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Protein

Protein phosphatase 1 regulatory subunit 12C

Gene

Ppp1r12c

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates myosin phosphatase activity.By similarity

GO - Molecular functioni

  • enzyme inhibitor activity Source: GO_Central
  • phosphatase regulator activity Source: GO_Central
  • protein kinase binding Source: InterPro

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 12C
Alternative name(s):
Protein phosphatase 1 myosin-binding subunit of 85 kDa
Short name:
Protein phosphatase 1 myosin-binding subunit p85
Gene namesi
Name:Ppp1r12cImported
Synonyms:Mbs851 Publication
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1924258 Ppp1r12c

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003158642 – 782Protein phosphatase 1 regulatory subunit 12CAdd BLAST781

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylserineBy similarity1
Modified residuei403PhosphoserineCombined sources1
Modified residuei411PhosphoserineBy similarity1
Modified residuei431PhosphoserineBy similarity1
Modified residuei454PhosphoserineBy similarity1
Modified residuei509PhosphoserineBy similarity1
Modified residuei560PhosphothreonineCombined sources1
Modified residuei647PhosphoserineCombined sources1

Post-translational modificationi

Phosphorylation at Thr-560 is essential for its interaction with PPP1CB.By similarity

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ3UMT1
MaxQBiQ3UMT1
PaxDbiQ3UMT1
PeptideAtlasiQ3UMT1
PRIDEiQ3UMT1

PTM databases

iPTMnetiQ3UMT1
PhosphoSitePlusiQ3UMT1

Expressioni

Gene expression databases

BgeeiENSMUSG00000019254 Expressed in 240 organ(s), highest expression level in brain
ExpressionAtlasiQ3UMT1 baseline and differential
GenevisibleiQ3UMT1 MM

Interactioni

Subunit structurei

PP1 comprises a catalytic subunit, PPP1CA, PPP1CB or PPP1CC, and one or several targeting or regulatory subunits. PPP1R12C mediates binding to myosin. Interacts via its N-terminus with PPP1CB. Interacts with IL16. Interacts with the coiled-coil domain of MPRIP. Interacts with NOD2 (By similarity).By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ3UMT1, 2 interactors
STRINGi10090.ENSMUSP00000013886

Structurei

3D structure databases

ProteinModelPortaliQ3UMT1
SMRiQ3UMT1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati104 – 133ANK 1Sequence analysisAdd BLAST30
Repeati137 – 166ANK 2Sequence analysisAdd BLAST30
Repeati230 – 259ANK 3Sequence analysisAdd BLAST30
Repeati263 – 292ANK 4Sequence analysisAdd BLAST30

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili301 – 332Sequence analysisAdd BLAST32
Coiled coili681 – 782Sequence analysisAdd BLAST102

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi8 – 96Ala-richSequence analysisAdd BLAST89

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG0505 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00760000119141
HOGENOMiHOG000290648
HOVERGENiHBG104929
InParanoidiQ3UMT1
KOiK17457
OMAiNSEGPAQ
OrthoDBiEOG091G06U5
TreeFamiTF105543

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017401 MYPT1/MYPT2/Mbs85
IPR031205 PPP1R12C
IPR031775 PRKG1_interact
PANTHERiPTHR24179:SF27 PTHR24179:SF27, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF15898 PRKG1_interact, 1 hit
PIRSFiPIRSF038141 PP1_12ABC_vert, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q3UMT1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGEDGPAAG PGAAAAAAAA RERRQEQLRQ WGARAGADPG PGERRARTVR
60 70 80 90 100
FERAAEFLAA CAGGDLDEAR LMLRAADPGP GSGAASDPAV PPPARAVLDS
110 120 130 140 150
TNADGISALH QACIDENLEV VRFLVEQGAT VNQADNEGWT PLHVAASCGY
160 170 180 190 200
LDIARYLLSH GANIAAVNSD GDLPLDLAES DAMEGLLKAE ITRRGVDVEA
210 220 230 240 250
AKRAEEELLL HDTRCWLNGG AMPEARHPRT GASALHVAAA KGYIEVMRLL
260 270 280 290 300
LQAGYDTELR DGDGWTPLHA AAHWGVEDAC RLLAEHGGGM DSLTHAGQRP
310 320 330 340 350
CDLADEDVMN LLEELAQKQE DLRNQKEGSQ GRGQESQVPS SSKHRRSSVC
360 370 380 390 400
RLSSREKISL QDLSKERRPG GAGGPPIGDE DEGGEASAEH PAVEPRALNG
410 420 430 440 450
VSSPVSSNPK SPVLPEEAPF SRRFGLQKTG STGALGPSER RATEGVLGLQ
460 470 480 490 500
RSASSSLLEK ASTQAREPRL ARITPTPAQK VPEPFTLYEA ATPPSLDHSV
510 520 530 540 550
PPSRREPGSI VKPNVLTASA APLADSRDRR RSYQMPVRDE ESESQRKARS
560 570 580 590 600
RLMRQSRRST QGVTLTDLKE AEKVAGKVPE PEQPALPSLD PSRRPRVPGV
610 620 630 640 650
ENAEGPAQRE APEGQGQGPQ AAREHRKAGH ERRGPAEGEE AGPAERSPEC
660 670 680 690 700
STVDGGSQVR RQHSQRDLVL ESKQEHEEPD GGFRKMYTEL RRENERLREA
710 720 730 740 750
LTETTLRLAQ LKVELERATQ RQERFAERPA LLELERFERR ALERKAAELE
760 770 780
EELKALSDLR ADNQRLKDEN AALIRVISKL SK
Length:782
Mass (Da):84,685
Last modified:October 11, 2005 - v1
Checksum:i83C2708E36BFBD7B
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6XWD4F6XWD4_MOUSE
Protein phosphatase 1 regulatory su...
Ppp1r12c
704Annotation score:
A0A0U1RPR6A0A0U1RPR6_MOUSE
Protein phosphatase 1 regulatory su...
Ppp1r12c
102Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti30Q → R in BAB27215 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010836 mRNA Translation: BAB27215.1
AK144691 mRNA Translation: BAE26017.1
CCDSiCCDS39735.1
RefSeqiNP_084110.2, NM_029834.3
UniGeneiMm.360391

Genome annotation databases

EnsembliENSMUST00000013886; ENSMUSP00000013886; ENSMUSG00000019254
GeneIDi232807
KEGGimmu:232807
UCSCiuc009exq.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK010836 mRNA Translation: BAB27215.1
AK144691 mRNA Translation: BAE26017.1
CCDSiCCDS39735.1
RefSeqiNP_084110.2, NM_029834.3
UniGeneiMm.360391

3D structure databases

ProteinModelPortaliQ3UMT1
SMRiQ3UMT1
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3UMT1, 2 interactors
STRINGi10090.ENSMUSP00000013886

PTM databases

iPTMnetiQ3UMT1
PhosphoSitePlusiQ3UMT1

Proteomic databases

EPDiQ3UMT1
MaxQBiQ3UMT1
PaxDbiQ3UMT1
PeptideAtlasiQ3UMT1
PRIDEiQ3UMT1

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000013886; ENSMUSP00000013886; ENSMUSG00000019254
GeneIDi232807
KEGGimmu:232807
UCSCiuc009exq.1 mouse

Organism-specific databases

CTDi54776
MGIiMGI:1924258 Ppp1r12c

Phylogenomic databases

eggNOGiKOG0505 Eukaryota
COG0666 LUCA
GeneTreeiENSGT00760000119141
HOGENOMiHOG000290648
HOVERGENiHBG104929
InParanoidiQ3UMT1
KOiK17457
OMAiNSEGPAQ
OrthoDBiEOG091G06U5
TreeFamiTF105543

Miscellaneous databases

PROiPR:Q3UMT1
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000019254 Expressed in 240 organ(s), highest expression level in brain
ExpressionAtlasiQ3UMT1 baseline and differential
GenevisibleiQ3UMT1 MM

Family and domain databases

CDDicd00204 ANK, 1 hit
Gene3Di1.25.40.20, 2 hits
InterProiView protein in InterPro
IPR002110 Ankyrin_rpt
IPR020683 Ankyrin_rpt-contain_dom
IPR036770 Ankyrin_rpt-contain_sf
IPR017401 MYPT1/MYPT2/Mbs85
IPR031205 PPP1R12C
IPR031775 PRKG1_interact
PANTHERiPTHR24179:SF27 PTHR24179:SF27, 1 hit
PfamiView protein in Pfam
PF12796 Ank_2, 2 hits
PF15898 PRKG1_interact, 1 hit
PIRSFiPIRSF038141 PP1_12ABC_vert, 1 hit
PRINTSiPR01415 ANKYRIN
SMARTiView protein in SMART
SM00248 ANK, 4 hits
SUPFAMiSSF48403 SSF48403, 1 hit
PROSITEiView protein in PROSITE
PS50297 ANK_REP_REGION, 1 hit
PS50088 ANK_REPEAT, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiPP12C_MOUSE
AccessioniPrimary (citable) accession number: Q3UMT1
Secondary accession number(s): Q9CWD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 98 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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