UniProtKB - Q3UM65 (Q3UM65_MOUSE)
Protein
Runt-related transcription factor
Gene
Runx1
Organism
Mus musculus (Mouse)
Status
Functioni
Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.UniRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 126 | Chloride 1UniRule annotation | 1 | |
Binding sitei | 130 | Chloride 1; via amide nitrogenUniRule annotation | 1 | |
Binding sitei | 153 | Chloride 2UniRule annotation | 1 | |
Binding sitei | 184 | Chloride 2; via amide nitrogenUniRule annotation | 1 |
GO - Molecular functioni
- ATP binding Source: InterPro
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: Ensembl
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: Ensembl
GO - Biological processi
- hemopoiesis Source: Ensembl
- positive regulation of granulocyte differentiation Source: Ensembl
- positive regulation of interleukin-2 production Source: Ensembl
Keywordsi
Molecular function | DNA-bindingUniRule annotationARBA annotation |
Biological process | Transcription, Transcription regulationUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Runt-related transcription factorUniRule annotation |
Gene namesi | Name:Runx1Imported |
Organismi | Mus musculus (Mouse)Imported |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:99852, Runx1 |
Subcellular locationi
Nucleus
- Nucleus UniRule annotationARBA annotation
Nucleus
- nucleoplasm Source: Ensembl
Keywords - Cellular componenti
NucleusARBA annotationExpressioni
Gene expression databases
Bgeei | ENSMUSG00000022952, Expressed in decidua and 275 other tissues |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 64 – 192 | RuntInterPro annotationAdd BLAST | 129 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 184 – 209 | DisorderedSequence analysisAdd BLAST | 26 | |
Regioni | 223 – 266 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 282 – 304 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 419 – 465 | DisorderedSequence analysisAdd BLAST | 47 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 184 – 200 | PolyampholyteSequence analysisAdd BLAST | 17 | |
Compositional biasi | 236 – 266 | PolarSequence analysisAdd BLAST | 31 | |
Compositional biasi | 422 – 453 | PolarSequence analysisAdd BLAST | 32 |
Phylogenomic databases
GeneTreei | ENSGT00940000159255 |
OrthoDBi | 562214at2759 |
TreeFami | TF321496 |
Family and domain databases
Gene3Di | 2.60.40.720, 1 hit 4.10.770.10, 1 hit |
InterProi | View protein in InterPro IPR000040, AML1_Runt IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR013524, Runt_dom IPR027384, Runx_central_dom_sf IPR013711, RunxI_C_dom IPR016554, TF_Runt-rel_RUNX |
PANTHERi | PTHR11950, PTHR11950, 1 hit |
Pfami | View protein in Pfam PF00853, Runt, 1 hit PF08504, RunxI, 1 hit |
PIRSFi | PIRSF009374, TF_Runt-rel_RUNX, 1 hit |
PRINTSi | PR00967, ONCOGENEAML1 |
SUPFAMi | SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS51062, RUNT, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.Show allAlign All
Q3UM65-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASDSIFESF PSYPQCFMRD ASTSRRFTPP STALSPGKMS EALPLGAPDG
60 70 80 90 100
GAALASKLRS GDRSMVEVLA DHPGELVRTD SPNFLCSVLP THWRCNKTLP
110 120 130 140 150
IAFKVVALGD VPDGTLVTVM AGNDENYSAE LRNATAAMKN QVARFNDLRF
160 170 180 190 200
VGRSGRGKSF TLTITVFTNP PQVATYHRAI KITVDGPREP RRHRQKLDDQ
210 220 230 240 250
TKPGSLSFSE RLSELEQLRR TAMRVSPHHP APTPNPRASL NHSTAFNPQP
260 270 280 290 300
QSQMQDARQI QPSPPWSYDQ SYQYLGSITS SSVHPATPIS PGRASGMTSL
310 320 330 340 350
SAELSSRLST APDLTAFGDP RQFPTLPSIS DPRMHYPGAF TYSPPVTSGI
360 370 380 390 400
GIGMSAMSSA SRYHTYLPPP YPGSSQAQAG PFQTGSPSYH LYYGASAGSY
410 420 430 440 450
QFSMVGGERS PPRILPPCTN ASTGAALLNP SLPSQSDVVE TEGSHSNSPT
460
NMPPARLEEA VWRPY
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketQ03347 | RUNX1_MOUSE | Runt-related transcription factor 1 | Runx1 Aml1, Cbfa2, Pebp2ab | 451 | Annotation score: | ||
G3UWD2 | G3UWD2_MOUSE | Runt-related transcription factor | Runx1 | 451 | Annotation score: | ||
G3X9W7 | G3X9W7_MOUSE | Runt-related transcription factor | Runx1 | 387 | Annotation score: | ||
A0A087WR05 | A0A087WR05_MOUSE | Runt-related transcription factor 1 | Runx1 | 68 | Annotation score: | ||
A0A087WPL0 | A0A087WPL0_MOUSE | Runt-related transcription factor 1 | Runx1 | 63 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL672278 Genomic DNA No translation available. CT025774 Genomic DNA No translation available. AK145098 mRNA Translation: BAE26233.1 |
RefSeqi | NP_001104491.1, NM_001111021.2 |
Genome annotation databases
Ensembli | ENSMUST00000023673; ENSMUSP00000023673; ENSMUSG00000022952 |
GeneIDi | 12394 |
KEGGi | mmu:12394 |
UCSCi | uc007zzj.3, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AL672278 Genomic DNA No translation available. CT025774 Genomic DNA No translation available. AK145098 mRNA Translation: BAE26233.1 |
RefSeqi | NP_001104491.1, NM_001111021.2 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q3UM65, 1 interactor |
Protocols and materials databases
Antibodypediai | 935, 1057 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000023673; ENSMUSP00000023673; ENSMUSG00000022952 |
GeneIDi | 12394 |
KEGGi | mmu:12394 |
UCSCi | uc007zzj.3, mouse |
Organism-specific databases
CTDi | 861 |
MGIi | MGI:99852, Runx1 |
Phylogenomic databases
GeneTreei | ENSGT00940000159255 |
OrthoDBi | 562214at2759 |
TreeFami | TF321496 |
Miscellaneous databases
BioGRID-ORCSi | 12394, 2 hits in 17 CRISPR screens |
ChiTaRSi | Runx1, mouse |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000022952, Expressed in decidua and 275 other tissues |
Family and domain databases
Gene3Di | 2.60.40.720, 1 hit 4.10.770.10, 1 hit |
InterProi | View protein in InterPro IPR000040, AML1_Runt IPR008967, p53-like_TF_DNA-bd IPR012346, p53/RUNT-type_TF_DNA-bd_sf IPR013524, Runt_dom IPR027384, Runx_central_dom_sf IPR013711, RunxI_C_dom IPR016554, TF_Runt-rel_RUNX |
PANTHERi | PTHR11950, PTHR11950, 1 hit |
Pfami | View protein in Pfam PF00853, Runt, 1 hit PF08504, RunxI, 1 hit |
PIRSFi | PIRSF009374, TF_Runt-rel_RUNX, 1 hit |
PRINTSi | PR00967, ONCOGENEAML1 |
SUPFAMi | SSF49417, SSF49417, 1 hit |
PROSITEi | View protein in PROSITE PS51062, RUNT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q3UM65_MOUSE | |
Accessioni | Q3UM65Primary (citable) accession number: Q3UM65 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | October 11, 2005 |
Last sequence update: | October 11, 2005 | |
Last modified: | December 2, 2020 | |
This is version 137 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |