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Protein

Ceroid-lipofuscinosis neuronal protein 5 homolog

Gene

Cln5

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in influencing the retrograde trafficking of lysosomal sorting receptors SORT1 and IGF2R from the endosomes to the trans-Golgi network by controlling the recruitment of retromer complex to the endosomal membrane. Regulates the localization and activation of RAB7A which is required to recruit the retromer complex to the endosomal membrane.By similarity

GO - Molecular functioni

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Ceroid-lipofuscinosis neuronal protein 5 homolog
Short name:
Protein CLN5
Cleaved into the following chain:
Gene namesi
Name:Cln5
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 14

Organism-specific databases

MGIiMGI:2442253 Cln5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 13CytoplasmicBy similarityAdd BLAST13
Transmembranei14 – 30Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST17
Topological domaini31 – 341LumenalBy similarityAdd BLAST311

Keywords - Cellular componenti

Lysosome, Membrane

Pathology & Biotechi

Keywords - Diseasei

Neurodegeneration, Neuronal ceroid lipofuscinosis

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_0000438010? – 341Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form
ChainiPRO_00003304711 – 341Ceroid-lipofuscinosis neuronal protein 5 homologAdd BLAST341

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi113N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi126N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi161N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi186N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi238N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi254N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi264N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

N-glycosylated with both high mannose and complex type sugars. Glycosylation is important for proper folding and trafficking to the lysosomes.By similarity
Ceroid-lipofuscinosis neuronal protein 5 homolog: The type II membrane signal anchor is proteolytically cleaved to produce a mature form that is transported to the lysosomes (Ceroid-lipofuscinosis neuronal protein 5 homolog, secreted form).By similarity
Can undergo proteolytic cleavage at the C-terminus, probably by a cysteine protease and may involve the removal of approximately 10-15 residues from the C-terminal end (PubMed:26342652).1 Publication

Keywords - PTMi

Glycoprotein

Proteomic databases

EPDiQ3UMW8
MaxQBiQ3UMW8
PaxDbiQ3UMW8
PRIDEiQ3UMW8

PTM databases

PhosphoSitePlusiQ3UMW8
SwissPalmiQ3UMW8

Expressioni

Tissue specificityi

Heart, kidney, liver, spleen, muscle and rectum (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000022125 Expressed in 264 organ(s), highest expression level in placenta labyrinth
ExpressionAtlasiQ3UMW8 baseline and differential
GenevisibleiQ3UMW8 MM

Interactioni

Subunit structurei

Interacts with PPT1, TPP1, CLN3, CLN6, CLN8, ATP5F1A and ATP5F1B (PubMed:19941651). Interacts with SORT1, RAB5A and RAB7A (By similarity).By similarity1 Publication

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022721

Structurei

3D structure databases

ProteinModelPortaliQ3UMW8
SMRiQ3UMW8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni287 – 326Membrane-anchoringBy similarityAdd BLAST40

Sequence similaritiesi

Belongs to the CLN5 family.Curated

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJEH Eukaryota
ENOG4110RH0 LUCA
GeneTreeiENSGT00390000010065
HOGENOMiHOG000060233
HOVERGENiHBG005345
InParanoidiQ3UMW8
KOiK12390
OMAiNAPFWCN
OrthoDBiEOG091G0B86
PhylomeDBiQ3UMW8
TreeFamiTF330864

Family and domain databases

InterProiView protein in InterPro
IPR026138 CLN5
PANTHERiPTHR15380 PTHR15380, 1 hit
PfamiView protein in Pfam
PF15014 CLN5, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q3UMW8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRGGPCGAH WRPALALALL GLATILGASP TSGQRWPVPY KRFSFRPKTD
60 70 80 90 100
PYCQAKYTFC PTGSPIPVMK DNDVIEVLRL QAPIWEFKYG DLLGHFKLMH
110 120 130 140 150
DAVGFRSTLT GKNYTIEWYE LFQLGNCTFP HLRPDKSAPF WCNQGAACFF
160 170 180 190 200
EGIDDKHWKE NGTLSVVATI SGNTFNKVAE WVKQDNETGI YYETWTVRAG
210 220 230 240 250
PGQGAQTWFE SYDCSNFVLR TYKKLAEFGT EFKKIETNYT KIFLYSGEPI
260 270 280 290 300
YLGNETSIFG PKGNKTLALA IKKFYGPFRP YLSTKDFLMN FLKIFDTVII
310 320 330 340
HRQFYLFYNF EYWFLPMKPP FVKITYEETP LPTRHTTFTD L
Length:341
Mass (Da):39,329
Last modified:October 11, 2005 - v1
Checksum:i1969A4003CAF0E4D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A2I3BRB6A0A2I3BRB6_MOUSE
Ceroid-lipofuscinosis neuronal prot...
Cln5
37Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti6 – 8PCG → TRP in AAH25487 (PubMed:15489334).Curated3
Sequence conflicti42R → H in BAC27797 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032293 mRNA Translation: BAC27797.1
AK144635 mRNA Translation: BAE25980.1
BC025487 mRNA Translation: AAH25487.1
CCDSiCCDS27314.1
RefSeqiNP_001028414.1, NM_001033242.1
UniGeneiMm.295289

Genome annotation databases

EnsembliENSMUST00000022721; ENSMUSP00000022721; ENSMUSG00000022125
GeneIDi211286
KEGGimmu:211286
UCSCiuc007uwg.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK032293 mRNA Translation: BAC27797.1
AK144635 mRNA Translation: BAE25980.1
BC025487 mRNA Translation: AAH25487.1
CCDSiCCDS27314.1
RefSeqiNP_001028414.1, NM_001033242.1
UniGeneiMm.295289

3D structure databases

ProteinModelPortaliQ3UMW8
SMRiQ3UMW8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000022721

PTM databases

PhosphoSitePlusiQ3UMW8
SwissPalmiQ3UMW8

Proteomic databases

EPDiQ3UMW8
MaxQBiQ3UMW8
PaxDbiQ3UMW8
PRIDEiQ3UMW8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000022721; ENSMUSP00000022721; ENSMUSG00000022125
GeneIDi211286
KEGGimmu:211286
UCSCiuc007uwg.1 mouse

Organism-specific databases

CTDi1203
MGIiMGI:2442253 Cln5

Phylogenomic databases

eggNOGiENOG410IJEH Eukaryota
ENOG4110RH0 LUCA
GeneTreeiENSGT00390000010065
HOGENOMiHOG000060233
HOVERGENiHBG005345
InParanoidiQ3UMW8
KOiK12390
OMAiNAPFWCN
OrthoDBiEOG091G0B86
PhylomeDBiQ3UMW8
TreeFamiTF330864

Miscellaneous databases

ChiTaRSiCln5 mouse
PROiPR:Q3UMW8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000022125 Expressed in 264 organ(s), highest expression level in placenta labyrinth
ExpressionAtlasiQ3UMW8 baseline and differential
GenevisibleiQ3UMW8 MM

Family and domain databases

InterProiView protein in InterPro
IPR026138 CLN5
PANTHERiPTHR15380 PTHR15380, 1 hit
PfamiView protein in Pfam
PF15014 CLN5, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCLN5_MOUSE
AccessioniPrimary (citable) accession number: Q3UMW8
Secondary accession number(s): Q8C054, Q8R152
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 29, 2008
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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