Zinc finger and BTB domain-containing 16

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• DNA binding Source: MGI
• DNA-binding transcription factor activity Source: MGI
• DNA-binding transcription repressor activity, RNA polymerase II-specific Source: MGI
• double-stranded DNA binding Source: MGI
• identical protein binding Source: MGI
• protein C-terminus binding Source: MGI
• protein domain specific binding Source: MGI
• protein homodimerization activity Source: UniProtKB
• RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: MGI

GO - Biological processⁱ

• anterior/posterior pattern specification Source: MGI <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Plzf regulates limb and axial skeletal patterning."
    Barna M., Hawe N., Niswander L., Pandolfi P.P.
    Nat. Genet. 25:166-172(2000) [PubMed] [Europe PMC] [Abstract]
• cartilage development Source: UniProtKB
• central nervous system development Source: UniProtKB <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors."
    Reid A., Gould A., Brand N., Cook M., Strutt P., Li J., Licht J., Waxman S., Krumlauf R., Zelent A.
    Blood 86:4544-4552(1995) [PubMed] [Europe PMC] [Abstract]
• embryonic digit morphogenesis Source: MGI
• embryonic hindlimb morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Plzf regulates limb and axial skeletal patterning."
    Barna M., Hawe N., Niswander L., Pandolfi P.P.
    Nat. Genet. 25:166-172(2000) [PubMed] [Europe PMC] [Abstract]
• embryonic pattern specification Source: MGIInferred from mutant phenotypeⁱ
  • "Plzf regulates limb and axial skeletal patterning."
    Barna M., Hawe N., Niswander L., Pandolfi P.P.
    Nat. Genet. 25:166-172(2000) [PubMed] [Europe PMC] [Abstract]
• forelimb morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Plzf regulates limb and axial skeletal patterning."
    Barna M., Hawe N., Niswander L., Pandolfi P.P.
    Nat. Genet. 25:166-172(2000) [PubMed] [Europe PMC] [Abstract]
• hemopoiesis Source: UniProtKBInferred from direct assayⁱ
  • "Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors."
    Reid A., Gould A., Brand N., Cook M., Strutt P., Li J., Licht J., Waxman S., Krumlauf R., Zelent A.
    Blood 86:4544-4552(1995) [PubMed] [Europe PMC] [Abstract]
• hindlimb morphogenesis Source: MGIInferred from mutant phenotypeⁱ
  • "Plzf regulates limb and axial skeletal patterning."
    Barna M., Hawe N., Niswander L., Pandolfi P.P.
    Nat. Genet. 25:166-172(2000) [PubMed] [Europe PMC] [Abstract]
• male germ-line stem cell asymmetric division Source: MGIInferred from mutant phenotypeⁱ
  • "Plzf is required in adult male germ cells for stem cell self-renewal."
    Buaas F.W., Kirsh A.L., Sharma M., McLean D.J., Morris J.L., Griswold M.D., de Rooij D.G., Braun R.E.
    Nat. Genet. 36:647-652(2004) [PubMed] [Europe PMC] [Abstract]
  • "Essential role of Plzf in maintenance of spermatogonial stem cells."
    Costoya J.A., Hobbs R.M., Barna M., Cattoretti G., Manova K., Sukhwani M., Orwig K.E., Wolgemuth D.J., Pandolfi P.P.
    Nat. Genet. 36:653-659(2004) [PubMed] [Europe PMC] [Abstract]
• mesonephros development Source: UniProtKBInferred from direct assayⁱ
  • "Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors."
    Reid A., Gould A., Brand N., Cook M., Strutt P., Li J., Licht J., Waxman S., Krumlauf R., Zelent A.
    Blood 86:4544-4552(1995) [PubMed] [Europe PMC] [Abstract]
• negative regulation of cell population proliferation Source: MGIInferred from mutant phenotypeⁱ
  • "Plzf regulates limb and axial skeletal patterning."
    Barna M., Hawe N., Niswander L., Pandolfi P.P.
    Nat. Genet. 25:166-172(2000) [PubMed] [Europe PMC] [Abstract]
• negative regulation of myeloid cell differentiation Source: UniProtKBInferred from direct assayⁱ
  • "Leukemia translocation gene, PLZF, is expressed with a speckled nuclear pattern in early hematopoietic progenitors."
    Reid A., Gould A., Brand N., Cook M., Strutt P., Li J., Licht J., Waxman S., Krumlauf R., Zelent A.
    Blood 86:4544-4552(1995) [PubMed] [Europe PMC] [Abstract]
• negative regulation of transcription, DNA-templated Source: MGI
• negative regulation of transcription by RNA polymerase II Source: MGI
• positive regulation of apoptotic process Source: MGIInferred from mutant phenotypeⁱ
  • "Plzf regulates limb and axial skeletal patterning."
    Barna M., Hawe N., Niswander L., Pandolfi P.P.
    Nat. Genet. 25:166-172(2000) [PubMed] [Europe PMC] [Abstract]
• positive regulation of cartilage development Source: UniProtKB
• positive regulation of chondrocyte differentiation Source: UniProtKB
• positive regulation of fat cell differentiation Source: UniProtKB
• positive regulation of NK T cell differentiation Source: UniProtKBInferred from mutant phenotypeⁱ
  • "The BTB-zinc finger transcriptional regulator PLZF controls the development of invariant natural killer T cell effector functions."
    Kovalovsky D., Uche O.U., Eladad S., Hobbs R.M., Yi W., Alonzo E., Chua K., Eidson M., Kim H.J., Im J.S., Pandolfi P.P., Sant'Angelo D.B.
    Nat. Immunol. 9:1055-1064(2008) [PubMed] [Europe PMC] [Abstract]
• positive regulation of ossification Source: UniProtKB
• positive regulation of transcription, DNA-templated Source: UniProtKB
• protein localization to nucleus Source: MGI
• regulation of transcription, DNA-templated Source: MGIInferred from mutant phenotypeⁱ
  • "Plzf regulates limb and axial skeletal patterning."
    Barna M., Hawe N., Niswander L., Pandolfi P.P.
    Nat. Genet. 25:166-172(2000) [PubMed] [Europe PMC] [Abstract]
• skeletal system development Source: MGIInferred from mutant phenotypeⁱ
  • "Plzf regulates limb and axial skeletal patterning."
    Barna M., Hawe N., Niswander L., Pandolfi P.P.
    Nat. Genet. 25:166-172(2000) [PubMed] [Europe PMC] [Abstract]
  • "Combined action of fluorouracil and two mutant genes on limb development in the mouse."
    Dagg C.P.
    J. Exp. Zool. 164:479-489(1967) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• identical protein binding Source: MGI
• protein C-terminus binding Source: MGI
• protein domain specific binding Source: MGI
• protein homodimerization activity Source: UniProtKB

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MDLTKMGMIQ LQNPSHPTGL LCKANQMRLA GTLCDVVIMV DSQEFHAHRT 
        60         70         80         90        100
VLACTSKMFE ILFHRNSQHY TLDFLSPKTF QQILEYAYTA TLQAKAEDLD 
       110        120        130        140        150
DLLYAAEILE IEYLEEQCLK ILETIQASDD NDTEATMADG GGEEEEDRKA 
       160        170        180        190        200
RYLKNIFISK HSSEESGYAS VAGQSLPGPM VDQSPSVSTS FGLSAMSPTK 
       210        220        230        240        250
AAVDSLMSIG QSLLQGTLQP PAGPEEPTLA GGGRHPGVAE VKMEMMQVDE 
       260        270        280        290        300
APGQDSPGAA ESSISGGMGD KLEERSKEGP GTPTRGSVIT SARELHYGRE 
       310        320        330        340        350
ESGEQLSPPV EAGQGPPGRQ EPLAPPVEKH LGIYSVLPNH KADAVLSMPS 
       360        370        380        390        400
SVTSGLHVQP ALAVSMDFST YGGLLPQGFI QRELFSKLGE LAVGMKAESR 
       410        420        430        440        450
PLGEQCSVCG VELPDNEAVE QHRKLHSGMK TYGCELCGKR FLDSLRLRMH 
       460        470        480        490        500
LLAHSAGAKA FVCDQCGAQF SKEDALETHR QTHTGTDMAV FCLLCGKRFQ 
       510        520        530        540        550
AQSALQQHME VHAGVRSYIC SECNRTFPSH TALKRHLRSH TGDHPYECEF 
       560        570        580        590        600
CGSCFRDEST LKSHKRIHTG EKPYECNGCG KKFSLKHQLE THYRVHTGEK 
       610        620        630        640        650
PFECKLCHQR SRDYSAMIKH LRTHNGASPY QCTICTEYCP SLSSMQKHMK 
       660        670 
GHKPEEIPPD WRIEKTYLYL CYV                              

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

Keywords - Technical termⁱ