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Entry version 123 (18 Sep 2019)
Sequence version 1 (11 Oct 2005)
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Protein

Sulfate anion transporter 1

Gene

Slc26a1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Mediates sulfate transport with high affinity. Mediates oxalate transport. Mediates bicarbonate transport. Does not accept succinate as cosubstrate.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAnion exchangeUniRule annotation, AntiportUniRule annotation, Ion transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Sulfate anion transporter 1UniRule annotation
Alternative name(s):
Solute carrier family 26 member 1UniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Slc26a1Imported
ORF Names:mCG_13597Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:2385894 Slc26a1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei73 – 93HelicalUniRule annotationAdd BLAST21
Transmembranei99 – 115HelicalUniRule annotationAdd BLAST17
Transmembranei181 – 207HelicalUniRule annotationAdd BLAST27
Transmembranei261 – 281HelicalUniRule annotationAdd BLAST21
Transmembranei293 – 313HelicalUniRule annotationAdd BLAST21
Transmembranei342 – 362HelicalUniRule annotationAdd BLAST21
Transmembranei382 – 404HelicalUniRule annotationAdd BLAST23
Transmembranei416 – 435HelicalUniRule annotationAdd BLAST20
Transmembranei479 – 504HelicalUniRule annotationAdd BLAST26

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000046959 Expressed in 65 organ(s), highest expression level in liver

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q3UPH6

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini540 – 690STASInterPro annotationAdd BLAST151

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the SLC26A/SulP transporter (TC 2.A.53) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG0236 Eukaryota
COG0659 LUCA

KEGG Orthology (KO)

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KOi
K14700

Database of Orthologous Groups

More...
OrthoDBi
690428at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR018045 S04_transporter_CS
IPR011547 SLC26A/SulP_dom
IPR001902 SLC26A/SulP_fam
IPR030331 SLC26A1
IPR002645 STAS_dom
IPR036513 STAS_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11814 PTHR11814, 1 hit
PTHR11814:SF31 PTHR11814:SF31, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01740 STAS, 1 hit
PF00916 Sulfate_transp, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52091 SSF52091, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00815 sulP, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01130 SLC26A, 1 hit
PS50801 STAS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3UPH6-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDASPEPQQK GGTLVLVRRQ PPVSQGLLET LKARLKKSCT CSMPCAQALV
60 70 80 90 100
QGLFPAIHWL PQYRLKEYLA GDVMSGLVIG IILVPQAIAY SLLAGLQPIY
110 120 130 140 150
SLYTSFFANL IYFLMGTSRH VNVGIFSLLC LMVGQVVDRE LQLAGFDPSQ
160 170 180 190 200
DSLGPKNNDS TLNNSATTLI IGLQDCRRDC YAIRVATALT LMAGLYQVLM
210 220 230 240 250
GILRLGFVST YLSQPLLDGF AMGASVTILT SQAKHMLGVQ IPRHQGLGMV
260 270 280 290 300
VHTWLSLLQN VGQANICDVV TSALCLGVLL AAKELSDRYR HRLKVPIPTE
310 320 330 340 350
LFVIVVATIV SHFGQLHTRF DSRVAGNIPT GFVAPQVPDP KIMWRVALDA
360 370 380 390 400
MSLALVGSAF SISLAEMFAR SHGYSVSANQ ELLAVGCCNV LPAFFHCFAT
410 420 430 440 450
SAALSKTLVK IATGCQTQLS SVVSAAVVLL VLLVLAPLFH DLQRCVLACI
460 470 480 490 500
IVVSLRGALR KVKDLPQLWR LSPADALVWV ATAATCVLVS TEAGLLAGVF
510 520 530 540 550
FSLLSLAGRT QRPRAALLAR IGDSTFYEDA AEFEGLLPPP EVRVFRFTGP
560 570 580 590 600
LYYANKDFFL RSLYRLTGLD AGHSATRKDQ GPEVGVSNRS LVDGKDLGSV
610 620 630 640 650
SSGAGLVVPL AFGFHTVVID CAPLLFLDVA GMATLKDLRR DYRALDITLL
660 670 680 690 700
LACCSPSVRD TLRKGGFLGE EQGAENELLF PSVHSAVEAA CARREELLAA

DSAL
Length:704
Mass (Da):75,788
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA6FA988522A6160A
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK143528 mRNA Translation: BAE25419.1
CH466529 Genomic DNA Translation: EDL20090.1
CH466529 Genomic DNA Translation: EDL20092.1

NCBI Reference Sequences

More...
RefSeqi
NP_001297621.1, NM_001310692.1
NP_777359.3, NM_174870.4
XP_006534974.1, XM_006534911.1
XP_011247743.1, XM_011249441.2
XP_017176343.1, XM_017320854.1
XP_017176344.1, XM_017320855.1
XP_017176345.1, XM_017320856.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
231583

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:231583

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK143528 mRNA Translation: BAE25419.1
CH466529 Genomic DNA Translation: EDL20090.1
CH466529 Genomic DNA Translation: EDL20092.1
RefSeqiNP_001297621.1, NM_001310692.1
NP_777359.3, NM_174870.4
XP_006534974.1, XM_006534911.1
XP_011247743.1, XM_011249441.2
XP_017176343.1, XM_017320854.1
XP_017176344.1, XM_017320855.1
XP_017176345.1, XM_017320856.1

3D structure databases

SMRiQ3UPH6
ModBaseiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi231583
KEGGimmu:231583

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10861
MGIiMGI:2385894 Slc26a1

Phylogenomic databases

eggNOGiKOG0236 Eukaryota
COG0659 LUCA
KOiK14700
OrthoDBi690428at2759

Miscellaneous databases

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000046959 Expressed in 65 organ(s), highest expression level in liver

Family and domain databases

InterProiView protein in InterPro
IPR018045 S04_transporter_CS
IPR011547 SLC26A/SulP_dom
IPR001902 SLC26A/SulP_fam
IPR030331 SLC26A1
IPR002645 STAS_dom
IPR036513 STAS_dom_sf
PANTHERiPTHR11814 PTHR11814, 1 hit
PTHR11814:SF31 PTHR11814:SF31, 1 hit
PfamiView protein in Pfam
PF01740 STAS, 1 hit
PF00916 Sulfate_transp, 1 hit
SUPFAMiSSF52091 SSF52091, 1 hit
TIGRFAMsiTIGR00815 sulP, 1 hit
PROSITEiView protein in PROSITE
PS01130 SLC26A, 1 hit
PS50801 STAS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3UPH6_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UPH6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: September 18, 2019
This is version 123 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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