
Domaini189 – 242LRRCTAdd BLAST54
Domaini243 – 329Ig-like C2-type 1Add BLAST87
Domaini339 – 425Ig-like C2-type 2Add BLAST87
Domaini430 – 517Ig-like C2-type 3Add BLAST88
Domaini518 – 607Ig-like C2-type 4Add BLAST90
Domaini1409 – 1467VWFCPROSITE-ProRule annotationAdd BLAST59

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the peroxidase family. XPO subfamily.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2408 Eukaryota
ENOG410XPZ3 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157666

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000016084

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q3UQ28

KEGG Orthology (KO)

More...KOi		K19511

Database of Orthologous Groups

More...OrthoDBi		276568at2759

TreeFam database of animal gene trees

More...TreeFami		TF314316

Family and domain databases

Conserved Domains Database

More...CDDi		cd09826 peroxidasin_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.640.10, 1 hit
2.60.40.10, 4 hits
3.80.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR019791 Haem_peroxidase_animal
IPR010255 Haem_peroxidase_sf
IPR037120 Haem_peroxidase_sf_animal
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR034828 Peroxidasin
IPR034824 Peroxidasin_peroxidase
IPR001007 VWF_dom

The PANTHER Classification System

More...PANTHERi		PTHR11475:SF75 PTHR11475:SF75, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF03098 An_peroxidase, 1 hit
PF07679 I-set, 4 hits
PF13855 LRR_8, 1 hit
PF00093 VWC, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00457 ANPEROXIDASE

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SM00406 IGv, 3 hits
SM00369 LRR_TYP, 5 hits
SM00082 LRRCT, 1 hit
SM00214 VWC, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF48113 SSF48113, 1 hit
SSF48726 SSF48726, 4 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50835 IG_LIKE, 4 hits
PS51450 LRR, 5 hits
PS50292 PEROXIDASE_3, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q3UQ28-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAVRPTRRCL LALLLCFAWW AMAVVASKQG AGCPSRCLCF RTTVRCMHLL 
        60         70         80         90        100
LEAVPAVAPQ TSILDLRFNR IREIQPGAFR RLRSLNTLLL NNNQIKKIPN 
       110        120        130        140        150
GAFEDLENLK YLYLYKNEIQ SIDRQAFKGL ASLEQLYLHF NQIETLDPES 
       160        170        180        190        200
FQHLPKLERL FLHNNRITHL VPGTFSQLES MKRLRLDSNA LHCDCEILWL 
       210        220        230        240        250
ADLLKTYAQS GNAQAAATCE YPRRIQGRSV ATITPEELNC ERPRITSEPQ 
       260        270        280        290        300
DADVTSGNTV YFTCRAEGNP KPEIIWLRNN NELSMKTDSR LNLLDDGTLM 
       310        320        330        340        350
IQNTQEADEG VYQCMAKNVA GEAKTQEVTL RYLGSPARPT FVIQPQNTEV 
       360        370        380        390        400
LVGESVTLEC SATGHPLPQI TWTRGDRTPL PIDPRVNITP SGGLYIQNVA 
       410        420        430        440        450
QSDSGEYTCF ASNSVDSIHA TAFIIVQALP QFTVTPQSRV VIEGQTVDFQ 
       460        470        480        490        500
CAAKGHPQPV IAWTKGGSQL SVDRRHLVLS SGTLRISGVA LHDQGQYECQ 
       510        520        530        540        550
AVNIIGSQKV VAHLTVQPRV TPVFASIPSD MTVEVGTNVQ LPCSSQGEPE 
       560        570        580        590        600
PAITWNKDGV QVTESGKFHI SPEGFLTIND VGTADAGRYE CVARNTIGYA 
       610        620        630        640        650
SVSMVLSVNV PDVSRNGDPY VATSIVEAIA TVDRAINSTR THLFDSRPRS 
       660        670        680        690        700
PNDLLALFRY PRDPYTVGQA RAGEIFERTL QLIQEHVQHG LMVDLNGTSY 
       710        720        730        740        750
HYNDLVSPQY LSLIANLSGC TAHRRVNNCS DMCFHQKYRT HDGTCNNLQH 
       760        770        780        790        800
PMWGASLTAF ERLLKAVYEN GFNTPRGINS QRQYNGHVLP MPRLVSTTLI 
       810        820        830        840        850
GTEVITPDEQ FTHMLMQWGQ FLDHDLDSTV VALSQARFSD GQHCSSVCSN 
       860        870        880        890        900
DPPCFSVMIP PNDPRVRSGA RCMFFVRSSP VCGSGMTSLL MNSVYPREQI 
       910        920        930        940        950
NQLTSYIDAS NVYGSTDHEA RSIRDLASHR GLLRQGIVQR SGKPLLPFAT 
       960        970        980        990       1000
GPPTECMRDE NESPIPCFLA GDHRANEQLG LTSMHTLWFR EHNRIAAELL 
      1010       1020       1030       1040       1050
KLNPHWDGDT VYHETRKIVG AEIQHITYRH WLPKILGEVG MKMLGEYRGY 
      1060       1070       1080       1090       1100
DPSVNAGIFN AFATAAFRFG HTLINPLLYR LDENFEPIPQ GHVPLHKAFF 
      1110       1120       1130       1140       1150
SPFRIVNEGG IDPLLRGLFG VAGKMRIPSQ LLNTELTERL FSMAHTVALD 
      1160       1170       1180       1190       1200
LAAINIQRGR DHGIPPYHDY RVYCNLSAAY TFEDLKNEIK SPVIREKLQR 
      1210       1220       1230       1240       1250
LYGSTLNIDL FPALMVEDLV PGSRLGPTLM CLLSTQFRRL RDGDRLWYEN 
      1260       1270       1280       1290       1300
PGVFSPAQLT QLKQTSLARI LCDNSDNITR VQQDVFRVAE FPHGYSSCED 
      1310       1320       1330       1340       1350
IPRVDLRVWQ DCCEDCRTRG QFNAFSYHFR GRRSLEFSYE DDKPTKRARW 
      1360       1370       1380       1390       1400
RKALSVKHGK HLSNATSATH EHLEGPATND LKEFVLEMQK IITDLRKQIN 
      1410       1420       1430       1440       1450
SLESRLSTTE CVDDSGESHG GNTKWKKDPC TVCECKNGQI TCFVEACQPA 
      1460       1470 
ACPQPVKVEG ACCPVCLKNT AEEKP
Length:1,475
Mass (Da):165,103
Last modified:July 27, 2011 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F49A5B0D4CDBEB6
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1W2P6L9A0A1W2P6L9_MOUSE
Peroxidasin homolog
Pxdn
1,295Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
D3Z5M7D3Z5M7_MOUSE
Peroxidasin homolog
Pxdn
307Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti549P → Q in BAE25216 (PubMed:16141072).Curated1
Sequence conflicti1298C → R in AAI12914 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK142872 mRNA Translation: BAE25216.1
AC159626 Genomic DNA No translation available.
AC165078 Genomic DNA No translation available.
BC112913 mRNA Translation: AAI12914.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS25856.1

NCBI Reference Sequences

More...RefSeqi		NP_852060.2, NM_181395.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000122328; ENSMUSP00000113703; ENSMUSG00000020674

Database of genes from NCBI RefSeq genomes

More...GeneIDi		69675

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:69675

UCSC genome browser

More...UCSCi		uc007ngl.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK142872 mRNA Translation: BAE25216.1
AC159626 Genomic DNA No translation available.
AC165078 Genomic DNA No translation available.
BC112913 mRNA Translation: AAI12914.1
CCDSiCCDS25856.1
RefSeqiNP_852060.2, NM_181395.2

3D structure databases

SMRiQ3UQ28
ModBaseiSearch...

Protein-protein interaction databases

BioGridi213608, 2 interactors
STRINGi10090.ENSMUSP00000113703

PTM databases

GlyConnecti2580
iPTMnetiQ3UQ28
PhosphoSitePlusiQ3UQ28

Proteomic databases

MaxQBiQ3UQ28
PaxDbiQ3UQ28
PRIDEiQ3UQ28

Genome annotation databases

EnsembliENSMUST00000122328; ENSMUSP00000113703; ENSMUSG00000020674
GeneIDi69675
KEGGimmu:69675
UCSCiuc007ngl.2 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		7837
MGIiMGI:1916925 Pxdn

Rodent Unidentified Gene-Encoded large proteins database

More...Rougei		Search...

Phylogenomic databases

eggNOGiKOG2408 Eukaryota
ENOG410XPZ3 LUCA
GeneTreeiENSGT00940000157666
HOGENOMiHOG000016084
InParanoidiQ3UQ28
KOiK19511
OrthoDBi276568at2759
TreeFamiTF314316

Enzyme and pathway databases

ReactomeiR-MMU-2243919 Crosslinking of collagen fibrils

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Pxdn mouse

Protein Ontology

More...PROi		PR:Q3UQ28

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000020674 Expressed in 239 organ(s), highest expression level in metanephros
ExpressionAtlasiQ3UQ28 baseline and differential
GenevisibleiQ3UQ28 MM

Family and domain databases

CDDicd09826 peroxidasin_like, 1 hit
Gene3Di1.10.640.10, 1 hit
2.60.40.10, 4 hits
3.80.10.10, 1 hit
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR019791 Haem_peroxidase_animal
IPR010255 Haem_peroxidase_sf
IPR037120 Haem_peroxidase_sf_animal
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR013106 Ig_V-set
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
IPR034828 Peroxidasin
IPR034824 Peroxidasin_peroxidase
IPR001007 VWF_dom
PANTHERiPTHR11475:SF75 PTHR11475:SF75, 1 hit
PfamiView protein in Pfam
PF03098 An_peroxidase, 1 hit
PF07679 I-set, 4 hits
PF13855 LRR_8, 1 hit
PF00093 VWC, 1 hit
PRINTSiPR00457 ANPEROXIDASE
SMARTiView protein in SMART
SM00409 IG, 4 hits
SM00408 IGc2, 4 hits
SM00406 IGv, 3 hits
SM00369 LRR_TYP, 5 hits
SM00082 LRRCT, 1 hit
SM00214 VWC, 1 hit
SUPFAMiSSF48113 SSF48113, 1 hit
SSF48726 SSF48726, 4 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 4 hits
PS51450 LRR, 5 hits
PS50292 PEROXIDASE_3, 1 hit
PS01208 VWFC_1, 1 hit
PS50184 VWFC_2, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPXDN_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UQ28
Secondary accession number(s): A4FU83, E9QNQ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: July 27, 2011
Last modified: September 18, 2019
This is version 132 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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