UniProtKB - Q3UMM4 (CDK10_MOUSE)

BLAST

>sp|Q3UMM4|CDK10_MOUSE Cyclin-dependent kinase 10 OS=Mus musculus OX=10090 GN=Cdk10 PE=1 SV=1
MAEVDLESDQIRLKCIRKEGFFTVPPEHRLGRCRSVKEFEKLNRIGEGTYGIVYRARDTQ
TDEIVALKKVRMDKEKDGIPISSLREITLLLRLRHPNIVELKEVVVGNHLESIFLVMGYC
EQDLASLLENMPTPFSEAQVKCIMLQVLRGLQYLHRNFIIHRDLKVSNLLMTDKGCVKTA
DFGLARAYGVPVKPMTPKVVTLWYRAPELLLGTTTQTTSIDMWAVGCILAELLAHKPLLP
GTSEIHQIDLIVQLLGTPSENIWPGFSKLPLAGQYSLRKQPYNNLKHKFPWLSEAGLRLL
NFLFMYDPKKRATSGDCLESSYFKEKPLPCEPELMPTFPHHRNKRAAPAAAEGQSKRCRP

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History
Entry version 116 (07 Nov 2018)
Sequence version 1 (11 Oct 2005)
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Protein

Cyclin-dependent kinase 10

Gene

Cdk10

Organism

Mus musculus (Mouse)

Status

Reviewed-Annotation score: -Experimental evidence at protein levelⁱ

Functionⁱ

Cyclin-dependent kinase that phosphorylates the transcription factor ETS2 (in vitro) and positively controls its proteasomal degradation (in cells). Involved in the regulation of actin cytoskeleton organization through the phosphorylation of actin dynamics regulators such as PKN2. Is a negative regulator of ciliogenesis through phosphorylation of PKN2 and promotion of RhoA signaling.By similarity

Catalytic activityⁱ

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	68	ATPPROSITE-ProRule annotation		1
Active siteⁱ	163	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	45 – 53	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
cyclin-dependent protein kinase activity
Source: MGI
Inferred from genetic interactionⁱ
- 24218572
cyclin-dependent protein serine/threonine kinase activity
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
protein serine/threonine kinase activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

cell projection organization Source: UniProtKB-KW
negative regulation of cilium assembly Source: UniProtKB
peptidyl-threonine phosphorylation Source: UniProtKB
positive regulation of MAPK cascade
Source: MGI
Inferred from genetic interactionⁱ
- 24218572
protein phosphorylation
Source: GO_Central
Inferred from biological aspect of ancestorⁱ
- 21873635
regulation of actin cytoskeleton organization Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Serine/threonine-protein kinase, Transferase
Biological process	Cilium biogenesis/degradation
Ligand	ATP-binding, Nucleotide-binding

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Cyclin-dependent kinase 10 (EC:2.7.11.22) Alternative name(s): Cell division protein kinase 10
Gene namesⁱ	Name:Cdk10
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 8

Organism-specific databases

MGIⁱ	MGI:2448549 Cdk10

Keywords - Cellular componentⁱ

Cell projection, Cytoplasm, Cytoskeleton

Pathology & Biotechⁱ

Disruption phenotypeⁱ

CDK10 knockout results in partial prenatal lethality. Surviving mice display severe growth retardation, a reduced volume of mineralized matrix in the head, femur, tibia and fibula, bifidity or clefting of C1 (atlas) or C2 (axis), and absence of the dens. Additional defects are present in the kidney, lung, heart, spleen, liver, and muscle. At cellular level, CDK10 knockout does not affect cell proliferation. However, knocked-out mouse embryonic fibroblasts (MEFs) develop longer cilia.1 Publication

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000261028	1 – 360	Cyclin-dependent kinase 10Add BLAST		360

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Modified residueⁱ	196	PhosphothreonineCombined sources		1

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q3UMM4
PaxDbⁱ	Q3UMM4
PRIDEⁱ	Q3UMM4

PTM databases

iPTMnetⁱ	Q3UMM4
PhosphoSitePlusⁱ	Q3UMM4

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000033862 Expressed in 236 organ(s), highest expression level in ear vesicle
CleanExⁱ	MM_CDK10
ExpressionAtlasⁱ	Q3UMM4 baseline and differential
Genevisibleⁱ	Q3UMM4 MM

Interactionⁱ

Subunit structureⁱ

Heterodimer with CCNQ, the interaction is required for kinase activity. Interacts with ETS2. Interacts with PRK2.By similarity

Protein-protein interaction databases

ComplexPortalⁱ	CPX-327 Cyclin M-CDK10 complex
STRINGⁱ	10090.ENSMUSP00000045527

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q3UMM4
SMRⁱ	Q3UMM4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	39 – 323	Protein kinasePROSITE-ProRule annotationAdd BLAST		285

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.Curated

Phylogenomic databases

eggNOGⁱ	KOG0663 Eukaryota ENOG410XQ50 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00910000144030
HOVERGENⁱ	HBG014652
InParanoidⁱ	Q3UMM4
KEGG Orthology (KO) More...KOⁱ	K02449
OMAⁱ	MTDKGCI
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G048P
PhylomeDBⁱ	Q3UMM4
TreeFamⁱ	TF101026

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit

Sequence (1+)ⁱ

Sequence statusⁱ: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show all Align All

Q3UMM4-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MAEVDLESDQ IRLKCIRKEG FFTVPPEHRL GRCRSVKEFE KLNRIGEGTY 
        60         70         80         90        100
GIVYRARDTQ TDEIVALKKV RMDKEKDGIP ISSLREITLL LRLRHPNIVE 
       110        120        130        140        150
LKEVVVGNHL ESIFLVMGYC EQDLASLLEN MPTPFSEAQV KCIMLQVLRG 
       160        170        180        190        200
LQYLHRNFII HRDLKVSNLL MTDKGCVKTA DFGLARAYGV PVKPMTPKVV 
       210        220        230        240        250
TLWYRAPELL LGTTTQTTSI DMWAVGCILA ELLAHKPLLP GTSEIHQIDL 
       260        270        280        290        300
IVQLLGTPSE NIWPGFSKLP LAGQYSLRKQ PYNNLKHKFP WLSEAGLRLL 
       310        320        330        340        350
NFLFMYDPKK RATSGDCLES SYFKEKPLPC EPELMPTFPH HRNKRAAPAA 
       360
AEGQSKRCRP

Length:360

Mass (Da):40,961

Last modified:October 11, 2005 - v1

Checksum:ⁱ9621FDB86E231E93

Computationally mapped potential isoform sequencesⁱ

There are 4 potential isoforms mapped to this entry.BLAST Align Show all Add to basket

Entry	Entry name	Protein names	Gene names	Length	Annotation

A0A1D5RLN0	A0A1D5RLN0_MOUSE	Cyclin-dependent kinase 10 Cyclin-dependent kinase 10	Cdk10	289	Annotation score:
A0A1D5RM75	A0A1D5RM75_MOUSE	Cyclin-dependent kinase 10 Cyclin-dependent kinase 10	Cdk10	140	Annotation score:
A0A1D5RLN1	A0A1D5RLN1_MOUSE	Cyclin-dependent kinase 10 Cyclin-dependent kinase 10	Cdk10	129	Annotation score:
A0A1D5RLY3	A0A1D5RLY3_MOUSE	Cyclin-dependent kinase 10 Cyclin-dependent kinase 10	Cdk10	115	Annotation score:

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ288857 mRNA Translation: ABB96224.1 AK133918 mRNA Translation: BAE21925.1 AK144801 mRNA Translation: BAE26074.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS22751.1
NCBI Reference Sequences More...RefSeqⁱ	NP_919426.2, NM_194444.2 NP_919428.1, NM_194446.2
UniGeneⁱ	Mm.190984

Genome annotation databases

Ensemblⁱ	ENSMUST00000036880; ENSMUSP00000045527; ENSMUSG00000033862
GeneIDⁱ	234854
KEGGⁱ	mmu:234854
UCSC genome browser More...UCSCⁱ	uc009nun.2 mouse

Similar proteinsⁱ

100% Identity
90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q3UMM4	Cyclin-dependent kinase 10		MOUSE		289	UniRef100_Q3UMM4
UPI0007EC490E		MOUSE		223
UPI0000357C34		MOUSE		244
UPI0003D78CF1		MOUSE		217

Protein	Similar proteins		Species	Score	Length	Source
Q3UMM4	Cyclin-dependent kinase 10		MOUSE		289	UniRef90_Q3UMM4
LOW QUALITY PROTEIN: cyclin-dependent kinase 10		LIPVE		371
Cell division protein kinase 10 (Fragment)		wild yak		369
Uncharacterized protein		MONDO		367
Cyclin dependent kinase 10		LOXAF		366
+119

Protein	Similar proteins		Species	Score	Length	Source
Q3UMM4	Cyclin-dependent kinase 10		HUMAN		360	UniRef50_Q15131
Cyclin-dependent kinase 10		BOVIN		361
CDK10 isoform 1		PANTR		360
Uncharacterized protein		PANPA		360
Cyclin-dependent kinase 10		CAMFR		428
+420

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	DQ288857 mRNA Translation: ABB96224.1 AK133918 mRNA Translation: BAE21925.1 AK144801 mRNA Translation: BAE26074.1
CCDSⁱ	CCDS22751.1
RefSeqⁱ	NP_919426.2, NM_194444.2 NP_919428.1, NM_194446.2
UniGeneⁱ	Mm.190984

3D structure databases

ProteinModelPortalⁱ	Q3UMM4
SMRⁱ	Q3UMM4
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

ComplexPortalⁱ	CPX-327 Cyclin M-CDK10 complex
STRINGⁱ	10090.ENSMUSP00000045527

PTM databases

iPTMnetⁱ	Q3UMM4
PhosphoSitePlusⁱ	Q3UMM4

Proteomic databases

MaxQBⁱ	Q3UMM4
PaxDbⁱ	Q3UMM4
PRIDEⁱ	Q3UMM4

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000036880; ENSMUSP00000045527; ENSMUSG00000033862
GeneIDⁱ	234854
KEGGⁱ	mmu:234854
UCSCⁱ	uc009nun.2 mouse

Organism-specific databases

CTDⁱ	8558
MGIⁱ	MGI:2448549 Cdk10

Phylogenomic databases

eggNOGⁱ	KOG0663 Eukaryota ENOG410XQ50 LUCA
GeneTreeⁱ	ENSGT00910000144030
HOVERGENⁱ	HBG014652
InParanoidⁱ	Q3UMM4
KOⁱ	K02449
OMAⁱ	MTDKGCI
OrthoDBⁱ	EOG091G048P
PhylomeDBⁱ	Q3UMM4
TreeFamⁱ	TF101026

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q3UMM4
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000033862 Expressed in 236 organ(s), highest expression level in ear vesicle
CleanExⁱ	MM_CDK10
ExpressionAtlasⁱ	Q3UMM4 baseline and differential
Genevisibleⁱ	Q3UMM4 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR008271 Ser/Thr_kinase_AS
Pfamⁱ	View protein in Pfam PF00069 Pkinase, 1 hit
SMARTⁱ	View protein in SMART SM00220 S_TKc, 1 hit
SUPFAMⁱ	SSF56112 SSF56112, 1 hit
PROSITEⁱ	View protein in PROSITE PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00108 PROTEIN_KINASE_ST, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	CDK10_MOUSE
Accessionⁱ	Q3UMM4Primary (citable) accession number: Q3UMM4 Secondary accession number(s): Q3UZD2
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
	Last sequence update:	October 11, 2005
	Last modified:	November 7, 2018
	This is version 116 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
Human and mouse protein kinases
Human and mouse protein kinases: classification and index

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UniProtKB - Q3UMM4 (CDK10_MOUSE)

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Cyclin-dependent kinase 10

Cdk10

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Cytoskeleton

Cytoskeleton

Nucleus

Other locations

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ