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Entry version 123 (02 Jun 2021)
Sequence version 1 (11 Oct 2005)
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Protein

Rho guanine nucleotide exchange factor 40

Gene

Arhgef40

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May act as a guanine nucleotide exchange factor (GEF).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-193648, NRAGE signals death through JNK
R-MMU-194840, Rho GTPase cycle
R-MMU-416482, G alpha (12/13) signalling events

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 40
Alternative name(s):
Protein SOLO
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Arhgef40
Synonyms:Solo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 14

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2685515, Arhgef40

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003148231 – 1517Rho guanine nucleotide exchange factor 40Add BLAST1517

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei262PhosphoserineBy similarity1
Modified residuei367PhosphothreonineBy similarity1
Modified residuei415PhosphoserineBy similarity1
Modified residuei929PhosphoserineBy similarity1
Modified residuei959PhosphoserineCombined sources1
Modified residuei1080PhosphoserineBy similarity1
Modified residuei1431PhosphoserineBy similarity1
Modified residuei1436PhosphoserineBy similarity1
Modified residuei1472PhosphoserineBy similarity1
Modified residuei1490PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q3UPH7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3UPH7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3UPH7

PeptideAtlas

More...
PeptideAtlasi
Q3UPH7

PRoteomics IDEntifications database

More...
PRIDEi
Q3UPH7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
283205 [Q3UPH7-1]
283206 [Q3UPH7-2]
283207 [Q3UPH7-3]
283208 [Q3UPH7-6]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3UPH7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3UPH7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed but enriched in brain. In brain, it is expressed at higher level in olfactory bulb and cerebellum and peaks perinatally (from E16 to P0.5).1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000004562, Expressed in uterus and 250 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q3UPH7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3UPH7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q3UPH7, 2 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000091331

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3UPH7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3UPH7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1083 – 1251DHPROSITE-ProRule annotationAdd BLAST169
Domaini1263 – 1370PHPROSITE-ProRule annotationAdd BLAST108

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni194 – 238DisorderedSequence analysisAdd BLAST45
Regioni254 – 514DisorderedSequence analysisAdd BLAST261
Regioni952 – 1011DisorderedSequence analysisAdd BLAST60
Regioni1464 – 1517DisorderedSequence analysisAdd BLAST54

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili754 – 792Sequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi202 – 216Pro residuesSequence analysisAdd BLAST15
Compositional biasi275 – 290Basic residuesSequence analysisAdd BLAST16
Compositional biasi303 – 318Polar residuesSequence analysisAdd BLAST16
Compositional biasi423 – 473Basic and acidic residuesSequence analysisAdd BLAST51
Compositional biasi474 – 505Polar residuesSequence analysisAdd BLAST32
Compositional biasi952 – 971Basic and acidic residuesSequence analysisAdd BLAST20
Compositional biasi975 – 993Polar residuesSequence analysisAdd BLAST19
Compositional biasi1487 – 1517Polar residuesSequence analysisAdd BLAST31

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0689, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161599

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3UPH7

Identification of Orthologs from Complete Genome Data

More...
OMAi
GAILMKL

Database of Orthologous Groups

More...
OrthoDBi
578732at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3UPH7

TreeFam database of animal gene trees

More...
TreeFami
TF334329

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.900.10, 1 hit
2.30.29.30, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR001849, PH_domain

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00621, RhoGEF, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00233, PH, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48065, SSF48065, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 10 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3UPH7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEPEPVEDCV QSTLAALYPP FEATAPTLLG QVFQVVERTY QEDALRYTLD
60 70 80 90 100
FLVPAKHLLA KVQQEACAQY SGFLFFHEGW PLCLHEQVVV QLAALPWQLL
110 120 130 140 150
RPGDFYLQVV PSAAQAPRLA LKCLAPGGGR VQELPVPSEA CAYLFTPEWL
160 170 180 190 200
QGINKDRPTG RLSTCLLSAP SGIQRLPWAE LVCPRFVHKE GLMVGHQPST
210 220 230 240 250
LPPELPSGPP GLPSSPLPEE VLGTRSPGDG HNAPAEGPEG EYVELLEVTL
260 270 280 290 300
PVRGSPVDAE ASGLSRTRTV PARKSTGGKG RHRRHRAWMN QKGLGSRDQD
310 320 330 340 350
GTRPPGEGSS TGASSDSPSG AEADPDATAL QASEPPAEAL GEAPESCLLS
360 370 380 390 400
GEAVGGVGQG AEGPPGTPRR TGKGNRRKKR AAGRGAGSRG GEGTSLSPRD
410 420 430 440 450
KEETRQQEVL VSLPSPSEQE PAECSLVKEK EDSGKQESES KEELKPADEK
460 470 480 490 500
EPARPEDYEP PEEEIRESEK EELTPQCTAG STGPEWFPSE PSTQPLETVQ
510 520 530 540 550
NVKGDSLPEE TPPVSVLDDP VVAWDLMASG FFVLTGGVDQ TGRALLTITP
560 570 580 590 600
PPPCLPEESS PSQETLSTAL RYLHSLLRPD LQLLGLTILL DLRKAPPLPP
610 620 630 640 650
ALLPALSQLQ DSGEPPLIQR LVILIHEDPP AELCGFQGAE LLSEKDLKRV
660 670 680 690 700
AKPEELQWDL GGHRDLSPNH WAEIHQEVAR LCTLCQGVLT SVRQAIEELE
710 720 730 740 750
GTAEPKEEEA VGMPEPLQKV LADPRLTALQ RNGGAILMRL RSAHSSKLEG
760 770 780 790 800
PGPAELYQEV DEAIHQLVRL SNLRVQQQEE RQRLRQVQQV LQWLSGPGEE
810 820 830 840 850
QLASFSMPGN SLSVLQETEL RFRAFSTEVQ ERLVQAREAL ALEEDLTSQK
860 870 880 890 900
VLDIFEQRLE QAESGLHRAL RLQRFFQQAH EWVDEGSARL AGAGSGREAL
910 920 930 940 950
LAALALRRAP EPSAGTFQEM RALALDLGSP AALREWGRCR ARCQELERRI
960 970 980 990 1000
QQQLGEEASP RSHRRRRADS ASSAGAQHGA HSPSPSLSSL LLPSSPGPRA
1010 1020 1030 1040 1050
APSHCSLTPC GEDYEEEGLE LAPETDGRPP RAVLIRGLEV TSTEVVDRTC
1060 1070 1080 1090 1100
SPREHVLLGR AGGPDGPWGI GTPRMERKRS ISAQQRLVSE LIACEQEYVT
1110 1120 1130 1140 1150
TLNEPVPLPG PELTPELRCT WAAALSVRER LRSFHGTHFL QELQGCAAHP
1160 1170 1180 1190 1200
LRIGACFLRH GDQFNLYAQF VKHRHKLESG LAALTPSVKG SMESSPCLPR
1210 1220 1230 1240 1250
ALQQPLEQLA RYGQLLEELL REAGPELSSE RQALRAAVQL LQEQEARGRD
1260 1270 1280 1290 1300
LLAVEAVRGC EIDLKEQGQL LHRDPFTVIC GRKKCLRHVF LFEDLLLFSK
1310 1320 1330 1340 1350
LKGSEGGSET FVYKQAFKTA DMGLTENIGD SGLCFELWFR RRRAREAYTL
1360 1370 1380 1390 1400
QATSPETKLK WTSSIAQLLW RQAAHNKELR VQQMVSMGIG NKPFLDIKAL
1410 1420 1430 1440 1450
GERTLSALLT GRAARTRASV AVSSFEHAGP SLPGLSPGAC SLPARVEEEA
1460 1470 1480 1490 1500
WDLDVKQISL ASETLDSSGD VSPGPRNSPS LQPPSPGSST PALTSGGILG
1510
LSRQSHSRAL SDPTTPL
Length:1,517
Mass (Da):165,132
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i63A0F5900AC42D2E
GO
Isoform 2 (identifier: Q3UPH7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1413-1460: Missing.
     1504-1504: Q → QAWLRGIK

Show »
Length:1,476
Mass (Da):160,998
Checksum:iFF60B1129A02EE1E
GO
Isoform 3 (identifier: Q3UPH7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1413-1460: Missing.

Show »
Length:1,469
Mass (Da):160,173
Checksum:iE8750272DC8ABE05
GO
Isoform 6 (identifier: Q3UPH7-6) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1413-1460: Missing.
     1505-1517: SHSRALSDPTTPL → AWLRGIKVRDQKQS

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.Curated
Show »
Length:1,470
Mass (Da):160,476
Checksum:iAE0F0F4DA26A28C8
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 10 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
S4R189S4R189_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef40
1,526Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2U9S4R2U9_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef40
1,191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1Y4S4R1Y4_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef40
179Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1S6S4R1S6_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef40
500Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2A6S4R2A6_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef40
115Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1R5S4R1R5_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef40
73Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2R3S4R2R3_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef40
89Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R1X0S4R1X0_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef40
45Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R237S4R237_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef40
85Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
S4R2G8S4R2G8_MOUSE
Rho guanine nucleotide exchange fac...
Arhgef40
44Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAH58405 differs from that shown. Reason: Erroneous initiation. Truncated N-terminus.Curated
The sequence BAD21386 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence BAE22088 differs from that shown. Probable cloning artifact.Curated
The sequence BAE33372 differs from that shown. Intron retention.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti381A → T in BAD21386 (PubMed:15449545).Curated1
Sequence conflicti381A → T in BAE33372 (PubMed:16141072).Curated1
Sequence conflicti392E → K in BAE22088 (PubMed:16141072).Curated1
Sequence conflicti501N → D in BAD21386 (PubMed:15449545).Curated1
Sequence conflicti501N → D in BAE33372 (PubMed:16141072).Curated1
Sequence conflicti862A → V in BAD21386 (PubMed:15449545).Curated1
Sequence conflicti1108L → P in BAD21386 (PubMed:15449545).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0303871413 – 1460Missing in isoform 2, isoform 3 and isoform 6. 2 PublicationsAdd BLAST48
Alternative sequenceiVSP_0303881504Q → QAWLRGIK in isoform 2. 1 Publication1
Alternative sequenceiVSP_0303891505 – 1517SHSRA…PTTPL → AWLRGIKVRDQKQS in isoform 6. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK131136 mRNA Translation: BAD21386.1 Different initiation.
AK134295 mRNA Translation: BAE22088.1 Sequence problems.
AK143527 mRNA Translation: BAE25418.1
AK147761 mRNA Translation: BAE28120.1
AK155659 mRNA Translation: BAE33372.1 Sequence problems.
BC058405 mRNA Translation: AAH58405.1 Different initiation.
BC059018 mRNA Translation: AAH59018.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS49488.1 [Q3UPH7-1]
CCDS49489.1 [Q3UPH7-2]
CCDS59616.1 [Q3UPH7-3]

NCBI Reference Sequences

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RefSeqi
NP_001139393.1, NM_001145921.1 [Q3UPH7-2]
NP_001139394.1, NM_001145922.1 [Q3UPH7-3]
NP_937892.2, NM_198249.4 [Q3UPH7-1]
XP_006519107.1, XM_006519044.3 [Q3UPH7-1]
XP_006519109.1, XM_006519046.2 [Q3UPH7-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000093813; ENSMUSP00000091331; ENSMUSG00000004562 [Q3UPH7-1]
ENSMUST00000100639; ENSMUSP00000098204; ENSMUSG00000004562 [Q3UPH7-2]
ENSMUST00000182061; ENSMUSP00000138128; ENSMUSG00000004562 [Q3UPH7-3]
ENSMUST00000182909; ENSMUSP00000138635; ENSMUSG00000004562 [Q3UPH7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
268739

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:268739

UCSC genome browser

More...
UCSCi
uc007tnr.2, mouse [Q3UPH7-1]
uc007tns.2, mouse [Q3UPH7-2]
uc007tnt.2, mouse [Q3UPH7-3]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK131136 mRNA Translation: BAD21386.1 Different initiation.
AK134295 mRNA Translation: BAE22088.1 Sequence problems.
AK143527 mRNA Translation: BAE25418.1
AK147761 mRNA Translation: BAE28120.1
AK155659 mRNA Translation: BAE33372.1 Sequence problems.
BC058405 mRNA Translation: AAH58405.1 Different initiation.
BC059018 mRNA Translation: AAH59018.1
CCDSiCCDS49488.1 [Q3UPH7-1]
CCDS49489.1 [Q3UPH7-2]
CCDS59616.1 [Q3UPH7-3]
RefSeqiNP_001139393.1, NM_001145921.1 [Q3UPH7-2]
NP_001139394.1, NM_001145922.1 [Q3UPH7-3]
NP_937892.2, NM_198249.4 [Q3UPH7-1]
XP_006519107.1, XM_006519044.3 [Q3UPH7-1]
XP_006519109.1, XM_006519046.2 [Q3UPH7-2]

3D structure databases

SMRiQ3UPH7
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ3UPH7, 2 interactors
STRINGi10090.ENSMUSP00000091331

PTM databases

iPTMnetiQ3UPH7
PhosphoSitePlusiQ3UPH7

Proteomic databases

jPOSTiQ3UPH7
MaxQBiQ3UPH7
PaxDbiQ3UPH7
PeptideAtlasiQ3UPH7
PRIDEiQ3UPH7
ProteomicsDBi283205 [Q3UPH7-1]
283206 [Q3UPH7-2]
283207 [Q3UPH7-3]
283208 [Q3UPH7-6]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
22091, 31 antibodies

The DNASU plasmid repository

More...
DNASUi
268739

Genome annotation databases

EnsembliENSMUST00000093813; ENSMUSP00000091331; ENSMUSG00000004562 [Q3UPH7-1]
ENSMUST00000100639; ENSMUSP00000098204; ENSMUSG00000004562 [Q3UPH7-2]
ENSMUST00000182061; ENSMUSP00000138128; ENSMUSG00000004562 [Q3UPH7-3]
ENSMUST00000182909; ENSMUSP00000138635; ENSMUSG00000004562 [Q3UPH7-1]
GeneIDi268739
KEGGimmu:268739
UCSCiuc007tnr.2, mouse [Q3UPH7-1]
uc007tns.2, mouse [Q3UPH7-2]
uc007tnt.2, mouse [Q3UPH7-3]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
55701
MGIiMGI:2685515, Arhgef40

Phylogenomic databases

eggNOGiKOG0689, Eukaryota
GeneTreeiENSGT00940000161599
InParanoidiQ3UPH7
OMAiGAILMKL
OrthoDBi578732at2759
PhylomeDBiQ3UPH7
TreeFamiTF334329

Enzyme and pathway databases

ReactomeiR-MMU-193648, NRAGE signals death through JNK
R-MMU-194840, Rho GTPase cycle
R-MMU-416482, G alpha (12/13) signalling events

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
268739, 0 hits in 54 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Arhgef40, mouse

Protein Ontology

More...
PROi
PR:Q3UPH7
RNActiQ3UPH7, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000004562, Expressed in uterus and 250 other tissues
ExpressionAtlasiQ3UPH7, baseline and differential
GenevisibleiQ3UPH7, MM

Family and domain databases

Gene3Di1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035899, DBL_dom_sf
IPR000219, DH-domain
IPR011993, PH-like_dom_sf
IPR001849, PH_domain
PfamiView protein in Pfam
PF00621, RhoGEF, 1 hit
SMARTiView protein in SMART
SM00233, PH, 1 hit
SUPFAMiSSF48065, SSF48065, 1 hit
PROSITEiView protein in PROSITE
PS50010, DH_2, 1 hit
PS50003, PH_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiARH40_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UPH7
Secondary accession number(s): Q3U1X1
, Q3UGT7, Q3UYX3, Q6KAS1, Q6PD04, Q6PDY3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2005
Last modified: June 2, 2021
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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