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Protein

Protein FAM198B

Gene

Fam198b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Names & Taxonomyi

Protein namesi
Recommended name:
Protein FAM198B
Alternative name(s):
Expressed in nerve and epithelium during development
Gene namesi
Name:Fam198b
Synonyms:Ened
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1915909 Fam198b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 36CytoplasmicSequence analysisAdd BLAST36
Transmembranei37 – 56Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST20
Topological domaini57 – 517ExtracellularSequence analysisAdd BLAST461

Keywords - Cellular componenti

Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002889031 – 517Protein FAM198BAdd BLAST517

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi287N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ3UPI1
PaxDbiQ3UPI1
PRIDEiQ3UPI1

PTM databases

iPTMnetiQ3UPI1
PhosphoSitePlusiQ3UPI1

Expressioni

Tissue specificityi

At E9.5, detected in heart and midgut. At later gestation stages, expressed in floor plate, peripheral nervous system, lens epithelium, skin, midline dorsal aorta, lung, kidney and testis.1 Publication

Gene expression databases

BgeeiENSMUSG00000027955 Expressed in 217 organ(s), highest expression level in cardiac ventricle
CleanExiMM_1110032E23RIK
ExpressionAtlasiQ3UPI1 baseline and differential
GenevisibleiQ3UPI1 MM

Structurei

3D structure databases

ProteinModelPortaliQ3UPI1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the FAM198 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IT3B Eukaryota
ENOG410YG4J LUCA
GeneTreeiENSGT00420000029769
HOGENOMiHOG000112372
InParanoidiQ3UPI1
OMAiCKLWSSR
OrthoDBiEOG091G04A0
PhylomeDBiQ3UPI1
TreeFamiTF330994

Family and domain databases

InterProiView protein in InterPro
IPR029207 FAM198
PANTHERiPTHR15905 PTHR15905, 1 hit
PfamiView protein in Pfam
PF15051 FAM198, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q3UPI1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTCPDKPGQL VNWFVCSLCA PRVCKLWSSR RPRTRRNLLL GTACAIYLGF
60 70 80 90 100
LVSQVGRGSF QHGQATDRGP PNGHDIFKVP FSEIPLDGTL APPELQGNGS
110 120 130 140 150
TLQPNVVYIT LRSKRSKPAN IRGTVKPKRR KKYAVASAAP DQEVLVRPSL
160 170 180 190 200
IQQEAARAAD AEVPGYVQGY LTKVGERPWR VLRGPGVRTR GSNLQQPRAR
210 220 230 240 250
ESNIRIYSES APSWLSKEDI RRMRLLADSE VASILPISKS GTRLLVLEGS
260 270 280 290 300
TSGSVPGCGP SPCGLLKQPL DMSEVFAFHL DRILGLNRTL PSVSRKLEFI
310 320 330 340 350
QDGRPRPIIL WDSSLASASN DSHSSVKITW GTYQRLLKQK CWLNGRVPRP
360 370 380 390 400
EWDCTEIHHH EWSKMALFDF LLQIYNRLDT NCCGFRPRKE DACIQNGLRS
410 420 430 440 450
NCEDQTSVTL AHIIQRKNDP RHLVFINNKG FFDRSEDNLN FKLLEGIREF
460 470 480 490 500
PESAVSVLKS QHLRQKLLQS LFLDQVYWES QGGRQGIEKL IDVIERRARI
510
LITYINAHGA RVLPMNE
Length:517
Mass (Da):58,298
Last modified:October 11, 2005 - v1
Checksum:iFA7B56FA8E3A85A5
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YXF7D3YXF7_MOUSE
Protein FAM198B
Fam198b
51Annotation score:

Sequence cautioni

The sequence BAC34959 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti275V → L in ACE82567 (PubMed:18956345).Curated1
Sequence conflicti275V → L in AAH56975 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU797522 mRNA Translation: ACE82567.1
AF285091 mRNA Translation: AAG00502.1
AK052367 mRNA Translation: BAC34959.1 Different initiation.
AK143522 mRNA Translation: BAE25414.1
BC056975 mRNA Translation: AAH56975.1
CCDSiCCDS17422.1
RefSeqiNP_573450.2, NM_133187.3
XP_006502047.1, XM_006501984.3
XP_006502048.1, XM_006501985.2
UniGeneiMm.427274
Mm.460017

Genome annotation databases

EnsembliENSMUST00000029567; ENSMUSP00000029567; ENSMUSG00000027955
ENSMUST00000118853; ENSMUSP00000114093; ENSMUSG00000027955
GeneIDi68659
KEGGimmu:68659
UCSCiuc008pny.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EU797522 mRNA Translation: ACE82567.1
AF285091 mRNA Translation: AAG00502.1
AK052367 mRNA Translation: BAC34959.1 Different initiation.
AK143522 mRNA Translation: BAE25414.1
BC056975 mRNA Translation: AAH56975.1
CCDSiCCDS17422.1
RefSeqiNP_573450.2, NM_133187.3
XP_006502047.1, XM_006501984.3
XP_006502048.1, XM_006501985.2
UniGeneiMm.427274
Mm.460017

3D structure databases

ProteinModelPortaliQ3UPI1
ModBaseiSearch...
MobiDBiSearch...

PTM databases

iPTMnetiQ3UPI1
PhosphoSitePlusiQ3UPI1

Proteomic databases

MaxQBiQ3UPI1
PaxDbiQ3UPI1
PRIDEiQ3UPI1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029567; ENSMUSP00000029567; ENSMUSG00000027955
ENSMUST00000118853; ENSMUSP00000114093; ENSMUSG00000027955
GeneIDi68659
KEGGimmu:68659
UCSCiuc008pny.2 mouse

Organism-specific databases

CTDi51313
MGIiMGI:1915909 Fam198b

Phylogenomic databases

eggNOGiENOG410IT3B Eukaryota
ENOG410YG4J LUCA
GeneTreeiENSGT00420000029769
HOGENOMiHOG000112372
InParanoidiQ3UPI1
OMAiCKLWSSR
OrthoDBiEOG091G04A0
PhylomeDBiQ3UPI1
TreeFamiTF330994

Miscellaneous databases

PROiPR:Q3UPI1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027955 Expressed in 217 organ(s), highest expression level in cardiac ventricle
CleanExiMM_1110032E23RIK
ExpressionAtlasiQ3UPI1 baseline and differential
GenevisibleiQ3UPI1 MM

Family and domain databases

InterProiView protein in InterPro
IPR029207 FAM198
PANTHERiPTHR15905 PTHR15905, 1 hit
PfamiView protein in Pfam
PF15051 FAM198, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiF198B_MOUSE
AccessioniPrimary (citable) accession number: Q3UPI1
Secondary accession number(s): B3VSA6
, Q6PGJ9, Q8C781, Q9ET25
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 87 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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