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UniProtKB - Q3UMU9 (HDGR2_MOUSE)

Entry version 127 (02 Dec 2020)
Sequence version 1 (17 Oct 2006)
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Protein

Hepatoma-derived growth factor-related protein 2

Gene

Hdgfl2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Involved in cellular growth control, through the regulation of cyclin D1 expression (By similarity). Associates with chromatin. Isoform 1 and isoform 3 bind to condensed chromatin in mitotic cells. Isoform 4 binds to non-condensed chromatin in the presence of HDGF.By similarity1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Hepatoma-derived growth factor-related protein 2
Short name:
HRP-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hdgfl2
Synonyms:Hdgfrp2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 17

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...MGIi		MGI:1194492, Hdgfl2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003176441 – 669Hepatoma-derived growth factor-related protein 2Add BLAST669

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei114PhosphoserineBy similarity1
Modified residuei137PhosphoserineBy similarity1
Modified residuei165PhosphoserineBy similarity1
Modified residuei229PhosphoserineBy similarity1
Modified residuei231PhosphoserineBy similarity1
Modified residuei233PhosphoserineBy similarity1
Modified residuei239PhosphoserineBy similarity1
Modified residuei268PhosphoserineBy similarity1
Modified residuei307PhosphoserineBy similarity1
Modified residuei366PhosphoserineCombined sources1
Modified residuei367PhosphoserineCombined sources1
Modified residuei391PhosphoserineBy similarity1
Modified residuei392PhosphoserineBy similarity1
Modified residuei393PhosphoserineBy similarity1
Modified residuei395PhosphoserineBy similarity1
Modified residuei450PhosphoserineCombined sources1
Modified residuei454PhosphoserineBy similarity1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki550Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei620PhosphoserineCombined sources1
Modified residuei628PhosphoserineCombined sources1
Modified residuei629PhosphoserineCombined sources1
Modified residuei635PhosphoserineCombined sources1
Modified residuei640PhosphoserineCombined sources1
Modified residuei659PhosphoserineCombined sources1
Modified residuei661PhosphoserineCombined sources1
Modified residuei669PhosphoserineCombined sources1
Isoform 4 (identifier: Q3UMU9-4)
Modified residuei567PhosphoserineCombined sources1
Isoform 2 (identifier: Q3UMU9-2)
Modified residuei619PhosphoserineCombined sources1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q3UMU9

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q3UMU9

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q3UMU9

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q3UMU9

PeptideAtlas

More...PeptideAtlasi		Q3UMU9

PRoteomics IDEntifications database

More...PRIDEi		Q3UMU9

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q3UMU9

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q3UMU9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSMUSG00000002833, Expressed in ear vesicle and 281 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q3UMU9, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with HDGF (PubMed:22212508). Isoform 4 selectively interacts with HDGF (N-terminally processed form).

Interacts with trimethylated 'Lys-36' of histone H3 (H3K36me3).

Interacts with trimethylated 'Lys-79' of histone H3 (H3K79me3), but has higher affinity for H3K36me3 (By similarity).

Interacts with IWS1 (By similarity).

By similarity1 Publication

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		200267, 8 interactors

Protein interaction database and analysis system

More...IntActi		Q3UMU9, 6 interactors

Molecular INTeraction database

More...MINTi		Q3UMU9

STRING: functional protein association networks

More...STRINGi		10090.ENSMUSP00000002911

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q3UMU9, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q3UMU9

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini7 – 64PWWPPROSITE-ProRule annotationAdd BLAST58

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili550 – 575Sequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi142 – 271Ser-richAdd BLAST130
Compositional biasi322 – 363Arg-richAdd BLAST42

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the HDGF family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1904, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000153942

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_034054_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q3UMU9

Identification of Orthologs from Complete Genome Data

More...OMAi		PHNFQAG

Database of Orthologous Groups

More...OrthoDBi		530959at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q3UMU9

TreeFam database of animal gene trees

More...TreeFami		TF105385

Family and domain databases

Conserved Domains Database

More...CDDi		cd05834, HDGF_related, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR035496, HDGF-rel_PWWP
IPR036218, HIVI-bd_sf
IPR021567, LEDGF_IBD
IPR000313, PWWP_dom
IPR035441, TFIIS/LEDGF_dom_sf

Pfam protein domain database

More...Pfami		View protein in Pfam
PF11467, LEDGF, 1 hit
PF00855, PWWP, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00293, PWWP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF140576, SSF140576, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS50812, PWWP, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q3UMU9-1) [UniParc]FASTAAdd to basket
Also known as: Isoform a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MPHAFKPGDL VFAKMKGYPH WPARIDDIAD GAVKPPPNKY PIFFFGTHET 
        60         70         80         90        100
AFLGPKDLFP YDKCKDKYGK PNKRKGFNEG LWEIQNNPHA SYSAPPPVSS 
       110        120        130        140        150
SDSEAPEADL GCGSDVDKDK ESRRVMTVTA VTTTATSDRM ESDSDSDKSS 
       160        170        180        190        200
DHSGLKRKTP VLKVSVSKRA RRASSDLDQA SVSPSEEDSE SPSESEKTSD 
       210        220        230        240        250
QDFTPEKKTA ARPPRRGPLG GRKKKKVPSA SDSDSKADSD GAKEEPVVTA 
       260        270        280        290        300
QPSPSSSSSS SSSSSSDSDV SVKKPPRGRK PAEKPPPKPR GRRPKPERPP 
       310        320        330        340        350
STSSSDSDSD SGEVDRISEW KRRDEERRRE LEARRRREQE EELRRLREQE 
       360        370        380        390        400
REEKERRKER AERGGSSGEE LEDEEPVKKR SRKARGRGTP SSSDSEPEGE 
       410        420        430        440        450
LGKEGKKLAK KSQLPGSESA RKPGQKEKRG RPDEKPRARP VKVERTRKRS 
       460        470        480        490        500
EGLSLERKGE KKKEPSVEER LQKLHSEIKF ALKVDNPDVR KCLSALEELG 
       510        520        530        540        550
TLQVTSQILQ KNTDVVATLK KIRRYKANKD VMAKAAEVYT RLKSRVLGPK 
       560        570        580        590        600
VEALQKVNKA GAEKERADNE KLEEQPGEQA PRELAEDEPS TDRSAPVNGE 
       610        620        630        640        650
ATSQKGENME DRAQEDGQDS EDGPRGGSSE ELHDSPRDNS DPAKPGNERQ 
       660 
DHERTRLASE SANDDNEDS
Length:669
Mass (Da):74,291
Last modified:October 17, 2006 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i01228985D4616848
GO
Isoform 2 (identifier: Q3UMU9-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     226-226: Missing.
     635-635: Missing.

Show »
Length:667
Mass (Da):74,075
Checksum:iE8B865571B20D78B
GO
Isoform 3 (identifier: Q3UMU9-3) [UniParc]FASTAAdd to basket
Also known as: Isoform b

The sequence of this isoform differs from the canonical sequence as follows:
     224-225: KK → KKHPTGYACPQ

Show »
Length:678
Mass (Da):75,246
Checksum:i034861DA18787C49
GO
Isoform 4 (identifier: Q3UMU9-4) [UniParc]FASTAAdd to basket
Also known as: Isoform c

The sequence of this isoform differs from the canonical sequence as follows:
     66-118: Missing.
     635-635: Missing.

Show »
Length:615
Mass (Da):68,530
Checksum:i71CD1E3AEE4761EE
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_04764866 – 118Missing in isoform 4. 1 PublicationAdd BLAST53
Alternative sequenceiVSP_031117224 – 225KK → KKHPTGYACPQ in isoform 3. 2 Publications2
Alternative sequenceiVSP_031118226Missing in isoform 2. 1 Publication1
Alternative sequenceiVSP_031119635Missing in isoform 2 and isoform 4. 2 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
D63850 mRNA Translation: BAA22896.1
FN687734 mRNA Translation: CBK52221.2
AK143616 mRNA Translation: BAE25467.1
AK144669 mRNA Translation: BAE25999.1
AK146813 mRNA Translation: BAE27453.1
AK146918 mRNA Translation: BAE27530.1
BC003741 mRNA Translation: AAH03741.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS28894.1 [Q3UMU9-1]
CCDS89122.1 [Q3UMU9-3]
CCDS89123.1 [Q3UMU9-2]

Protein sequence database of the Protein Information Resource

More...PIRi		JC5662

NCBI Reference Sequences

More...RefSeqi		NP_001291713.1, NM_001304784.2 [Q3UMU9-3]
NP_001291714.1, NM_001304785.2 [Q3UMU9-2]
NP_001317982.1, NM_001331053.1
NP_032259.1, NM_008233.4 [Q3UMU9-1]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSMUST00000002911; ENSMUSP00000002911; ENSMUSG00000002833 [Q3UMU9-2]
ENSMUST00000225843; ENSMUSP00000153249; ENSMUSG00000002833 [Q3UMU9-3]
ENSMUST00000226053; ENSMUSP00000152948; ENSMUSG00000002833 [Q3UMU9-1]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		15193

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		mmu:15193

UCSC genome browser

More...UCSCi		uc008dau.2, mouse [Q3UMU9-1]
uc008dav.3, mouse [Q3UMU9-2]
uc008daw.2, mouse [Q3UMU9-3]
uc012avq.2, mouse [Q3UMU9-4]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D63850 mRNA Translation: BAA22896.1
FN687734 mRNA Translation: CBK52221.2
AK143616 mRNA Translation: BAE25467.1
AK144669 mRNA Translation: BAE25999.1
AK146813 mRNA Translation: BAE27453.1
AK146918 mRNA Translation: BAE27530.1
BC003741 mRNA Translation: AAH03741.1
CCDSiCCDS28894.1 [Q3UMU9-1]
CCDS89122.1 [Q3UMU9-3]
CCDS89123.1 [Q3UMU9-2]
PIRiJC5662
RefSeqiNP_001291713.1, NM_001304784.2 [Q3UMU9-3]
NP_001291714.1, NM_001304785.2 [Q3UMU9-2]
NP_001317982.1, NM_001331053.1
NP_032259.1, NM_008233.4 [Q3UMU9-1]

3D structure databases

SMRiQ3UMU9
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi200267, 8 interactors
IntActiQ3UMU9, 6 interactors
MINTiQ3UMU9
STRINGi10090.ENSMUSP00000002911

PTM databases

iPTMnetiQ3UMU9
PhosphoSitePlusiQ3UMU9

Proteomic databases

EPDiQ3UMU9
jPOSTiQ3UMU9
MaxQBiQ3UMU9
PaxDbiQ3UMU9
PeptideAtlasiQ3UMU9
PRIDEiQ3UMU9

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		42428, 137 antibodies

Genome annotation databases

EnsembliENSMUST00000002911; ENSMUSP00000002911; ENSMUSG00000002833 [Q3UMU9-2]
ENSMUST00000225843; ENSMUSP00000153249; ENSMUSG00000002833 [Q3UMU9-3]
ENSMUST00000226053; ENSMUSP00000152948; ENSMUSG00000002833 [Q3UMU9-1]
GeneIDi15193
KEGGimmu:15193
UCSCiuc008dau.2, mouse [Q3UMU9-1]
uc008dav.3, mouse [Q3UMU9-2]
uc008daw.2, mouse [Q3UMU9-3]
uc012avq.2, mouse [Q3UMU9-4]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		84717
MGIiMGI:1194492, Hdgfl2

Phylogenomic databases

eggNOGiKOG1904, Eukaryota
GeneTreeiENSGT00940000153942
HOGENOMiCLU_034054_0_0_1
InParanoidiQ3UMU9
OMAiPHNFQAG
OrthoDBi530959at2759
PhylomeDBiQ3UMU9
TreeFamiTF105385

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		15193, 0 hits in 14 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		Hdgfl2, mouse

Protein Ontology

More...PROi		PR:Q3UMU9
RNActiQ3UMU9, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSMUSG00000002833, Expressed in ear vesicle and 281 other tissues
GenevisibleiQ3UMU9, MM

Family and domain databases

CDDicd05834, HDGF_related, 1 hit
Gene3Di1.20.930.10, 1 hit
InterProiView protein in InterPro
IPR035496, HDGF-rel_PWWP
IPR036218, HIVI-bd_sf
IPR021567, LEDGF_IBD
IPR000313, PWWP_dom
IPR035441, TFIIS/LEDGF_dom_sf
PfamiView protein in Pfam
PF11467, LEDGF, 1 hit
PF00855, PWWP, 1 hit
SMARTiView protein in SMART
SM00293, PWWP, 1 hit
SUPFAMiSSF140576, SSF140576, 1 hit
PROSITEiView protein in PROSITE
PS50812, PWWP, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHDGR2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q3UMU9
Secondary accession number(s): D6CHX5
, O35540, Q3UIH6, Q99L92
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 5, 2008
Last sequence update: October 17, 2006
Last modified: December 2, 2020
This is version 127 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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