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Entry version 112 (31 Jul 2019)
Sequence version 1 (11 Oct 2005)
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Protein

Voltage-dependent L-type calcium channel subunit alpha

Gene

Cacna1s

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death.UniRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalcium channelUniRule annotation, Ion channel, Voltage-gated channelUniRule annotation
Biological processCalcium transport, Ion transport, Transport
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Voltage-dependent L-type calcium channel subunit alphaUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Cacna1sImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:88294 Cacna1s

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei34 – 51HelicalSequence analysisAdd BLAST18
Transmembranei71 – 91HelicalSequence analysisAdd BLAST21
Transmembranei103 – 124HelicalSequence analysisAdd BLAST22
Transmembranei175 – 197HelicalSequence analysisAdd BLAST23
Transmembranei257 – 278HelicalSequence analysisAdd BLAST22
Transmembranei290 – 312HelicalSequence analysisAdd BLAST23
Transmembranei412 – 429HelicalSequence analysisAdd BLAST18
Transmembranei449 – 467HelicalSequence analysisAdd BLAST19
Transmembranei541 – 560HelicalSequence analysisAdd BLAST20
Transmembranei613 – 640HelicalSequence analysisAdd BLAST28
Transmembranei774 – 796HelicalSequence analysisAdd BLAST23
Transmembranei816 – 837HelicalSequence analysisAdd BLAST22
Transmembranei849 – 875HelicalSequence analysisAdd BLAST27
Transmembranei895 – 924HelicalSequence analysisAdd BLAST30
Transmembranei1021 – 1047HelicalSequence analysisAdd BLAST27
Transmembranei1101 – 1119HelicalSequence analysisAdd BLAST19
Transmembranei1131 – 1151HelicalSequence analysisAdd BLAST21
Transmembranei1226 – 1244HelicalSequence analysisAdd BLAST19
Transmembranei1317 – 1341HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3UPG8 MM

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini1475 – 1508Ca_chan_IQInterPro annotationAdd BLAST34

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni654 – 691DisorderedSequence analysisAdd BLAST38
Regioni710 – 736DisorderedSequence analysisAdd BLAST27
Regioni1662 – 1681DisorderedSequence analysisAdd BLAST20
Regioni1687 – 1725DisorderedSequence analysisAdd BLAST39

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi654 – 689PolyampholyteSequence analysisAdd BLAST36

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisSAAS annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2301 Eukaryota
ENOG410XNP6 LUCA

Database of Orthologous Groups

More...
OrthoDBi
172471at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.120.350, 4 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031688 CAC1F_C
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR005450 VDCC_L_a1ssu
IPR005446 VDCC_L_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf

The PANTHER Classification System

More...
PANTHERi
PTHR45628:SF9 PTHR45628:SF9, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16885 CAC1F_C, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00167 CACHANNEL
PR01630 LVDCCALPHA1
PR01634 LVDCCALPHA1S

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01062 Ca_chan_IQ, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q3UPG8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
EILPRPPRAL FCLTLQNPLR KACISIVEWK PFETIILLTI FANCVALAVY
60 70 80 90 100
LPMPEDDNNT LNLGLEKLEY FFLIVFSIEA AMKIIAYGFL FHQDAYLRSG
110 120 130 140 150
WNVLDFIIVF LGVFTVILEQ VNIIQTNTAP MSSKGAGLDV KALRAFRVLR
160 170 180 190 200
PLRLVSGVPS LQVVLNSIFK AMLPLFHIAL LVLFMVIIYA IIGLELFKGK
210 220 230 240 250
MHKTCYFIGT DIVATVENEK PSPCARTGSG RPCTINGSEC RGGWPGPNHG
260 270 280 290 300
ITHFDNFGFS MLTVYQCISM EGWTDVLYWV NDAIGNEWPW IYFVTLILLG
310 320 330 340 350
SFFILNLVLG VLSGEFTKER EKAKSRGTFQ KLREKQQLEE DLRGYMSWIT
360 370 380 390 400
QGEVMDVDDL REGKLSLDEG GSDTESLYEI EGLNKIIQFI RHWRQWNRVF
410 420 430 440 450
RWKCHDLVKS KVFYWLVILI VALNTLSIAS EHHNQPLWLT HLQDVANRVL
460 470 480 490 500
LTLFTIEMLM KMYGLGLRQY FMSIFNRFDC FVVCSGILEI LLVESGAMSP
510 520 530 540 550
LGISVLRCIR LLRLFKITKY WTSLSNLVAS LLNSIRSIAS LLLLLFLFII
560 570 580 590 600
IFALLGMQLF GGRYDFEDTE VRRSNFDNFP QALISVFQVL TGEDWNSVMY
610 620 630 640 650
NGIMAYGGPT YPGVLVCIYF IILFVCGNYI LLNVFLAIAV DNLAEAESLT
660 670 680 690 700
SAQKAKAEER KRRKMSKGLP DKSEEERATV TKKLEQKSKG EGIPTTAKLK
710 720 730 740 750
IDEFESNVNE VKDPYPSADF PGDDEEDEPE IPVSPRPRPL AELQLKEKAV
760 770 780 790 800
PIPEASSFFI FSPTNKIRVL CHRIVNATWF TNFILLFILL SSAALAAEDP
810 820 830 840 850
IRADSMRNQI LEYFDYVFTA VFTVEIVLKM TTYGAFLHKG SFCRNYFNIL
860 870 880 890 900
DLLVVAVSLI SMGLESSAIS VVKILRVLRV LRPLRAINRA KGLKHVVQCV
910 920 930 940 950
FVAIRTIGNI VLVTTLLQFM FACIGVQLFK GKFYSCNDLS KMTEEECRGY
960 970 980 990 1000
YYIYKDGDPT QIELRPRQWI HNDFHFDNVL SAMMSLFTVS TFEGWPQLLY
1010 1020 1030 1040 1050
KAIDSNEEDT GPVYNNRVEM AIFFIIYIIL IAFFMMNIFV GFVIVTFQEQ
1060 1070 1080 1090 1100
GETEYKNCEL DKNQRQCVQY ALKARPLRCY IPKNPYQYQV WYVVTSSYFE
1110 1120 1130 1140 1150
YLMFALIMLN TICLGMQHYN QSEQMNHISD ILNVAFTIIF TLEMVLKLIA
1160 1170 1180 1190 1200
FKPRGYFGDP WNVFDFLIVI GSIIDVILSE IDDPDESARI SSAFFRLFRV
1210 1220 1230 1240 1250
MRLVKLLNRA EGVRTLLWTF IKSFQALPYV ALLIVMLFFI YAVIGMQMFG
1260 1270 1280 1290 1300
KIAMVDGTQI NRNNNFQTFP QAVLLLFRCA TGEAWQEILL ACSYGKLCDP
1310 1320 1330 1340 1350
ESDYAPGEEH TCGTNFAYYY FISFYMLCAF LIINLFVAVI MDNFDYLTRD
1360 1370 1380 1390 1400
WSILGPHHLD EFKAIWAEYD PEAKGRIKHL DVVTLLRRIQ PPLGFGKFCP
1410 1420 1430 1440 1450
HRVACKRLVG MNMPLNSDGT VTFNATLFAL VRTALKIKTE GNFEQANEEL
1460 1470 1480 1490 1500
RAIIKKIWKR TSMKLLDQVI PPIGDDEVTV GKFYATFLIQ EHFRKFMKRQ
1510 1520 1530 1540 1550
EEYYGYRPKK DTVQIQAGLR TIEEEAAPEI HRAISGDLTA EEELERAMVE
1560 1570 1580 1590 1600
AAMEEGIFRR TGGLFGQVDN FLERTNSLPP VMANQRPLQF AEIEMEELES
1610 1620 1630 1640 1650
PVFLEDFPQN PGTHPLARAN TNNANANVAY GNSSHRNNPV FSSICYEREF
1660 1670 1680 1690 1700
LGEADMPVTR EGPLSQPCRA SGPHSRSHVD KLKRPMTQRG MPEGQVPPSP
1710 1720 1730 1740 1750
CQLSQAEHPV QKEGKGPTSR FLETPNSRNF EEHVPRNSAH RCTAPATAML
1760 1770 1780 1790 1800
IQEALVRGGL DSLAADANFV MATGQALADA CQMEPEEVEV AATELLKQES
1810
PEGGAVPWEP
Length:1,810
Mass (Da):206,066
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE22F1DFCC4A7820F
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei1Imported1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK143541 mRNA Translation: BAE25427.1

NCBI Reference Sequences

More...
RefSeqi
NP_055008.2, NM_014193.2

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
12292

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK143541 mRNA Translation: BAE25427.1
RefSeqiNP_055008.2, NM_014193.2

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

GeneIDi12292

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
779
MGIiMGI:88294 Cacna1s

Phylogenomic databases

eggNOGiKOG2301 Eukaryota
ENOG410XNP6 LUCA
OrthoDBi172471at2759

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Cacna1s mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

GenevisibleiQ3UPG8 MM

Family and domain databases

Gene3Di1.20.120.350, 4 hits
InterProiView protein in InterPro
IPR031688 CAC1F_C
IPR031649 GPHH_dom
IPR005821 Ion_trans_dom
IPR014873 VDCC_a1su_IQ
IPR005450 VDCC_L_a1ssu
IPR005446 VDCC_L_a1su
IPR002077 VDCCAlpha1
IPR027359 Volt_channel_dom_sf
PANTHERiPTHR45628:SF9 PTHR45628:SF9, 1 hit
PfamiView protein in Pfam
PF08763 Ca_chan_IQ, 1 hit
PF16885 CAC1F_C, 1 hit
PF16905 GPHH, 1 hit
PF00520 Ion_trans, 4 hits
PRINTSiPR00167 CACHANNEL
PR01630 LVDCCALPHA1
PR01634 LVDCCALPHA1S
SMARTiView protein in SMART
SM01062 Ca_chan_IQ, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ3UPG8_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UPG8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: July 31, 2019
This is version 112 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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