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Entry version 106 (02 Jun 2021)
Sequence version 1 (11 Oct 2005)
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Protein

Myelin regulatory factor-like protein

Gene

Myrfl

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi108 – 400NDT80PROSITE-ProRule annotationAdd BLAST293

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDNA-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Myelin regulatory factor-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Myrfl
Synonyms:Gm239
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2685085, Myrfl

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei624 – 644HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004209561 – 904Myelin regulatory factor-like proteinAdd BLAST904

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q3UN70

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q3UN70

PRoteomics IDEntifications database

More...
PRIDEi
Q3UN70

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
291400

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q3UN70

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q3UN70

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000034057, Expressed in intestine and 82 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q3UN70, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000037477

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q3UN70, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q3UN70

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini446 – 554Peptidase S74PROSITE-ProRule annotationAdd BLAST109

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni46 – 132DisorderedSequence analysisAdd BLAST87
Regioni656 – 688DisorderedSequence analysisAdd BLAST33

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili538 – 575Sequence analysisAdd BLAST38

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi95 – 132Polar residuesSequence analysisAdd BLAST38

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the MRF family.Curated

Keywords - Domaini

Coiled coil, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG3661, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063626

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_004919_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q3UN70

Identification of Orthologs from Complete Genome Data

More...
OMAi
QVKGACY

Database of Orthologous Groups

More...
OrthoDBi
311898at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q3UN70

TreeFam database of animal gene trees

More...
TreeFami
TF312888

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025719, MYRF_C2
IPR026932, MYRF_ICA
IPR024061, NDT80_DNA-bd_dom
IPR008967, p53-like_TF_DNA-bd
IPR030392, S74_ICA

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13887, MRF_C1, 1 hit
PF13888, MRF_C2, 1 hit
PF05224, NDT80_PhoG, 1 hit
PF13884, Peptidase_S74, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49417, SSF49417, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51688, ICA, 1 hit
PS51517, NDT80, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q3UN70-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDVLGENEAL QQFFEAQGAS GTLENPALDT SLLEEFLGND FDLGALQRQL
60 70 80 90 100
PDTPPYSASD PRSPPQVKGA CCRTPRPPAG RIPAAFLHST TAPGPLPEHP
110 120 130 140 150
SQSMAGQTHS SFQNGYPESS HPATCRHQTG PSRLGTSCSF HQQPLCHVPG
160 170 180 190 200
SSLPPTKKRK HSQIQEDSWD CSSWAHYFRP MTTRSQSIEV QDHDREGRNG
210 220 230 240 250
MPVDQCSPAL KWQPYQSVPW HSLLNSRYEK LPEVGYQVVT DKGFTFSPVD
260 270 280 290 300
EAFVCQKKNH FQITVHIQVW GSPKFVKTQV GLKPIEKFYL KAFGIKVEAT
310 320 330 340 350
NQVIAIEQSQ ADRSKKTFDP VKIDLLTDQV TKVTLGRLHF SETTANNMRK
360 370 380 390 400
KGKPNPDQRY FMLVVGLYAA NQDQFYLLAA HISERIIVRA SNPGQFENDS
410 420 430 440 450
DALWQRGQVP ESIVCHGRVG INTDTPDEAL VVCGNMKVMG TVMHPSDSRV
460 470 480 490 500
KENIQEVDTN EQLRRIAQMR IVQYDYKPEF ASAMGINTAH QTGMIAQEVQ
510 520 530 540 550
EILPRAVREV GDVTGGNGET LENFLMVDKD QIFMENVGAV KQLCKLTNNL
560 570 580 590 600
EERIEELEIW NKKLARLKRL SSSWKSSISE ASSISKLSRA VSASSARRTG
610 620 630 640 650
SKKPTKVSFS GRKQSCPNWV FQTLVVVLIA VMAFCALTIV ALYILSLKDQ
660 670 680 690 700
DRRSPNLPLS NMTSSPEPAL SSTAPTSAPH TTPETTQTSL QVPEITFCEI
710 720 730 740 750
LPCQETYCCP VWGPRILFSS PAQRQLEAER EIHQRQWAED KSKSFLTSSA
760 770 780 790 800
LISPDWESDW IDTTIASIQI VEIQQMIDRR YCSRMLHCGP GHYNYNIPVN
810 820 830 840 850
KNTPTNVKFS LEINTTEPLI VFQCKYTLGN ICFRSQRERT QSDGEDAQMT
860 870 880 890 900
QGYQHIWRLP VARFSDSAYH FRVAAPDLAD CSTDPFFAGI FFTDYFFYFY

RRCN
Length:904
Mass (Da):101,689
Last modified:October 11, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9E66E53A34B3221
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti682T → N in BAE25858 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK144411 mRNA Translation: BAE25877.1
AK144383 mRNA Translation: BAE25858.1
AC123720 Genomic DNA No translation available.
AC132304 Genomic DNA No translation available.
BC150915 mRNA Translation: AAI50916.1
BC150923 mRNA Translation: AAI50924.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS36066.1

NCBI Reference Sequences

More...
RefSeqi
NP_001028505.1, NM_001033333.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000048229; ENSMUSP00000037477; ENSMUSG00000034057

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
237558

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:237558

UCSC genome browser

More...
UCSCi
uc007hci.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK144411 mRNA Translation: BAE25877.1
AK144383 mRNA Translation: BAE25858.1
AC123720 Genomic DNA No translation available.
AC132304 Genomic DNA No translation available.
BC150915 mRNA Translation: AAI50916.1
BC150923 mRNA Translation: AAI50924.1
CCDSiCCDS36066.1
RefSeqiNP_001028505.1, NM_001033333.3

3D structure databases

SMRiQ3UN70
ModBaseiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000037477

PTM databases

iPTMnetiQ3UN70
PhosphoSitePlusiQ3UN70

Proteomic databases

MaxQBiQ3UN70
PaxDbiQ3UN70
PRIDEiQ3UN70
ProteomicsDBi291400

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
62193, 5 antibodies

Genome annotation databases

EnsembliENSMUST00000048229; ENSMUSP00000037477; ENSMUSG00000034057
GeneIDi237558
KEGGimmu:237558
UCSCiuc007hci.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
196446
MGIiMGI:2685085, Myrfl

Phylogenomic databases

eggNOGiKOG3661, Eukaryota
GeneTreeiENSGT00530000063626
HOGENOMiCLU_004919_1_0_1
InParanoidiQ3UN70
OMAiQVKGACY
OrthoDBi311898at2759
PhylomeDBiQ3UN70
TreeFamiTF312888

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
237558, 0 hits in 52 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Myrfl, mouse

Protein Ontology

More...
PROi
PR:Q3UN70
RNActiQ3UN70, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000034057, Expressed in intestine and 82 other tissues
GenevisibleiQ3UN70, MM

Family and domain databases

InterProiView protein in InterPro
IPR025719, MYRF_C2
IPR026932, MYRF_ICA
IPR024061, NDT80_DNA-bd_dom
IPR008967, p53-like_TF_DNA-bd
IPR030392, S74_ICA
PfamiView protein in Pfam
PF13887, MRF_C1, 1 hit
PF13888, MRF_C2, 1 hit
PF05224, NDT80_PhoG, 1 hit
PF13884, Peptidase_S74, 1 hit
SUPFAMiSSF49417, SSF49417, 1 hit
PROSITEiView protein in PROSITE
PS51688, ICA, 1 hit
PS51517, NDT80, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMRFL_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UN70
Secondary accession number(s): Q3UN89
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 6, 2013
Last sequence update: October 11, 2005
Last modified: June 2, 2021
This is version 106 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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