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Protein

Inactive phospholipase D5

Gene

Pld5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Caution

In contrast to other members of the family, it lacks the conserved active sites, suggesting that it has no phospholipase activity.Curated

GO - Molecular functioni

Names & Taxonomyi

Protein namesi
Recommended name:
Inactive phospholipase D5
Short name:
Inactive PLD 5
Alternative name(s):
Inactive choline phosphatase 5
Inactive phosphatidylcholine-hydrolyzing phospholipase D5
Gene namesi
Name:Pld5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 1

Organism-specific databases

MGIiMGI:2442056 Pld5

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 68CytoplasmicSequence analysisAdd BLAST68
Transmembranei69 – 89HelicalSequence analysisAdd BLAST21
Topological domaini90 – 536ExtracellularSequence analysisAdd BLAST447

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002886071 – 536Inactive phospholipase D5Add BLAST536

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi121N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi302N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ3UNN8
PRIDEiQ3UNN8

PTM databases

iPTMnetiQ3UNN8
PhosphoSitePlusiQ3UNN8

Expressioni

Gene expression databases

BgeeiENSMUSG00000055214 Expressed in 17 organ(s), highest expression level in cerebellum
CleanExiMM_PLD5
ExpressionAtlasiQ3UNN8 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069326

Structurei

3D structure databases

ProteinModelPortaliQ3UNN8
SMRiQ3UNN8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini215 – 242PLD phosphodiesterase 1PROSITE-ProRule annotationAdd BLAST28
Domaini434 – 460PLD phosphodiesterase 2PROSITE-ProRule annotationAdd BLAST27

Sequence similaritiesi

Belongs to the phospholipase D family.Curated

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3603 Eukaryota
ENOG410XQZ4 LUCA
GeneTreeiENSGT00390000009798
HOGENOMiHOG000293407
HOVERGENiHBG108266
InParanoidiQ3UNN8
KOiK16861
OrthoDBiEOG091G07LR
PhylomeDBiQ3UNN8
TreeFamiTF313378

Family and domain databases

InterProiView protein in InterPro
IPR032803 PLDc_3
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13918 PLDc_3, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 1 hit

Sequences (3+)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3UNN8-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEIRQHEWLS ASPHEGFEQM RLKSRPKEPS PSLTRVGANF YSSVKQQDYS
60 70 80 90 100
ASVWLRRKDK LEHSQQKCIV IFALVCCFAV LVALIFSAVD IMGEDEDGLS
110 120 130 140 150
EKNCQNKCRI ALVENIPEGL NYSEDAPFHL PLFQGWMNLL NMAKKSVDIV
160 170 180 190 200
SSHWDLNHTH PAACQGQRLF EKLLQLTSQN IEVKLVSDVT ADSKVLEALK
210 220 230 240 250
LKGAEVTYMN MTAYNKGRLQ SSFWIVDKQH VYIGSAGLDW RSLGQMKELG
260 270 280 290 300
VIFYNCSCLV LDLQRIFALY SSLKFKSRVP QTWSKRLYGV YDNEKKLQLQ
310 320 330 340 350
LNETKSQAFV SNSPKLFCPK NRSFDIDAIY SVIDDAKQYV YIAVTDYLPI
360 370 380 390 400
SSTSSKRTYW PDLDGKIREA LVLRSVKVRL LISFWKETDP LTFNFISSLK
410 420 430 440 450
AICTEIANCS LKVKFFDLER ENACATKEQK NQTFPKLNRN KYMVTDGAAY
460 470 480 490 500
IGNFDWVGND FTQNAGTGLV INQADVRDNR SIIKQLKDVF ERDWYSPYAK
510 520 530
SIQPTKQPNC SSLSKLKSPS KQPAMANATG REPLSV
Length:536
Mass (Da):61,066
Last modified:October 11, 2005 - v1
Checksum:i6A9D11644CF0FBBF
GO
Isoform 2 (identifier: Q3UNN8-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-91: Missing.

Note: No experimental confirmation available.
Show »
Length:445
Mass (Da):50,616
Checksum:i203DA401107D2E6E
GO
Isoform 3 (identifier: Q3UNN8-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-208: Missing.

Show »
Length:328
Mass (Da):37,523
Checksum:i36B745F4E372D86E
GO

Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3YYN6D3YYN6_MOUSE
Inactive phospholipase D5
Pld5
474Annotation score:
D6RCJ9D6RCJ9_MOUSE
Inactive phospholipase D5
Pld5
109Annotation score:
D3YZ01D3YZ01_MOUSE
Inactive phospholipase D5
Pld5
67Annotation score:

Sequence cautioni

The sequence AAI00429 differs from that shown. Reason: Erroneous termination at position 456. Translated as Trp.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0257281 – 208Missing in isoform 3. 1 PublicationAdd BLAST208
Alternative sequenceiVSP_0257291 – 91Missing in isoform 2. 1 PublicationAdd BLAST91

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136851 mRNA Translation: BAE23146.1
AK136888 mRNA Translation: BAE23156.1
AK144116 mRNA Translation: BAE25709.1
BC100428 mRNA Translation: AAI00429.1 Sequence problems.
CCDSiCCDS15552.1 [Q3UNN8-1]
RefSeqiNP_001182745.1, NM_001195816.1
NP_795890.2, NM_176916.4 [Q3UNN8-1]
XP_006496963.1, XM_006496900.3 [Q3UNN8-3]
XP_011237130.1, XM_011238828.1 [Q3UNN8-3]
XP_011237131.1, XM_011238829.2
XP_017176664.1, XM_017321175.1
UniGeneiMm.338001

Genome annotation databases

EnsembliENSMUST00000065967; ENSMUSP00000069326; ENSMUSG00000055214 [Q3UNN8-1]
GeneIDi319455
KEGGimmu:319455
UCSCiuc007dtw.1 mouse [Q3UNN8-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK136851 mRNA Translation: BAE23146.1
AK136888 mRNA Translation: BAE23156.1
AK144116 mRNA Translation: BAE25709.1
BC100428 mRNA Translation: AAI00429.1 Sequence problems.
CCDSiCCDS15552.1 [Q3UNN8-1]
RefSeqiNP_001182745.1, NM_001195816.1
NP_795890.2, NM_176916.4 [Q3UNN8-1]
XP_006496963.1, XM_006496900.3 [Q3UNN8-3]
XP_011237130.1, XM_011238828.1 [Q3UNN8-3]
XP_011237131.1, XM_011238829.2
XP_017176664.1, XM_017321175.1
UniGeneiMm.338001

3D structure databases

ProteinModelPortaliQ3UNN8
SMRiQ3UNN8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000069326

PTM databases

iPTMnetiQ3UNN8
PhosphoSitePlusiQ3UNN8

Proteomic databases

PaxDbiQ3UNN8
PRIDEiQ3UNN8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000065967; ENSMUSP00000069326; ENSMUSG00000055214 [Q3UNN8-1]
GeneIDi319455
KEGGimmu:319455
UCSCiuc007dtw.1 mouse [Q3UNN8-1]

Organism-specific databases

CTDi200150
MGIiMGI:2442056 Pld5

Phylogenomic databases

eggNOGiKOG3603 Eukaryota
ENOG410XQZ4 LUCA
GeneTreeiENSGT00390000009798
HOGENOMiHOG000293407
HOVERGENiHBG108266
InParanoidiQ3UNN8
KOiK16861
OrthoDBiEOG091G07LR
PhylomeDBiQ3UNN8
TreeFamiTF313378

Miscellaneous databases

PROiPR:Q3UNN8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000055214 Expressed in 17 organ(s), highest expression level in cerebellum
CleanExiMM_PLD5
ExpressionAtlasiQ3UNN8 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR032803 PLDc_3
IPR001736 PLipase_D/transphosphatidylase
PfamiView protein in Pfam
PF13918 PLDc_3, 1 hit
SMARTiView protein in SMART
SM00155 PLDc, 2 hits
PROSITEiView protein in PROSITE
PS50035 PLD, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLD5_MOUSE
AccessioniPrimary (citable) accession number: Q3UNN8
Secondary accession number(s): Q3UVW3, Q497Q7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 29, 2007
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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