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Protein
Submitted name:

Sema domain, seven thrombospondin repeats (Type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (Semaphorin) 5A, isoform CRA_a

Gene

Sema5a

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-416700 Other semaphorin interactions
R-MMU-5173214 O-glycosylation of TSR domain-containing proteins

Names & Taxonomyi

Protein namesi
Submitted name:
Sema domain, seven thrombospondin repeats (Type 1 and type 1-like), transmembrane domain (TM) and short cytoplasmic domain, (Semaphorin) 5A, isoform CRA_aImported
Submitted name:
Semaphorin-5AImported
Gene namesi
Name:Sema5aImported
ORF Names:mCG_141513Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:107556 Sema5a

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei968 – 990HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 22Sequence analysisAdd BLAST22
ChainiPRO_501509749123 – 1074Sequence analysisAdd BLAST1052

Keywords - PTMi

Disulfide bondSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000022231 Expressed in 346 organ(s), highest expression level in female gonad

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 484SemaInterPro annotationAdd BLAST450

Keywords - Domaini

SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000119134
HOVERGENiHBG062356
KOiK06841
OMAiCGTMDQG
OrthoDBiEOG091G01T5
TreeFamiTF329951

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.20.100.10, 6 hits
InterProiView protein in InterPro
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF01403 Sema, 1 hit
PF00090 TSP_1, 5 hits
SMARTiView protein in SMART
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SM00209 TSP1, 6 hits
SUPFAMiSSF101912 SSF101912, 1 hit
SSF82895 SSF82895, 6 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit
PS50092 TSP1, 6 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q3UPZ0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKGACILAWL FSSLGVWRLA RPETQDPAKC QRAEHPVVSY KEIGPWLREF
60 70 80 90 100
RAENAVDFSR LTFDPGQKEL VVGARNYLFR LELEDLSLIQ AVEWECDEAT
110 120 130 140 150
KKACYSKGKS KEECQNYIRV LLVGGDRLFT CGTNAFTPVC TIRSLSNLTE
160 170 180 190 200
IHDQISGMAR CPYSPQHNST ALLTASGELY AATAMDFPGR DPAIYRSLGT
210 220 230 240 250
LPPLRTAQYN SKWLNEPNFV SSYDIGNFTY FFFRENAVEH DCGKTVFSRA
260 270 280 290 300
ARVCKNDIGG RFLLEDTWTT FMKARLNCSR PGEVPFYYNE LQGTFFLPEL
310 320 330 340 350
DLIYGIFTTN VNSIAASAVC VFNLSAISQA FNGPFKYQEN SRSAWLPYPN
360 370 380 390 400
PNPNFQCGTM DQGLYVNLTE RNLQDAQKFI LMHEVVQPVT TVPSFMEDNS
410 420 430 440 450
RFSHLAVDVV QGRETLVHII YLATDYGTIK KVRAPLSQSS GSCLLEEIEL
460 470 480 490 500
FPERRSEPIR SLQILHSQSV LFVGLQEHVA KIPLKRCHFH QTRSACIGAQ
510 520 530 540 550
DPYCGWDAVM KKCTSLEESL SMTQWDQSIP TCPTRNLTVD GSFGPWSPWT
560 570 580 590 600
PCTHTDGTAV GSCLCRSRSC DSPAPQCGGW QCEGPRMEIT NCSRNGGWTP
610 620 630 640 650
WTSWSPCSTT CGIGFQVRQR SCSNPTPRHG GRVCVGQNRE ERYCNEHLLC
660 670 680 690 700
PPHVFWTGWG PWERCTAQCG GGIQARRRTC ENGPDCAGCN VEYQPCNTNA
710 720 730 740 750
CPELKKTTPW TPWTPVNISD NGGHYEQRFR YTCKARLPDP NLLEVGRQRI
760 770 780 790 800
EMRYCSSDGT SGCSTDGLSG DFLRAGRYSA HTVNGAWSAW TSWSQCSRDC
810 820 830 840 850
SRGIRNRKRV CNNPEPKFGG MPCLGPSLEF QECNILPCPV DGVWSCWSSW
860 870 880 890 900
SKCSATCGGG HYMRTRSCSN PAPAYGGDIC LGLHTEEALC NTQTCPESWS
910 920 930 940 950
EWSDWSVCDA SGTQVRARQC ILLFPVGSQC SGNTTESRPC VFDSNFIPEV
960 970 980 990 1000
SVARSSSVEE KRCGEFNMFH MMAVGLSSSI LGCLLTLLVY TYCQRYQQQS
1010 1020 1030 1040 1050
HDATVIHPVS PAALNSSITN HINKLDKYDS VEAIKAFNKN NLILEERNKY
1060 1070
FNPHLTGKTY SNAYFTDLNN YDEY
Length:1,074
Mass (Da):120,321
Last modified:October 11, 2005 - v1
Checksum:i3A231A2E0D880C1C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q62217SEM5A_MOUSE
Semaphorin-5A
Sema5a Semaf, SemF
1,077Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110236 Genomic DNA No translation available.
AC113289 Genomic DNA No translation available.
AC137123 Genomic DNA No translation available.
AK141612 mRNA Translation: BAE24765.1
AK143026 mRNA Translation: BAE25254.1
CH466541 Genomic DNA Translation: EDL08867.1
RefSeqiNP_033180.2, NM_009154.2
XP_006520106.1, XM_006520043.3
XP_011243642.1, XM_011245340.1
UniGeneiMm.260374

Genome annotation databases

EnsembliENSMUST00000067458; ENSMUSP00000069024; ENSMUSG00000022231
GeneIDi20356
KEGGimmu:20356
UCSCiuc007vku.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC110236 Genomic DNA No translation available.
AC113289 Genomic DNA No translation available.
AC137123 Genomic DNA No translation available.
AK141612 mRNA Translation: BAE24765.1
AK143026 mRNA Translation: BAE25254.1
CH466541 Genomic DNA Translation: EDL08867.1
RefSeqiNP_033180.2, NM_009154.2
XP_006520106.1, XM_006520043.3
XP_011243642.1, XM_011245340.1
UniGeneiMm.260374

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067458; ENSMUSP00000069024; ENSMUSG00000022231
GeneIDi20356
KEGGimmu:20356
UCSCiuc007vku.1 mouse

Organism-specific databases

CTDi9037
MGIiMGI:107556 Sema5a

Phylogenomic databases

eggNOGiKOG3611 Eukaryota
ENOG410XQZC LUCA
GeneTreeiENSGT00760000119134
HOVERGENiHBG062356
KOiK06841
OMAiCGTMDQG
OrthoDBiEOG091G01T5
TreeFamiTF329951

Enzyme and pathway databases

ReactomeiR-MMU-416700 Other semaphorin interactions
R-MMU-5173214 O-glycosylation of TSR domain-containing proteins

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022231 Expressed in 346 organ(s), highest expression level in female gonad

Family and domain databases

Gene3Di2.130.10.10, 1 hit
2.20.100.10, 6 hits
InterProiView protein in InterPro
IPR016201 PSI
IPR001627 Semap_dom
IPR036352 Semap_dom_sf
IPR027231 Semaphorin
IPR000884 TSP1_rpt
IPR036383 TSP1_rpt_sf
IPR015943 WD40/YVTN_repeat-like_dom_sf
PANTHERiPTHR11036 PTHR11036, 1 hit
PfamiView protein in Pfam
PF01403 Sema, 1 hit
PF00090 TSP_1, 5 hits
SMARTiView protein in SMART
SM00423 PSI, 1 hit
SM00630 Sema, 1 hit
SM00209 TSP1, 6 hits
SUPFAMiSSF101912 SSF101912, 1 hit
SSF82895 SSF82895, 6 hits
PROSITEiView protein in PROSITE
PS51004 SEMA, 1 hit
PS50092 TSP1, 6 hits
ProtoNetiSearch...

Entry informationi

Entry nameiQ3UPZ0_MOUSE
AccessioniPrimary (citable) accession number: Q3UPZ0
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 126 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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