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Protein

RNA polymerase II elongation factor ELL2

Gene

Ell2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (By similarity). Plays a role in immunoglobulin secretion in plasma cells: directs efficient alternative mRNA processing, influencing both proximal poly(A) site choice and exon skipping, as well as immunoglobulin heavy chain (IgH) alternative processing. Probably acts by regulating histone modifications accompanying transition from membrane-specific to secretory IgH mRNA expression.By similarity2 Publications

GO - Biological processi

Keywordsi

Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-6807505 RNA polymerase II transcribes snRNA genes

Names & Taxonomyi

Protein namesi
Recommended name:
RNA polymerase II elongation factor ELL2
Gene namesi
Name:Ell2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2183438 Ell2

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003229741 – 639RNA polymerase II elongation factor ELL2Add BLAST639

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei501PhosphoserineCombined sources1
Modified residuei579PhosphoserineBy similarity1

Post-translational modificationi

Ubiquitinated by SIAH1, leading to its degradation by the proteaseome. Interaction with AFF4 stabilizeS ELL2 and prevent ELL2 ubiquitination (By similarity).By similarity

Keywords - PTMi

Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbiQ3UKU1
PRIDEiQ3UKU1

PTM databases

iPTMnetiQ3UKU1
PhosphoSitePlusiQ3UKU1

Expressioni

Gene expression databases

BgeeiENSMUSG00000001542 Expressed in 292 organ(s), highest expression level in blood
CleanExiMM_ELL2
ExpressionAtlasiQ3UKU1 baseline and differential
GenevisibleiQ3UKU1 MM

Interactioni

Subunit structurei

Component of the super elongation complex (SEC), at least composed of EAF1, EAF2, CDK9, MLLT3/AF9, AFF (AFF1 or AFF4), the P-TEFb complex and ELL (ELL, ELL2 or ELL3). Component of the little elongation complex (LEC), at least composed of ELL (ELL, ELL2 or ELL3), ZC3H8, ICE1 and ICE2. Interacts with AFF4; the interaction is direct and leads to stabilize ELL2 and prevent ELL2 ubiquitination. Interacts with EAF1 and EAF2 (By similarity).By similarity

Protein-protein interaction databases

IntActiQ3UKU1, 1 interactor
STRINGi10090.ENSMUSP00000001583

Structurei

3D structure databases

ProteinModelPortaliQ3UKU1
SMRiQ3UKU1
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ELL/occludin family.Curated

Phylogenomic databases

eggNOGiKOG4796 Eukaryota
ENOG410ZNGU LUCA
GeneTreeiENSGT00550000074378
HOGENOMiHOG000112356
HOVERGENiHBG005578
InParanoidiQ3UKU1
KOiK15183
OMAiTIRKTHS
OrthoDBiEOG091G043D
TreeFamiTF326161

Family and domain databases

InterProiView protein in InterPro
IPR031176 ELL/occludin
IPR031179 ELL2
IPR019464 ELL_N
IPR010844 Occludin_ELL
IPR036390 WH_DNA-bd_sf
PANTHERiPTHR23288 PTHR23288, 1 hit
PTHR23288:SF8 PTHR23288:SF8, 1 hit
PfamiView protein in Pfam
PF10390 ELL, 1 hit
PF07303 Occludin_ELL, 1 hit
SUPFAMiSSF46785 SSF46785, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 5 potential isoforms that are computationally mapped.iShow all

Q3UKU1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAGGAAGLR EEQRYGLACG RLGQDNITVL HVKLTETAIR ALETYQSHKN
60 70 80 90 100
LIPFRPSIQF QGLQGLMKIP KNDPFNEVQN FNFYLSNVGR DNPQGSFDCI
110 120 130 140 150
QQTLSSSGAS QLNCLGFIQD KITVCATNDS YQMTRERMTQ AEEESRNRST
160 170 180 190 200
KVIKPGGPYV GKRVQIRKAP QAISDTVPER KRSTPMNPAN TIRKMHSGNS
210 220 230 240 250
VSQRPYRDRV IHLLALKAYK KPELLARLQK DGVNQKDKNS LGAILQQVAN
260 270 280 290 300
LNPKDLSYTL KDYVFKELQR DWPGYSETDR QTLDLVLSRK LNPSQNASTS
310 320 330 340 350
RSESPLCSSK DAASSPQKRP LDSDFIDPLM NKKARISHLT NRVPPTLNGY
360 370 380 390 400
LNPTSEKSCA GLLPPPAAAA IPTLSPLPST HLPVSNPPQT VNSNSNSPST
410 420 430 440 450
PEGLGTQDLP VDSFSQNGSI FEDQQEKYTS RTCLETLPPS SALLKCPKPM
460 470 480 490 500
EEEHPVSHKK SKKKSKKHKE KDQIKKLDIE TMEEKEEDLQ REETAKLSNA
510 520 530 540 550
SPNPNEGVKE GCTASMEPSS ALELPDYLIK YIAIVSYEQR QNYKDDFNAE
560 570 580 590 600
YDEYRALHAR METVARRFIK LDAQRKRLSP GSKEYQNVHE EVLQEYQKIK
610 620 630
QSSPNYHEEK YRCEYLHNKL AHIKRLIGEF DQQQAESWH
Length:639
Mass (Da):72,125
Last modified:July 27, 2011 - v2
Checksum:iD97846C943AC12FB
GO

Computationally mapped potential isoform sequencesi

There are 5 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1Y7VLE0A0A1Y7VLE0_MOUSE
RNA polymerase II elongation factor...
Ell2
172Annotation score:
A0A1Y7VNQ8A0A1Y7VNQ8_MOUSE
RNA polymerase II elongation factor...
Ell2
111Annotation score:
A0A1Y7VMV7A0A1Y7VMV7_MOUSE
RNA polymerase II elongation factor...
Ell2
169Annotation score:
A0A1Y7VKD2A0A1Y7VKD2_MOUSE
RNA polymerase II elongation factor...
Ell2
90Annotation score:
A0A1Y7VIP4A0A1Y7VIP4_MOUSE
RNA polymerase II elongation factor...
Ell2
181Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti286V → E in BAE26710 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK145868 mRNA Translation: BAE26710.1
CT025556 Genomic DNA No translation available.
CCDSiCCDS36734.1
RefSeqiNP_620403.2, NM_138953.2
UniGeneiMm.21288

Genome annotation databases

EnsembliENSMUST00000001583; ENSMUSP00000001583; ENSMUSG00000001542
GeneIDi192657
KEGGimmu:192657
UCSCiuc007rfu.1 mouse

Similar proteinsi

Entry informationi

Entry nameiELL2_MOUSE
AccessioniPrimary (citable) accession number: Q3UKU1
Secondary accession number(s): E9QPE1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 18, 2008
Last sequence update: July 27, 2011
Last modified: September 12, 2018
This is version 87 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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