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Protein

Histone deacetylase

Gene

Hdac3

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Catalytic activityi

Hydrolysis of an N6-acetyl-lysine residue of a histone to yield a deacetylated histone.UniRule annotationSAAS annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei93SubstrateUniRule annotation1
Active sitei135Proton acceptorUniRule annotation1
Binding sitei143Substrate; via carbonyl oxygenUniRule annotation1
Metal bindingi170Divalent metal cationUniRule annotation1
Metal bindingi172Divalent metal cationUniRule annotation1
Metal bindingi259Divalent metal cationUniRule annotation1
Binding sitei298SubstrateUniRule annotation1

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulatorUniRule annotationSAAS annotation, HydrolaseUniRule annotationSAAS annotation
Biological processTranscription, Transcription regulationUniRule annotationSAAS annotation
LigandMetal-bindingUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-3214815 HDACs deacetylate histones
R-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Names & Taxonomyi

Protein namesi
Recommended name:
Histone deacetylaseUniRule annotationSAAS annotation (EC:3.5.1.98UniRule annotationSAAS annotation)
Gene namesi
Name:Hdac3Imported
ORF Names:mCG_128932Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:1343091 Hdac3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

NucleusUniRule annotationSAAS annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000024454 Expressed in 289 organ(s), highest expression level in skeletal muscle tissue

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ3UM33, 1 interactor
Q3UM33, 1 interactor

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 313Hist_deacetylInterPro annotationAdd BLAST292

Sequence similaritiesi

Belongs to the histone deacetylase family. HD Type 1 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiKOG1342 Eukaryota
COG0123 LUCA
GeneTreeiENSGT00910000144047
HOGENOMiHOG000225180
HOVERGENiHBG057112
KOiK11404
OMAiPRAWTHL
OrthoDBiEOG091G067J
TreeFamiTF352182

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR003084 His_deacetylse_1
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037913 His_deacetylse_1, 1 hit
PRINTSiPR01270 HDASUPER
PR01271 HISDACETLASE
SUPFAMiSSF52768 SSF52768, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q3UM33-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAKTVAYFYD PDVGNFHYGA GHPMKPHRLA LTHSLVLHYG LYKKMIVFKP
60 70 80 90 100
YQASQHDMCR FHSEDYIDFL QRVSPTNMQG FTKSLNAFNV GDDCPVFPGL
110 120 130 140 150
FEFCSRYTGA SLQGATQLNN KICDIAINWA GGLHHAKKFE ASGFCYVNDI
160 170 180 190 200
VIGILELLKY HPRVLYIDID IHHGDGVQEA FYLTDRVMTV SFHKYGNYFF
210 220 230 240 250
PGTGDMYEVG AESGRYYCLN VPLRDGIDDQ SYKHLFQPVI SQVVDFYQPT
260 270 280 290 300
CIVLQCGADS LGCDRLGCFN LSIRGHGECV EYVKSFNIPL LVLGGGGYTV
310 320 330 340 350
RNVARCWTYE TSLLVEEAIS EELPYSEYFE YFAPDFTLHP DVSTRIENQN
360 370 380 390 400
SRQYLDQIRQ TIFENLKMLN HAPSVQIHDV PADLLTYDRT DEADAEERGP
410 420
EENYSRPEAP NEFYDGDHDN DKESDVEI
Length:428
Mass (Da):48,821
Last modified:October 11, 2005 - v1
Checksum:i1CB84DE250C3BB2C
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
O88895HDAC3_MOUSE
Histone deacetylase 3
Hdac3
424Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129315 Genomic DNA No translation available.
BC139300 mRNA Translation: AAI39301.1
BC139301 mRNA Translation: AAI39302.1
AK145158 mRNA Translation: BAE26265.1
CH466528 Genomic DNA Translation: EDL10110.1
RefSeqiNP_034541.2, NM_010411.2
UniGeneiMm.20521

Genome annotation databases

EnsembliENSMUST00000043498; ENSMUSP00000037981; ENSMUSG00000024454
GeneIDi15183
KEGGimmu:15183
UCSCiuc008erl.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC129315 Genomic DNA No translation available.
BC139300 mRNA Translation: AAI39301.1
BC139301 mRNA Translation: AAI39302.1
AK145158 mRNA Translation: BAE26265.1
CH466528 Genomic DNA Translation: EDL10110.1
RefSeqiNP_034541.2, NM_010411.2
UniGeneiMm.20521

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ3UM33, 1 interactor
Q3UM33, 1 interactor

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000043498; ENSMUSP00000037981; ENSMUSG00000024454
GeneIDi15183
KEGGimmu:15183
UCSCiuc008erl.1 mouse

Organism-specific databases

CTDi8841
MGIiMGI:1343091 Hdac3

Phylogenomic databases

eggNOGiKOG1342 Eukaryota
COG0123 LUCA
GeneTreeiENSGT00910000144047
HOGENOMiHOG000225180
HOVERGENiHBG057112
KOiK11404
OMAiPRAWTHL
OrthoDBiEOG091G067J
TreeFamiTF352182

Enzyme and pathway databases

ReactomeiR-MMU-3214815 HDACs deacetylate histones
R-MMU-400206 Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha)

Miscellaneous databases

ChiTaRSiHdac3 mouse
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024454 Expressed in 289 organ(s), highest expression level in skeletal muscle tissue

Family and domain databases

Gene3Di3.40.800.20, 1 hit
InterProiView protein in InterPro
IPR000286 His_deacetylse
IPR003084 His_deacetylse_1
IPR023801 His_deacetylse_dom
IPR037138 His_deacetylse_dom_sf
IPR023696 Ureohydrolase_dom_sf
PANTHERiPTHR10625 PTHR10625, 1 hit
PfamiView protein in Pfam
PF00850 Hist_deacetyl, 1 hit
PIRSFiPIRSF037913 His_deacetylse_1, 1 hit
PRINTSiPR01270 HDASUPER
PR01271 HISDACETLASE
SUPFAMiSSF52768 SSF52768, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ3UM33_MOUSE
AccessioniPrimary (citable) accession number: Q3UM33
Entry historyiIntegrated into UniProtKB/TrEMBL: October 11, 2005
Last sequence update: October 11, 2005
Last modified: November 7, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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