UniProtKB - Q3ULA2 (FBW1A_MOUSE)
F-box/WD repeat-containing protein 1A
Btrc
Functioni
Caution
: protein ubiquitination Pathwayi
This protein is involved in the pathway protein ubiquitination, which is part of Protein modification.4 PublicationsView all proteins of this organism that are known to be involved in the pathway protein ubiquitination and in Protein modification.
GO - Molecular functioni
- beta-catenin binding Source: BHF-UCL
- protein dimerization activity Source: InterPro
- protein phosphorylated amino acid binding Source: BHF-UCL
- ubiquitin ligase activator activity Source: MGI
- ubiquitin ligase-substrate adaptor activity Source: MGI
- ubiquitin protein ligase activity Source: BHF-UCL
GO - Biological processi
- branching involved in mammary gland duct morphogenesis Source: MGI
- cellular response to organic cyclic compound Source: MGI
- mammary gland epithelial cell proliferation Source: MGI
- negative regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of circadian rhythm Source: UniProtKB
- positive regulation of proteolysis Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of ubiquitin protein ligase activity Source: MGI
- proteasome-mediated ubiquitin-dependent protein catabolic process Source: UniProtKB
- protein catabolic process Source: MGI
- protein dephosphorylation Source: UniProtKB
- protein destabilization Source: UniProtKB
- protein K48-linked ubiquitination Source: MGI
- protein polyubiquitination Source: BHF-UCL
- protein ubiquitination Source: MGI
- regulation of canonical Wnt signaling pathway Source: ParkinsonsUK-UCL
- regulation of cell cycle Source: MGI
- regulation of circadian rhythm Source: UniProtKB
- regulation of I-kappaB kinase/NF-kappaB signaling Source: MGI
- regulation of proteasomal protein catabolic process Source: MGI
- rhythmic process Source: UniProtKB-KW
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
- ubiquitin-dependent protein catabolic process Source: UniProtKB
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Biological process | Biological rhythms, Ubl conjugation pathway, Wnt signaling pathway |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Names & Taxonomyi
Protein namesi | Recommended name: F-box/WD repeat-containing protein 1ABy similarityImportedAlternative name(s): Beta-TrCP protein E3RS-IkappaBImported Beta-transducin repeat-containing proteinImported Short name: Beta-TrCP1 Publication E3RSIkappaBBy similarity Short name: mE3RS-IkappaB1 Publication F-box and WD repeats protein beta-TrCPBy similarity HOS1 Publication Ubiquitin ligase FWD11 PublicationImported pIkappaB-E3 receptor subunit1 Publication |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1338871, Btrc |
Subcellular locationi
Cytosol
- cytosol Source: Reactome
Nucleus
- nucleus Source: ParkinsonsUK-UCL
Other locations
- cytoplasm Source: ParkinsonsUK-UCL
- SCF ubiquitin ligase complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Disruption phenotypei
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000393571 | 1 – 605 | F-box/WD repeat-containing protein 1AAdd BLAST | 605 |
Proteomic databases
MaxQBi | Q3ULA2 |
PaxDbi | Q3ULA2 |
PeptideAtlasi | Q3ULA2 |
PRIDEi | Q3ULA2 |
PTM databases
iPTMneti | Q3ULA2 |
PhosphoSitePlusi | Q3ULA2 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000025217, Expressed in camera-type eye and 298 other tissues |
ExpressionAtlasi | Q3ULA2, baseline and differential |
Genevisiblei | Q3ULA2, MM |
Interactioni
Subunit structurei
Homodimer. Self-associates.
Component of the SCF(BTRC) complex, composed of SKP1, CUL1 and BTRC. Direct interaction with SKP1 with SKP1 occurs via the F-box domain.
Interacts with phosphorylated ubiquitination substrates SMAD3 and SMAD4.
Interacts with phosphorylated ubiquitination substrates CTNNB1, NFKBIA, NFKBIB, NFKBIE, NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, CDC25A, DLG1, FBXO5 and SNAI1; the interaction requires the phosphorylation of the 2 serine residues in the substrate destruction motif D-S-G-X(2,3,4)-S. Binds UBQLN1.
Interacts with CDC34 and UBE2R2.
Interacts with FBXW11.
Interacts with CUL4A and DDB1.
Part of a SCF(BTRC)-like complex lacking CUL1, which is associated with phosphorylated NKBIA and RELA; RELA interacts directly with NFKBIA.
Interacts with the phosphorylated form of GLI3.
Interacts with CLU.
Interacts with PER1 (phosphorylated), PER2 (phosphorylated) and PER3.
Interacts with phosphorylated ubiquitination substrate CEP68 (By similarity).
Interacts with ZC3H12A; this interaction occurs when ZC3H12A is phosphorylated in a IKBKB/IKKB-dependent manner (PubMed:22037600).
Interacts with HSF1; this interaction occurs during mitosis and induces HSF1 ubiquitin-dependent degradation, a process inhibited by CDC20 (By similarity).
Interacts with NFE2L1 (PubMed:21911472).
Interacts with INAVA (By similarity).
Interacts with IL10RA; this interaction leads to IL10RA ubiquitination and subsequent degradation (By similarity).
Interacts with REST (By similarity).
By similarity9 PublicationsGO - Molecular functioni
- beta-catenin binding Source: BHF-UCL
- protein dimerization activity Source: InterPro
- protein phosphorylated amino acid binding Source: BHF-UCL
Protein-protein interaction databases
BioGRIDi | 198403, 26 interactors |
CORUMi | Q3ULA2 |
IntActi | Q3ULA2, 16 interactors |
MINTi | Q3ULA2 |
STRINGi | 10090.ENSMUSP00000070728 |
Miscellaneous databases
RNActi | Q3ULA2, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 182 – 228 | F-boxPROSITE-ProRule annotationAdd BLAST | 47 | |
Repeati | 301 – 338 | WD 1Sequence analysisAdd BLAST | 38 | |
Repeati | 341 – 378 | WD 2Sequence analysisAdd BLAST | 38 | |
Repeati | 381 – 418 | WD 3Sequence analysisAdd BLAST | 38 | |
Repeati | 424 – 461 | WD 4Sequence analysisAdd BLAST | 38 | |
Repeati | 464 – 503 | WD 5Sequence analysisAdd BLAST | 40 | |
Repeati | 505 – 541 | WD 6Sequence analysisAdd BLAST | 37 | |
Repeati | 553 – 590 | WD 7Sequence analysisAdd BLAST | 38 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 128 – 177 | Homodimerization domain DBy similarityAdd BLAST | 50 | |
Regioni | 190 – 228 | Required for down-regulation of SNAI1By similarityAdd BLAST | 39 |
Domaini
Keywords - Domaini
Repeat, WD repeatPhylogenomic databases
eggNOGi | KOG0281, Eukaryota |
GeneTreei | ENSGT00940000159672 |
HOGENOMi | CLU_000288_103_6_1 |
InParanoidi | Q3ULA2 |
OrthoDBi | 666965at2759 |
PhylomeDBi | Q3ULA2 |
TreeFami | TF105679 |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR021977, Beta-TrCP_D IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12125, Beta-TrCP_D, 1 hit PF12937, F-box-like, 1 hit PF00400, WD40, 6 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM01028, Beta-TrCP_D, 1 hit SM00256, FBOX, 1 hit SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit PS00678, WD_REPEATS_1, 6 hits PS50082, WD_REPEATS_2, 7 hits PS50294, WD_REPEATS_REGION, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 5 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MDPAEAVLQE KALKFMCSMP RSLWLGCSSL ADSMPSLRCL YNPGTGALTA
60 70 80 90 100
FQNSSEREDC NNGEPPRKII PEKNSLRQTY NSCARLCINQ ETVCLTSTAM
110 120 130 140 150
KTENCVAKAK LANGTSSMIV PKQRKLSASY EKEKELCVKY FEQWSESDQV
160 170 180 190 200
EFVEHLISQM CHYQHGHINS YLKPMLQRDF ITALPARGLD HIAENILSYL
210 220 230 240 250
DAKSLCAAEL VCKEWYRVTS DGMLWKKLIE RMVRTDSLWR GLAERRGWGQ
260 270 280 290 300
YLFKNKPPDE NAPPNSFYRA LYPKIIQDIE TIESNWRCGR HSLQRIHCRS
310 320 330 340 350
ETSKGVYCLQ YDDQKIVSGL RDNTIKIWDK STLECKRILT GHTGSVLCLQ
360 370 380 390 400
YDERVIITGS SDSTVRVWDV NAGEMLNTLI HHCEAVLHLR FNNGMMVTCS
410 420 430 440 450
KDRSIAVWDM ASPTDITLRR VLVGHRAAVN VVDFDDKYIV SASGDRTIKV
460 470 480 490 500
WNTSTCEFVR TLNGHKRGIA CLQYRDRLVV SGSSDNTIRL WDIECGACLR
510 520 530 540 550
VLEGHEELVR CIRFDNKRIV SGAYDGKIKV WDLMAALDPR APAGTLCLRT
560 570 580 590 600
LVEHSGRVFR LQFDEFQIVS SSHDDTILIW DFLNDPAAHA EPPRSPSRTY
TYISR
Computationally mapped potential isoform sequencesi
There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A286YDT6 | A0A286YDT6_MOUSE | F-box/WD repeat-containing protein ... | Btrc | 506 | Annotation score: | ||
A0A286YE08 | A0A286YE08_MOUSE | F-box/WD repeat-containing protein ... | Btrc | 150 | Annotation score: | ||
A0A286YCS1 | A0A286YCS1_MOUSE | F-box/WD repeat-containing protein ... | Btrc | 111 | Annotation score: | ||
A0A286YCD6 | A0A286YCD6_MOUSE | F-box/WD repeat-containing protein ... | Btrc | 54 | Annotation score: | ||
A0A286YDI3 | A0A286YDI3_MOUSE | F-box/WD repeat-containing protein ... | Btrc | 34 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 193 | A → T in AAD41025 (PubMed:10531037).Curated | 1 | |
Sequence conflicti | 226 | K → E in BAE33798 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 297 | H → R in BAE26547 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 352 | D → G in AAD04181 (PubMed:9990853).Curated | 1 | |
Sequence conflicti | 377 | N → D in AAD41025 (PubMed:10531037).Curated | 1 | |
Sequence conflicti | 380 | I → T in AAD41025 (PubMed:10531037).Curated | 1 | |
Sequence conflicti | 523 | A → R in AAD41025 (PubMed:10531037).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_053208 | 17 – 52 | Missing in isoform 2. 5 PublicationsAdd BLAST | 36 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF099932 mRNA Translation: AAD08701.1 AF110396 mRNA Translation: AAD41025.1 AF112979 mRNA Translation: AAD04181.1 AF081887 mRNA Translation: AAD17755.1 AF391190 , AF391178, AF391179, AF391180, AF391181, AF391182, AF391183, AF391184, AF391185, AF391186, AF391187, AF391188, AF391189 Genomic DNA Translation: AAL40929.1 AK145624 mRNA Translation: BAE26547.1 AK156660 mRNA Translation: BAE33798.1 AK220183 mRNA Translation: BAD90368.1 Different initiation. CH466534 Genomic DNA Translation: EDL41951.1 BC003989 mRNA Translation: AAH03989.1 |
CCDSi | CCDS29860.1 [Q3ULA2-1] CCDS38002.1 [Q3ULA2-2] |
RefSeqi | NP_001032847.2, NM_001037758.2 [Q3ULA2-1] NP_001273394.1, NM_001286465.1 [Q3ULA2-1] NP_001273395.1, NM_001286466.1 NP_033901.1, NM_009771.3 [Q3ULA2-2] |
Genome annotation databases
Ensembli | ENSMUST00000065601; ENSMUSP00000070728; ENSMUSG00000025217 [Q3ULA2-1] ENSMUST00000111936; ENSMUSP00000107567; ENSMUSG00000025217 [Q3ULA2-2] |
GeneIDi | 12234 |
KEGGi | mmu:12234 |
UCSCi | uc008hqx.2, mouse [Q3ULA2-1] uc008hqz.2, mouse [Q3ULA2-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF099932 mRNA Translation: AAD08701.1 AF110396 mRNA Translation: AAD41025.1 AF112979 mRNA Translation: AAD04181.1 AF081887 mRNA Translation: AAD17755.1 AF391190 , AF391178, AF391179, AF391180, AF391181, AF391182, AF391183, AF391184, AF391185, AF391186, AF391187, AF391188, AF391189 Genomic DNA Translation: AAL40929.1 AK145624 mRNA Translation: BAE26547.1 AK156660 mRNA Translation: BAE33798.1 AK220183 mRNA Translation: BAD90368.1 Different initiation. CH466534 Genomic DNA Translation: EDL41951.1 BC003989 mRNA Translation: AAH03989.1 |
CCDSi | CCDS29860.1 [Q3ULA2-1] CCDS38002.1 [Q3ULA2-2] |
RefSeqi | NP_001032847.2, NM_001037758.2 [Q3ULA2-1] NP_001273394.1, NM_001286465.1 [Q3ULA2-1] NP_001273395.1, NM_001286466.1 NP_033901.1, NM_009771.3 [Q3ULA2-2] |
3D structure databases
SMRi | Q3ULA2 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 198403, 26 interactors |
CORUMi | Q3ULA2 |
IntActi | Q3ULA2, 16 interactors |
MINTi | Q3ULA2 |
STRINGi | 10090.ENSMUSP00000070728 |
PTM databases
iPTMneti | Q3ULA2 |
PhosphoSitePlusi | Q3ULA2 |
Proteomic databases
MaxQBi | Q3ULA2 |
PaxDbi | Q3ULA2 |
PeptideAtlasi | Q3ULA2 |
PRIDEi | Q3ULA2 |
Protocols and materials databases
Antibodypediai | 31277, 353 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000065601; ENSMUSP00000070728; ENSMUSG00000025217 [Q3ULA2-1] ENSMUST00000111936; ENSMUSP00000107567; ENSMUSG00000025217 [Q3ULA2-2] |
GeneIDi | 12234 |
KEGGi | mmu:12234 |
UCSCi | uc008hqx.2, mouse [Q3ULA2-1] uc008hqz.2, mouse [Q3ULA2-2] |
Organism-specific databases
CTDi | 8945 |
MGIi | MGI:1338871, Btrc |
Rougei | Search... |
Phylogenomic databases
eggNOGi | KOG0281, Eukaryota |
GeneTreei | ENSGT00940000159672 |
HOGENOMi | CLU_000288_103_6_1 |
InParanoidi | Q3ULA2 |
OrthoDBi | 666965at2759 |
PhylomeDBi | Q3ULA2 |
TreeFami | TF105679 |
Enzyme and pathway databases
UniPathwayi | UPA00143 |
Miscellaneous databases
BioGRID-ORCSi | 12234, 0 hits in 17 CRISPR screens |
ChiTaRSi | Btrc, mouse |
PROi | PR:Q3ULA2 |
RNActi | Q3ULA2, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000025217, Expressed in camera-type eye and 298 other tissues |
ExpressionAtlasi | Q3ULA2, baseline and differential |
Genevisiblei | Q3ULA2, MM |
Family and domain databases
Gene3Di | 2.130.10.10, 1 hit |
InterProi | View protein in InterPro IPR021977, Beta-TrCP_D IPR036047, F-box-like_dom_sf IPR001810, F-box_dom IPR020472, G-protein_beta_WD-40_rep IPR015943, WD40/YVTN_repeat-like_dom_sf IPR001680, WD40_repeat IPR019775, WD40_repeat_CS IPR017986, WD40_repeat_dom IPR036322, WD40_repeat_dom_sf |
Pfami | View protein in Pfam PF12125, Beta-TrCP_D, 1 hit PF12937, F-box-like, 1 hit PF00400, WD40, 6 hits |
PRINTSi | PR00320, GPROTEINBRPT |
SMARTi | View protein in SMART SM01028, Beta-TrCP_D, 1 hit SM00256, FBOX, 1 hit SM00320, WD40, 7 hits |
SUPFAMi | SSF50978, SSF50978, 1 hit SSF81383, SSF81383, 1 hit |
PROSITEi | View protein in PROSITE PS50181, FBOX, 1 hit PS00678, WD_REPEATS_1, 6 hits PS50082, WD_REPEATS_2, 7 hits PS50294, WD_REPEATS_REGION, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FBW1A_MOUSE | |
Accessioni | Q3ULA2Primary (citable) accession number: Q3ULA2 Secondary accession number(s): Q3U0Q4 Q9Z159 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 20, 2010 |
Last sequence update: | April 20, 2010 | |
Last modified: | December 2, 2020 | |
This is version 145 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - PATHWAY comments
Index of metabolic and biosynthesis pathways