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Protein

Glycerol-3-phosphate dehydrogenase 1-like protein

Gene

Gpd1l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Plays a role in regulating cardiac sodium current; decreased enzymatic activity with resulting increased levels of glycerol 3-phosphate activating the DPD1L-dependent SCN5A phosphorylation pathway, may ultimately lead to decreased sodium current; cardiac sodium current may also be reduced due to alterations of NAD(H) balance induced by DPD1L.By similarity

Catalytic activityi

sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei43NADBy similarity1
Binding sitei99NADBy similarity1
Binding sitei122SubstrateBy similarity1
Binding sitei155NAD; via amide nitrogenBy similarity1
Active sitei206Proton acceptorBy similarity1
Binding sitei271NADBy similarity1
Binding sitei298NAD; via amide nitrogenBy similarity1
Binding sitei300NADBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 17NADBy similarity6

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Enzyme and pathway databases

ReactomeiR-MMU-1483166 Synthesis of PA

Names & Taxonomyi

Protein namesi
Recommended name:
Glycerol-3-phosphate dehydrogenase 1-like protein (EC:1.1.1.8)
Gene namesi
Name:Gpd1l
Synonyms:Kiaa0089
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 9

Organism-specific databases

MGIiMGI:1289257 Gpd1l

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002865121 – 351Glycerol-3-phosphate dehydrogenase 1-like proteinAdd BLAST351

Proteomic databases

MaxQBiQ3ULJ0
PaxDbiQ3ULJ0
PeptideAtlasiQ3ULJ0
PRIDEiQ3ULJ0

PTM databases

iPTMnetiQ3ULJ0
PhosphoSitePlusiQ3ULJ0
SwissPalmiQ3ULJ0

Expressioni

Gene expression databases

BgeeiENSMUSG00000050627 Expressed in 245 organ(s), highest expression level in cleaving embryo
CleanExiMM_GPD1L
ExpressionAtlasiQ3ULJ0 baseline and differential
GenevisibleiQ3ULJ0 MM

Interactioni

Subunit structurei

Interacts with SCN5A.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi237162, 1 interactor
IntActiQ3ULJ0, 1 interactor
MINTiQ3ULJ0
STRINGi10090.ENSMUSP00000117509

Structurei

3D structure databases

ProteinModelPortaliQ3ULJ0
SMRiQ3ULJ0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni271 – 272Substrate bindingBy similarity2

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG2711 Eukaryota
COG0240 LUCA
GeneTreeiENSGT00390000003114
HOGENOMiHOG000246855
HOVERGENiHBG003669
InParanoidiQ3ULJ0
KOiK00006
OMAiNFRSAKH
OrthoDBiEOG091G0DO6
PhylomeDBiQ3ULJ0
TreeFamiTF300836

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006168 G3P_DH_NAD-dep
IPR006109 G3P_DH_NAD-dep_C
IPR017751 G3P_DH_NAD-dep_euk
IPR011128 G3P_DH_NAD-dep_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF07479 NAD_Gly3P_dh_C, 1 hit
PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFiPIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSiPR00077 GPDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03376 glycerol3P_DH, 1 hit

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All

Isoform 1 (identifier: Q3ULJ0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAPLKVCI VGSGNWGSAV AKIIGSNVKT LQKFSSTVKM WVFEETVNGR
60 70 80 90 100
KLTDIINNDH ENVKYLPGHK LPENVVAVPN LSEAVQDADL LVFVIPHQFI
110 120 130 140 150
HKICDEITGR VPEKALGITL IKGIDEGPDG LKLISDIIRE KMGIDISVLM
160 170 180 190 200
GANIASEVAA EKFCETTIGS KVMQNGLLFK ELLQTPNFRI TVVDDADTVE
210 220 230 240 250
LCGALKNIVA VGAGFCDGLR CGDNTKAAVI RLGLMEMIAF AKIFCKGQVS
260 270 280 290 300
TATFLESCGV ADLITTCYGG RNRRVAEAFA RTGKTIEELE KELLNGQKLQ
310 320 330 340 350
GPQTSAEVYR ILRQKGLLDK FPLFTAVYQI CYEGRPVTQM LSCLQSHPEH

I
Length:351
Mass (Da):38,226
Last modified:May 15, 2007 - v2
Checksum:iBE192D41F592E577
GO
Isoform 2 (identifier: Q3ULJ0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     321-351: Missing.

Note: No experimental confirmation available.
Show »
Length:320
Mass (Da):34,634
Checksum:i690C96D09F52BC54
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D3Z0L6D3Z0L6_MOUSE
Glycerol-3-phosphate dehydrogenase ...
Gpd1l
117Annotation score:

Sequence cautioni

The sequence AAH37729 differs from that shown. Reason: Erroneous initiation.Curated
The sequence BAD32164 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti26S → G in BAC36001 (PubMed:16141072).Curated1
Sequence conflicti179F → S in BAC36001 (PubMed:16141072).Curated1
Sequence conflicti202C → W in BAC36001 (PubMed:16141072).Curated1
Sequence conflicti212G → V in BAC36001 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_025062321 – 351Missing in isoform 2. 1 PublicationAdd BLAST31

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172886 mRNA Translation: BAD32164.1 Different initiation.
AK050572 mRNA Translation: BAC34327.1
AK075845 mRNA Translation: BAC36001.1
AK145475 mRNA Translation: BAE26458.1
BC037729 mRNA Translation: AAH37729.1 Different initiation.
CCDSiCCDS23598.1 [Q3ULJ0-1]
RefSeqiNP_780589.3, NM_175380.5 [Q3ULJ0-1]
UniGeneiMm.38198

Genome annotation databases

EnsembliENSMUST00000084853; ENSMUSP00000081913; ENSMUSG00000050627 [Q3ULJ0-2]
ENSMUST00000146623; ENSMUSP00000117509; ENSMUSG00000050627 [Q3ULJ0-1]
GeneIDi333433
KEGGimmu:333433
UCSCiuc009ryj.2 mouse [Q3ULJ0-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK172886 mRNA Translation: BAD32164.1 Different initiation.
AK050572 mRNA Translation: BAC34327.1
AK075845 mRNA Translation: BAC36001.1
AK145475 mRNA Translation: BAE26458.1
BC037729 mRNA Translation: AAH37729.1 Different initiation.
CCDSiCCDS23598.1 [Q3ULJ0-1]
RefSeqiNP_780589.3, NM_175380.5 [Q3ULJ0-1]
UniGeneiMm.38198

3D structure databases

ProteinModelPortaliQ3ULJ0
SMRiQ3ULJ0
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi237162, 1 interactor
IntActiQ3ULJ0, 1 interactor
MINTiQ3ULJ0
STRINGi10090.ENSMUSP00000117509

PTM databases

iPTMnetiQ3ULJ0
PhosphoSitePlusiQ3ULJ0
SwissPalmiQ3ULJ0

Proteomic databases

MaxQBiQ3ULJ0
PaxDbiQ3ULJ0
PeptideAtlasiQ3ULJ0
PRIDEiQ3ULJ0

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000084853; ENSMUSP00000081913; ENSMUSG00000050627 [Q3ULJ0-2]
ENSMUST00000146623; ENSMUSP00000117509; ENSMUSG00000050627 [Q3ULJ0-1]
GeneIDi333433
KEGGimmu:333433
UCSCiuc009ryj.2 mouse [Q3ULJ0-1]

Organism-specific databases

CTDi23171
MGIiMGI:1289257 Gpd1l
RougeiSearch...

Phylogenomic databases

eggNOGiKOG2711 Eukaryota
COG0240 LUCA
GeneTreeiENSGT00390000003114
HOGENOMiHOG000246855
HOVERGENiHBG003669
InParanoidiQ3ULJ0
KOiK00006
OMAiNFRSAKH
OrthoDBiEOG091G0DO6
PhylomeDBiQ3ULJ0
TreeFamiTF300836

Enzyme and pathway databases

ReactomeiR-MMU-1483166 Synthesis of PA

Miscellaneous databases

PROiPR:Q3ULJ0
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050627 Expressed in 245 organ(s), highest expression level in cleaving embryo
CleanExiMM_GPD1L
ExpressionAtlasiQ3ULJ0 baseline and differential
GenevisibleiQ3ULJ0 MM

Family and domain databases

Gene3Di1.10.1040.10, 1 hit
InterProiView protein in InterPro
IPR008927 6-PGluconate_DH-like_C_sf
IPR013328 6PGD_dom2
IPR006168 G3P_DH_NAD-dep
IPR006109 G3P_DH_NAD-dep_C
IPR017751 G3P_DH_NAD-dep_euk
IPR011128 G3P_DH_NAD-dep_N
IPR036291 NAD(P)-bd_dom_sf
PfamiView protein in Pfam
PF07479 NAD_Gly3P_dh_C, 1 hit
PF01210 NAD_Gly3P_dh_N, 1 hit
PIRSFiPIRSF000114 Glycerol-3-P_dh, 1 hit
PRINTSiPR00077 GPDHDRGNASE
SUPFAMiSSF48179 SSF48179, 1 hit
SSF51735 SSF51735, 1 hit
TIGRFAMsiTIGR03376 glycerol3P_DH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGPD1L_MOUSE
AccessioniPrimary (citable) accession number: Q3ULJ0
Secondary accession number(s): Q6A0D2
, Q8BVZ7, Q8BWM5, Q8CFN6
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: November 7, 2018
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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