UniProtKB - Q3UQ17 (Q3UQ17_MOUSE)
Protein
Submitted name:
Zinc finger and BTB domain-containing 16
Gene
Zbtb16
Organism
Mus musculus (Mouse)
Status
Functioni
GO - Molecular functioni
- DNA binding Source: MGI
- DNA-binding transcription factor activity Source: MGI
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: GO_Central
- DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
- double-stranded DNA binding Source: MGI
- identical protein binding Source: MGI
- protein C-terminus binding Source: MGI
- protein domain specific binding Source: MGI
- protein homodimerization activity Source: UniProtKB
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI
GO - Biological processi
- anterior/posterior pattern specification Source: MGI
- cartilage development Source: UniProtKB
- central nervous system development Source: UniProtKB
- embryonic digit morphogenesis Source: MGI
- embryonic hindlimb morphogenesis Source: MGI
- embryonic pattern specification Source: MGI
- forelimb morphogenesis Source: MGI
- hemopoiesis Source: UniProtKB
- hindlimb morphogenesis Source: MGI
- male germ-line stem cell asymmetric division Source: MGI
- mesonephros development Source: UniProtKB
- negative regulation of cell population proliferation Source: MGI
- negative regulation of myeloid cell differentiation Source: UniProtKB
- negative regulation of transcription, DNA-templated Source: MGI
- negative regulation of transcription by RNA polymerase II Source: MGI
- positive regulation of apoptotic process Source: MGI
- positive regulation of cartilage development Source: UniProtKB
- positive regulation of chondrocyte differentiation Source: UniProtKB
- positive regulation of fat cell differentiation Source: UniProtKB
- positive regulation of NK T cell differentiation Source: UniProtKB
- positive regulation of ossification Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- protein localization to nucleus Source: MGI
- regulation of transcription, DNA-templated Source: MGI
- regulation of transcription by RNA polymerase II Source: GO_Central
- skeletal system development Source: MGI
Keywordsi
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Submitted name: Zinc finger and BTB domain-containing 16Imported |
Gene namesi | Name:Zbtb16Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:103222, Zbtb16 |
Subcellular locationi
Cytosol
- cytosol Source: MGI
Nucleus
- nuclear body Source: UniProtKB
- nuclear speck Source: UniProtKB
- nucleus Source: MGI
- PML body Source: UniProtKB
Plasma Membrane
- plasma membrane Source: MGI
Other locations
- protein-containing complex Source: MGI
- transcription repressor complex Source: MGI
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000066687, Expressed in skin of back and 298 other tissues |
Interactioni
GO - Molecular functioni
- identical protein binding Source: MGI
- protein C-terminus binding Source: MGI
- protein domain specific binding Source: MGI
- protein homodimerization activity Source: UniProtKB
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000091374 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 34 – 96 | BTBInterPro annotationAdd BLAST | 63 | |
Domaini | 404 – 431 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 432 – 459 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 461 – 488 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 490 – 517 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 518 – 545 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 546 – 573 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 574 – 601 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 602 – 629 | C2H2-typeInterPro annotationAdd BLAST | 28 | |
Domaini | 630 – 657 | C2H2-typeInterPro annotationAdd BLAST | 28 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 215 – 236 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 250 – 325 | DisorderedSequence analysisAdd BLAST | 76 |
Keywords - Domaini
Zinc-fingerPROSITE-ProRule annotationPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154616 |
HOGENOMi | CLU_026420_0_0_1 |
OMAi | MGLIQLQ |
OrthoDBi | 1318335at2759 |
TreeFami | TF350825 |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
i Sequence
Sequence statusi: Complete.
Q3UQ17-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDLTKMGMIQ LQNPSHPTGL LCKANQMRLA GTLCDVVIMV DSQEFHAHRT
60 70 80 90 100
VLACTSKMFE ILFHRNSQHY TLDFLSPKTF QQILEYAYTA TLQAKAEDLD
110 120 130 140 150
DLLYAAEILE IEYLEEQCLK ILETIQASDD NDTEATMADG GGEEEEDRKA
160 170 180 190 200
RYLKNIFISK HSSEESGYAS VAGQSLPGPM VDQSPSVSTS FGLSAMSPTK
210 220 230 240 250
AAVDSLMSIG QSLLQGTLQP PAGPEEPTLA GGGRHPGVAE VKMEMMQVDE
260 270 280 290 300
APGQDSPGAA ESSISGGMGD KLEERSKEGP GTPTRGSVIT SARELHYGRE
310 320 330 340 350
ESGEQLSPPV EAGQGPPGRQ EPLAPPVEKH LGIYSVLPNH KADAVLSMPS
360 370 380 390 400
SVTSGLHVQP ALAVSMDFST YGGLLPQGFI QRELFSKLGE LAVGMKAESR
410 420 430 440 450
PLGEQCSVCG VELPDNEAVE QHRKLHSGMK TYGCELCGKR FLDSLRLRMH
460 470 480 490 500
LLAHSAGAKA FVCDQCGAQF SKEDALETHR QTHTGTDMAV FCLLCGKRFQ
510 520 530 540 550
AQSALQQHME VHAGVRSYIC SECNRTFPSH TALKRHLRSH TGDHPYECEF
560 570 580 590 600
CGSCFRDEST LKSHKRIHTG EKPYECNGCG KKFSLKHQLE THYRVHTGEK
610 620 630 640 650
PFECKLCHQR SRDYSAMIKH LRTHNGASPY QCTICTEYCP SLSSMQKHMK
660 670
GHKPEEIPPD WRIEKTYLYL CYV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113548 Genomic DNA No translation available. CT009741 Genomic DNA No translation available. BC138775 mRNA Translation: AAI38776.1 AK142947 mRNA Translation: BAE25227.1 |
RefSeqi | NP_001028496.1, NM_001033324.2 XP_006510321.1, XM_006510258.2 |
Genome annotation databases
Ensembli | ENSMUST00000093852; ENSMUSP00000091374; ENSMUSG00000066687 ENSMUST00000216150; ENSMUSP00000150887; ENSMUSG00000066687 |
GeneIDi | 235320 |
KEGGi | mmu:235320 |
UCSCi | uc009pil.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AC113548 Genomic DNA No translation available. CT009741 Genomic DNA No translation available. BC138775 mRNA Translation: AAI38776.1 AK142947 mRNA Translation: BAE25227.1 |
RefSeqi | NP_001028496.1, NM_001033324.2 XP_006510321.1, XM_006510258.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 10090.ENSMUSP00000091374 |
Protocols and materials databases
Antibodypediai | 897, 374 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000093852; ENSMUSP00000091374; ENSMUSG00000066687 ENSMUST00000216150; ENSMUSP00000150887; ENSMUSG00000066687 |
GeneIDi | 235320 |
KEGGi | mmu:235320 |
UCSCi | uc009pil.1, mouse |
Organism-specific databases
CTDi | 7704 |
MGIi | MGI:103222, Zbtb16 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000154616 |
HOGENOMi | CLU_026420_0_0_1 |
OMAi | MGLIQLQ |
OrthoDBi | 1318335at2759 |
TreeFami | TF350825 |
Miscellaneous databases
BioGRID-ORCSi | 235320, 0 hits in 17 CRISPR screens |
ChiTaRSi | Zbtb16, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000066687, Expressed in skin of back and 298 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00651, BTB, 1 hit PF00096, zf-C2H2, 3 hits |
SMARTi | View protein in SMART SM00225, BTB, 1 hit SM00355, ZnF_C2H2, 9 hits |
SUPFAMi | SSF54695, SSF54695, 1 hit SSF57667, SSF57667, 4 hits |
PROSITEi | View protein in PROSITE PS50097, BTB, 1 hit PS00028, ZINC_FINGER_C2H2_1, 8 hits PS50157, ZINC_FINGER_C2H2_2, 9 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3UQ17_MOUSE | |
Accessioni | Q3UQ17Primary (citable) accession number: Q3UQ17 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 141 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |